Cited by 84Dementia and Cognitive Impairment ResearchHealth disparities and outcomesCardiovascular Health and Risk Factors

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia

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Abstract

Importance Birth in a group of predominantly southern US states is robustly linked to increased stroke risk. Given the role of cerebrovascular disease in dementia risk, geographic patterning may also occur for dementia incidence. Objective To determine whether birth in 9 high stroke mortality states (HSMSs) is associated with dementia in a diverse cohort of individuals living in Northern California. Design, setting, and participants An observational cohort study included 7423 members of Kaiser Permanente Northern California (KPNC), an integrated health care delivery system, with health survey and clinical examination data available. Data were collected between 1964 and 1973 when the individuals were middle-aged and 1996 and 2015 when participants were in later life. Exposures Self-reported state of birth in an HSMS (top quintile of states for stroke mortality). Main outcomes and measures Dementia diagnoses obtained from electronic health records from January 1, 1996, to October 15, 2015. Place of birth, race, educational level, and midlife vascular risk factors data were collected between 1964 and 1973. Results Of the 7423 persons included in the analysis, 4049 (54.5%) were women; 1354 (18.2%) were black. The mean (SD) age of study participants at their first visit between 1963 and 1974 was 42.94 (1.73) years and mean (SD) age at the beginning of follow-up for dementia in 1996 was 71.14 (2.72) years. Dementia was diagnosed in 2254 (30.4%) of the participants and was more comm…

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Crossref · 10.1001/jamaneurol.2017.1553

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Metadata

Authors
Gilsanz, P., Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., & Whitmer, R. A.
Affiliations
  • Kaiser Permanente (US)
  • University of California, Los Angeles (US)
  • University of California, San Francisco (US)
Corresponding author
Whitmer, Rachel A.
Venue
JAMA Neurology
Published
2017-09-01
Volume
74
Issue
9
Pages
1056
ISSN
2168-6149 (ISSN-L)
OpenAlex
W2739898286
Cited by
84
References
2
Citations by year
2026: 5 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 10 · 2018: 5 · 2017: 1
FWCI
4.95
Type
journal article
Language
en
Open access
Locations
  • JAMA Neurology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (K99AG053410, RF1AG052132, RF1AG050782, T32AG049663)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
dementia risk, birthplace, Southern United States, racial disparities, Black people, cerebrovascular disease, educational attainment, middle-aged adults, older adults, stroke mortality, socioeconomic status, health disparities, life course epidemiology, social determinants of health
MeSH terms
Adult, Aged, Black or African American, California, Dementia, Female, Humans, Male, Middle Aged, Residence Characteristics, Risk, Southeastern United States, Cohort Studies, Incidence, Stroke

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