Cited by 744Dementia and Cognitive Impairment ResearchSleep and related disordersSleep and Wakefulness Research

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Sleep Quality and Preclinical Alzheimer Disease

Open access

Ju, Yo-El S., McLeland, Jennifer S., Toedebusch, Cristina D., Xiong, Chengjie, Fagan, Anne M., Duntley, Stephen P., Morris, John C., Holtzman, David M.·2013·JAMA Neurology

DOI 10.1001/jamaneurol.2013.2334PMC PMC3676720

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Sleep and circadian problems are very common in Alzheimer disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid (Aβ), a key molecule involved in AD pathogenesis. OBJECTIVE: To test whether Aβ deposition in preclinical AD, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep. DESIGN: Cross-sectional study conducted from October 2010 to June 2012. SETTING: General community volunteers at the Washington University Knight Alzheimer's Disease Research Center. PARTICIPANTS: Cognitively normal individuals (n = 145) 45 years and older were recruited from longitudinal studies of memory and aging at the Washington University Knight Alzheimer's Disease Research Center. Valid actigraphy data were recorded in 142. The majority (124 of 142) were recruited from the Adult Children Study, in which all were aged 45 to 75 years at baseline and 50% have a parental history of late-onset AD. The rest were recruited from a community volunteer cohort in which all were older than 60 years and healthy at baseline. MAIN OUTCOME MEASURES: Sleep was objectively measured using actigraphy for 2 weeks. Sleep efficiency, which is the percentage of time in bed spent asleep, was the primary measure of sleep quality. Total sleep time was the primary measure of sleep quantity. Cerebrospinal fluid Aβ42 levels were used to determine whether amyloid deposition was present or absent. Concurrent sleep diaries provided nap information. RESULTS: Amyloid deposition, as assessed by Aβ42 levels, was present in 32 participants (22.5%). This group had worse sleep quality, as measured by sleep efficiency (80.4% vs 83.7%), compared with those without amyloid deposition, after correction for age, sex, and APOEε4 allele carrier status (P = .04). In contrast, quantity of sleep was not significantly different between groups, as measured by total sleep time. Frequent napping, 3 or more days per week, was associated with amyloid deposition (31.2% vs 14.7%; P = .03). CONCLUSIONS AND RELEVANCE: Amyloid deposition in the preclinical stage of AD appears to be associated with worse sleep quality but not with changes in sleep quantity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamaneurol.2013.2334

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 14×
“Studies of individuals with both amyloid deposition and evidence of neuronal injury such as elevated CSF tau levels—ie, stage 2 of preclinical AD8— will shed light on the interaction between sleep and pathological progression in AD.”
Influential
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Self-citation
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citation
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Self-citation
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Self-citation
Alzheimer’s Disease Neuroimaging Initiative
Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowski, J. Q., Toga, A. W., & Beckett, L. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-72076-0_18 · Cited by 1,493
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265
Self-citation
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ 42 in humans
Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246
Self-citation
Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137

Show all 39 references

Research works printed but not linked: 2

[12]Roh JH Huang Y Bero AW Sleep-wake cycle and diurnal fluctuation of amyloid-β as biomarkers of brain amyloid pathology. Science Translational Medicine 5 150 150ra122 PMC3654377 22956200
[20]Huang Y Potter R Sigurdson W Normal Amyloid-β Dynamics Decline with Age and Amyloid Deposition. Archives of Neurology In Press

