Association of light physical activity measured by accelerometry and incidence of coronary heart disease and cardiovascular disease in older women

LaCroix, Andrea Z.; Bellettiere, John; Rillamas-Sun, Eileen; Di, Chongzhi; Evenson, Kelly R.; Lewis, Cora E.; Buchner, David M.; Stefanick, Marcia L.; Lee, I-Min; Rosenberg, Dori E.; LaMonte, Michael J.; for the Women’s Health Initiative (WHI)

doi:10.1001/jamanetworkopen.2019.0419

Cited by 162Physical Activity and HealthCardiovascular Health and Risk FactorsCardiovascular and exercise physiology

Association of light physical activity measured by accelerometry and incidence of coronary heart disease and cardiovascular disease in older women

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LaCroix, Andrea Z., Bellettiere, John, Rillamas-Sun, Eileen, Di, Chongzhi, Evenson, Kelly R., Lewis, Cora E., Buchner, David M., Stefanick, Marcia L. +4 more·2019·JAMA Network Open

DOI 10.1001/jamanetworkopen.2019.0419PMC PMC6484645

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Abstract

Importance: To our knowledge, no studies have examined light physical activity (PA) measured by accelerometry and heart disease in older women. Objective: To investigate whether higher levels of light PA were associated with reduced risks of coronary heart disease (CHD) or cardiovascular disease (CVD) in older women. Design, Setting, and Participants: Prospective cohort study of older women from baseline (March 2012 to April 2014) through February 28, 2017, for up to 4.91 years. The setting was community-dwelling participants from the Women's Health Initiative. Participants were ambulatory women with no history of myocardial infarction or stroke. Exposures: Data from accelerometers worn for a requested 7 days were used to measure light PA. Main Outcomes and Measures: Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% CIs for physician-adjudicated CHD and CVD events across light PA quartiles adjusting for possible confounders. Light PA was also analyzed as a continuous variable with and without adjustment for moderate to vigorous PA (MVPA). Results: Among 5861 women (mean [SD] age, 78.5 [6.7] years), 143 CHD events and 570 CVD events were observed. The HRs for CHD in the highest vs lowest quartiles of light PA were 0.42 (95% CI, 0.25-0.70; P for trend <.001) adjusted for age and race/ethnicity and 0.58 (95% CI, 0.34-0.99; P for trend = .004) after additional adjustment for education, current smoking, alcohol consumption, physical functioning, comorbidity, and self-rated health. Corresponding HRs for CVD in the highest vs lowest quartiles of light PA were 0.63 (95% CI, 0.49-0.81; P for trend <.001) and 0.78 (95% CI, 0.60-1.00; P for trend = .004). The HRs for a 1-hour/day increment in light PA after additional adjustment for MVPA were 0.86 (95% CI, 0.73-1.00; P for trend = .05) for CHD and 0.92 (95% CI, 0.85-0.99; P for trend = .03) for CVD. Conclusions and Relevance: The present findings support the conclusion that all movement counts for the prevention of CHD and CVD in older women. Large, pragmatic randomized trials are needed to test whether increasing light PA among older women reduces cardiovascular risk.

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The existing evidence regarding associations between light-intensity physical activity and risks for developing cardiovascular events in the general population is conflicting.
“The existing evidence regarding associations between LPA and risks for developing cardiovascular events in the general population is conflicting.13, 14, 15, 16”
From Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes (2025) · cites this paper as [13]
The Discussion reports inconsistent previous findings on light physical activity and cardiovascular mortality, which supports the claim that some cardiovascular evidence was conflicting. But the Introduction says no studies had yet evaluated light physical activity and incident CHD or CVD in adults overall. The paper therefore does not support describing evidence about *developing cardiovascular events* in the general population as conflicting. (LLM, conf=0.86)
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Lin, H., Sardana, M., Zhang, Y., Liu, C., Trinquart, L., Benjamin, E. J., Manders, E. S., Fusco, K., Kornej, J., Hammond, M. M., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317578 · Cited by 67 · see citing works
Effectiveness of a Text-Based Gamification Intervention to Improve Physical Activity Among Postpartum Individuals With Hypertensive Disorders of Pregnancy: A Randomized Clinical Trial.
