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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Abstract
Exosomes are small membrane vesicles found in cell culture supernatants and in different biological fluids. Exosomes form in a particular population of endosomes, called multivesicular bodies (MVBs), by inward budding into the lumen of the compartment. Upon fusion of MVBs with the plasma membrane, these internal vesicles are secreted. Exosomes possess a defined set of membrane and cytosolic proteins. The physiological function of exosomes is still a matter of debate, but increasing results in various experimental systems suggest their involvement in multiple biological processes. Because both cell‐culture supernatants and biological fluids contain different types of lipid membranes, it is critical to perform high‐quality exosome purification. This unit describes different approaches for exosome purification from various sources, and discusses methods to evaluate the purity and homogeneity of the purified exosome preparations.
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“For electron microscopy (EM) analysis of EVs, samples were prepared as per the protocol described previously72.”
From GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain (2021) · cites this paper as [72]
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B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Self-citationZitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266
Self-citationIdentification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643
Self-citationThéry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564
Self-citationHeijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488
Exosomal-like vesicles are present in human blood plasma
Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348
Self-citationPan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242
Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228
Molecular Characterization of Dendritic Cell-Derived Exosomes
Théry, C., Régnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.599 · Cited by 1,065
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Items 701–800 of 1,062
Guo, Z., Wang, X., Yang, Y., Chen, W., Zhang, K., Teng, B., Huang, C., Zhao, Q., & Qiu, Z. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.08.021 · Cited by 181
High-quality milk exosomes as oral drug delivery system
Zhong, J., Xia, B., Shan, S., Zheng, A., Zhang, S., Chen, J., & Liang, X. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121126 · Cited by 180
The Complete Exosome Workflow Solution: From Isolation to Characterization of RNA Cargo
Schageman, J. J., Zeringer, E., Li, M., Barta, T. J., Lea, K., Gu, J. H., Magdaleno, S. M., Setterquist, R. A., & Vlassov, A. V. (2013) · BioMed Research International · doi:10.1155/2013/253957 · Cited by 179
Nakazaki, M., Morita, T., Lankford, K. L., Askenase, P. W., & Kocsis, J. D. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12137 · Cited by 182
Residual matrix from different separation techniques impacts exosome biological activity
Paolini, L., Zendrini, A., Noto, G. D., Busatto, S., Lottini, E., Radeghieri, A., Dossi, A., Caneschi, A., Ricotta, D., & Bergese, P. (2016) · Scientific Reports · doi:10.1038/srep23550 · Cited by 185
Extracellular Vesicle Isolation and Analysis by Western Blotting
Kowal, E. J. K., Ter‐Ovanesyan, D., Regev, A., & Church, G. M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7253-1_12 · Cited by 175
Zhai, L.-Y., Li, M., Pan, W., Chen, Y., Li, M., Jian-xin, P., Zheng, L., Chen, J.-X., & Duan, W. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b12725 · Cited by 182
Secretion of tau via an unconventional non-vesicular mechanism
Merezhko, M., Brunello, C. A., Yan, X., Vihinen, H., Jokitalo, E., Uronen, R.-L., & Huttunen, H. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.078 · Cited by 166
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Kayagaki, N., Stowe, I. B., Alegre, K. O., Deshpande, I., Wu, S., Lin, Z., Kornfeld, O. S., Lee, B. L., Zhang, J., Liu, J., et al. (2023) · Nature · doi:10.1038/s41586-023-06191-5 · Cited by 195
Jalabert, A., Vial, G., Guay, C., Wiklander, O. P. B., Nordin, J. Z., Aswad, H., Forterre, A., Meugnier, E., Pesenti, S., Regazzi, R., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3882-y · Cited by 177
Beckett, K., Monier, S., Palmer, L., Alexandre, C., Green, H., Bonneil, É., Raposo, G., Thibault, P., Borgne, R. L., & Vincent, J. (2012) · Traffic · doi:10.1111/tra.12016 · Cited by 177
Self-citationJeppesen, D. K., Nawrocki, A., Jensen, S. G., Thorsen, K., Whitehead, B. J., Howard, K. A., Dyrskjøt, L., Orntoft, T. F., Larsen, M. R., & Ostenfeld, M. S. (2013) · PROTEOMICS · doi:10.1002/pmic.201300452 · Cited by 182
Mukherjee, K., Ghoshal, B., Ghosh, S., Chakrabarty, Y., Shwetha, S., Das, S., & Bhattacharyya, S. N. (2016) · The EMBO Reports · doi:10.15252/embr.201541930 · Cited by 184
Lung cancer exosomes as drivers of epithelial mesenchymal transition
Rahman, M. A., Barger, J. F., Lovat, F., Gao, M., Otterson, G. A., & Nana-Sinkam, P. S. (2016) · Oncotarget · doi:10.18632/oncotarget.10243 · Cited by 177
Wang, X., Omar, O., Vazirisani, F., Thomsen, P., & Ekström, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193059 · Cited by 176
Rapid Detection of Exosomal MicroRNAs Using Virus‐Mimicking Fusogenic Vesicles
Gao, X., Li, S., Ding, F., Fan, H.-J., Shi, L., Zhu, L., Li, J., Feng, J., Zhu, X., & Zhang, C. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901997 · Cited by 177
Swanson, W. B., Zhang, Z., Xiu, K., Gong, T., Eberle, M., Wang, Z., & Ma, P. X. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.052 · Cited by 180
Suharta, S., Barlian, A., Hidajah, A. C., Notobroto, H. B., Ana, I. D., Indariani, S., Wungu, T. D. K., & Wijaya, C. H. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15787 · Cited by 178
Lokossou, A. G., Kouakanou, L., Schumacher, A., & Zenclussen, A. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.849012 · Cited by 201
Exosomes from Bronchoalveolar Fluid of Tolerized Mice Prevent Allergic Reaction
Prado, N., Marazuela, E. G., Segura, É., Fernández‐García, H., Villalba, M., Théry, C., Rodrı́guez, R., & Batanero, E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1519 · Cited by 176
Self-citationForterre, A. V., Jalabert, A., Berger, E., Baudet, M., Chikh, K., Errazuriz-Cerda, E., Larichaudy, J. D., Chanon, S., Weiss‐Gayet, M., Hesse, A.-M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084153 · Cited by 176
Park, S.-J., Kim, J. M., Kim, J., Hur, J., Park, S., Kim, K. H., Shin, H., & Chwae, Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811432115 · Cited by 182
Exosomal therapy—a new frontier in regenerative medicine
Muthu, S., Bapat, A., Jain, R., Jeyaraman, N., & Jeyaraman, M. (2021) · Stem Cell Investigation · doi:10.21037/sci-2020-037 · Cited by 185
Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes
Ahadi, A., Brennan, S. E., Kennedy, P. J., Hutvágner, G., & Tran, N. (2016) · Scientific Reports · doi:10.1038/srep24922 · Cited by 175
Tang, N., Sun, B., Gupta, A. A., Rempel, H. C., & Pulliam, L. (2016) · The FASEB Journal · doi:10.1096/fj.201600368rr · Cited by 172
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
Zhao, Y., Zhao, M., Jiang, S., Wu, J., Liu, J., Yuan, X., Shen, D., Zhang, J., Zhou, N., He, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14450-6 · Cited by 181
Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies
Karch, C. M. M., Jeng, A. T., & Goate, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.380642 · Cited by 185
Ingato, D., Lee, J. U., Sim, S. J., & Kwon, Y. J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.016 · Cited by 177
Davidson, S. M., Boulanger, C. M., Aïkawa, E., Badimón, L., Barile, L., Binder, C. J., Brisson, A. R., Buzás, E. I., Emanueli, C., Jansen, F., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac031 · Cited by 178
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Zhang, B., Yin, Y., Lai, R. C., & Lim, S. K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00518 · Cited by 172
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Lopera-Vásquez, R., Hamdi, M., Maillo, V., Gutiérrez‐Adán, A., Bermejo‐Álvarez, P., Ramírez, M. Á., Yáñez‐Mó, M., & Rizos, D. V. (2017) · Reproduction · doi:10.1530/rep-16-0384 · Cited by 182
Lakhter, A. J., Pratt, R. E., Moore, R. E., Doucette, K. K., Maier, B. F., DiMeglio, L. A., & Sims, E. K. (2018) · Diabetologia · doi:10.1007/s00125-018-4559-5 · Cited by 169
Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid
Emelyanov, A., Shtam, T. A., Kamyshinsky, R. A., Garaeva, L. A., Верлов, Н. А., Miliukhina, I. V., Kudrevatykh, A., Владимирович, Г. Г., Zabrodskaya, Y., Pchelina, S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227949 · Cited by 175
A rapid, automated surface protein profiling of single circulating exosomes in human blood
Kibria, G., Ramos, E. K., Lee, K. E., Bedoyan, S., Huang, S., Samaeekia, R., Athman, J. J., Harding, C. V., Lötvall, J. O., Harris, L. N., et al. (2016) · Scientific Reports · doi:10.1038/srep36502 · Cited by 170
Perets, N., Hertz, S., London, M., & Offen, D. (2018) · Molecular Autism · doi:10.1186/s13229-018-0240-6 · Cited by 172
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Wozniak, A. L., Adams, A., King, K. E., Dunn, W., Christenson, L. K., Hung, W., & Weinman, S. A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201912074 · Cited by 180
Xu, D., Di, K., Fan, B., Wu, J., Gu, X., Sun, Y., Khan, A., Li, P., & Li, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.948959 · Cited by 181
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Kastelowitz, N., & Yin, H. H. (2014) · ChemBioChem · doi:10.1002/cbic.201400043 · Cited by 174
Saadeldin, I. M., Kim, S. J., Choi, Y. B., & Lee, B. C. (2014) · Cellular Reprogramming · doi:10.1089/cell.2014.0003 · Cited by 173
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Badawy, A. A., El‐Magd, M. A., & AlSadrah, S. A. (2018) · Integrative Cancer Therapies · doi:10.1177/1534735418786000 · Cited by 177
Lee-Chang, C., Rashidi, A., Miska, J. M., Zhang, P., Pituch, K. C., Hou, D., Xiao, T., Fischietti, M., Kang, S. J., Appin, C., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0240 · Cited by 174
Xie, X., Song, Q., Dai, C., Cui, S., Tang, R., Li, S., Chang, J. K., Li, P., Wang, J., Li, J., et al. (2023) · General Psychiatry · doi:10.1136/gpsych-2023-101143 · Cited by 171
Walker, J. D., Maier, C. L., & Pober, J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1548 · Cited by 170
Petersen, K. E., Manangón, E., Hood, J. L., Wickline, S. A., Fernández, D. P., Johnson, W. P., & Gale, B. K. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8040-0 · Cited by 176
Bidarimath, M., Khalaj, K., Kridli, R. T., Kan, F. W. K., Koti, M., & Tayade, C. (2017) · Scientific Reports · doi:10.1038/srep40476 · Cited by 170
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Pan, S., Pei, L., Zhang, A., Zhang, Y., Zhang, C., Huang, M., Huang, Z., Liu, B., Wang, L., Ma, L., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119606 · Cited by 172
Jahangard, Y., Monfared, H., Moradi, A., Zare, M., Mirnajafi-Zadeh, J., & Mowla, S. J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00564 · Cited by 162
Zhang, J., Zhang, J., Zhang, Y., Liu, W., Ni, W., Huang, X., Yuan, J., Zhao, B., Xiao, H., & Xue, F. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15784 · Cited by 169
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Wu, J., Li, Y., Hu, X.-B., Huang, S. Q., & Xiang, D. (2021) · Drug Delivery · doi:10.1080/10717544.2020.1869866 · Cited by 168
Shi, L., Zhu, W., Huang, Y., Zhuo, L., Wang, S., Chen, S., Zhang, B., & Ke, B. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.989 · Cited by 169
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Koritzinsky, E. H., Street, J. M., Star, R. A., & Yuen, P. S. T. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25387 · Cited by 165
Chen, J., & Chopp, M. (2018) · Stroke · doi:10.1161/strokeaha.117.018292 · Cited by 152
Wang, F., Cao, C., Han, K., Zhao, Y.-X., Cai, M.-Y., Xiang, Z., Zhang, J., Chen, J.-W., Zhong, L.-P., Huang, Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122478 · Cited by 162
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Rajput, A., Varshney, A., Bajaj, R., & Pokharkar, V. (2022) · Molecules · doi:10.3390/molecules27217289 · Cited by 172
Laso-García, F., Ramos‐Cejudo, J., Carrillo-Salinas, F. J., Otero‐Ortega, L., Feliú, A., Frutos, M. G.-D., Mecha, M., Díez‐Tejedor, E., Guaza, C., & Gutiérrez‐Fernández, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202590 · Cited by 169
Kanmert, D., Cantlon, A., Muratore, C., Jin, M., O’Malley, T. T., Lee, G. S., Young‐Pearse, T. L., Selkoe, D. J., & Walsh, D. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0387-15.2015 · Cited by 169
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Yao, M., Cui, B., Zhang, W., Ma, W., Zhao, G.-F., & Xing, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118658 · Cited by 162
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo, G., Fierli, D., Romancino, D. P., Picciotto, S., Barone, M. E., Aranyos, A., Božič, D., Morsbach, S., Raccosta, S., Stanly, C., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12081 · Cited by 161
Mizenko, R. R., Brostoff, T., Rojalin, T., Koster, H. J., Swindell, H. S., Leiserowitz, G. S., Wang, A., & Carney, R. P. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00987-1 · Cited by 161
Gehrmann, U., Qazi, K. R., Johansson, C., Hultenby, K. R., Karlsson, M. A., Lundeberg, L., Gabrielsson, S., & Scheynius, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021480 · Cited by 161
Yeh, Y.-Y., Özer, H. G., Lehman, A. M., Maddocks, K. J., Yu, L., Johnson, A. J., & Byrd, J. C. (2015) · Blood · doi:10.1182/blood-2014-12-618470 · Cited by 164
Extracellular vesicles from infected cells: potential for direct pathogenesis
Schwab, A., Meyering, S. S., Lepene, B., Iordanskiy, S., van Hoek, M. L., Hakami, R. M., & Kashanchi, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01132 · Cited by 166
Tetherin is an exosomal tether
Edgar, J. R., Manna, P. T., Nishimura, S., Banting, G., & Robinson, M. S. (2016) · eLife · doi:10.7554/elife.17180 · Cited by 161
Campos‐Silva, C., Suárez, H., Jara‐Acevedo, R., Linares-Espinós, E., Martínez‐Piñeiro, L., Yáñez‐Mó, M., & Valés‐Gómez, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-38516-8 · Cited by 161
Reshke, R., Taylor, J. A., Savard, A., Guo, H., Rhym, L. H., Kowalski, P. S., Trung, M. T., Campbell, C. M., Little, W., Anderson, D. G., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0502-4 · Cited by 165
Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance
Sullivan, J. A., Tomita, Y., Jankowska−Gan, E., Lema, D. A., Arvedson, M. P., Nair, A., Bracamonte‐Baran, W., Zhou, Y., Meyer, K. K., Zhong, W., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.081 · Cited by 170
Serratì, S., Guida, M., Fonte, R., Summa, S. D., Strippoli, S., Iacobazzi, R. M., Quarta, A., Risi, I. D., Guida, G., Paradiso, A., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01490-9 · Cited by 170
Chaiyadet, S., Sotillo, J., Smout, M. J., Cantacessi, C., Jones, M. K., Johnson, M. S., Turnbull, L., Whitchurch, C. B., Potriquet, J., Laohaviroj, M., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv291 · Cited by 161
Giacomini, E., Vago, R., Sanchez, A. M., Podini, P., Zarovni, N., Murdica, V., Rizzo, R., Bortolotti, D., Candiani, M., & Viganò, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-05549-w · Cited by 160
Kooijmans, S. A. A., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2018) · Nanoscale · doi:10.1039/c7nr06966a · Cited by 169
Ma, X., Huang, M., Zheng, M., Dai, C., Song, Q., Zhang, Q., Li, Q., Gu, X. Q., Chen, H., Jiang, G., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.019 · Cited by 163
Inhibition of Glioma Cells’ Proliferation by Doxorubicin-Loaded Exosomes via Microfluidics
Thakur, A., Sidu, R. K., Zou, H., Alam, M. K., Yang, M., & Lee, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s263956 · Cited by 162
Yang, S., Liang, X., Song, J. M., Li, C., Liu, A., Luo, Y., Ma, H., Tan, Y. J., & Zhang, X. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02404-8 · Cited by 162
Mesenchymal Stem Cell-Derived Exosomes: New Opportunity in Cell-Free Therapy
Sarvar, D. P., Shamsasenjan, K., & Akbarzadehlaleh, P. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.041 · Cited by 161
Singh, A., Fedele, C., Lu, H., Nevalainen, M. T., Keen, J. H., & Languino, L. R. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0058 · Cited by 159
Li, S., Zhan, J., Wang, Y., Lin, X., Zhong, J., Wang, Y., Tan, P., He, J., Cui, X., Chen, Y., et al. (2019) · Cell & Bioscience · doi:10.1186/s13578-018-0263-x · Cited by 165
Zhu, G., Pei, L., Fan, L., Yin, H., Li, X., He, W., Liu, N., & Gou, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28941 · Cited by 159
Oksvold, M. P., Kullmann, A., Forfang, L., Kierulf, B., Li, M., Brech, A., Vlassov, A. V., Smeland, E. B., Neurauter, A. A., & Pedersen, K. W. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.05.010 · Cited by 159
Marimpietri, D., Petretto, A., Raffaghello, L., Pezzolo, A., Gagliani, M. C., Tacchetti, C., Mauri, P., Melioli, G., & Pistoia, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075054 · Cited by 159
Metadata
- Authors
- Théry, C., Amigorena, S., Raposo, G., & Clayton, A.
- Affiliations
- Institut Curie (FR)
- Institut Curie Paris France
- Cardiff University (GB)
- Venue
- Current Protocols in Cell Biology
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 30
- Issue
- 1
- Pages
- Unit 3.22-Unit 3.22
- ISSN
- 1934-2500 (ISSN-L)
- 1934-2616
- OpenAlex
- W1877686344
- Cited by
- 5,766
- References
- 30
- Citations by year
- 2026: 206 · 2025: 356 · 2024: 485 · 2023: 502 · 2022: 558 · 2021: 641 · 2020: 620 · 2019: 521 · 2018: 452 · 2017: 390 · 2016: 301 · 2015: 259 · 2014: 177 · 2013: 106 · 2012: 85
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Protocols in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, exosome isolation, multivesicular bodies, cell culture supernatant, biological fluids, exosome characterization, membrane vesicles, exosome function
- MeSH terms
- Animals, Culture Media, Electrophoresis, Polyacrylamide Gel, Flow Cytometry, Humans, Immunohistochemistry, Ultracentrifugation, Cell Culture Techniques, Secretory Vesicles, Microscopy, Electron, Transmission
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