The DOI matches its Crossref record; 69 of the 71 references it cites were found in a registry or an index.
Comparison of Pharmaceutical, Psychological, and Exercise Treatments for Cancer-Related Fatigue: A Meta-analysis
Open accessAbstract
IMPORTANCE: Cancer-related fatigue (CRF) remains one of the most prevalent and troublesome adverse events experienced by patients with cancer during and after therapy. OBJECTIVE: To perform a meta-analysis to establish and compare the mean weighted effect sizes (WESs) of the 4 most commonly recommended treatments for CRF-exercise, psychological, combined exercise and psychological, and pharmaceutical-and to identify independent variables associated with treatment effectiveness. DATA SOURCES: PubMed, PsycINFO, CINAHL, EMBASE, and the Cochrane Library were searched from the inception of each database to May 31, 2016. STUDY SELECTION: Randomized clinical trials in adults with cancer were selected. Inclusion criteria consisted of CRF severity as an outcome and testing of exercise, psychological, exercise plus psychological, or pharmaceutical interventions. DATA EXTRACTION AND SYNTHESIS: Studies were independently reviewed by 12 raters in 3 groups using a systematic and blinded process for reconciling disagreement. Effect sizes (Cohen d) were calculated and inversely weighted by SE. MAIN OUTCOMES AND MEASURES: Severity of CRF was the primary outcome. Study quality was assessed using a modified 12-item version of the Physiotherapy Evidence-Based Database scale (range, 0-12, with 12 indicating best quality). RESULTS: From 17 033 references, 113 unique studies articles (11 525 unique participants; 78% female; mean age, 54 [range, 35-72] years) published from January 1, 1999, through May 31, 2016, had sufficient data. Studies were of good quality (mean Physiotherapy Evidence-Based Database scale score, 8.2; range, 5-12) with no evidence of publication bias. Exercise (WES, 0.30; 95% CI, 0.25-0.36; P < .001), psychological (WES, 0.27; 95% CI, 0.21-0.33; P < .001), and exercise plus psychological interventions (WES, 0.26; 95% CI, 0.13-0.38; P < .001) improved CRF during and after primary treatment, whereas pharmaceutical interventions did not (WES, 0.09; 95% CI, 0.00-0.19; P = .05). Results also suggest that CRF treatment effectiveness was associated with cancer stage, baseline treatment status, experimental treatment format, experimental treatment delivery mode, psychological mode, type of control condition, use of intention-to-treat analysis, and fatigue measures (WES range, -0.91 to 0.99). Results suggest that the effectiveness of behavioral interventions, specifically exercise and psychological interventions, is not attributable to time, attention, and education, and specific intervention modes may be more effective for treating CRF at different points in the cancer treatment trajectory (WES range, 0.09-0.22). CONCLUSIONS AND RELEVANCE: Exercise and psychological interventions are effective for reducing CRF during and after cancer treatment, and they are significantly better than the available pharmaceutical options. Clinicians should prescribe exercise or psychological interventions as first-line treatments for CRF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“fewer than 10% of prior interventions targeting cancer-related fatigue have included patients with metastatic disease [42].”
From Pilot randomized trial of an acceptance-based telehealth intervention for women with ovarian cancer and PARP inhibitor-related fatigue (2023) · cites this paper as [42]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moderate intensity combined aerobic plus resistance training sessions performed 2–3 times per week or twice weekly moderate intensity resistance training may also be effective(21, 24–26), and the latter particularly in prostate cancer(27).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Existing behavioral symptom management interventions for cancer survivors have been primarily developed and tested among older cancer survivors (aged > 40) [27–32].”
From Improving symptom management for survivors of young adult cancer: rationale and study protocol for a pilot randomized controlled trial (2024) · cites this paper as [29]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“prior exercise and psychosocial interventions for cancer-related fatigue have beenlong and demanding, requiring an average of 43 one-hour sessions [42]”
From Pilot randomized trial of an acceptance-based telehealth intervention for women with ovarian cancer and PARP inhibitor-related fatigue (2023) · cites this paper as [42]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Physical activity training has proven effective and is recommended in guidelines for treating CRF.10,42”
From Exploring the dynamic interconnectedness of protective and perpetuating factors of cancer-related fatigue (2023) · cites this paper as [42]
The cited source says what the claim attributes to it.
In the citing paper
“the few studies that have included patients with advanced cancers have demonstrated smaller effect sizes compared with early-stage cancers [42].”
From Pilot randomized trial of an acceptance-based telehealth intervention for women with ovarian cancer and PARP inhibitor-related fatigue (2023) · cites this paper as [42]
The cited source says what the claim attributes to it.
In the citing paper
“Patients are also recommended various forms of psychotherapy [10,11,12], such as relaxation and guided imagery [13,14], mindfulness meditation (mindfulness-based stress reduction) [14], music therapy [15,16], occupational therapy [17,18,19], and breathing exercises [20,21,22].”
From The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic (2023) · cites this paper as [11]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The basis for screening and intervention is the National Comprehensive Cancer Network guideline on fatigue [38–42].”
From The BrEasT cancer afTER-CARE (BETTER-CARE) programme to improve breast cancer follow-up: design and feasibility study results of a cluster-randomised complex intervention trial (2024) · cites this paper as [39]
Experimental — accuracy not yet measuredIn the citing paper
“The effect of exercise was strongest for moderate to vigorous intensity exercise whereas the effect for low intensity training was weak and this level of exercise is unlikely to reduce fatigue(22, 24, 26, 28).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [26]
In the citing paper
“The effect of exercise was strongest for moderate to vigorous intensity exercise whereas the effect for low intensity training was weak and this level of exercise is unlikely to reduce fatigue(22, 24, 26, 28).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386 · Cited by 14,225
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
Verhagen, A. P., de Vet, H. C. W., de Bie, R. A., Kessels, A. G. H., Boers, M., Bouter, L. M., & Knipschild, P. G. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00131-0 · Cited by 2,470
Publication Bias in Meta‐Analysis: Prevention, Assessment and Adjustments
(2005) · doi:10.1002/0470870168 · Cited by 2,368
Research works printed but not linked: 1
- [46]Higgins JPT Green S Cochrane Collaboration: Cochrane Handbook for Systematic Reviews of Interventions Hoboken, NJ Wiley-Blackwell 2008
Cited by
Sorted by citations
Items 101–200 of 932
Self-management support for cancer-related fatigue: A systematic review
Agbejule, O. A., Hart, N. H., Ekberg, S., Crichton, M., & Chan, R. J. (2022) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2022.104206 · Cited by 52
Twomey, R., Martin, T., Temesi, J., Culos-Reed, S. N., & Millet, G. Y. (2018) · BMC Cancer · doi:10.1186/s12885-018-4668-z · Cited by 51
Jim, H., Hyland, K. A., Nelson, A. M., Pinilla-Ibarz, J. A., Sweet, K. L., Gielissen, M. F. M., Bulls, H. W., Hoogland, A. I., Jacobsen, P. B., & Knoop, H. (2019) · Cancer · doi:10.1002/cncr.32521 · Cited by 47
Roberts, G. J., Dumas, D., McNeish, D., & Coté, B. (2021) · Review of Educational Research · doi:10.3102/00346543211051423 · Cited by 47
Kleckner, A. S., Reschke, J. E., Kleckner, I. R., Magnuson, A. M., Amitrano, A. M., Culakova, E., Shayne, M., Netherby, C. S., Czap, S., Janelsins, M. C., et al. (2022) · Cancers · doi:10.3390/cancers14174202 · Cited by 47
Self-citationPsychosocial interventions for cancer survivors: a meta-analysis of effects on positive affect
Salsman, J. M., Pustejovsky, J. E., Schueller, S. M., Hernandez, R., Berendsen, M., McLouth, L. E. S., & Moskowitz, J. T. (2019) · Journal of Cancer Survivorship · doi:10.1007/s11764-019-00811-8 · Cited by 45
Chronic fatigue and associated factors among long-term survivors of cancers in young adulthood
Bøhn, S., Thorsen, L., Kiserud, C. E., Fosså, S. D., Lie, H. C., Loge, J. H., Wisløff, T. F., Haugnes, H. S., & Reinertsen, K. V. (2019) · Acta Oncologica · doi:10.1080/0284186x.2018.1557344 · Cited by 46
Dennett, A. M., Sarkies, M., Shields, N., Peiris, C. L., Williams, C., & Taylor, N. F. (2021) · Journal of Physiotherapy · doi:10.1016/j.jphys.2020.12.008 · Cited by 44
Timilshina, N., Breunis, H., TOMLINSON, G. A., Brandwein, J. M., Buckstein, R. J., Durbano, S., & Alibhai, S. M. H. (2018) · Leukemia · doi:10.1038/s41375-018-0162-5 · Cited by 44
Haussmann, A., Ungar, N., Gabrian, M., Tsiouris, A., Sieverding, M., Wiskemann, J., & Steindorf, K. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4279-x · Cited by 44
Fatigue in Cancer Patients in Palliative Care—A Review on Pharmacological Interventions
Klasson, C., Frankling, M. H., Hagelin, C. L., & Björkhem‐Bergman, L. (2021) · Cancers · doi:10.3390/cancers13050985 · Cited by 45
A study of chronic fatigue in Norwegian cervical cancer survivors
Steen, R., Dahl, A. A., Hess, S. L., & Kiserud, C. E. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.05.028 · Cited by 43
Home-based rehabilitation in inoperable non-small cell lung cancer—the patient experience
Edbrooke, L., Denehy, L., Granger, C. L., Kapp, S., & Aranda, S. K. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04783-4 · Cited by 43
The association between fatigue and pain symptoms and decreased physical activity after cancer
Romero, S. A. D., Jones, L. W., Bauml, J. M., Li, Q. S., Cohen, R. B., & Mao, J. J. J. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4203-4 · Cited by 46
Bernard, P., Savard, J., Steindorf, K., Sweegers, M. G., Courneya, K. S., Newton, R. U., Aaronson, N. K., Jacobsen, P. B., May, A. M., Galvao, D. A., et al. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109746 · Cited by 46
Cheung, D. S. T., Yeung, W., Chau, P. H., Lam, T., Yang, M., Lai, K., Ip, C. Y., Lao, L., & Lin, C. (2020) · European Journal of Cancer Care · doi:10.1111/ecc.13314 · Cited by 42
Coletta, A. M., Basen‐Engquist, K., & Schmitz, K. H. (2022) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_349635 · Cited by 44
Bade, B. C., Faiz, S. A., Ha, D. M., Tan, M., Barton‐Burke, M., Cheville, A. L., Escalante, C. P., Gozal, D., Granger, C. L., Presley, C. J., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202210-1963st · Cited by 46
Pashaki, A. S., Sheida, F., Shoar, L. M., Hashem, T., Fazilat‐Panah, D., Motehaver, A. N., Motlagh, A. G., Nikzad, S., Bakhtiari, M., Tapak, L., et al. (2023) · Integrative Cancer Therapies · doi:10.1177/15347354231168624 · Cited by 41
van Vulpen, J. K., Schmidt, M. E., Velthuis, M. J., Wiskemann, J., Schneeweiß, A., Vermeulen, R. C. H., Habermann, N., Ulrich, C. M., Peeters, P. H. M., van der Wall, E., et al. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4608-7 · Cited by 41
Coutiño-Escamilla, L., Piña‐Pozas, M., Tobı́as, A., Gamboa-Loira, B., & López‐Carrillo, L. (2019) · The Breast · doi:10.1016/j.breast.2019.01.006 · Cited by 41
Management of Fatigue in Patients with Advanced Cancer
Stone, P. C., Candelmi, D., Kandola, K., Montero, L., Smetham, D., Suleman, S., Fernando, A., & Rojí, R. (2023) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-01045-0 · Cited by 40
Wang, B., Thapa, S., Zhou, T., Liu, H., Li, L., Peng, G., & Yu, S. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04717-0 · Cited by 41
Haussmann, A., Schmidt, M. E., Illmann, M., Schröter, M., Hielscher, T., Cramer, H., Maatouk, I., Horneber, M., & Steindorf, K. (2022) · Cancers · doi:10.3390/cancers14082016 · Cited by 48
Torregrosa, C., Chorin, F., Beltran, E. E. M., Neuzillet, C., & Cardot‐Ruffino, V. (2022) · Cancers · doi:10.3390/cancers14215402 · Cited by 47
The Effect of Acupressure on Relieving Cancer-Related Fatigue
Hsieh, S.-H., Wu, C.-R., Romadlon, D. S., Hasan, F., Chen, P., & Chiu, H. (2021) · Cancer Nursing · doi:10.1097/ncc.0000000000000997 · Cited by 40
Fitbit Usage in Patients With Breast Cancer Undergoing Chemotherapy
Dreher, N., Hadeler, E. K., Hartman, S. J., Wong, E. C., Acerbi, I., Rugo, H. S., Majure, M. C., Chien, A. J., Esserman, L. J., & Melisko, M. (2019) · Clinical Breast Cancer · doi:10.1016/j.clbc.2019.05.005 · Cited by 42
Soidán, J. L. G., Pérez-Ribao, I., Leirós‐Rodríguez, R., & Soto-Rodríguez, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17144986 · Cited by 36
The use of methylphenidate to relieve fatigue
Rojí, R., & Centeno, C. (2017) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000296 · Cited by 36
Pérez, A. M. L., Collado‐Mateo, D., Mayo, X., Liguori, G. A., Humphreys, L. J., Copeland, R. J., & Jiménez, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-94476-y · Cited by 42
Ullmann, E., Perry, S. W., Licinio, J., Wong, M., Dremencov, E., Zavjalov, E. L., Shevelev, O. B., Хоцкин, Н. В., Koncevaya, G. V., Khotskina, А. S., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00047 · Cited by 36
Huang, J., Yang, H., Wei, J., Liu, X., Du, Y., Yang, L., Li, Y., Yao, W., & Wang, R. (2019) · Clinical Rehabilitation · doi:10.1177/0269215519889394 · Cited by 36
Cancer-Related Fatigue—Is There a Role for Complementary and Integrative Medicine?
David, A., Hausner, D., & Frenkel, M. A. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01135-6 · Cited by 35
Cancer-related fatigue—pharmacological interventions: systematic review and network meta-analysis
Chow, R., Bruera, E. D., Sanatani, M. S., Chiu, L., Prsic, E. H., Boldt, G., & Lock, M. I. (2021) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2021-003244 · Cited by 35
Herranz‐Gómez, A., Cuenca‐Martínez, F., Suso‐Martí, L., Varangot‐Reille, C., Prades-Monfort, M., Calatayud, J., & Casaña, J. (2023) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2023.01.008 · Cited by 42
Malveiro, C., Correia, I. R., Cargaleiro, C., Magalhães, J. P., de Matos, L. V., Hilário, S., Sardinha, L. B., & Cardoso, M. J. (2023) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2023.08.178 · Cited by 37
Machado, P., Pimenta, S., Garcia, A. L., Nogueira, T., Silva, S., dos Santos, C. L., Martins, M. V., Canha, A., Oliveiros, B., Martins, R. A., et al. (2023) · Annals of Surgical Oncology · doi:10.1245/s10434-023-14503-2 · Cited by 77
Larsen, M. H., Larsen, E. H., Ruud, E., Mellblom, A. V., Helland, S., & Lie, H. C. (2021) · Journal of Cancer Survivorship · doi:10.1007/s11764-021-01066-y · Cited by 34
Jones, J. M., Howell, D., Longo, C. J., Olson, K. L., Bedard, P. L., Amir, E., Zheng, S., Chow, B., & Avery, L. M. (2023) · Journal of Cancer Survivorship · doi:10.1007/s11764-023-01451-9 · Cited by 39
Pethybridge, R., Teleni, L., & Chan, R. J. (2020) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2020.101795 · Cited by 33
Brennan, L. K., Sadeghi, F., O’Neill, L. M., Guinan, E. M., Smyth, L., Sheill, G., Smyth, E., Doyle, S. L., Timon, C., Connolly, D., et al. (2022) · Cancers · doi:10.3390/cancers14112707 · Cited by 33
Which Exercise Approaches Work for Relieving Cancer-Related Fatigue? A Network Meta-analysis
Dong, B., Qi, Y., Lü, L., Liu, T., Wang, S., Zhang, Y., Yuan, Y., Cheng, H., Chen, Q., Fang, Q., et al. (2023) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2023.11251 · Cited by 33
Pérez, I. M. M., Pérez, S. E. M., García, R. P., Lupgens, D. D. Z., Martínez, G. B., González, C. R., Yáñez, N. K., & Hernández, F. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-35503-y · Cited by 32
Advances in the care of breast cancer survivors
Cathcart-Rake, E. J., Tevaarwerk, A. J., Haddad, T. C., D’Andre, S. D., & Ruddy, K. J. (2023) · BMJ · doi:10.1136/bmj-2022-071565 · Cited by 35
Kim, B. H., Yu, S. J., Kang, W., Cho, S. B., Park, S. Y., Kim, S. U., & Kim, D. Y. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15727 · Cited by 32
Fatigue, a major still underestimated issue
Ripamonti, C. I., Antonuzzo, A., Bossi, P., Cavalieri, S., Roila, F., & Fatigoni, S. (2018) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000451 · Cited by 32
Yeh, M.-H., Chao, C.-H., Koo, M., Chen, C.-Y., Yeh, C.-C., & Li, T. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.01.004 · Cited by 31
Giaccone, L., Felicetti, F., Butera, S., Faraci, D., Cerrano, M., Dionisi‐Vici, M., Brunello, L., Fortunati, N., Brignardello, E., & Bruno, B. (2020) · Journal of Blood Medicine · doi:10.2147/jbm.s206027 · Cited by 37
Kleckner, I. R., Jusko, T. A., Culakova, E., Chung, K., Kleckner, A. S., Asare, M., Inglis, J. E., Loh, K. P., Peppone, L. J., Miller, J. M., et al. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06304-6 · Cited by 31
Self-citationMeyer-Schwickerath, C., Morawietz, C., Baumann, F. T., Huber, G., & Wiskemann, J. (2021) · Disability and Rehabilitation · doi:10.1080/09638288.2021.1938247 · Cited by 30
Doré, I., Plante, A., Peck, S. S., Bedrossian, N., & Sabiston, C. M. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06469-2 · Cited by 31
Chandeying, N., & Thongseiratch, T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.784615 · Cited by 33
Machado, P., Morgado, M., Raposo, J., Mendes, M., Silva, C. G., & Morais, N. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-06856-3 · Cited by 37
Pelzer, F., Loef, M., Martin, D. D., & Baumgartner, S. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-06921-x · Cited by 31
The metabolic basis of cancer-related fatigue
Dantzer, R., Chelette, B. M., Vichaya, E. G., West, A. P., & Grossberg, A. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106035 · Cited by 36
Dietary supplements and fatigue in patients with breast cancer: a systematic review
Pereira, P. T. V. T., Reis, A. D., Diniz, R. R., Lima, F. A., Leite, R. D., Silva, M. C. P. D., Guerra, R. N. M., Vieira, É. B. D. M., & Garcia, J. B. S. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4857-0 · Cited by 33
The Role of Physical Activity in Managing Fatigue in Cancer Survivors
Ferrer, B.-C. S., van Roekel, E. H., & Lynch, B. M. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0234-1 · Cited by 31
Symptom-based interventions to promote quality survivorship
Amidei, C. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy100 · Cited by 30
Xu, Y., Wang, X. S., Chen, Y., Shi, Q., Chen, T. H., & Li, P. (2019) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2019.10.018 · Cited by 30
Pancreatic cancer: Best supportive care
Védié, A., & Neuzillet, C. (2019) · La Presse Médicale · doi:10.1016/j.lpm.2019.02.032 · Cited by 29
Interventions for multidimensional aspects of breast cancer-related fatigue: a meta-analytic review
Vannorsdall, T. D., Straub, E., Saba, C., Blackwood, M., Zhang, J., Stearns, K., & Smith, K. L. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05752-y · Cited by 33
Symptoms During Outpatient Cancer Treatment and Options for their Management
Tewes, M., Baumann, F. T., Teufel, M., & Ostgathe, C. (2021) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2021.0028 · Cited by 31
Cheville, A. L., Smith, S. R., Barksdale, T., & Asher, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-62539-5.00029-1 · Cited by 33
Cancer Pain and Opioid Use Disorder
Ganguly, A. (2022) · ONCOLOGY · doi:10.46883/2022.25920973 · Cited by 30
Exercise medicine in cancer care
Cormie, P., Trevaskis, M., Thornton‐Benko, E., & Zopf, E. M. (2020) · Australian Journal of General Practice · doi:10.31128/ajgp-08-19-5027 · Cited by 28
Cheng, P., Xu, L., Zhang, J., Liu, W., & Zhu, J. (2021) · Journal of Palliative Medicine · doi:10.1089/jpm.2020.0468 · Cited by 29
Fatigue and quality of life among thyroid cancer survivors without persistent or recurrent disease
Maki, Y., Horiuchi, K., & Okamoto, T. (2022) · Endocrine Connections · doi:10.1530/ec-21-0506 · Cited by 31
Schmidt, M. E., Milzer, M., Weiß, C., Reinke, P., Grapp, M., & Steindorf, K. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-06833-w · Cited by 28
Bøhn, S., Vandraas, K. F., Kiserud, C. E., Dahl, A. A., Thorsen, L., Ewertz, M., Lie, H. C., Falk, R. S., & Reinertsen, K. V. (2022) · Journal of Cancer Survivorship · doi:10.1007/s11764-022-01202-2 · Cited by 29
Ispoglou, T., McCullough, D., Windle, A., Nair, S., Cox, N. J., White, H., Burke, D., Kanatas, A. N., & Prokopidis, K. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.009 · Cited by 28
Integrated Rehabilitation for Breast Cancer Survivors
Cheville, A. L., McLaughlin, S. A., Haddad, T. C., Lyons, K. D., Newman, R. M., & Ruddy, K. J. (2018) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000001017 · Cited by 28
A nationwide survey of fatigue in cancer patients in Taiwan: an unmet need
Rau, K.-M., Shun, S., Chiou, T.-J., Lu, C.-H., Ko, W.-H., Lee, M.-Y., Huang, W.-T., Yeh, K., Chang, C., & Hsieh, R. (2020) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyaa038 · Cited by 27
Lu, L., Gavin, A., Drummond, F. J., & Sharp, L. (2020) · Journal of Cancer Survivorship · doi:10.1007/s11764-020-00906-7 · Cited by 27
Neuzillet, C., Anota, A., Foucaut, A.-M., Védié, A., Antoun, S., Barnoud, D., Bouleuc, C., Chorin, F., Cottet, V., Fontaine, E. M., et al. (2020) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2020-002751 · Cited by 27
Schmitter, M., Spijker, J., Smit, F., Tendolkar, I., Derksen, A.-M., Oostelbos, P., Wijnen, B. F. M., van Doesum, T., Smits, J. A. J., & Vrijsen, J. N. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02989-z · Cited by 27
Wyatt, G. K., Lehto, R. H., Niyogi, P. G., Brewer, S., Victorson, D. E., Pace, T. W. W., Badger, T. A., & Sikorskii, A. E. (2021) · Research in Nursing & Health · doi:10.1002/nur.22169 · Cited by 27
Machado, P., Pimenta, S., Oliveiros, B., Ferreira, J. P., Martins, R. A., & Cruz, J. (2021) · Cancers · doi:10.3390/cancers13194975 · Cited by 28
Zhang, S., Gong, F., Liu, J., Liu, T., Yang, J., & Hu, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113004 · Cited by 27
Hussey, C., & Gupta, A. (2022) · Cancer Investigation · doi:10.1080/07357907.2022.2105349 · Cited by 27
Psychological Factors Predict Higher Odds and Impairment of Post-COVID Symptoms: A Prospective Study
Milde, C., Glombiewski, J. A., Wilhelm, M., & Schemer, L. (2023) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001214 · Cited by 28
Ciruelos, E., García-Sáenz, J. Á., Gavilá, J., Martín, M., Rodriguez, C. A., & Rodríguez-Lescure, Á. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03383-x · Cited by 26
Exercise and Physical Activity in Patients with Osteosarcoma and Survivors
Garcia, M. B., Ness, K. K., & Schadler, K. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43032-0_16 · Cited by 26
Oxaliplatin induces muscle loss and muscle‐specific molecular changes in Mice
Feather, C. E., Lees, J. G., Makker, P. G. S., Goldstein, D., Kwok, J. B., Moalem‐Taylor, G., & Polly, P. (2017) · Muscle & Nerve · doi:10.1002/mus.25966 · Cited by 26
Felser, S., Behrens, M., Liese, J., Strüder, D., Rhode, K., Junghanß, C., & Große-Thie, C. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420918935 · Cited by 24
Radiotherapy-Induced Fatigue in Breast Cancer Patients
Kowalczyk, L., Deutschmann, C., Crevenna, R., Konrad, S., Singer, C. F., & Farr, A. (2020) · Breast Care · doi:10.1159/000509410 · Cited by 26
Addison, S., Shirima, D., Aboagye-Mensah, E. B., Dunovan, S. G., Pascal, E. Y., Lustberg, M. B., Arthur, E. K., & Nolan, T. S. (2021) · Journal of Cancer Survivorship · doi:10.1007/s11764-021-01094-8 · Cited by 26
Starreveld, D. E. J., Daniels, L. A., Kieffer, J. M., Valdimarsdottir, H. B., de Geus, J., Lanfermeijer, M., Someren, E. J. W. V., Habers, G. E. A., Bosch, J. A., Janus, C. P. M., et al. (2021) · Cancers · doi:10.3390/cancers13194948 · Cited by 25
Evidence-Based Care for People with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis
Sharpe, M., Chalder, T., & White, P. D. (2021) · Journal of General Internal Medicine · doi:10.1007/s11606-021-07188-4 · Cited by 27
VanderVeen, B. N., Cardaci, T. D., Madero, S. S., McDonald, S. J., Bullard, B. M., Price, R. L., Carson, J. A., Fan, D., & Murphy, E. A. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00325.2022 · Cited by 29
Patient–physician communication about cancer-related fatigue: a survey of patient-perceived barriers
Milzer, M., Wagner, A. S., Schmidt, M. E., Maatouk, I., Hermann, S., Cancer Registry of Baden-Württemberg, Kiermeier, S., & Steindorf, K. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05555-8 · Cited by 25
Symptom Management and Palliative Care in Pancreatic Cancer
Rabow, M. W., Petzel, M. Q. B., & Adkins, S. H. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000293 · Cited by 25
Wong, M. L., Paul, S. M., Mastick, J., Ritchie, C. S., Steinman, M. A., Walter, L. C., & Miaskowski, C. A. (2018) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2018.08.006 · Cited by 28
Tian, H., Chen, Y., Sun, M., Huang, L., Xu, G., Yang, C., Luo, Q., Zhao, L., Wei, Z., & Liang, F. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1071326 · Cited by 26
Kim, S. H., Sung, J. H., Yoo, S., Kim, S., Lee, K., Oh, E. G., & Lee, J. (2023) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2023.102404 · Cited by 28
Henriksson, A., Johansson, B., Radu, C., Berntsen, S., Igelström, H., & Nordin, K. (2020) · Acta Oncologica · doi:10.1080/0284186x.2020.1851046 · Cited by 24
Amiri, A., Chovanec, M., Oliva, V., Sedliak, M., Mego, M., Ukropec, J., & Ukropcová, B. (2021) · Andrology · doi:10.1111/andr.13078 · Cited by 26
Exercise interventions for adults with cancer receiving radiation therapy alone
Trommer, M., Marnitz, S., Skoetz, N., Rupp, R., Niels, T., Morgenthaler, J., Theurich, S., von Bergwelt‐Baildon, M., Baues, C., & Baumann, F. T. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013448.pub2 · Cited by 22
Nonpharmacological interventions for cancer-related fatigue: A comprehensive literature review
Zuo, S., Cheng, H., Wang, Z., Liu, T., Chen, S., Li, T., & Lü, L. (2023) · Asia-Pacific Journal of Oncology Nursing · doi:10.1016/j.apjon.2023.100230 · Cited by 27
Chow, S. L.-M., Wan, B. A., Pidduck, W., Zhang, L., DeAngelis, C., Chan, S., Yee, C., Drost, L., Leung, E., Sousa, P., et al. (2019) · Clinical Breast Cancer · doi:10.1016/j.clbc.2019.05.007 · Cited by 24
Reed, N., Glen, H., Gerrard, G., Good, J., Lei, M., Lyon, A. R., Strachan, M. W. J., Wadsley, J., & Newbold, K. L. (2019) · Clinical Oncology · doi:10.1016/j.clon.2019.11.010 · Cited by 24
Metadata
- Authors
- Mustian, K. M., Alfano, C. M., Heckler, C., Kleckner, A. S., Kleckner, I. R., Leach, C. R., Mohr, D., Palesh, O. G., Peppone, L. J., Piper, B. F., Scarpato, J., Smith, T., Sprod, L. K., & Miller, S. M.
- Affiliations
- University of Rochester Medicine (US)
- American Cancer Society (US)
- Northwestern University (US)
- Stanford Cancer Institute (US)
- National University (US)
- Fox Chase Cancer Center (US)
- University of North Carolina Wilmington (US)
- Corresponding author
- Mustian, Karen M.
- ORCID
- Venue
- JAMA Oncology
- Publisher
- American Medical Association (AMA)
- Published
- 2017-07-01
- Volume
- 3
- Issue
- 7
- Pages
- 961
- ISSN
- 2374-2437 (ISSN-L)
- PMC
- PMC5557289
- OpenAlex
- W2593266874
- Cited by
- 932
- References
- 71
- Citations by year
- 2026: 126 · 2025: 97 · 2024: 96 · 2023: 109 · 2022: 129 · 2021: 116 · 2020: 97 · 2019: 78 · 2018: 57 · 2017: 25
- FWCI
- 30.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Oncology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001422)
- National Cancer Institute (R01CA181659, K07CA168911, R25CA102618, R01CA181064, UG1CA189961, R21CA185678, T32CA102618)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- cancer-related fatigue, exercise therapy, psychological intervention, pharmacotherapy, treatment effectiveness comparison, cancer survivors, cancer patients, fatigue severity, quality of evidence, publication bias, treatment effect heterogeneity, exercise duration, exercise frequency
- MeSH terms
- Modafinil, Central Nervous System Stimulants, Benzhydryl Compounds, Dextroamphetamine, Exercise Therapy, Fatigue, Glucocorticoids, Humans, Methylphenidate, Methylprednisolone, Neoplasms, Psychotherapy, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Paroxetine, Wakefulness-Promoting Agents, Dexmethylphenidate Hydrochloride
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
