Cited by 744Dementia and Cognitive Impairment ResearchSleep and related disordersSleep and Wakefulness Research

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Sleep Quality and Preclinical Alzheimer Disease

Open access

Ju, Yo-El S., McLeland, Jennifer S., Toedebusch, Cristina D., Xiong, Chengjie, Fagan, Anne M., Duntley, Stephen P., Morris, John C., Holtzman, David M.·2013·JAMA Neurology

DOI 10.1001/jamaneurol.2013.2334PMC PMC3676720

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Sleep and circadian problems are very common in Alzheimer disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid (Aβ), a key molecule involved in AD pathogenesis. OBJECTIVE: To test whether Aβ deposition in preclinical AD, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep. DESIGN: Cross-sectional study conducted from October 2010 to June 2012. SETTING: General community volunteers at the Washington University Knight Alzheimer's Disease Research Center. PARTICIPANTS: Cognitively normal individuals (n = 145) 45 years and older were recruited from longitudinal studies of memory and aging at the Washington University Knight Alzheimer's Disease Research Center. Valid actigraphy data were recorded in 142. The majority (124 of 142) were recruited from the Adult Children Study, in which all were aged 45 to 75 years at baseline and 50% have a parental history of late-onset AD. The rest were recruited from a community volunteer cohort in which all were older than 60 years and healthy at baseline. MAIN OUTCOME MEASURES: Sleep was objectively measured using actigraphy for 2 weeks. Sleep efficiency, which is the percentage of time in bed spent asleep, was the primary measure of sleep quality. Total sleep time was the primary measure of sleep quantity. Cerebrospinal fluid Aβ42 levels were used to determine whether amyloid deposition was present or absent. Concurrent sleep diaries provided nap information. RESULTS: Amyloid deposition, as assessed by Aβ42 levels, was present in 32 participants (22.5%). This group had worse sleep quality, as measured by sleep efficiency (80.4% vs 83.7%), compared with those without amyloid deposition, after correction for age, sex, and APOEε4 allele carrier status (P = .04). In contrast, quantity of sleep was not significantly different between groups, as measured by total sleep time. Frequent napping, 3 or more days per week, was associated with amyloid deposition (31.2% vs 14.7%; P = .03). CONCLUSIONS AND RELEVANCE: Amyloid deposition in the preclinical stage of AD appears to be associated with worse sleep quality but not with changes in sleep quantity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamaneurol.2013.2334

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 14×
“Studies of individuals with both amyloid deposition and evidence of neuronal injury such as elevated CSF tau levels—ie, stage 2 of preclinical AD8— will shed light on the interaction between sleep and pathological progression in AD.”
Influential
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Self-citation
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citation
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Self-citation
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Self-citation
Alzheimer’s Disease Neuroimaging Initiative
Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowski, J. Q., Toga, A. W., & Beckett, L. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-72076-0_18 · Cited by 1,493
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265
Self-citation
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ 42 in humans
Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246
Self-citation
Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137

Show all 39 references

Research works printed but not linked: 2

[12]Roh JH Huang Y Bero AW Sleep-wake cycle and diurnal fluctuation of amyloid-β as biomarkers of brain amyloid pathology. Science Translational Medicine 5 150 150ra122 PMC3654377 22956200
[20]Huang Y Potter R Sigurdson W Normal Amyloid-β Dynamics Decline with Age and Amyloid Deposition. Archives of Neurology In Press