Sorted by citations

Items 301–400 of 744

Effects of long sleep time and irregular sleep–wake rhythm on cognitive function in older people
Okuda, M., Noda, A., Iwamoto, K., Nakashima, H., Takeda, K., Miyata, S., Yasuma, F., Ozaki, N., & Shimouchi, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-85817-y · Cited by 32
Fractal motor activity regulation and sex differences in preclinical Alzheimer's disease pathology
Gao, L., Li, P., Gaba, A., Musiek, E. S., Ju, Y. S., & Hu, K. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12211 · Cited by 29
Self-citation
Alzheimer’s disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets
Marde, V. S., Atkare, U. A., Gawali, S. V., Tiwari, P. L., Badole, S. P., Wankhede, N. L., Taksande, B. G., Upaganlawar, A., Umekar, M. J., & Kale, M. B. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102961 · Cited by 29
The past, present, and future of sleep measurement in mild cognitive impairment and early dementia—towards a core outcome set: a scoping review
Blackman, J., Morrison, H. D., Lloyd, K., Gimson, A., Banerjee, L. V., Green, S. F., Cousins, R., Rudd, S., Harding, S. A., & Coulthard, E. J. (2022) · SLEEP · doi:10.1093/sleep/zsac077 · Cited by 26
A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis
Needham, H., Torpey, G., Flores, C. C., Davis, C. J., Vanderheyden, W. M., & Gerstner, J. R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.798994 · Cited by 29
The relationship between sleep and cognitive function in patients with prediabetes and type 2 diabetes
Saetung, S., Nimitphong, H., Siwasaranond, N., Sumritsopak, R., Jindahra, P., Krairit, O., Thakkinstian, A., Anothaisintawee, T., & Reutrakul, S. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1166-3 · Cited by 30
Sex and Sleep Disruption as Contributing Factors in Alzheimer’s Disease
Johnson, C. E., Duncan, M. J., & Murphy, M. P. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230527 · Cited by 34
Sleep features and long-term incident neurodegeneration: a polysomnographic study
Ibrahim, A., Cesari, M., Heidbreder, A., Defrancesco, M., Brandauer, E., Seppi, K., Kiechl, S. J., Högl, B., & Stefani, A. (2023) · SLEEP · doi:10.1093/sleep/zsad304 · Cited by 30
Interaction between the progression of Alzheimer's disease and fractal degradation
Li, P., Yu, L., Yang, J., Lo, M., Hu, C., Buchman, A. S., Bennett, D. A., & Hu, K. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.023 · Cited by 27
Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study
Brachem, C., Winkler, A., Tebrügge, S., Weimar, C., Erbel, R., Jöckel, K., Stang, A., Dragano, N., Moebus, S., Kowall, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63511-9 · Cited by 31
Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer's disease
Jorge, C., Targa, A., Benitez, I. D., Dakterzada, F., Torres, G., Mínguez, O., Carnes, A., Pujol, M., Gibert, A., Ortega, R. L., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00523-2020 · Cited by 27
The role of sleep disturbances in cognitive function and depressive symptoms among community‐dwelling elderly with sleep complaints
Ji, X., & Fu, Y. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5401 · Cited by 29
Memory-relevant nap sleep physiology in healthy and pathological aging
Ladenbauer, J., Ladenbauer, J., Külzow, N., & Flöel, A. (2021) · SLEEP · doi:10.1093/sleep/zsab002 · Cited by 28
Exploring the bi-directional relationship between sleep and beta-amyloid
Brown, B. M., Rainey‐Smith, S. R., Bucks, R. S., Weinborn, M., & Martins, R. N. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000285 · Cited by 31
Circadian Rhythm Neuropeptides in Drosophila: Signals for Normal Circadian Function and Circadian Neurodegenerative Disease
He, Q., Wu, B., Price, J. L., & Zhao, Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040886 · Cited by 28
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Constantino, N. J., Ashley, C. C., & Macauley, S. L. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70294 · Cited by 29
Aberrant Axonal Arborization of PDF Neurons Induced by Aβ42-Mediated JNK Activation Underlies Sleep Disturbance in an Alzheimer’s Model
Song, Q., Feng, G., Huang, Z., Chen, X., Chen, Z., & Ping, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0165-z · Cited by 26
Objective Daytime Napping is Associated with Disease Severity and Inflammation in Patients with Mild to Moderate Dementia1
Basta, M., Koutentaki, E., Vgontzas, A. N., Zaganas, I. V., Vogiatzi, E., Gouna, G., Bourbouli, M., Panagiotakis, S. H., Kapetanaki, S., Fernández‐Mendoza, J., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190483 · Cited by 26
Progressive Changes in Sleep and Its Relations to Amyloid-β Distribution and Learning in Single App Knock-In Mice
Maezono, S. E. B., Kanuka, M., Tatsuzawa, C., Morita, M., Kawano, T., Kashiwagi, M., Nondhalee, P., Sakaguchi, M., Saito, T., Saido, T. C., et al. (2020) · eNeuro · doi:10.1523/eneuro.0093-20.2020 · Cited by 30
The psychological consequences of (perceived) ionizing radiation exposure: a review on its role in radiation-induced cognitive dysfunction
Collett, G., Craenen, K., Young, W. R., Gilhooly, M., & Anderson, R. M. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1793017 · Cited by 32
Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
Resciniti, N. V., Yelverton, V., Kase, B. E., Zhang, J., & Lohman, M. C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010351 · Cited by 27
Towards early detection of neurodegenerative diseases: A gut feeling
Makdissi, S., Parsons, B., & Cara, F. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1087091 · Cited by 28
Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure
Alosco, M. L., Brickman, A. M., Spitznagel, M. B., Griffith, E. Y., Narkhede, A., Cohen, R. A., Sweet, L. H., Hughes, J. W., Rosneck, J., & Gunstad, J. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-42 · Cited by 26
Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases
Hafycz, J. M., & Naidoo, N. N. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00140 · Cited by 28
Subclinical Hearing Loss, Longer Sleep Duration, and Cardiometabolic Risk Factors in Japanese General Population
Nakajima, K., Kanda, E., Hosobuchi, A., & Suwa, K. (2014) · International Journal of Otolaryngology · doi:10.1155/2014/218218 · Cited by 25
Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer’s Disease: Insights From Preclinical Models, Clinical Data, and Future Directions
Clement, A., Wiborg, O., & Asuni, A. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00056 · Cited by 28
Poor sleep accelerates hippocampal and posterior cingulate volume loss in cognitively normal healthy older adults
Liu, C., Lee, S. H., Loewenstein, D., Galvin, J. E., Camargo, C. J., & Alperin, N. J. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13538 · Cited by 25
Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia
Orlando, I. F., O’Callaghan, C., Lam, A. K. F., McKinnon, A. C., Tan, J. B., Michaelian, J. C., Kong, S. D. X., D'Rozario, A. L., & Naismith, S. L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02335-1 · Cited by 25
Sleep and Attention in Alzheimer's Disease.
Hennawy, M., Sabovich, S., Liu, C. S., Herrmann, N., & Lanctôt, K. L. (2019) · Europe PMC (PubMed Central) · Cited by 24
Corticothalamic network dysfunction and Alzheimer’s disease
Jagirdar, R., & Chin, J. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.014 · Cited by 24
THE ALZHEIMER’S PREVENTION CLINIC AT WEILL CORNELL MEDICAL COLLEGE / NEW YORK - PRESBYTERIAN HOSPITAL: RISK STRATIFICATION AND PERSONALIZED EARLY INTERVENTION
Seifan, A., & Isaacson, R. (2015) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2015.81 · Cited by 25
The Discovery of Suvorexant: Lessons Learned That Can Be Applied to Other CNS Drug Development Efforts
Uslaner, J. M., Herring, W. J., & Coleman, P. J. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00110 · Cited by 23
Subjective cognitive decline and self‐reported sleep problems: The SCIENCe project
Exalto, L. G., Hendriksen, H. M. A., Barkhof, F., van den Bosch, K. A., Ebenau, J. L., van Leeuwenstijn‐Koopman, M., Prins, N. D., Teunissen, C. E., Visser, L. N. C., Scheltens, P., et al. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12287 · Cited by 24
Brain changes associated with sleep disruption in cognitively unimpaired older adults: A short review of neuroimaging studies
André, C., Lanièpce, A., Chételat, G., & Rauchs, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101252 · Cited by 30
Associations among sleep quality, sleep duration, and Alzheimer’s disease biomarkers: A systematic review and meta-analysis
Chen, C., Zhang, M., Wang, Z., Deng, J., Bao, Y., Shi, J., Lu, L., & Shi, L. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70096 · Cited by 24
Circadian rhythm disturbances in Alzheimer’s disease: insights from plaque-free and plaque-burdened stages in APPSWE/PS1dE9 mice
Yang, H., Niu, L., Tian, L., Hu, Y., Cheng, C., Li, S., & Le, W. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01724-8 · Cited by 23
The STOP-Bang and Berlin questionnaires to identify obstructive sleep apnoea in Alzheimer's disease patients
Jorge, C., Benitez, I. D., Torres, G., Dakterzada, F., Mínguez, O., Huerto, R. P., Pujol, M., Carnes, A., Gaeta, A. M., Dalmases, M., et al. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.01.033 · Cited by 22
Absence of Relationship Between Self-Reported Sleep Measures and Amyloid Load in Elderly Subjects
Gabelle, A., Gutierrez, L., Jaussent, I., Bouallègue, F. B., de Verbizier, D., Navucet, S., Grasselli, C., Bennys, K., Marelli, C., David, R., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00989 · Cited by 23
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Ba, L., Huang, L., He, Z., Deng, S., Xie, Y., Zhang, M., Jacob, C., Antonecchia, E., Liu, Y., Xiao, W., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.759983 · Cited by 27
Reduced slow-wave activity and autonomic dysfunction during sleep precede cognitive deficits in Alzheimer’s disease transgenic mice