Lewey, J., Murphy, S., Zhang, D.-Z., Putt, M., Elovitz, M., Riis, V. M., Patel, M. S., & Levine, L. (2022) · JAMA cardiology · doi:10.1001/jamacardio.2022.0553 · Cited by 61 · see citing works
Short Physical Performance Battery and Incident Cardiovascular Events Among Older Women
Bellettiere, J., LaMonte, M. J., Unkart, J., Liles, S., Laddu, D., Manson, J. E., Banack, H. R., Seguin‐Fowler, R. A., Chavez, P., Tinker, L. F., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016845 · Cited by 62 · see citing works
Accelerometry-assessed physical activity and sedentary time and associations with chronic disease and hospital visits – a prospective cohort study with 15 years follow-up
Dohrn, I.-M., Welmer, A.-K., & Hagströmer, M. (2019) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-019-0878-2 · Cited by 57 · see citing works
“[11], we did not find associations between light-intensity PA and risk of being diagnosed with a chronic disease.”
Background
Association of daily composition of physical activity and sedentary behaviour with incidence of cardiovascular disease in older adults
Yerramalla, M. S., McGregor, D., van Hees, V. T., Fayossé, A., Dugravot, A., Tabák, Á. G., Chen, M., CHASTIN, S. F. M., & Sabia, S. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01157-0 · Cited by 59 · see citing works
“Most prospective studies using objective measures have not accounted for this co-dependency and treated SB [19, 20], LIPA [11, 20, 22] and MVPA [3, 20] as independent behaviours.”
Background
Wearable Technology To Reduce Sedentary Behavior And CVD Risk In Older Adults: A Pilot Randomized Clinical Trial
Roberts, L. M., Jaeger, B. C., Baptista, L. C. P., Harper, S. A., Gardner, A. K., Jackson, E. A., Pekmezi, D., Sandesara, B. D., Manini, T. M., Anton, S. D., et al. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s222655 · Cited by 56 · see citing works
“Conclusion: The addition of wearable technology intervention appeared to positively influence daily activity patterns and changes in blood pressure – potentially improving risk factors for CVD.”
BackgroundInfluential
Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women?
Vaccarezza, M., Papa, V., Milani, D., Gonelli, A., Secchiero, P., Zauli, G., Gemmati, D., & Tisato, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041477 · Cited by 53 · see citing works
Dose–Response Association Between Accelerometer-Assessed Physical Activity and Incidence of Functional Disability in Older Japanese Adults: A 6-Year Prospective Study
Chen, T., Honda, T., Chen, S., Narazaki, K., & Kumagai, S. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa046 · Cited by 51 · see citing works
“Recent prospective evidence has linked accelerometer-measured LPA with all-cause mortality (6,34,35) and incidence of cardiovascular diseases (36) in older adults.”
Background
Association of accelerometer-measured physical activity and sedentary behavior with incident cardiovascular disease, myocardial infarction, and ischemic stroke: The women's health study
Peter‐Marske, K. M., Evenson, K. R., Moore, C. C., Cuthbertson, C. C., Howard, A. G., Shiroma, E. J., Buring, J. E., & Lee, I. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.028180 · Cited by 50 · see citing works
“Good 3520 (22) 1318 (33) 943 (24) 698 (17) 561 (14)”
Effect of Gamification With and Without Financial Incentives to Increase Physical Activity Among Veterans Classified as Having Obesity or Overweight
Agarwal, A., Waddell, K. J., Small, D. S., Evans, C. N., Harrington, T. O., Djaraher, R., Oon, A. L., & Patel, M. S. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.16256 · Cited by 45 · see citing works
Associations of Daily Steps and Step Intensity With Incident Diabetes in a Prospective Cohort Study of Older Women: The OPACH Study
Garduno, A. C., LaCroix, A. Z., LaMonte, M. J., Dunstan, D. W., Evenson, K. R., Wang, G., Di, C., Schumacher, B. T., & Bellettiere, J. (2022) · Diabetes Care · doi:10.2337/dc21-1202 · Cited by 48 · see citing works
What is the best diet for cardiovascular wellness? A comparison of different nutritional models
Migliaccio, S., Brasacchio, C., Pivari, F., Salzano, C., Barrea, L., Muscogiuri, G., Savastano, S., Colao, A., & on behalf of Obesity Programs of nutrition, E. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0018-0 · Cited by 39 · see citing works
Cardiovascular disease risk and all-cause mortality associated with accelerometer-measured physical activity and sedentary time ‒ a prospective population-based study in older adults
Länsitie, M., Kangas, M., Jokelainen, J. J., Venojärvi, M., Timonen, M., Keinänen-Kiukaanniemi, S., & Korpelainen, R. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03414-8 · Cited by 43 · see citing works
“More time spent in moderate-to-vigorous physical activity (MVPA) [4, 5] as well as in light [6] and total PA [4, 5] has been associated with lower incidence of cardiovascular disease (CVD) in middle-aged and older adults.”
Background
Relationship Between Sarcopenia, Obesity, Osteoporosis, and Cardiometabolic Health Conditions and Physical Activity Levels in Korean Older Adults
Park, H., Jung, W., Kim, S.-W., & Lim, K. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.706259 · Cited by 36 · see citing works
Cardiometabolic disease in the older person: prediction and prevention for the generalist physician
Sinclair, A. J., & Abdelhafiz, A. H. (2020) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000193 · Cited by 34 · see citing works
Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management
Subramanian, V., Tucker, W. J., Peters, A. E., Upadhya, B., Kitzman, D. W., & Pandey, A. (2025) · Circulation Research · doi:10.1161/circresaha.125.325531 · Cited by 34 · see citing works
Resilience and CVD-protective Health Behaviors in Older Women: Examining Racial and Ethnic Differences in a Cross-Sectional Analysis of the Women’s Health Initiative
Springfield, S., Qin, F., Hedlin, H., Eaton, C., Rosal, M., Taylor, H., Staudinger, U., & Stefanick, M. (2020) · Nutrients · doi:10.3390/nu12072107 · Cited by 26 · see citing works
“Using the 2019 American Heart Association’s physical activity recommendation as a guide, we classified whether participants achieved ≥ 150 min of total physical activity per week [40], noting that even light-intensity exercise provides significant health benefits in older women [41,42].”
Method
Determinants of Sedentary Behaviour in Individuals with COPD: A Qualitative Exploration Guided by the Theoretical Domains Framework
Wshah, A., Selzler, A., Hill, K., Brooks, D., & Goldstein, R. S. (2020) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412555.2019.1708883 · Cited by 30 · see citing works
Accelerometer-Measured Physical Activity, Sedentary Time, and Heart Failure Risk in Women Aged 63 to 99 Years
LaMonte, M. J., LaCroix, A. Z., Nguyen, S., Evenson, K. R., Di, C., Stefanick, M. L., Hyde, E. T., Anuskiewicz, B., & Eaton, C. B. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2023.5692 · Cited by 29 · see citing works
Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer
Biswas, R. K., Ahmadi, M. N., Bauman, A. E., Milton, K. E., Koemel, N. A., & Stamatakis, E. A. (2025) · Nature Communications · doi:10.1038/s41467-025-63475-2 · Cited by 31 · see citing works
“Theprolongedtimesspent in lightintensity activity in this cohort, and the weak dose-response association we observed, are relatively consistentwithpriordevice-basedstudiesandmeta-analysesthathave examined light intensity 15,20,33,34 .”
Associations between physical function and device-based measures of physical activity and sedentary behavior patterns in older adults: moving beyond moderate-to-vigorous intensity physical activity
Walker, R. L., Greenwood-Hickman, M. A., Bellettiere, J., LaCroix, A. Z., Wing, D., Higgins, M., Richmire, K., Larson, E. B., Crane, P. K., & Rosenberg, D. E. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02163-4 · Cited by 28 · see citing works
“Emphasizing more standing [8] or light intensity physical activity [9] and reduced or broken up sedentary behavior [10] throughout the day could bring benefits of increased activity to a wider portion of the population, even without increases in MVPA [11].”
Background
Evaluation of Light Physical Activity Measured by Accelerometry and Mobility Disability During a 6-Year Follow-up in Older Women
Glass, N., Bellettiere, J., Jain, P., LaMonte, M. J., LaCroix, A. Z., & Initiative, W. H. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.0005 · Cited by 27 · see citing works
Examining the Dose–Response Relationship between Physical Activity and Health Outcomes
Wasfy, M. M., & Lee, I.-M. M. (2022) · NEJM Evidence · doi:10.1056/evidra2200190 · Cited by 26 · see citing works
A positive psychology-motivational interviewing program to promote physical activity in type 2 diabetes: The BEHOLD-16 pilot randomized trial
Huffman, J. C., Golden, J., Massey, C. N., Feig, E. H., Chung, W.-J., Millstein, R. A., Brown, L., Gianangelo, T., Healy, B. C., Wexler, D. J., et al. (2021) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.12.001 · Cited by 26 · see citing works
Testing the effectiveness of community-engaged citizen science to promote physical activity, foster healthier neighborhood environments, and advance health equity in vulnerable communities: The Steps for Change randomized controlled trial design and methods
King, A. C., Campero, M. I., Garcia, D. M., Blanco-Velazquez, I., Banchoff, A., Fierros, F., Escobar, M., Cortes, A. L., Sheats, J. L., Hua, J., et al. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106526 · Cited by 26 · see citing works
Contributions of the Women’s Health Initiative to Cardiovascular Research
LaMonte, M. J., Manson, J. E., Anderson, G. L., Baker, L. D., Bea, J. W., Eaton, C. B., Follis, S., Hayden, K. M., Kooperberg, C. L., LaCroix, A. Z., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.05.016 · Cited by 27 · see citing works
Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review
Liang, Y., Wang, C. I., & Hsiao, C. K. (2024) · Journal of Medical Internet Research · doi:10.2196/59497 · Cited by 25 · see citing works
Testing the Implementation of Function-focused Care in Assisted Living Settings
Resnick, B. M., Boltz, M. P., Galik, E. M., Fix, S., Holmes, S., Zhu, S., & Barr, E. J. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.09.026 · Cited by 24 · see citing works
Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes
Liang, Y. Y., He, Y., Huang, P., Feng, H., Li, H., Ai, S., Du, J., Xue, H., Liu, Y., Zhang, J., et al. (2025) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.100973 · Cited by 23 · see citing works
“13 (cid:2) 16 Adults with metabolic syndromes are more likely to spend their time in LPA or sedentary behavior (SB) compared to the general population.”
Association between Objective Activity Intensity and Heart Rate Variability: Cardiovascular Disease Risk Factor Mediation (CARDIA)
Pope, Z., Gabriel, K. P., Whitaker, K. M., Chen, L. Y., Schreiner, P. J., Jacobs, D. R., Sternfeld, B., Carr, J. J., Lloyd‐Jones, D. M., & Pereira, M. A. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002259 · Cited by 23 · see citing works
Cannabis use, sedentary behavior, and physical activity in a nationally representative sample of US adults
Ong, L. Q., Bellettiere, J., Alvarado, C., Chavez, P., & Berardi, V. (2021) · Harm Reduction Journal · doi:10.1186/s12954-021-00496-2 · Cited by 25 · see citing works
Cohort profile: the Women’s Health Accelerometry Collaboration
Evenson, K. R., Bellettiere, J., Cuthbertson, C. C., Di, C., Dushkes, R., Howard, A. G., Parada, H., Schumacher, B. T., Shiroma, E. J., Wang, G., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-052038 · Cited by 22 · see citing works
Longitudinal Changes in Physical Activity during Pregnancy: National Institute of Child Health and Human Development Fetal Growth Studies
Mitro, S. D., Peddada, S., Gleason, J. L., HE, D., Whitcomb, B. W., Russo, L. M., Grewal, J., Zhang, C., Yisahak, S. F., Hinkle, S. N., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002947 · Cited by 22 · see citing works