Sorted by citations

Items 401–500 of 744

Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer’s disease
Song, J., Cui, S., Cui, X., Hu, X., Ma, Y., Ding, H., Ye, H., & Zhang, Y.-H. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0125-y · Cited by 16
Disruption of sleep macro- and microstructure in Alzheimer’s disease: overlaps between neuropsychology, neurophysiology, and neuroimaging
Kegyes-Brassai, A. C., Pierson-Bartel, R., Bolla, G., Kamondi, A., & Horvath, A. A. (2024) · GeroScience · doi:10.1007/s11357-024-01357-z · Cited by 15
Chronotype-Dependent Sleep Loss Is Associated with a Lower Amplitude in Circadian Rhythm and a Higher Fragmentation of REM Sleep in Young Healthy Adults
von Gall, C., Holub, L., Pfeffer, M., & Eickhoff, S. B. (2023) · Brain Sciences · doi:10.3390/brainsci13101482 · Cited by 17
Wie Schlaf und Alzheimer-Krankheit zusammenhängen
Busche, M. A., Kekuš, M., & Förstl, H. (2016) · Der Nervenarzt · doi:10.1007/s00115-016-0122-0 · Cited by 17
Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats
Hector, A., Provost, C., Delignat‐Lavaud, B., Bouamira, K., Menaouar, C.-A., Mongrain, V., & Brouillette, J. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01316-4 · Cited by 14
Therapeutic implications of hypothalamic-pituitaryadrenal-axis modulation in Alzheimer’s disease: A narrative review of pharmacological and lifestyle interventions
Watermeyer, T., Robb, C. E., Gregory, S., & Udeh‐Momoh, C. T. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100877 · Cited by 15
Cognitive behavioral therapy (CBT) for preventing Alzheimer’s disease
Reid, L. D., Avens, F. E., & Walf, A. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.024 · Cited by 16
Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events
Uji, M., Li, X., Saotome, A., Katsumata, R., Waggoner, R. A., Suzuki, C., Ueno, K., Aritake‐Okada, S., & Tamaki, M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509626122 · Cited by 15
Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Perspective and Therapeutic Potential
Namgyal, D., & Lim, C. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s561326 · Cited by 16
Sleep Disturbance is Associated With Higher Plasma Aβ Levels in Cognitively Normal Adults—A Population-Based Cross-Sectional Study
Gao, Y., Wei, S., Gao, F., Gao, L., Dang, L., Shang, S., Chen, C., Huo, K., Wang, J., Wang, J., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.615838 · Cited by 15
Sleep Disorders in Mild Cognitive Impairment
Randhi, B., Gutlapalli, S. D., Pu, J., Zaidi, M. F., Patel, M., Atluri, L. M., Gonzalez, N. A., Sakhamuri, N., Athiyaman, S., & Hamid, P. (2023) · Cureus · doi:10.7759/cureus.36202 · Cited by 14
Comparison between sub-chronic and chronic sleep deprivation-induced behavioral and neuroimmunological abnormalities in mice: Focusing on glial cell phenotype polarization
Niazi, N. U. K., Huang, C.-Y., Yang, Z., Zhang, Y., & Song, C. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115067 · Cited by 17
Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women
Milton, S., Cavaillès, C., Ancoli‐Israel, S., Stone, K. L., Yaffe, K. S., & Leng, Y. (2025) · Neurology · doi:10.1212/wnl.0000000000213403 · Cited by 15
A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study
Wilcox, M. E., Lim, A. S. P., McAndrews, M. P., Wennberg, R. A., Pinto, R. L., Black, S. E., Walczak, K. D., Friedrich, J. O., Taglione, M. S., & Rubenfeld, G. D. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015600 · Cited by 14
Circadian wheel running behavior is altered in an APP/E4 mouse model of late onset Alzheimer's disease
Boggs, K. N., Kakalec, P. A., Smith, M. L., Howell, S., & Flinn, J. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.021 · Cited by 13
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer’s Disease
Roland, J. P., & Bliwise, D. L. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00891-1 · Cited by 14
Hypersomnia in Neurodegenerative Diseases
Bhat, S., & Chokroverty, S. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.03.017 · Cited by 14
Normal Aging
Bliwise, D. L., & Scullin, M. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00003-9 · Cited by 14
Differences in Subjective Memory Impairment, Depressive Symptoms, Sleep, and Physical Activity in African American and Asian American Elderly
Lee, M., Nam, J.-H., Yi, E., Bhimla, A., Nelson, J., & Grace, X. (2021) · Brain Sciences · doi:10.3390/brainsci11091155 · Cited by 15
Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
Gisabella, B., Babu, J., Valeri, J., Rexrode, L., & Pantazopoulos, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.646678 · Cited by 16
Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers
Stankeviciute, L. S., Tort‐Colet, N., Fernández‐Arcos, A., Sánchez‐Benavides, G., Minguillón, C., Fauria, K., Holst, S. C., Garcés, P., Mueggler, T., Zetterberg, H., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70353 · Cited by 13
The LC-NE system as a potential target for neuromodulation to ameliorate non-motor symptoms in Parkinson's disease
Zaehle, T., Galazky, I., & Krauel, K. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102901 · Cited by 12
Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer’s Disease
Yang, E., Wang, J., Woodie, L. N., Greene, M. W., & Kaddoumi, A. (2023) · Molecules · doi:10.3390/molecules28145592 · Cited by 12
Using gamma-band transcranial alternating current stimulation (tACS) to improve sleep quality and cognition in patients with mild neurocognitive disorders due to Alzheimer’s disease: A study protocol for a randomized controlled trial
Lu, H., Li, J., Yang, N. S., LAM, L. C. W., Ma, S. L., Wing, Y. K., & Zhang, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289591 · Cited by 12
Remote evaluation of sleep to enhance understanding of early dementia due to Alzheimer’s Disease (RESTED-AD): an observational cohort study protocol
Blackman, J., Morrison, H. D., Gabb, V. G., Biswas, B., Li, H., Turner, N. L., Jolly, A., Trender, W. R., Hampshire, A., Whone, A. L., et al. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04288-0 · Cited by 12
Spousal Educational Attainment and Sleep Duration Among American Older Adults
Sheehan, C., & Iida, M. (2020) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaa206 · Cited by 12
Connection between sleeping patterns and cognitive deterioration in women with Alzheimer’s disease
Corbí, A., & Burgos, D. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02327-x · Cited by 12
Validation of actigraphy for sleep measurement in children with cerebral palsy
Xue, B., Licis, A., Boyd, J., Hoyt, C. R., & Ju, Y.-E. S. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2021.12.016 · Cited by 12
Self-citation
Sleepiness in neurological disorders
Dubessy, A., & Arnulf, I. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2023.07.005 · Cited by 12
Sleep-Cognition Hypothesis In maritime Pilots, what is the effect of long-term work-related poor sleep on cognition and amyloid accumulation in healthy middle-aged maritime pilots: methodology of a case–control study
Thomas, J., Ooms, S. J., Verbeek, M. M., Booij, J., Rijpkema, M., Kessels, R. P. C., Overeem, S., & Claassen, J. A. H. R. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026992 · Cited by 11
Sleep Evaluation by Actigraphy for Patients With Alzheimer Disease—Reply
Ju, Y. S., & Holtzman, D. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3490 · Cited by 12
Self-citation
Employing Deep-Learning Approach for the Early Detection of Mild Cognitive Impairment Transitions through the Analysis of Digital Biomarkers
Narasimhan, R., Gopalan, M., Sikkandar, M. Y., Alassaf, A., AlMohimeed, I., Alhussaini, K., Aleid, A., & Sheik, S. B. (2023) · Sensors · doi:10.3390/s23218867 · Cited by 12
Evaluating a novel 24-hour rest/activity rhythm marker of preclinical β-amyloid deposition
Spira, A. P., Liu, F., Zipunnikov, V., Bilgel, M., Rabinowitz, J. A., An, Y., Di, J., Bai, J., Wanigatunga, S., Wu, M. N., et al. (2024) · SLEEP · doi:10.1093/sleep/zsae037 · Cited by 11
BACE1 as an early biomarker and its relevance to risk factors for Alzheimer’s disease
Ohno, M. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111475 · Cited by 12
Effect of Sleep Disturbance on Cognitive Function in Elderly Individuals: A Prospective Cohort Study
Kim, D., Lee, I. H., Lee, B. C., & Lee, C. Y. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071036 · Cited by 11
Sleep and Health in Older Adulthood: Recent Advances and the Path Forward
Spira, A. P. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx263 · Cited by 11
Detecting Chronic Diseases from Sleep-Wake Behaviour and Clinical Features
Fallmann, S., & Chen, L. (2018) · International Conference on Systems and Informatics (ICSAI) · doi:10.1109/icsai.2018.8599388 · Cited by 11
Associations of informant-based sleep reports with Alzheimer’s disease pathologies
Shokouhi, S. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s215208 · Cited by 11
Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology
Hantke, N. C., Kaye, J., Mattek, N., Wu, C.-Y., Dodge, H. H., Beattie, Z., & Woltjer, R. (2023) · PLOS ONE · doi:10.1371/journal.pone.0286812 · Cited by 10
Night‐to‐night variability in sleep and amyloid beta burden in normal aging
Jouvencel, A., Baillet, M., Meyer, M., Dilharreguy, B., Lamare, F., Pérès, K., Helmer, C., Dartigues, J., Amieva, H., Mayo, W., et al. (2023) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12460 · Cited by 9
Sleep and physical activity measures are associated with resting-state network segregation in non-demented older adults
Callow, D. D., Spira, A. P., Zipunnikov, V., Lu, H., Wanigatunga, S., Rabinowitz, J. A., Albert, M., Bakker, A., & Soldan, A. (2024) · NeuroImage Clinical · doi:10.1016/j.nicl.2024.103621 · Cited by 11
Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases
Rehman, M. U., Sehar, N., Rasool, I., Aldossari, R. M., Wani, A. B., Rashid, S. M., Wali, A. F., Ali, A., Arafah, A. M., & Khan, A. (2024) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.6104 · Cited by 10
Circadian rhythms are associated with higher amyloid-β and tau and poorer cognition in older adults
Eckhardt, J. L., Isenberg, L., Aslanyan, V., Monreal, T. K., Stradford, J., Fenton, L. E., Contreras, J. A., Mack, W. J., & Pa, J. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf322 · Cited by 13
Sleep in Normal Aging, Alzheimer's Disease, and Mild Cognitive Impairment
Gagnon, J., Lafrenière, A., Rauchs, G., Petit, D., & Carrier, J. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00045-1 · Cited by 13
Subjective sleep parameters in prodromal Alzheimer’s disease: a case-control study
Borges, C. R., Piovezan, R. D., Poyares, D. R., Busatto, G. F., Studart‐Neto, A., Coutinho, A. M., Tufik, S. B., Nitríni, R., & Brucki, S. M. D. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1503 · Cited by 10
Neuropsychiatric Inventory–Questionnaire Assessed Nighttime Behaviors in Cognitively Asymptomatic Patients with Pathologically Confirmed Alzheimer’s Disease Predict More Rapid Cognitive Deterioration
Atayde, A. L., Fischer, C. E., Schweizer, T. A., & Muñoz, D. G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215276 · Cited by 10
Sleep slow waves’ negative-to-positive-phase transition: a marker of cognitive and apneic status in aging
Lafrenière, A., Lina, J., Hernandez, J., Bouchard, M., Gosselin, N., & Carrier, J. (2022) · SLEEP · doi:10.1093/sleep/zsac246 · Cited by 12
Abnormal cerebellar-prefrontal cortical pathways in obstructive sleep apnea with/without mild cognitive impairment
Shu, Y., Chen, L., Li, K., Li, H., Kong, L., Liu, X., Li, P., Xie, W., Zeng, Y., & Peng, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002184 · Cited by 11
The natural history study of preclinical genetic Creutzfeldt-Jakob Disease (CJD): a prospective longitudinal study protocol
Bregman, N., Shiner, T., Kavé, G., Alcalay, R. N., Gana‐Weisz, M., Goldstein, O., Glinka, T., Aizenstein, O., Bashat, D. B., Alcalay, Y., et al. (2023) · BMC Neurology · doi:10.1186/s12883-023-03193-8 · Cited by 10
Sleep is Essential for Mental Health: Potential Role of Slow Oscillations
Aquino, G., Alfì, G., Riemann, D. W., Laurino, M., Menicucci, D., Piarulli, A., Palagini, L., & Gemignani, A. (2024) · Current Sleep Medicine Reports · doi:10.1007/s40675-024-00277-w · Cited by 15
Epidemiology: Principles and Application in Sleep Medicine
Partinen, M., & Kronholm, E. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_28 · Cited by 10
The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function
Handa, S. S., Baba, S., Yamashita, K., Nishizaka, M., & Ando, S. (2019) · Annals of Nuclear Medicine · doi:10.1007/s12149-019-01349-6 · Cited by 11
Association Between Informant-Reported Sleep Disturbance and Incident Dementia: An Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set
Lee, W., Gray, S. L., Barthold, D., Maust, D. T., & Marcum, Z. A. (2020) · Journal of Applied Gerontology · doi:10.1177/0733464820967202 · Cited by 12
Cross‐sectional and prospective associations between self‐reported sleep characteristics and cognitive function in men and women: The Midlife in the United States study
Schneider, A. C., Moon, C., Whitaker, K. M., Zhang, D., Carr, L. J., Bao, W., & Xiao, Q. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13515 · Cited by 10
Sleep Quality Improvement Enhances Neuropsychological Recovery and Reduces Blood Aβ42/40 Ratio in Patients with Mild–Moderate Cognitive Impairment
Huang, H., Li, M., Zhang, M., Qiu, J., Cheng, H., Mou, X., Chen, Q., Li, T., Peng, J., & Li, B. (2021) · Medicina · doi:10.3390/medicina57121366 · Cited by 12
Relationship between Sleep, Physical Fitness, Brain Microstructure, and Cognition in Healthy Older Adults
Mueller, C., Nenert, R. E., Catiul, C., Pilkington, J., Szaflarski, J. P., & Amara, A. W. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149016 · Cited by 9
Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model
Zhao, Q., Yokomizo, S., Perle, S. J., Lee, Y. F., Zhou, H., Miller, M. R., Li, H., Gerashchenko, D., Gomperts, S. N., Bacskai, B. J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-73082-8 · Cited by 10
Association of Sleep Spindle Activity With Cognitive Decline in Early Clinical Stages of Alzheimer Disease
Bender, A. C., Berezuk, C., Pellerin, K. R., You, J. C., Sarkis, R. A., & Lam, A. D. (2025) · Neurology · doi:10.1212/wnl.0000000000214459 · Cited by 10
Obstructive sleep apnea and dementia: A role to play?
Kinugawa, K. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2023.08.006 · Cited by 9
Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson’s disease
Specketer, K., Zabetian, C. P., Edwards, K. L., Tian, L., Quinn, J. F., Peterson‐Hiller, A. L., Chung, K. A., Hu, S., Montine, T. J., & Cholerton, B. (2019) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2019.1623180 · Cited by 9
Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseases
Smith, S. K., & Musiek, E. S. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.02.005 · Cited by 10
Sleep inhibition induced by amyloid‐β oligomers is mediated by the cellular prion protein
Gallo, F. D., Bianchi, S., Bertani, I., Messa, M., Colombo, L., Balducci, C., Salmona, M., Imeri, L., & Chiesa, R. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13187 · Cited by 10
Association Between Amyloid Accumulation and Sleep in Patients With Idiopathic REM Sleep Behavior Disorder
Lee, H., Cho, H., Choe, Y. S., Seo, S. W., & Joo, E. Y. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.547288 · Cited by 8
Self-reported sleep relates to microstructural hippocampal decline in ß-amyloid positive Adults beyond genetic risk
Grydeland, H., Sederevičius, D., Wang, Y., Bartrés‐Faz, D., Bertram, L., Dobričić, V., Düzel, S., Ebmeier, K. P., Lindenberger, U., Nyberg, L. H., et al. (2021) · SLEEP · doi:10.1093/sleep/zsab110 · Cited by 8
Sleep Dysregulation Is Associated with 18 F-FDG PET and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease
Fernandes, M., Chiaravalloti, A., Nuccetelli, M., Placidi, F., Izzi, F., Camedda, R., Bernardini, S., Sancesario, G., Schillaci, O., Mercuri, N. B., et al. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220111 · Cited by 9
Sleeping well and staying in rhythm to stave off dementia
Malkani, R. G., & Zee, P. C. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.007 · Cited by 9
Midpoint of sleep is associated with sleep quality in older adults with and without symptomatic Alzheimer’s disease
Sauers, S. C., Toedebusch, C. D., Richardson, R., Spira, A. P., Morris, J. C., Holtzman, D. M., & Lucey, B. P. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae023 · Cited by 9
Self-citation
Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer’s disease pathology
Egroo, M. V., Beckers, E., Ashton, N. J., Blennow, K., Zetterberg, H., & Jacobs, H. I. L. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01653-y · Cited by 10
Sleep Alterations and Cognitive Decline
Lucey, B. P. (2025) · Seminars in Neurology · doi:10.1055/a-2557-8422 · Cited by 9
The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers
Nolan, E., Sun, Y., Shi, H., Archer, D. B., Perry, A., Pechman, K. R., Shashikumar, N., Landman, B. A., Gogniat, M. A., Liu, D., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70364 · Cited by 9
Pharmacological and Non-Pharmacological Interventions to Improve Sleep in People with Cognitive Impairment: A Systematic Review and Meta-Analysis
Crowley, P., O’Donovan, M. R., Leahy, P., Flanagan, E., & Ó’Caoimh, R. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22060956 · Cited by 10
Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
Gan, J., Chen, Z., Han, J., Ma, L., Liu, S., Wang, X., & Ji, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.765701 · Cited by 8
Sleep Biomarkers Help Predict the Development of Alzheimer Disease
Grigg-Damberger, M. M., & Foldvary‐Schaefer, N. (2022) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000818 · Cited by 9
Does Long-Term Shift Work Increase the Risk of Dementia? A Systematic Review and Meta-Analysis
Hai, Y., Xue, Y., & Wang, Y.-H. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221141535 · Cited by 8
Potential Clinical Applications and Future Prospect of Wireless and Mobile Electroencephalography on the Assessment of Cognitive Impairment
Li, F., Egawa, N., Yoshimoto, S., Mizutani, H., Kobayashi, K., Tachibana, N., & Takahashi, R. (2019) · Bioelectricity · doi:10.1089/bioe.2019.0001 · Cited by 8
Cerebrospinal Fluid Hypocretin and Nightmares in Dementia Syndromes
Trotti, L. M., Bliwise, D. L., Keating, G. L., Rye, D. B., & Hu, W. T. (2021) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000509585 · Cited by 8
Adiponectin improves amyloid‐β 31‐35‐induced circadian rhythm disorder in mice
Yuan, Y., Li, C., Guo, S., Sun, C., Ning, N., Hao, H., Wang, L., Bian, Y., Liu, H., & Wang, X. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16932 · Cited by 8
Sleep, Breathing, and Neurologic Disorders
Chokroverty, S., & Provini, F. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_41 · Cited by 9
Sleep and Neurodegeneration: Examining Potential Physiological Mechanisms
McConnell, B. V., Deng, Y., & Lucey, B. P. (2025) · Current Sleep Medicine Reports · doi:10.1007/s40675-024-00316-6 · Cited by 10
Association between sleep quality and mild cognitive impairment in Chinese patients with type 2 diabetes mellitus: a cross-sectional study
Maimaitituerxun, R., Wang, H., Chen, W., Xiang, J., Xie, Y., Xiao, F., Wu, X. Y., Chen, L., Yang, J., Liu, A., et al. (2025) · BMC Public Health · doi:10.1186/s12889-025-22338-7 · Cited by 8
Alzheimer's disease and insomnia: a bibliometric study and visualization analysis
Tian, Z., Jiang, B., Jin, M., Yu, X., Chen, Q., & Wang, J. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1542607 · Cited by 8
Towards proactively improving sleep: machine learning and wearable device data forecast sleep efficiency 4–8 hours before sleep onset
Sakal, C., Chen, T., Xu, W., Zhang, W., Yu, Y., & Li, X. (2025) · SLEEP · doi:10.1093/sleep/zsaf113 · Cited by 7
Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease
van den Berg, M., Heymans, L., Toen, D. V., Adhikari, M. H., Audekerke, J. V., Verschuuren, M., Pintelon, I., Vos, W. H. D., der Linden, A. V., Verhoye, M., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02016-w · Cited by 8
Associations between sleep quality, plasma neurofilament light, and cognition in older adults without dementia
Guo, H.-H., Liang, D.-X., Zhang, Q., Fu, Y., Huang, L.-Y., Sheng, Z.-H., Tan, L., & Wang, Z.-T. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03389-1 · Cited by 14
Sleep and Cognition in the Elderly
Rauchs, G., Carrier, J., & Peigneux, P. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00071 · Cited by 7
Altered sleep behavior strengthens face validity in the ArcAβ mouse model for Alzheimer’s disease
Altunkaya, A., Deichsel, C., Kreuzer, M., Nguyen, D.-M., Wintergerst, A.-M., Rammes, G., Schneider, G. H., & Fenzl, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-51560-3 · Cited by 11
Sleep-wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice
Valencia-Sánchez, S., Davis, M., Martensen, J., Hoeffer, C. A., Link, C. D., & Opp, M. R. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.027 · Cited by 7
Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer’s disease
Kollarik, S., Bimbiryte, D., Sethi, A., Dias, I., Moreira, C. G., & Noaín, D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1519225 · Cited by 8
Possible Role of Orexin in the Pathogenesis of Alzheimer Disease
Ferini‐Strambi, L. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2819 · Cited by 7
Evaluation of waist-worn actigraphy monitors for the assessment of sleep in older adults with and without Alzheimer’s disease
Khou, C. S., Rendzia, B., & Watts, A. S. (2018) · Journal of Rehabilitation and Assistive Technologies Engineering · doi:10.1177/2055668318777989 · Cited by 7
Sleep and wakefulness disorders in neurodegenerative diseases
Yakovleva, O. V., Poluektov, M. G., Levin, O. S., & Lyashenko, E. A. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20181184283 · Cited by 7
CLOCK Genetic Variations Are Associated With Age-Related Changes in Sleep Duration and Brain Volume
Kim, S. E., Kim, S., Kim, H. J., Kim, R. E. Y., Kim, S.-A., Shin, C., & Lee, H. W. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab365 · Cited by 8
The Impact of Stressful Life Events in Alzheimer’s Disease
Giannouli, V. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_55-1 · Cited by 7
Do later-born birth cohorts of septuagenarians sleep better? A prospective population-based study of two birth cohorts of 70-year-olds
Skoog, J., Jönsson, H., Sigström, R., Östling, S., Falk, H., Wærn, M., Thorvaldsson, V., Skoog, I. G., & Johansson, B. E. A. (2018) · SLEEP · doi:10.1093/sleep/zsy204 · Cited by 8
The role of actigraphy in detecting and characterizing the early phases of Alzheimer’s disease
Winer, J. R. (2024) · SLEEP · doi:10.1093/sleep/zsae076 · Cited by 6
Amyloid profile is associated with sleep quality in preclinical but not in prodromal Alzheimer’s disease older adults
Borges, C. R., Poyares, D. R., Studart‐Neto, A., Coutinho, A. M., Cassimiro, L., Avolio, I., Piovezan, R. D., Trés, E. S., Teixeira, T. B. M., Barbosa, B. J. A. P., et al. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.07.028 · Cited by 6
The impacts of sex and the 5xFAD model of Alzheimer’s disease on the sleep and spatial learning responses to feeding time
Campbell, K. J., Jiang, P., Olker, C. J., Lin, X., Kim, S. Y., Lee, C., Song, E. J., Turek, F. W., & Vitaterna, M. H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1430989 · Cited by 7
Long-term hydroxychloroquine therapy improves the quality of sleep in patients with primary Sjögren’s syndrome: a real-world study
Guan, P., Sun, C., Chen, Z., Chen, J., & Ran, R. (2020) · Annals of Palliative Medicine · doi:10.21037/apm-20-1380 · Cited by 6
Metabotropic glutamate receptor function and regulation of sleep-wake cycles
Holter, K. M., Pierce, B. E., & Gould, R. W. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2022.11.002 · Cited by 6
Interactions of Polyphenolic Gallotannins with Amyloidogenic Polypeptides Associated with Alzheimer’s Disease: From Molecular Insights to Physiological Significance
Khalifa, J., Bourgault, S., & Gaudreault, R. (2023) · Current Alzheimer Research · doi:10.2174/0115672050277001231213073043 · Cited by 6

Authors: Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Ju, Yo-El S.
McLeland, Jennifer S.
Xiong, Chengjie
Fagan, Anne M.
Morris, John C.
Holtzman, David M.
Venue: JAMA Neurology
Publisher: American Medical Association (AMA)
Published: 2013-05-01
Volume: 70
Issue: 5
Pages: 587
ISSN: 2168-6149 (ISSN-L)
DOI: 10.1001/jamaneurol.2013.2334
PMC: PMC3676720
OpenAlex: W2143790126
Cited by: 744
References: 39
Citations by year: 2026: 45 · 2025: 74 · 2024: 59 · 2023: 67 · 2022: 53 · 2021: 68 · 2020: 86 · 2019: 65 · 2018: 49 · 2017: 51 · 2016: 44 · 2015: 40 · 2014: 31 · 2013: 12
FWCI: 30.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (KL2TR000450, UL1TR000448)
National Institute on Aging (P 50 AG05681, L30 AG043312, P50AG005681, P01 AG0 3991, P01AG003991, P01AG026276)
National Institute of Neurological Disorders and Stroke (P01NS074969)
National Center for Research Resources (KL2RR024994, UL1RR024992)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: preclinical Alzheimer's disease, sleep quality, sleep efficiency, total sleep time, amyloid deposition, amyloid-beta, napping, actigraphy, APOE ε4, circadian rhythm, cognitively normal older adults
MeSH terms: Aged, Alzheimer Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Peptide Fragments, Sleep Wake Disorders, Time Factors, Amyloid beta-Peptides, Actigraphy, Prodromal Symptoms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep Quality and Preclinical Alzheimer Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks