Cited by 744Dementia and Cognitive Impairment ResearchSleep and related disordersSleep and Wakefulness Research

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Sleep Quality and Preclinical Alzheimer Disease

Open access

Ju, Yo-El S., McLeland, Jennifer S., Toedebusch, Cristina D., Xiong, Chengjie, Fagan, Anne M., Duntley, Stephen P., Morris, John C., Holtzman, David M.·2013·JAMA Neurology

DOI 10.1001/jamaneurol.2013.2334PMC PMC3676720

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Sleep and circadian problems are very common in Alzheimer disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid (Aβ), a key molecule involved in AD pathogenesis. OBJECTIVE: To test whether Aβ deposition in preclinical AD, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep. DESIGN: Cross-sectional study conducted from October 2010 to June 2012. SETTING: General community volunteers at the Washington University Knight Alzheimer's Disease Research Center. PARTICIPANTS: Cognitively normal individuals (n = 145) 45 years and older were recruited from longitudinal studies of memory and aging at the Washington University Knight Alzheimer's Disease Research Center. Valid actigraphy data were recorded in 142. The majority (124 of 142) were recruited from the Adult Children Study, in which all were aged 45 to 75 years at baseline and 50% have a parental history of late-onset AD. The rest were recruited from a community volunteer cohort in which all were older than 60 years and healthy at baseline. MAIN OUTCOME MEASURES: Sleep was objectively measured using actigraphy for 2 weeks. Sleep efficiency, which is the percentage of time in bed spent asleep, was the primary measure of sleep quality. Total sleep time was the primary measure of sleep quantity. Cerebrospinal fluid Aβ42 levels were used to determine whether amyloid deposition was present or absent. Concurrent sleep diaries provided nap information. RESULTS: Amyloid deposition, as assessed by Aβ42 levels, was present in 32 participants (22.5%). This group had worse sleep quality, as measured by sleep efficiency (80.4% vs 83.7%), compared with those without amyloid deposition, after correction for age, sex, and APOEε4 allele carrier status (P = .04). In contrast, quantity of sleep was not significantly different between groups, as measured by total sleep time. Frequent napping, 3 or more days per week, was associated with amyloid deposition (31.2% vs 14.7%; P = .03). CONCLUSIONS AND RELEVANCE: Amyloid deposition in the preclinical stage of AD appears to be associated with worse sleep quality but not with changes in sleep quantity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamaneurol.2013.2334

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 14×
“Studies of individuals with both amyloid deposition and evidence of neuronal injury such as elevated CSF tau levels—ie, stage 2 of preclinical AD8— will shed light on the interaction between sleep and pathological progression in AD.”
Influential
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Self-citation
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citation
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Self-citation
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Self-citation
Alzheimer’s Disease Neuroimaging Initiative
Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowski, J. Q., Toga, A. W., & Beckett, L. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-72076-0_18 · Cited by 1,493
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265
Self-citation
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ 42 in humans
Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246
Self-citation
Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137

Show all 39 references

Research works printed but not linked: 2

[12]Roh JH Huang Y Bero AW Sleep-wake cycle and diurnal fluctuation of amyloid-β as biomarkers of brain amyloid pathology. Science Translational Medicine 5 150 150ra122 PMC3654377 22956200
[20]Huang Y Potter R Sigurdson W Normal Amyloid-β Dynamics Decline with Age and Amyloid Deposition. Archives of Neurology In Press

Sorted by citations

Items 601–700 of 744

Sleep factors affecting mental health: mechanics and trigger factors
Sexton–Radek, K. (2025) · Frontiers in Sleep · doi:10.3389/frsle.2025.1441521 · Cited by 4
Dietary B-complex vitamins and sleep quality in relation to cognitive impairment among older adults: non-linear associations and evidence of additive interaction
Zhang, M., Wang, Y., Zhang, Y., Gao, Q., Hu, F., Wang, Y., Shao, C., & Cai, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1694999 · Cited by 1
Long‐term forgetting, sleep, and tau in autosomal‐dominant Alzheimer's disease
You, J. C., Bender, A. C., Berezuk, C., Noriega-Makarskyy, D. T., Baena, A. Y., Munera, D., Pardilla‐Delgado, E., Ramirez-Gomez, L. A., Aguillon, D. F., Giudicessi, A., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71235 · Cited by 1
Zolpidem restores sleep and decreases amyloid in a mouse model
Yu, L., Yokomizo, S., Doan, T. H., Zhao, Q., Ganne, A., Balasubramaniam, M., & Kastanenka, K. V. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71175 · Cited by 3
Deep sleep slow wave–spindle coupling is selectively linked to plasma amyloid-β levels in older adults in clinical trials
Wunderlin, M., Wicki, K., Teunissen, C. E., & Züst, M. A. (2026) · Scientific Reports · doi:10.1038/s41598-026-47886-9 · Cited by 2
Dual orexin receptor antagonism with lemborexant enhances microglial clearance of β-amyloid in mice
Sharma, A., 瀬川英美子, Chen, X., Park, S., Wang, S., Irmen, R. E., Constantino, N. J., Wang, C., Kanan, M. F., Colonna, M., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00948-y · Cited by 1
Immune cell subsets linking insomnia trajectories and incident cognitive impairment: a prospective cohort study
Chen, L., Fu, J., Jia, X., Zhang, L., Jin, X., 吳淑惠, Zhu, B., Sun, K., Fu, D., Wang, Y., et al. (2026) · BMC Medicine · doi:10.1186/s12916-026-04925-6
Stress, stress systems, and Alzheimer's disease
Eberly, S. G., Phumsatitpong, C., Munro, C. E., Neylan, T. C., Kaufer, D., & Ehrenberg, A. J. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71542 · Cited by 1
Aging ADNP syndrome mice exhibit mutation/sex-dependent disruption of motor behavior and circadian rhythmicity
Galushkin, A., Giladi, E., & Gozes, I. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107509 · Cited by 1
Sleep and episodic memory: a review of the literature in young healthy subjects and potential links between sleep changes and memory impairment observed during aging and Alzheimer’s disease
Kang, D. W., Lim, H. K., Jung, W. S., Jeong, J., Kim, T., Han, J., Lee, C. U., & Hong, S. (2015) · Cited by 1
Sleep Evaluation by Actigraphy
Kawada, T. (2015) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbu219 · Cited by 1
Sleep Pattern: Preventing Factors for Alzheimer Disease
Khorgami, Z., & Sugaya, K. (2015) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2015/19333 · Cited by 1
Circadian Rhythm Sleep Disorder in Alzheimer’s Disease-A consideration in relation with the Neuropathological and Neuroendocrinal alternation
Umetsu, M. (2014) · Brain Disorders & Therapy · doi:10.4172/2168-975x.1000124 · Cited by 1
Nonpharmacologic Activity Interventions to Prevent Alzheimer’s Disease
Carlson, M. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00022-8 · Cited by 1
Wie Schlaf und Alzheimer-Krankheit zusammenhängen: Insomnie, Amnesie und Amyloid
Busche, M. A., Kekuš, M., & Förstl, H. (2017) · Der Nervenarzt · Cited by 1
Schlaf und Demenz
Hermann, D. M., & Frohnhofen, H. (2018) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-018-0182-4 · Cited by 1
Validation of blood-based transcriptomic circadian phenotyping in older adults
Smith, S. K., Tran, P., Madden, K. A., Boyd, J., Braun, R., Musiek, E. S., & Ju, Y. S. (2022) · SLEEP · doi:10.1093/sleep/zsac148 · Cited by 2
Self-citation
Sleep deprivation: A toxicogenic drive for neurodegenerative diseases and public health issue
Afonne, O. J., Ifediba, E. C., & Afonne, A. J. (2022) · Advances in Health and Behavior · doi:10.25082/ahb.2022.01.006 · Cited by 1
Atualizações sobre a doença de Alzheimer e seus estágios clínicos
Moreira, G. F., Coscarelli, L. P., Jardim, M. C. D., Araújo, I. M. M., Grossi, B. D., Guidi, R. A., Menezes, Y. C. D. C., Silva, I. M., Calmon, M. Z., Neto, C. A. B., et al. (2022) · Brazilian Journal of Health Review · doi:10.34119/bjhrv5n6-016 · Cited by 1
Research Progress on the Impact of Sleep Disorders on Alzheimer’s Disease
陈, 慧. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.12101301 · Cited by 1
Bases celulares y moleculares de la cronopatología en la enfermedad de Alzheimer
Rodríguez, B. B. B., & Rodríguez, M. G. (2024) · eNeurobiología · doi:10.25009/eb.v15i37.2629 · Cited by 1
Progress in the causes of sleep disorders during the early-stage Alzheimer’s disease
Li, Y., Li, Z., & Wang, Y. (2024) · E3S Web of Conferences · doi:10.1051/e3sconf/202455305048 · Cited by 1
Spatial differences in gene expression across the dorsal raphe nucleus in a model of early Alzheimer's disease
Kolling, L. J., Chimenti, M. S., & Marcinkiewcz, C. A. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241299119 · Cited by 1
Sleep in aging adults with Down syndrome and its association with Alzheimer's disease
Hartley, S. L., & Esbensen, A. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818845-3.00008-6 · Cited by 1
Moving towards core sleep outcomes in neurodegenerative disease—the time is now
Sarkis, R. A., & Lucey, B. P. (2022) · SLEEP · doi:10.1093/sleep/zsac112 · Cited by 1
Self-Reported Sleep and β-Amyloid Deposition in Older Adults
Kawada, T. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6417 · Cited by 1
Comment on “Sleep disturbances and later cognitive status: a multi-centre study”
Monastero, R., & Baschi, R. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.11.53 · Cited by 1
Sleep and dementia
Malkani, R. G., & Avidan, A. Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00340-6 · Cited by 1
Sleep Effects on Cognition with Aging
Scullin, M. K. (2016) · Springer eBooks · doi:10.1007/978-981-287-080-3_154-1 · Cited by 1
Deep Brain Stimulation of Nucleus Basalis of Meynert improves learning in rat model of dementiaPreprint
Kumbhare, D., Rajagopal, M., Toms, J., Freelin, A. H., Weistroffer, G. R., McComb, N., Karnam, S., Azghadi, A., Murnane, K. S., Baron, M. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.05.588271 · Cited by 1
(outdated draft) Somatostatin and the pathophysiology of Alzheimer’s diseasePreprint
Almeida, V. N. (2024) · Qeios · doi:10.32388/goy6dk.2
Hypothalamic MCH neurons links tau pathology to sleep disruptionPreprint
Pang, K., Guo, S., Yang, R., Kumar, A., Morse, W. D., Xu, L., Liu, Q., Jiang, D., & Zhong, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.31.729026 · Cited by 1
Melatonin Level s i n Alzheimer Disease
Vgenopoulou, I., Katsa, M. E., & Tzavella, F. (2015)
Le rôle du sommeil dans la consolidation mnésique : effets de l’âge et de la maladie d’Alzheimer
Malle, C., Eustache, F., & Rauchs, G. (2015) · Biologie Aujourd hui · doi:10.1051/jbio/2015024
Sleep Disruption Leads to Amyloid-Beta Deposition in Mice, Researchers Find
Collins, T. R. (2015) · Neurology Today · doi:10.1097/01.nt.0000460025.37121.3b
Disturbed Sleep Is Associated with Increased Amyloid-Beta and Long-Term Memory Impairment, Study Suggests
Samson, K. (2015) · Neurology Today · doi:10.1097/01.nt.0000469534.31353.60
Can Dementia Be Delayed? What You Need to Know to Counsel Your Older Patients
Morgan, E. A., Heagerty, B., & Eckstrom, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-28137-7_1
Alzheimer’s Disease and the Sleep–Wake Cycle
Bero, A. W., & Tsai, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802851-3.00010-3
SLEEP ALTERATIONS IN MOUSE GENETIC MODELS OF HUMAN DISEASE
Sethi, M. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.522
Sleep, Adenosine, and Neurodegeneration
Bjorness, T. E., & Greene, R. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803724-9.00006-5
Sleep Problems in Alzheimer’s Disease
Molano, J. R. V. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0076-1
Article Sleep Interacts with Ab to Modulate Intrinsic Neuronal Excitability
Tabuchi, M., Lone, S. R., Liu, S., Liu, Q., Zhang, J., Spira, A. P., & Wu, M. N. (2015)
Sleep in elderly with due emphasis on dementia
Tiwari, S. (2018) · Sleep Medicine and Disorders International Journal · doi:10.15406/smdij.2018.02.00039
CHOLINE, SLEEP DISTURBANCES, AND ALZHEIMER’S DISEASE
Pak, V. M., & Newton, S. (2018) · Journal of Aging Research and Lifestyle · doi:10.14283/jarcp.2018.17
Consequences of Untreated Obstructive Sleep Apnea
Kanter, B. S. (2017) · Touro Scholar (Touro College)
P34 Disrupted activity patterns in evening and morning chronotypes between mild cognitive impaired patients and older, non-impaired controls
Rackoll, T., Neumann, K., Paßmann, S., Grittner, U., Külzow, N., Ladenbauer, J., & Flöel, A. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.04.687
Investigation into the molecular complexity of Alzheimer's disease : an amyloid-β centered approach
Cioffi, F. (2019) · doi:10.3990/1.9789036548410
Improving sleep and cognition in young adults and the elderly
Cordi, M. J. (2014) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-111343
Insulin resistance and sleep apnea
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00004-3
Understanding Alzheimer’s disease through the genetics of sleep
Lee, E. (2020) · International Psychogeriatrics · doi:10.1017/s1041610220000162
Circadian fragmentation: a harbinger of Alzheimer's disease?
Musiek, E. S. (2020) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(20)30021-0
O PROGRAMA DE MONITORIA DA UFRA: REPENSANDO A PRESENCIALIDADE
Mota, T. C. D. F., & Lima, M. N. A. (2020) · doi:10.22533/at.ed.05820011214
INTERAÇÃO ENTRE OS ASPECTOS SOCIODEMOGRÁFICOS, SONOLÊNCIA DIURNA E NÍVEIS DE ATIVIDADE FÍSICA EM PROFESSORES UNIVERSITÁRIOS DURANTE A PANDEMIA DA COVID-19
da Silva, E. N., Souza, A. P. D. S., Silva, M. R. M., Leite, S. C. P., de Lira, P. C., Silva, R. K. P., da Silva, K. G., Filho, P. T. A., Fernandes, M. S. D. S., da Silva, A. B. J., et al. (2020) · doi:10.22533/at.ed.0582001128
PARTICULARIDADES DE LA ENSEÑANZA UNIVERSITARIA EN TIEMPOS DE PANDEMIA EN AMÉRICA LATINA
García, R. Y. A., León, L. A. H., & Rodrigues, W. (2020) · doi:10.22533/at.ed.05820011215
O ENSINO EM TEMPOS DE PANDEMIA: SOU PROFESSOR, E AGORA?
Bitencourt, G. D. A., & Trindade, R. F. S. (2020) · doi:10.22533/at.ed.05820011212
Neurologie et sommeil
Barateau, L., Carlander, B., Evangelista, E., Chenini, S., Nobili, L., & Dauvilliers, Y. A. (2019) · Elsevier eBooks · doi:10.1016/b978-2-294-74892-9.00019-9
Sleep and cognition
Tripathi, M., & Rai, N. (2014) · Indian Journal of Sleep Medicine · doi:10.5958/0974-0155.2015.00003.0
Protocol for a scoping review of measurement of sleep in mild cognitive impairment and early dementia
Blackman, J., Morrison, H. D., Harding, S. A., Lloyd, K., & Coulthard, E. J. (2021) · AMRC Open Research · doi:10.12688/amrcopenres.12981.1
WITHDRAWN: Sleep Treatment Improves Neuropsychological Symptoms and Reduces Blood Aβ42/pTau Protein in Alzheimer's Disease Patients: a Longitudinal StudyPreprint
Li, B., Huang, H., Li, M., Zhang, M., Qiu, J., Chen, H., Mou, X., Chen, Q., Li, T. C., & Peng, J. (2021) · Research Square · doi:10.21203/rs.3.rs-138356/v1
Insomnia is Associated with Depression and Anxiety in Patients Undergoing Noncardiac SurgeryPreprint
Huang, X. D., Wei, C., Wang, J., Lin, D., Zhang, J., Hao, Y., Wu, D., & Wu, A. (2020) · doi:10.21203/rs.3.rs-32571/v1
Acylated Ghrelin Increases in Young Adults with Obesity Due to Lack of Sleep
Campos, V., & Reyna-Echeveste, E. I. (2021) · Endocrinology and Disorders · doi:10.31579/26401045/079
Consequences of endogenous and virally-induced hyperphosphorylated tau on behavior and cognition in a rat model of Alzheimer’s diseasePreprint
Kelberman, M. A., Anderson, C. R., Chlan, E., Rorabaugh, J. M., McCann, K. E., & Weinshenker, D. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.30.466530
Glenfatik sistemin yapısı, fonksiyonları ve klinik açıdan önemi
Kuşat, T., & Sur, E. (2021) · Eurasian journal of veterinary sciences · doi:10.15312/eurasianjvetsci.2021.357
The relationship between cognitive function and sleep disturbance
Hashimoto, K. (2021) · Tenri Medical Bulletin · doi:10.12936/tenrikiyo.24-011
Sleep in older adults
Neikrug, A. B., Lu, Y., Chao, T., & Ancoli‐Israel, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00209-7
Dynamics of brain-fluid circulation are altered in the mature-onset Tet-off APP mouse model of amyloidosisPreprint
Ben-Nejma, I. R. H., Keliris, A., Vanreusel, V., Ponsaerts, P., der Linden, A. V., & Keliris, G. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.11.483807
What is the Relationship Between Sleep and Alzheimer’s Disease? A Narrative Review
Gobraeil, S., & Rizq, G. (2022) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.334
Natürlichen Takt der inneren Uhr herstellen
(2020) · psychopraxis neuropraxis · doi:10.1007/s00739-019-00618-3
Sleep Effects on Cognition with Aging
Scullin, M. K. (2017) · Springer eBooks · doi:10.1007/978-981-287-082-7_154
睡眠からアプローチする認知症予防
総一郎, 宮., Kitamura, T., & 明子, 野. (2019) · Nippon Jibiinkoka Gakkai Kaiho · doi:10.3950/jibiinkoka.122.1475
The relationship between physical activity and sleep status among older adults requiring nursing care in the community
Mizuno, T., Isaka, M., Kuramoto, T., Inoue, T. M., & Kamide, K. (2022) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.59.528
The natural history study of preclinical genetic Creutzfeldt-Jakob Disease (CJD): A prospective longitudinal study protocolPreprint
Bregman, N., Shiner, T., Kavé, G., Roy, A., Gana‐Weisz, M., Goldstein, O., Glinka, T., Aizenstein, O., Dafna, B. B., Alcalay, Y., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2326711/v1
Sommeil, fatigue, troubles du sommeil et troubles cognitifs
André, C., & Rauchs, G. (2021) · De Boeck Supérieur eBooks · doi:10.3917/dbu.azouv.2021.01.0077
Prediction of Cognitive Decline by Behavioral Symptoms in Neuropsychiatric Disorders
Barekatain, M., Sadeghpour, S., Rajabi, F., & Maracy, M. R. (2022) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs-126596
Sleep and other neurologic diseases
Malhotra, R. K., & Ju, Y. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-65403-6.00035-4
Self-citation
Obstructive Sleep Apnea
Gelener, P., & Yıldız, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-22483-6_130-1 · Cited by 1
Interaction effect of midday napping duration and depressive symptoms on subjective memory impairment among older people in China: evidence from the China health and retirement longitudinal study database
Tang, L., Wang, Y., Zhan, N.-N., Li, C.-Y., Zhuang, Z., Lyu, Q.-Y., & Xiong, P. (2023) · BMC Public Health · doi:10.1186/s12889-023-16928-6 · Cited by 1
Estudo comparativo da qualidade de vida dos discentes do 1o e 6 o ano da Faculdade de Medicina de Campos em relação aos pilares de estilo de vida
Azevedo, M. J. D. A. B. E., Gimenes, M. C. B., Rodrigues, R. B. R., & Neto, M. D. L. (2023) · Congresso Brasileiro de Medicina do Estilo de Vida · doi:10.61661/congresso.cbmev.6.2023.48
Cross-phenotype associations between Alzheimer’s Disease and its comorbidities may provide clues to progressionPreprint
Moore, A. K., & Ritchie, M. D. (2023) · medRxiv · doi:10.1101/2023.11.06.23297993
Paradoxical effects of daytime sleepiness and memory in African Americans at risk for Alzheimer’s disease
Lucey, B. P. (2023) · SLEEP · doi:10.1093/sleep/zsad301
Relação entre a composição corporal e indicadores metabólicos com a actimetria do sono no adulto
Machado, L. A. M. W. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2023.tde-10112023-163029
The effect of long-term sleep disruption on the brain – looking beyond amyloidPreprint
Mentink, L. J., van Osch, M. J. P., Bakker, L. J., Rikkert, M. G. M. O., Beckmann, C. F., Claassen, J. A. H. R., & Haak, K. V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.15.571841
Sleep Disorders and Neurodegeneration
de Almondes, K. M., & Paiva, T. (2024) · Advances in medical technologies and clinical practice book series · doi:10.4018/979-8-3693-0851-6.ch011
Additional file 1 of Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Zhao, Q., Maci, M., Miller, M. R., Zhou, H., Zhang, F., Algamal, M., Lee, Y. F., Hou, S. S., Perle, S. J., Le, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24715423
Características do sono de idosos sem demência classificados de acordo com o perfil ß-amiloide
Borges, C. R. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2024.tde-24062024-142745
Pharmacological enhancement of slow-wave activity improves cognition and reduces amyloidosis at an early stage in a mouse model of Alzheimer’s diseasePreprint
Kollarik, S., Bimbiryte, D., Sethi, A., Dias, I., Moreira, C. G., & Noaín, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.02.616223
The power of the rocking cradle: improving sleep function by gentle vibration
Hopkins, M. A., & Tabuchi, M. (2024) · SLEEP · doi:10.1093/sleep/zsae245
Resting After Learning Facilitates Memory Consolidation and Reverses Spatial Reorientation Impairments in ‘New Surroundings’ in 3xTg-AD MicePreprint
Stimmell, A. C., Alday, L. J., Diaz, J. M., Moseley, S. C., Cushing, S. D., Salvador, E., Ragsdale, S. M., & Wilber, A. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.12.622722
Characteristics of Physical and Psychophysiological Functions in Community-dwelling Older People with Sleep Disorders
NISHII, K., Ito, R., MATSUMOTO, Y., KONDO, H., Kubo, T., Murakami, T., Tazaki, F., Nakamura, M., & Imaoka, M. (2025) · Rigakuryoho Kagaku · doi:10.1589/rika.40.51
Sleep in the elderly: Healthy sleep for healthy aging
Hrnčić, D., Šutulović, N., Mladenović, D. R., Vesković, M. N., Djuric, E., Rašić-Marković, A., & Stanojlović, O. P. (2024) · Medicinski podmladak · doi:10.5937/mp75-54248
Grounding as a complementary intervention for Alzheimer's disease: Mechanisms, evidence, and potential therapeutic applications
Kshirsagar, S., Deshmukh, H., Reddy, A. P., Reddy, A. P., & Reddy, P. H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251334666
Neurologically altered brain activity may not look like aged brain activity: Implications for brain-age modeling and biomarker strategiesPreprint
Gemein, L. A. W., Gaubert, S., Paquet, C., Paillard, J., Holst, S. C., Tveitstøl, T., Haraldsen, I., Hawellek, D. J., Hipp, J. F., & Engemann, D. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.15.648903
The Exposome and Lifestyle Medicine: Research Gaps
Infante-García, M. M., Pavlovska, I., Gonzalez-Rivas, J. P., Nieto-Martínez, R. E., & Mechanick, J. I. (2025) · Springer eBooks · doi:10.1007/978-3-031-82888-1_16
Imaging Alzheimer’s Retinopathy
Gaire, B. P., Koronyo, Y., Shi, H., Rentsendorj, A., Dumitrascu, O. M., Vit, J., Doustar, J., Black, K. L., Fuchs, D.-T. S., & Koronyo‐Hamaoui, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-72156-4_6
Alzheimer’s disease risk gene Wwox protects against amyloid pathology through metabolic reprogrammingPreprint
Lucas-Clarke, H. J., Maddison, D. C., Amadio, L., Buhl, E., O’Hare, K., Regnault, C., Peters, O. M., Hodge, J. J. L., & Smith, G. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.01.651195
Association of sleep disorders with APOE gene polymorphisms among the residents aged 25—64 years of the Novosibirsk city: WHO «MONICA psychosocial study»
Гафаров, В. В., Громова, Е. А., Шахтшнейдер, Е. В., Tripelgorn, A. N., Gagulin, I. V., & Гафарова, А. В. (2025) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20252805175
Slow wave–spindle coupling during deep sleep is selectively linked to Plasma Amyloid-β levels in Older AdultsPreprint
Wunderlin, M., Wicki, K., Teunissen, C. E., & Züst, M. A. (2025) · Research Square · doi:10.21203/rs.3.rs-7085440/v1
Interplay between circadian rhythms and epigenetics in neural stem cells and Alzheimer’s disease
Alves, T. C., Musílek, K., & Monti, B. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102808
Big Hardware
Bainbridge, W. A. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009343602.010
Biology of the blood–brain barrier (BBB)
Wang, D. J. J., & Shao, X. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32974-6.00004-5

Authors: Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Ju, Yo-El S.
McLeland, Jennifer S.
Xiong, Chengjie
Fagan, Anne M.
Morris, John C.
Holtzman, David M.
Venue: JAMA Neurology
Publisher: American Medical Association (AMA)
Published: 2013-05-01
Volume: 70
Issue: 5
Pages: 587
ISSN: 2168-6149 (ISSN-L)
DOI: 10.1001/jamaneurol.2013.2334
PMC: PMC3676720
OpenAlex: W2143790126
Cited by: 744
References: 39
Citations by year: 2026: 45 · 2025: 74 · 2024: 59 · 2023: 67 · 2022: 53 · 2021: 68 · 2020: 86 · 2019: 65 · 2018: 49 · 2017: 51 · 2016: 44 · 2015: 40 · 2014: 31 · 2013: 12
FWCI: 30.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (KL2TR000450, UL1TR000448)
National Institute on Aging (P 50 AG05681, L30 AG043312, P50AG005681, P01 AG0 3991, P01AG003991, P01AG026276)
National Institute of Neurological Disorders and Stroke (P01NS074969)
National Center for Research Resources (KL2RR024994, UL1RR024992)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: preclinical Alzheimer's disease, sleep quality, sleep efficiency, total sleep time, amyloid deposition, amyloid-beta, napping, actigraphy, APOE ε4, circadian rhythm, cognitively normal older adults
MeSH terms: Aged, Alzheimer Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Peptide Fragments, Sleep Wake Disorders, Time Factors, Amyloid beta-Peptides, Actigraphy, Prodromal Symptoms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep Quality and Preclinical Alzheimer Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks