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Cited by 170Nutritional Studies and DietDementia and Cognitive Impairment ResearchFatty Acid Research and Health

Association of the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet With the Risk of Dementia

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Chen, Hui, Dhana, Klodian, Huang, Yuhui, Huang, Liyan, Tao, Yang, Liu, Xiaoran, Melo van Lent, Debora, Zheng, Yan +3 more·2023·JAMA Psychiatry
DOI 10.1001/jamapsychiatry.2023.0800PMC PMC10157510
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Abstract

Importance: Dementia threatens the well-being of older adults, making efforts toward prevention of great importance. Objective: To evaluate the association of the Mediterranean–Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet with the risk of dementia in 3 prospective studies and a meta-analysis. Design, Setting, and Participants: Cohort analyses included the Whitehall II study (WII), the Health and Retirement Study (HRS), and the Framingham Heart Study Offspring cohort (FOS), and the meta-analysis included 11 cohort studies. Participants were middle-aged and older women and men from WII in 2002 to 2004, HRS in 2013, and FOS in 1998 to 2001 without dementia at the study baseline. Data were analyzed from May 25 to September 1, 2022. Exposures: MIND diet score was measured using food frequency questionnaires, and scores ranged from 0 to 15, with a higher score indicating higher adherence to the MIND diet. Main Outcome and Measures: Incident all-cause dementia, with cohort-specific definitions. Results: Included in this study were 8358 participants (mean [SD] age, 62.2 [6.0] years; 5777 male [69.1%]) from WII, 6758 participants (mean [SD] age, 66.5 [10.4] years; 3965 female [58.7%]) from HRS, and 3020 participants (mean [SD] age, 64.2 [9.1] years; 1648 female [54.6%]) from FOS. The mean (SD) baseline MIND diet score was 8.3 (1.4) in WII, 7.1 (1.9) in HRS, and 8.1 (1.6) in FOS. Over 166 516 person-years, a total of 775 participants (220 in WII, 338 in HRS, and 217 in FOS) developed incident dementia. In the multivariable-adjusted Cox proportional hazard model, higher MIND diet score was associated with lower risk of dementia (pooled hazard ratio [HR] for every 3-point increment, 0.83; 95% CI, 0.72-0.95; P for trend = .01; I 2 = 0%). The associations were consistently observed in subgroups defined by sex, age, smoking status, and body mass index. In the meta-analysis of 11 cohort studies with 224 049 participants (5279 incident dementia cases), the highest tertile of MIND diet score was associated with lower risk of dementia compared with the lowest tertile (pooled HR, 0.83; 95% CI, 0.76-0.90; I 2 = 35%). Conclusions and Relevance: Results suggest that adherence to the MIND diet was associated with lower risk of incident dementia in middle-aged and older adults. Further studies are warranted to develop and refine the specific MIND diet for different populations.

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  • A subsequent larger meta-analysis of three cohort studies with 224,049 participants found higher adherence to the MIND diet score was associated with lower risk of dementia (HR 0.83, 0.72-0.95 per 3-point increment).

    “A subsequent larger meta-analysis of three cohort studies with 224 049 participants found higher adherence to the MIND diet score was associated with lower risk of dementia (HR for every 3point increment, 0.83; 0.72 -0.95; I 2 = 0%). (324)”

    From Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission (2024) · cites this paper as [324]

    The Results report an HR of 0.83 (95% CI, 0.72–0.95; I² = 0%) per 3-point MIND diet score increment for the three cohorts, which included 18,136 participants. The 224,049-participant meta-analysis instead included 11 cohorts and reported an HR of 0.83 (95% CI, 0.76–0.90) comparing the highest and lowest score tertiles. The claim combines the sample size from one analysis with the estimate from the other. (LLM, conf=0.95)

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Cited by

Sorted by citations

Authors
Chen, H., Dhana, K., Huang, Y., Huang, L., Tao, Y., Liu, X., Melo van Lent, D., Zheng, Y., Ascherio, A., Willett, W., & Yuan, C.
Affiliations
  • Second Affiliated Hospital of Zhejiang University (CN)
  • Rush University Medical Center (US)
  • Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas
  • Fudan University (CN)
  • Harvard University (US)
Corresponding author
Yuan, Changzheng
ORCID
Venue
JAMA Psychiatry
Publisher
American Medical Association (AMA)
Published
2023-06-01
Volume
80
Issue
6
Pages
630
ISSN
2168-622X (ISSN-L)
DOI
10.1001/jamapsychiatry.2023.0800
PMC
PMC10157510
OpenAlex
W4367835000
Cited by
170
References
12
Citations by year
2026: 56 · 2025: 54 · 2024: 50 · 2023: 10
FWCI
8.39
Type
journal article
Language
en
Open access
Locations
  • JAMA Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council (MR/T033371/1)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
MIND diet, dementia risk, dementia prevention, dietary adherence, Mediterranean diet, DASH diet, neurodegenerative diseases, older adults, middle-aged adults, incident dementia, Whitehall II, Health and Retirement Study, cognitive decline, Alzheimer's disease, vascular dementia, cardiovascular risk factors, sex differences
MeSH terms
Dietary Approaches To Stop Hypertension, Aged, Dementia, Female, Humans, Male, Middle Aged, Prospective Studies, Cohort Studies, Diet, Mediterranean

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