“This may be because exercise interventions can be easily assigned in trials; because of evidence that moderate/vigorous activity has greater cardiovascular benefits than light activity (47); or because activities like commuting, childcare, and walking at work are not thought to affect health (despite evidence of poten…”
Background
Modeling the cardiometabolic benefits of sleep in older women: exploring the 24-hour day
Full, K. M., Gallo, L. C., Malhotra, A., Bellettiere, J., Kerr, J., Arredondo, E. M., Stone, K. L., Zaslavsky, O., Lewis, C. E., Lin, X., et al. (2019) · SLEEP · doi:10.1093/sleep/zsz205 · Cited by 19 · see citing works
Accelerometer‐Derived Daily Life Movement Classified by Machine Learning and Incidence of Cardiovascular Disease in Older Women: The OPACH Study
Nguyen, S., Bellettiere, J., Wang, G., Di, C., Natarajan, L., LaMonte, M. J., & LaCroix, A. Z. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023433 · Cited by 20 · see citing works
Diurnal patterns of sedentary behavior and changes in physical function over time among older women: a prospective cohort study
Reuter, C., Bellettiere, J., Liles, S., Di, C., Sears, D. D., LaMonte, M. J., Stefanick, M. L., LaCroix, A. Z., & Natarajan, L. (2020) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-00992-x · Cited by 20 · see citing works
Physical Activity, Fitness, and Cardiovascular Health
Bradley, S. M., Michos, E. D., & Miedema, M. D. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.8343 · Cited by 19 · see citing works
Physical activity and sedentary time in a rural adult population in Malawi compared with an age-matched US urban population
Pratt, M., Sallis, J. F., Cain, K. L., Conway, T. L., Palacios-López, A., Zezza, A., Spoon, C., Geremia, C. M., Gaddis, I., Amankwah, A., et al. (2020) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2020-000812 · Cited by 17 · see citing works
Physical Activity in the Treatment and Prevention of Heart Failure: An Update
LaMonte, M. J., & Eaton, C. B. (2021) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000869 · Cited by 18 · see citing works
Isotemporal Substitution of Sedentary Behavior With Moderate to Vigorous Physical Activity Is Associated With Lower Risk of Disability: A Prospective Longitudinal Cohort Study
Chiba, I., Lee, S., Bae, S., Makino, K., Shinkai, Y., Katayama, O., Harada, K., Yamashiro, Y., Takayanagi, N., & Shimada, H. (2022) · Physical Therapy · doi:10.1093/ptj/pzac002 · Cited by 17 · see citing works
Accelerometer-measured light-intensity physical activity and the risk of cardiovascular disease or death in older adults: A meta-analysis
Xie, B., Cai, X., Zhu, Y., Sun, Z., Qiu, S., & Wu, T. (2022) · Kardiologia Polska · doi:10.33963/kp.a2022.0120 · Cited by 17 · see citing works
Daily and hourly patterns of physical activity and sedentary behavior of older adults: Atherosclerosis risk in communities (ARIC) study
Dooley, E. E., Pompeii, L. A., Palta, P., Martínez-Amezcua, P., Hornikel, B., Evenson, K. R., Schrack, J. A., & Gabriel, K. P. (2022) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2022.101859 · Cited by 17 · see citing works
Compositional association of 24‐h movement behavior with incident major adverse cardiac events and all‐cause mortality
Niemelä, M., Kiviniemi, A. M., Ikäheimo, T. M., Tulppo, M. P., Korpelainen, R., Jämsä, T. J., & Farrahi, V. (2023) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14315 · Cited by 16 · see citing works
Revisiting the association of sedentary behavior and physical activity with all-cause mortality using a compositional approach: the Women's Health Study
Migueles, J. H., Lee, I.-M. M., Cadenas‐Sánchez, C., Ortega, F. B., Buring, J. E., & Shiroma, E. J. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01173-0 · Cited by 17 · see citing works
“Recent studies have shown that LPA and SB are independently associated with health [2, 3].”
BackgroundResultInfluential
Recent Trends in Adherence of Physical Activity and Sedentary Behavior—We Need to Move More and Sit Less
Piercy, K. L. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.7575 · Cited by 16 · see citing works
Associations between Intensity, Frequency, Duration, and Volume of Physical Activity and the Risk of Stroke in Middle- and Older-Aged Chinese People: A Cross-Sectional Study
Yang, D., Bian, Y., Zeng, Z., Cui, Y., Wang, Y., & Yu, C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17228628 · Cited by 15 · see citing works
“Several previous studies have supported our results [12,41,42].”
Result
A Digital Lifestyle Coach (E-Supporter 1.0) to Support People With Type 2 Diabetes: Participatory Development Study
Hietbrink, E. A. G., Middelweerd, A., van Empelen, P., Preuhs, K., Konijnendijk, A., Nijeweme-d’Hollosy, W. O., Schrijver, L. K., Laverman, G. D., & Vollenbroek-Hutten, M. M. R. (2023) · JMIR Human Factors · doi:10.2196/40017 · Cited by 14 · see citing works
Community-Dwelling Older Adults and Physical Activity Recommendations: Patterns of Aerobic, Strengthening, and Balance Activities
Wingood, M., Bonnell, L. N., LaCroix, A. Z., Rosenberg, D. E., Walker, R. L., Bellettiere, J., Greenwood-Hickman, M. A., Wing, D., & Gell, N. (2021) · Journal of Aging and Physical Activity · doi:10.1123/japa.2021-0194 · Cited by 14 · see citing works
Reallocating time from device-measured sleep, sedentary behaviour or light physical activity to moderate-to-vigorous physical activity is associated with lower cardiovascular disease risk
Walmsley, R., Chan, S., Smith-Byrne, K., Ramakrishnan, R., Woodward, M., Rahimi, K., Dwyer, T., Bennett, D., & Doherty, A. (2020) · doi:10.1101/2020.11.10.20227769 · Cited by 12 · see citing works
Device-Measured Physical Activity and Sedentary Behavior in Relation to Cardiovascular Diseases and All-Cause Mortality: Systematic Review and Meta-Analysis of Prospective Cohort Studies
Liew, S. J., Petrunoff, N., Neelakantan, N., van Dam, R. M., & Müller‐Riemenschneider, F. (2022) · AJPM Focus · doi:10.1016/j.focus.2022.100054 · Cited by 14 · see citing works
COVID-19: Insights into long-term manifestations and lockdown impacts
Hilbold, E. A., Bär, C., & Thum, T. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.02.006 · Cited by 14 · see citing works
Physical activity, well-being, and priorities of older women during the COVID-19 pandemic: a survey of Women’s Health Initiative Strong and Healthy (WHISH) intervention participants
Wegner, L., Mendoza-Vasconez, A. S., Mackey, S., McGuire, V. M., To, C., White, B., King, A. C., & Stefanick, M. L. (2021) · Translational Behavioral Medicine · doi:10.1093/tbm/ibab122 · Cited by 13 · see citing works
Objectively Measured Physical Activity Levels and Associated Factors in Older US Women During the COVID-19 Pandemic: Cross-sectional Study
Choudhury, R., Park, J., Thiamwong, L., Xie, R., & Stout, J. R. (2022) · JMIR Aging · doi:10.2196/38172 · Cited by 12 · see citing works
Ecological Momentary Assessment of Associations Between Social Interactions and Physical Activity Outcomes Among Women in Midlife With CVD Risk Conditions
Arigo, D., Brown, M. M., Shank, F., & Young, C. M. (2022) · Annals of Behavioral Medicine · doi:10.1093/abm/kaac031 · Cited by 12 · see citing works
Associations of Wearable Ring Measured Sleep, Sedentary Time, and Physical Activity With Cardiometabolic Health: A Compositional Data Analysis Approach
Niemelä, M., Maijala, A., Nauha, L., Jämsä, T. J., Korpelainen, R., & Farrahi, V. (2024) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14710 · Cited by 11 · see citing works
“Previous studies have mainly investigated separate associations between one or few movement behaviors, cardiometabolic health, and disease risk and failed to fully account for time spent in all other behaviors [2, 4, 6, 7, 9].”
Association of dog ownership with accelerometer-measured physical activity and daily steps in 70-year-old individuals: a population-based cross-sectional study
Ballin, M., Antonsson, O., Rosenqvist, V., Nordström, P., & Nordström, A. (2021) · BMC Public Health · doi:10.1186/s12889-021-12401-4 · Cited by 13 · see citing works
“Other studies in older adults have observed beneficial associations between LPA and subjective wellbeing [33, 34], metabolic syndrome [26], mobility disability [35], and cardiovascular disease [8, 9].”
Background
Women's Health Initiative Strong and Healthy (WHISH): A pragmatic physical activity intervention trial for cardiovascular disease prevention
Stefanick, M. L., Kooperberg, C. L., & LaCroix, A. Z. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.106815 · Cited by 11 · see citing works
Association between cardiac autonomic function and physical activity in patients at high risk of sudden cardiac death: a cohort study
Sun, X., Zhao, S., Chen, K., Hua, W., Su, Y., Liu, X., Xu, W., Wang, F., Fan, X., Dai, Y., et al. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01200-0 · Cited by 11 · see citing works
Associations Among Physical Activity Level and Skeletal Muscle Antioxidants in Older Adults
Timmerman, K. L., Ballard, K. D., Deal, M. A., Tagariello, L. C., Karrow, J. M., Volk, G. A., Meisler, A. J., Connors, I. D., & Mott, R. E. (2020) · Journal of Physical Activity and Health · doi:10.1123/jpah.2020-0082 · Cited by 10 · see citing works
Reliability and Validity of the Function-Focused Care Checklist for Caregivers
Resnick, B. M., Boltz, M. P., & Galik, E. M. (2020) · Rehabilitation Nursing · doi:10.1097/rnj.0000000000000294 · Cited by 10 · see citing works
“One effective way to increase older adults’ participation in function and physical activity is through implementation of a function-focused philosophy of care (Lee et al., 2019; Resnick et al., 2013).”
Background
Reallocating just 10 min to moderate-to-vigorous physical activity from other components of 24-hour movement behaviors improves cardiovascular health in adults
Ji, Y., ATAKAN, M. M., Yan, X., Wu, J., Kuang, J., & Peng, L. (2024) · BMC Public Health · doi:10.1186/s12889-024-19255-6 · Cited by 9 · see citing works
“It is worth noting that for the elderly, engaging in LPA yields comparatively greater advantages when reallocating equivalent time from SB [19, 49], which may result in disparities in findings.”
Background
DIET AND LIFESTYLE GUIDELINES AND DESIRABLE LEVELS OF RISK FACTORS AND PROTECTIVE FACTORS FOR PREVENTION OF DEMENTIA: A SCIENTIFIC STATE-MENT FROM JOINT SYMPOSIUM OF JAAS AND APCNS
Watanabe, S. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.17.003006 · Cited by 9 · see citing works
“The prevalence of dementia continues to increase worldwide, although incidence in the western world may have declined on account of better management of CVDs and improvement in diet and lifestyle, at least among higher social classes, leading to improvement in neuronal health [70].”
BackgroundInfluential
Beetroot supplementation in women enjoying exercise together (BEE SWEET): Rationale, design and methods
Baranauskas, M. N., Altherr, C. A., Gruber, A. H., Coggan, A. R., Raglin, J. S., Gupta, S. K., & Carter, S. J. (2020) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2020.100693 · Cited by 8 · see citing works
Cardiovascular risk and functional burden at midlife: Prospective associations of isotemporal reallocations of accelerometer-measured physical activity and sedentary time in the CARDIA study
Full, K. M., Whitaker, K. M., Gabriel, K. P., Lewis, C. E., Sternfeld, B., Sidney, S., Reis, J. P., Jacobs, D. R., Gibbs, B. B., & Schreiner, P. J. (2021) · Preventive Medicine · doi:10.1016/j.ypmed.2021.106626 · Cited by 8 · see citing works
Knowledge, Attitudes, and Practices Among Elderly CHD Patients Towards Self-Perceived Health Abilities
Ren, L., Li, Z., Wu, J. W., Duan, L., & Gao, J. (2024) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s463043 · Cited by 8 · see citing works
“5–7 Following a CHD diagnosis, the abilities encompass adherence to routine health check-ups, medications (such as statins, antiplatelet agents, and beta-blockers), and participation in cardiac rehabilitation.”
Background
The association of physical activity fragmentation with all-cause mortality in Hispanics: a prospective cohort study
Mediano, M. F. F., Mok, Y., Ballew, S. H., Gonzalez, F., Sotres‐Alvarez, D., Mossavar‐Rahmani, Y., Kaplan, R. C., Carlson, J., Alver, S., Daviglus, M. L., et al. (2025) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2025.100996 · Cited by 8 · see citing works
Reported and Device-Based Physical Activity By Race/Ethnic Groups in Young-Old Women
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Abstract 042: Accelerometer-measured Light Physical Activity is Heart Healthy in Older Women: The OPACH Study
LaCroix, A. Z., Bellettiere, J., Rillamas‐Sun, E., Evenson, K. R., Di, C., Büchner, D. M., Stefanick, M. L., Lee, I.-M. M., Lewis, C. E., & LaMonte, M. J. (2018) · Circulation · doi:10.1161/circ.137.suppl_1.042
Light Physical Activity and Incident Coronary Heart Disease and Cardiovascular Disease Among Older Women—A Call for Action
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Both light intensity and moderate-to-vigorous physical activity measured by accelerometry are favorably associated with cardiometabolic risk factors in older women: the Objective Physical Activity and Cardiovascular Health (OPACH) Study
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Physical Activity and Coronary Heart Disease in Women
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Authors: LaCroix, A. Z., Bellettiere, J., Rillamas-Sun, E., Di, C., Evenson, K. R., Lewis, C. E., Buchner, D. M., Stefanick, M. L., Lee, I.-M., Rosenberg, D. E., LaMonte, M. J., & (WHI), F. T. W. H. I.
Affiliations: University of California San Diego (US)
San Diego State University (US)
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
Fred Hutch Cancer Center (US)
University of North Carolina at Chapel Hill (US)
University of Alabama at Birmingham (US)
University of Illinois at Urbana-Champaign, Champaign
Stanford Medicine (US)
Brigham and Women's Hospital (US)
Kaiser Permanente Washington Health Research Institute (US)
University at Buffalo, State University of New York (US)
Corresponding author: LaCroix, Andrea Z.
ORCID: LaCroix, Andrea Z.
Bellettiere, John
Di, Chongzhi
Evenson, Kelly R.
Lewis, Cora E.
Stefanick, Marcia L.
Lee, I-Min
Rosenberg, Dori E.
LaMonte, Michael J.
Venue: JAMA Network Open
Publisher: American Medical Association (AMA)
Published: 2019-03-15
Volume: 2
Issue: 3
Pages: e190419
ISSN: 2574-3805 (ISSN-L)
DOI: 10.1001/jamanetworkopen.2019.0419
PMC: PMC6484645
OpenAlex: W2921167015
Cited by: 162
References: 43
Citations by year: 2026: 10 · 2025: 18 · 2024: 22 · 2023: 15 · 2022: 27 · 2021: 30 · 2020: 28 · 2019: 11
FWCI: 16.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: JAMA Network Open (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UA Campus Repository (The University of Arizona) (acceptedVersion, cc-by)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: U.S. Department of Health and Human Services
Women's Health Initiative
National Institutes of Health
National Heart, Lung, and Blood Institute (HHSN268201600018C, HHSN268201600004C, HHSN268201600001C, HHSN268201600003C, HHSN268201600002C, R01HL130483, T32HL079891)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
Topics: Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: light physical activity, accelerometry, coronary artery disease, cardiovascular disease, older women, moderate-to-vigorous physical activity, heart disease risk, Women's Health Initiative, community-dwelling women, physical activity measurement
MeSH terms: Aged, Cardiovascular Diseases, Coronary Disease, Female, Humans, Prospective Studies, Risk Factors, United States, Cohort Studies, Exercise, Proportional Hazards Models, Risk Reduction Behavior, Independent Living, Accelerometry

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Association of light physical activity measured by accelerometry and incidence of coronary heart disease and cardiovascular disease in older women

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