Chen, C.-W., Kwok, Y., Cheng, Y., Huang, Y., Kuo, T. B. J., Wu, C.-H., Du, P.-J., Yang, A. C., & Yang, C. C. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-38214-6 · Cited by 27
A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer’s disease mouse model
Warfield, A. E., Gupta, P., Ruhmann, M. M., Jeffs, Q. L., Guidone, G. C., Rhymes, H. W., Thompson, M. I., & Todd, W. D. (2023) · Nature Communications · doi:10.1038/s41467-023-40546-w · Cited by 31
Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates
Shively, C. A., Agnès Lacreuse, A., Frye, B. M., Rothwell, E. S., & Moro, M. (2021) · American Journal of Primatology · doi:10.1002/ajp.23309 · Cited by 24
DA-JC1 improves learning and memory by antagonizing Aβ31–35-induced circadian rhythm disorder
Wang, L., Zhang, R., Hou, X., Wang, C., Guo, S., Ning, N., Sun, C., Yuan, Y., Li, L., Hölscher, C., et al. (2019) · Molecular Brain · doi:10.1186/s13041-019-0432-9 · Cited by 25
An Actigraphy-Based Validation Study of the Sleep Disorder Inventory in the Nursing Home
Hjetland, G. J., Nordhus, I. H., Pallesen, S., Cummings, J. L., Tractenberg, R. E., Thun, E., Kolberg, E., & Flo, E. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00173 · Cited by 25
Sleep profile predicts the cognitive decline of mild-moderate Alzheimer’s disease patients
Targa, A., Benitez, I. D., Dakterzada, F., Carnes, A., Pujol, M., Jorge, C., Mínguez, O., Dalmases, M., Sánchez‐de‐la‐Torre, M., Barbé, F., et al. (2021) · SLEEP · doi:10.1093/sleep/zsab117 · Cited by 23
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Ben-Nejma, I. R. H., Keliris, A., Vanreusel, V., Ponsaerts, P., der Linden, A. V., & Keliris, G. A. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01175-z · Cited by 24
Multi-Modal Home Sleep Monitoring in Older Adults
Toedebusch, C. D., McLeland, J., Schaibley, C., Banks, I. R., Boyd, J., Morris, J. C., Holtzman, D. M., & Lucey, B. P. (2019) · Journal of Visualized Experiments · doi:10.3791/58823 · Cited by 23
Self-citation
Effects of shift work on sleep and cognitive function among male miners
Zhao, X., Han, K., Gao, Y., Li, N., Wang, L., Yu, L., Song, M., & Wang, X. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113716 · Cited by 22
Beyond the sleep-amyloid interactions in Alzheimer’s disease pathogenesis
Ning, S., & Jorfi, M. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00118.2019 · Cited by 22
Falls Risk, Circadian Rhythms and Melatonin: Current Perspectives
Goswami, N., Abulafia, C., Vigo, D. E., Moser, M., Cornélissen, G., & Cardinali, D. P. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s283342 · Cited by 21
The Association of Insomnia with Depression and Anxiety Symptoms in Patients Undergoing Noncardiac Surgery
Huang, X. D., Wu, D., Wu, A., Wei, C.-W., & Jian-dong, G. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s296986 · Cited by 21
Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer’s Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant
Beuckmann, C. T., Suzuki, H., Musiek, E. S., Ueno, T., Sato, T., Bando, M., Osada, Y., & Moline, M. L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201054 · Cited by 21
Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer’s disease
Sadleir, K. R., & Vassar, R. J. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171838 · Cited by 22
Differential associations of age and Alzheimer's disease with sleep and rest-activity rhythms across the adult lifespan
Park, J. E., Lee, Y. J., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Hwang, J. Y., Yoon, H., Choe, Y. M., Kim, Y. K., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.006 · Cited by 21
Failure in a population: Tauopathy disrupts homeostatic set-points in emergent dynamics despite stability in the constituent neurons
McGregor, J. N., Farris, C. A., Ensley, S., Schneider, A. M., Fosque, L. J., Wang, C., Tilden, E. I., Liu, Y., Tu, J., Elmore, H., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.08.006 · Cited by 23
Self-citation
Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies
Choe, Y. M., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Sohn, B. K., Kim, Y. K., Shin, S. A., Sohn, C., Lee, Y. J., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0536-6 · Cited by 21
The pathway to secondary prevention of Alzheimer's disease
McDade, E., Bednar, M. M., Brashear, H. R., Miller, D. S., Maruff, P., Randolph, C., Ismail, Z., Carrillo, M. C., Weber, C. J., Bain, L. J., et al. (2020) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12069 · Cited by 20
Subjective Sleep Quality in Amnestic Mild Cognitive Impairment Elderly and Its Possible Relationship With Plasma Amyloid-β
Liu, Y., Chen, L., Huang, S., Zhang, C., Lv, Z., Luo, J., Shang, P., Wang, Y., & Xie, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.611432 · Cited by 20
Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies
Spira, A. P., Zipunnikov, V., Raman, R., Choi, J., Di, J., Bai, J., Carlsson, C. M., Mintzer, J. E., Marshall, G. A., Porsteinsson, A. P., et al. (2021) · SLEEP Advances · doi:10.1093/sleepadvances/zpab015 · Cited by 20
A New Perspective on the Treatment of Alzheimer’s Disease and Sleep Deprivation‐Related Consequences: Can Curcumin Help?
Akkol, E. K., Bardakçı, H., Yücel, Ç., Karatoprak, G. Ş., Karpuz, B., & Khan, H. Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6168199 · Cited by 22
The Dose and Duration-dependent Association between Melatonin Treatment and Overall Cognition in Alzheimer’s Dementia: A Network Meta- Analysis of Randomized Placebo-Controlled Trials
Shiue, Y., Tseng, P., Zeng, B., Chen, Y., Yang, C., Su, K., Chen, T., Wu, Y., Tu, Y., Lin, P., et al. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220420122322 · Cited by 21
Sleep structure assessed by objective measurement in patients with mild cognitive impairment: A meta-analysis
Wei, J., Wang, M., Guo, Y., Liu, Y., & Dong, X. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.12.010 · Cited by 21
Sleep disorders and cognitive alterations in women
Guarnieri, B. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.04.214 · Cited by 20
Mathematical Model Shows How Sleep May Affect Amyloid-β Fibrillization
Hoore, M., Khailaie, S., Montaseri, G., Mitra, T., & Meyer‐Hermann, M. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.07.011 · Cited by 22
Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease
Uddin, M. S., Sumsuzzman, D. M., Jeandet, P., Behl, T., Rauf, A., Amran, M. S., & Ashraf, G. M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03325-x · Cited by 23
Sleep Disturbance and Alzheimer’s Disease: The Glial Connection
Sunkaria, A., & Bhardwaj, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03578-0 · Cited by 19
Sleep-Related Changes Prior to Cognitive Dysfunction
Pérez‐Carbonell, L., & Iranzo, Á. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01258-2 · Cited by 20
The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health
Ibrahim, A., Högl, B., & Stefani, A. (2024) · Clinical and Translational Neuroscience · doi:10.3390/ctn8010011 · Cited by 19
Sleep duration, sleep efficiency, and amyloid β among cognitively healthy later-life adults: a systematic review and meta-analysis
Moon, C., Schneider, A. C., Cho, Y.-E., Zhang, M., Dang, H., & Vu, K. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05010-4 · Cited by 22
The Relationship Between Apolipoprotein ε4 Carrier Status and Sleep Characteristics in Cognitively Normal Older Adults
Kahya, M., Vidoni, E. D., Burns, J. M., Thompson, A. N., Meyer, K., & Siengsukon, C. F. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717720301 · Cited by 20
Sleep and Dementia
Vaou, O., Lin, S. H., Branson, C. O., & Auerbach, S. H. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0112-9 · Cited by 22
Objective sleep assessments for healthy people in environmental research: A literature review
Xu, X., & Lian, Z. (2022) · Indoor Air · doi:10.1111/ina.13034 · Cited by 20
Long-Term Occupational Sleep Loss and Post-Retirement Cognitive Decline or Dementia
Thomas, J., Overeem, S., & Claassen, J. A. H. R. (2019) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000504020 · Cited by 19
Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression
Fjell, A. M., Sederevičius, D., Sneve, M. H., de Lange, A. G., Bråthen, A. C. S., Idland, A., Watne, L. O., Wang, Y., Reinbold, C. S., Dobričić, V., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz228 · Cited by 18
RETRACTED: Test-retest reliability of coupling between cerebrospinal fluid flow and global brain activity after normal sleep and sleep deprivation
Zhao, W., Rao, J., Wang, R., Chai, Y., Mao, T., Quan, P., Deng, Y., Chen, W., Wang, S., Guo, B., et al. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121097 · Cited by 20
Retracted
Alzheimer’s Disease Is Responsible for Progressive Age-Dependent Differential Expression of Various Protein Cascades in Retina of Mice
Iqbal, J., Zhang, K., Jin, N., Zhao, Y., Liu, X., Liu, Q., Ni, J., & Shen, L. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00710 · Cited by 18
Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos
Agudelo, C., Tarraf, W., Wu, B., Wallace, D. M., Patel, S. R., Redline, S. S., Kaur, S., Daviglus, M. L., Zee, P. C., Simonelli, G., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12250 · Cited by 18
Links between the brain and body during sleep: implications for memory processing
Whitehurst, L. N., Subramoniam, A., Krystal, A. D., & Prather, A. A. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2021.12.007 · Cited by 21
Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease
Forte, N. R., Fernández-Rilo, A. C., Palomba, L., Marfella, B., Piscitelli, F., de Girolamo, P., Costanzo, A. D., Marzo, V. D., & Cristino, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1004002 · Cited by 18
A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease
Harenbrock, J., Holling, H., Reid, G., & Koychev, I. G. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100068 · Cited by 20
Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage
Kreuzer, M., Keating, G. L., Fenzl, T., Härtner, L., Sinon, C. G., Hajjar, I. M., Ciavatta, V. T., Rye, D. B., & García, P. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239290 · Cited by 17
Sleep Deprivation, a Link Between Post-Traumatic Stress Disorder and Alzheimer’s Disease
Delic, V., Ratliff, W. A., & Citron, B. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201378 · Cited by 19
Depressive Symptoms are the Main Predictor for Subjective Sleep Quality in Patients with Mild Cognitive Impairment—A Controlled Study
Seidel, S., Dal‐Bianco, P., Pablik, E., Müller, N., Schadenhofer, C., Lamm, C., Klösch, G., Moser, D., Klug, S., Pußwald, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128139 · Cited by 18
Resetting the Aging Clock: Implications for Managing Age-Related Diseases
Nobrega, A. K. D., Luz, K. V., & Lyons, L. C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_9 · Cited by 20
Comparison of single-channel EEG, actigraphy, and sleep diary in cognitively normal and mildly impaired older adults
Chou, C. A., Toedebusch, C. D., Redrick, T., Freund, D., McLeland, J., Morris, J. C., Holtzman, D. M., & Lucey, B. P. (2020) · SLEEP Advances · doi:10.1093/sleepadvances/zpaa006 · Cited by 17
Self-citation
Mutant β 1 -adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy
Dong, Q., Ptáček, L. J., & Fu, Y. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221686120 · Cited by 17
Association of Sleep Disturbances With Brain Amyloid and Tau Burden, Cortical Atrophy, and Cognitive Dysfunction Across the AD Continuum
Yoon, S. H., Kim, H., Lee, J., Chun, J., Sohn, Y. H., Lee, P. H., Ryu, Y. H., Cho, H., Yoo, H. S., & Lyoo, C. H. (2023) · Neurology · doi:10.1212/wnl.0000000000207917 · Cited by 18
Memory performance mediates subjective sleep quality associations with cerebrospinal fluid Alzheimer's disease biomarker levels and hippocampal volume among individuals with mild cognitive symptoms
Stankeviciute, L. S., Blackman, J., Tort‐Colet, N., Fernández‐Arcos, A., Sánchez‐Benavides, G., Suárez‐Calvet, M., Iranzo, Á., Molinuevo, J. L., Gispert, J. D., Coulthard, E. J., et al. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14108 · Cited by 17
Body Composition, Dietary, and Gustatory Function Assessment in People With Alzheimer’s Disease
Martín, I. S. M., Barato, V. P., Oliva, S. L., Rodríguez, M., Yurrita, L. C., Cabañas, M. J. C., Rojo, S. S., de la Calle, L., Díaz, E. Á., Santos, Y. Q., et al. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518782173 · Cited by 17
Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study
Fu, Y., Wang, Z.-T., Qu, Y., Wang, X.-T., Ma, Y., Bi, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215017 · Cited by 21
Associated factors for cognition of physically independent elderly people living in residential care facilities for the aged in Sri Lanka
Gamage, M. W. K., Hewage, C., & Pathirana, K. D. (2019) · BMC Psychiatry · doi:10.1186/s12888-018-2003-5 · Cited by 21
Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease
Khandayataray, P., & Murthy, M. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.066 · Cited by 19
Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study
Hoile, R., Tabet, N., Smith, H. E., Bremner, S. A., Cassell, J., & Ford, E. M. (2019) · Aging & Mental Health · doi:10.1080/13607863.2019.1695737 · Cited by 18
Sleep duration and efficiency are associated with plasma amyloid-β in non-demented older people
Liu, Y., Chen, L., Huang, S., Lv, Z., Hu, L., Luo, J., Shang, P., Wang, Y., & Xie, H. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05271-6 · Cited by 18
Predicting positron emission tomography brain amyloid positivity using interpretable machine learning models with wearable sensor data and lifestyle factors
Kimura, N., Aota, T., Aso, Y., Yabuuchi, K., Sasaki, K., Masuda, T., Eguchi, A., Maeda, Y., Aoshima, K., & Matsubara, E. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01363-x · Cited by 18
Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles
Hosseininasab, S. S. M., Ebrahimi, R., Yaghoobpoor, S., Kazemi, K., Khakpour, Y., Hajibeygi, R., Mohamadkhani, A., Fathi, M., Vakili, K. G., Tavasol, A., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1513095 · Cited by 20
Sleep in older adults and in subjects with dementia
Frohnhofen, H., Schlitzer, J., & Netzer, N. C. (2017) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-017-1289-0 · Cited by 18
In vivo Brainstem Imaging in Alzheimer’s Disease: Potential for Biomarker Development
Braun, D. J., & Eldik, L. J. V. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00266 · Cited by 16
Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases
Seifan, A., Ganzer, C. A., Ryon, K. A., Lin, M. K., Mahmudur, R., Henriquez, A. M., Shih, C., Jacobs, A. R., Greenwald, M., & Isaacson, R. (2019) · Current Aging Science · doi:10.2174/1874609812666190204094233 · Cited by 16
PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment: a 10‐year follow‐up study
Bessi, V., Giacomucci, G., Mazzeo, S., Bagnoli, S., Padiglioni, S., Balestrini, J., Tomaiuolo, G., Piaceri, I., Carraro, M., Bracco, L., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14518 · Cited by 17

Authors: Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Ju, Yo-El S.
McLeland, Jennifer S.
Xiong, Chengjie
Fagan, Anne M.
Morris, John C.
Holtzman, David M.
Venue: JAMA Neurology
Publisher: American Medical Association (AMA)
Published: 2013-05-01
Volume: 70
Issue: 5
Pages: 587
ISSN: 2168-6149 (ISSN-L)
DOI: 10.1001/jamaneurol.2013.2334
PMC: PMC3676720
OpenAlex: W2143790126
Cited by: 744
References: 39
Citations by year: 2026: 45 · 2025: 74 · 2024: 59 · 2023: 67 · 2022: 53 · 2021: 68 · 2020: 86 · 2019: 65 · 2018: 49 · 2017: 51 · 2016: 44 · 2015: 40 · 2014: 31 · 2013: 12
FWCI: 30.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (KL2TR000450, UL1TR000448)
National Institute on Aging (P 50 AG05681, L30 AG043312, P50AG005681, P01 AG0 3991, P01AG003991, P01AG026276)
National Institute of Neurological Disorders and Stroke (P01NS074969)
National Center for Research Resources (KL2RR024994, UL1RR024992)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: preclinical Alzheimer's disease, sleep quality, sleep efficiency, total sleep time, amyloid deposition, amyloid-beta, napping, actigraphy, APOE ε4, circadian rhythm, cognitively normal older adults
MeSH terms: Aged, Alzheimer Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Peptide Fragments, Sleep Wake Disorders, Time Factors, Amyloid beta-Peptides, Actigraphy, Prodromal Symptoms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep Quality and Preclinical Alzheimer Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks