Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266

Identification and proteomic profiling of exosomes in human urine

Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488

Exosomal-like vesicles are present in human blood plasma

Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228

Molecular Characterization of Dendritic Cell-Derived Exosomes

Théry, C., Régnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.599 · Cited by 1,065

A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker

Santangelo, A., Imbrucè, P., Gardenghi, B., Belli, L., Agushi, R., Tamanini, A., Munari, S., Bossi, A., Scambi, I., Benati, D., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2639-x · Cited by 160

Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis

Jiang, M., Fang, H., Shao, S., Dang, E., Zhang, J., Qiao, P., Yang, A., & Wang, G. (2019) · The FASEB Journal · doi:10.1096/fj.201900642r · Cited by 157

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Ahmadi, M., & Rezaie, J. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02426-5 · Cited by 165

Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

Du, S., Zhang, X., Jia, Y., Peng, P., Kong, Q., Jiang, S., Li, Y., Li, C., Ding, Z., & Liu, L. (2023) · Theranostics · doi:10.7150/thno.82607 · Cited by 158

Protein and small non‐coding RNA‐enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

Nowacki, F. C., Swain, M., Klychnikov, O. I., Niazi, U. H. K., Ivens, A. C., Quintana, J. F., Hensbergen, P. J., Hokke, C. H., Buck, A. H., & Hoffmann, K. F. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.28665 · Cited by 162

Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles

Giebel, B., Kordelas, L., & Börger, V. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.09.06 · Cited by 161

Recent advances and challenges in the recovery and purification of cellular exosomes

Ayala‐Mar, S., Donoso‐Quezada, J., Gallo‐Villanueva, R. C., Pérez‐González, V. H., & González‐Valdez, J. (2019) · Electrophoresis · doi:10.1002/elps.201800526 · Cited by 162

Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density‐based fractionation of urine

Dhondt, B., Geeurickx, E., Tulkens, J., Deun, J. V., Vergauwen, G., Lippens, L., Miinalainen, I., Rappu, P., Heino, J., Ost, P., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1736935 · Cited by 159

Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact

Spitzberg, J. D., Ferguson, S. W., Yang, K. S., Peterson, H. M., Carlson, J., & Weissleder, R. (2023) · Nature Communications · doi:10.1038/s41467-023-36932-z · Cited by 158

Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

Simón, D., García‐García, E., Royo, F., Falcón‐Pérez, J. M., & Ávila, J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.11.022 · Cited by 166

Exosomes in Cancer Microenvironment and Beyond: have we Overlooked these Extracellular Messengers?

Ge, R., Tan, E., Sharghi-Namini, S., & Asada, H. H. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0110-2 · Cited by 159

Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside

Wu, K., Xing, F., Wu, S.-Y., & Watabe, K. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.10.001 · Cited by 158

Physical exosome:exosome interactions

Beit-Yannai, E., Tabak, S., & Stamer, W. D. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13479 · Cited by 149

Ultrafiltration and size exclusion chromatography combined with asymmetrical‐flow field‐flow fractionation for the isolation and characterisation of extracellular vesicles from urine

Oeyen, E., Mol, K. V., Baggerman, G., Willems, H., Boonen, K., Rolfo, C. D., Pauwels, P., Jacobs, A., Schildermans, K., Cho, W. C. S., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1490143 · Cited by 156

Towards artificial intelligence-enabled extracellular vesicle precision drug delivery

Greenberg, Z., Graim, K. S., & He, M. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114974 · Cited by 166

Intervertebral disc degeneration—Current therapeutic options and challenges

Samanta, A., Lufkin, T., & Kraus, P. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1156749 · Cited by 168

Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane Vesicles

Tseliou, E., Fouad, J., Reich, H., Slipczuk, L. N., de Couto, G., Aminzadeh, M. A., Middleton, R., Valle, J., Weixin, L., & Marbán, E. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.068 · Cited by 160

Proteomic profiling of human plasma exosomes identifies PPARγ as an exosome-associated protein

Looze, C. A., Yui, D., Leung, L., Ingham, M., Kaler, M. M., Yao, X., Wu, W. W., Shen, R., Daniels, M. P., & Levine, S. J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.050 · Cited by 155

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients

Akers, J. C., Ramakrishnan, V., Kim, R., Phillips, S., Kaimal, V., Mao, Y. Q., Hua, W., Yang, I., Fu, C.-C., Nolan, J. P., et al. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1784-3 · Cited by 155

Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment

Penfornis, P., Vallabhaneni, K. C., Whitt, J. D., & Pochampally, R. R. (2015) · International Journal of Cancer · doi:10.1002/ijc.29417 · Cited by 159

The potential of mesenchymal stem cell therapy for chronic lung disease

Cruz, F. F., & Rocco, P. R. M. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1679628 · Cited by 155

Small RNA‐sequence analysis of plasma‐derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers

Sundar, I. K., Li, D., & Rahman, I. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1684816 · Cited by 155

MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma

Vignard, V., Labbé, M., Marec, N., André-Grégoire, G., Jouand, N., Fonteneau, J., Labarrière, N., & Fradin, D. (2019) · Cancer immunology research · doi:10.1158/2326-6066.cir-19-0522 · Cited by 131

Exosomes: Isolation, characterization, and biomedical applications

Alzhrani, G. N., Alanazi, S. T., Alsharif, S. Y., Albalawi, A. M., Alsharif, A. A., Abdel‐Maksoud, M. S., & Elsherbiny, N. M. (2021) · Cell Biology International · doi:10.1002/cbin.11620 · Cited by 158

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

Yamamoto, S., Niida, S., Azuma, E., Yanagibashi, T., Muramatsu, M., Huang, T., Sagara, H., Higaki, S., Ikutani, M., Nagai, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep08505 · Cited by 157

Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes

Moghadam, B. Y., Hou, W.-C., Corredor, C., Westerhoff, P. K., & Posner, J. D. (2012) · Langmuir · doi:10.1021/la302654s · Cited by 154

High-yield isolation of extracellular vesicles using aqueous two-phase system

Shin, H., Han, C., Labuz, J. M., Kim, J., Kim, J., Cho, S., Gho, Y. S., Takayama, S., & Park, J. (2015) · Scientific Reports · doi:10.1038/srep13103 · Cited by 158

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

Rankin-Turner, S., Vader, P., O'Driscoll, L., Giebel, B., Heaney, L. M., & Davies, O. G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.012 · Cited by 161

Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer

Qu, X., Liu, B., Wang, L., Liu, L., Zhao, W., Liu, C., Ding, J., Zhao, S., Xu, B., Yu, H., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100936 · Cited by 154

In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts

Le Bihan, M.-C., Bigot, A., Jensen, S. S., Dennis, J. L., Rogowska-Wrzesinska, A., Lainé, J., Gache, V., Furling, D., Jensen, O. N., Voit, T., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.09.008 · Cited by 153

Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes

Hazan‐Halevy, I., Rosenblum, D., Weinstein, S., Bairey, O., Raanani, P., & Peer, D. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.04.026 · Cited by 152

Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC

Battke, C., Ruiss, R., WELSCH, U. N., Wimberger, P., Lang, S., Jochum, S., & Zeidler, R. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-0979-5 · Cited by 155

Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform

Webber, J. P., Stone, T., Katilius, E., Smith, B. C., Gordon, B., Mason, M. D., Tabi, Z., Brewis, I. A., & Clayton, A. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.032136 · Cited by 162

Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

Singh, V. V., Kerur, N., Bottero, V., Dutta, S., Chakraborty, S., Ansari, M. A., Paudel, N., Leela, C., & Chandran, B. (2013) · Journal of Virology · doi:10.1128/jvi.03282-12 · Cited by 160

Designed proteins induce the formation of nanocage-containing extracellular vesicles

Votteler, J., Ogohara, C., Yi, S., Hsia, Y., Nattermann, U., Belnap, D. M., King, N. P., & Sundquist, W. I. (2016) · Nature · doi:10.1038/nature20607 · Cited by 149

Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer

Qiu, Y., Yang, Y., Yang, R., Liu, C., Hsu, J.-M., Jiang, Z., Sun, L., Wei, Y., Li, C., Yu, D., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01896-1 · Cited by 156

Establishment of a simplified dichotomic size‐exclusion chromatography for isolating extracellular vesicles toward clinical applications

Guo, J., Wu, C., Lin, X., Zhou, J., Zhang, J., Zheng, W., Wang, T., & Cui, Y. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12145 · Cited by 157

Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo

Almiñana, C., Tsikis, G., Labas, V., Uzbekov, R. E., da Silveira, J. C., Bauersachs, S., & Mermillod, P. (2018) · BMC Genomics · doi:10.1186/s12864-018-4982-5 · Cited by 154

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

Haney, M. J., Klyachko, N. L., Harrison, E. B., Zhao, Y., Kabanov, A. V., & Batrakova, E. V. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801271 · Cited by 151

Extracellular vesicle therapy for retinal diseases

Mead, B., & Tomarev, S. I. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100849 · Cited by 157

Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

Wu, K., Feng, J., Lyu, F., Xing, F., Sharma, S., Liu, Y., Wu, S.-Y., Zhao, D., Tyagi, A., Deshpande, R. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25473-y · Cited by 152

Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation

Ou, B., Liu, Y., Gao, Z., Xu, J., Yan, Y., Li, Y., & Zhang, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05317-3 · Cited by 158

Induction of Exosome Release in Primary B Cells Stimulated via CD40 and the IL-4 Receptor

Saunderson, S. C., Schuberth, P., Dunn, A. C., Miller, L., Hock, B. D., MacKay, P. A., Koch, N., Jack, R. W., & McLellan, A. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8146 · Cited by 151

Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes

Cossetti, C., Lugini, L., Astrologo, L., Saggio, I., Fais, S., & Spadafora, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101629 · Cited by 151

Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions

Matta, J., Baratin, M., Chiche, L., Forel, J.-M., Cognet, C., Thomas, G., Farnarier, C., Pipéroglou, C., Papazian, L., Chaussabel, D., et al. (2013) · Blood · doi:10.1182/blood-2013-01-481705 · Cited by 151

Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

Yang, Y., Hong, Y., Nam, G., Chung, J. H., Koh, E., & Kim, I. (2017) · Advanced Materials · doi:10.1002/adma.201605604 · Cited by 151

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

Sproviero, D., Salvia, S. L., Giannini, M., Crippa, V., Gagliardi, S., Bernuzzi, S., Diamanti, L., Ceroni, M., Pansarasa, O., Poletti, A., et al. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00487 · Cited by 159

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

Jhan, Y., Prasca-Chamorro, D., Zuniga, G. P., Moore, D. M., Kumar, S. A., Gaharwar, A. K., & Bishop, C. J. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118802 · Cited by 157

Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology

Verma, M., Lam, T. K., Hebert, E. F., & Divi, R. L. (2015) · BMC Clinical Pathology · doi:10.1186/s12907-015-0005-5 · Cited by 157

Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

Ohno, S., Drummen, G. P. C., & Kuroda, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020172 · Cited by 152

Mesenchymal stromal cell-derived exosome-rich fractionated secretome confers a hepatoprotective effect in liver injury

Damania, A., Jaiman, D., Teotia, A. K., & Kumar, A. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0752-6 · Cited by 147

pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery

Lee, H., Park, H., Noh, G. J., & Lee, E. S. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.141 · Cited by 150

Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats

Narbute, K., Piļipenko, V., Pupure, J., Dzirkale, Z., Jonavičė, U., Tunaitis, V., Kriaučiūnaitė, K., Jarmalavičiūtė, A., Jansone, B., Kluša, V., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0162 · Cited by 150

Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy

Naseri, M., Bozorgmehr, M., Zöller, M., Pirmardan, E. R., & Madjd, Z. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1779991 · Cited by 154

Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today

Bazzan, E., Tinè, M., Casara, A., Biondini, D., Semenzato, U., Cocconcelli, E., Balestro, E., Damin, M., Radu, C. M., Turato, G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126417 · Cited by 159

TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis

Yu, Z., Wen, Y., Jiang, N., Li, Z., Guan, J., Zhang, Y., Deng, C., Zhao, L., Zheng, S. G., Zhu, Y., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121484 · Cited by 153

Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

Ma, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

Bulloj, A., Leal, M. C., Xu, H., Castaño, E. M., & Morelli, L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1206 · Cited by 149

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

Kharaziha, P., Chioureas, D., Rutishauser, D., Baltatzis, G., Lennartsson, L., Fonseca, P., Azimi, A., Hultenby, K. R., Zubarev, R. A., Ullén, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3226 · Cited by 149

Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes

Stevanato, L., Thanabalasundaram, L., Vysokov, N. V., & Sinden, J. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146353 · Cited by 152

Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

Wang, W., Luo, J., & Wang, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800484 · Cited by 151

A Label-Free Platform for Identification of Exosomes from Different Sources

Yan, Z., Dutta, S., Liu, Z., Yu, X., Mesgarzadeh, N., Ji, F., Bitan, G., & Xie, Y. (2019) · ACS Sensors · doi:10.1021/acssensors.8b01564 · Cited by 149

The Endothelium as a Driver of Liver Fibrosis and Regeneration

Lafoz, E., Ruart, M., Anton, A., Oncins, A., & Hernández–Gea, V. (2020) · Cells · doi:10.3390/cells9040929 · Cited by 152

Galectin‐3, a Biomarker Linking Oxidative Stress and Inflammation With the Clinical Outcomes of Patients With Atherothrombosis

Madrigal‐Matute, J., Lindholt, J. S., Fernandez‐Garcia, C. E., Benito‐Martín, A., Burillo, E., Zalba, G., Beloqui, Ó., Llamas‐Granda, P., Ortíz, A., Egido, J., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000785 · Cited by 148

Panax notoginseng: derived exosome-like nanoparticles attenuate ischemia reperfusion injury via altering microglia polarization

Li, S., Zhang, R., Wang, A., Li, Y., Zhang, M., Kim, J., Zhu, Y., Wang, Q., Zhang, Y., Wei, Y., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02161-1 · Cited by 154

Roles of exosomes and microvesicles in disease pathogenesis

Ohno, S., Ishikawa, A., & Kuroda, M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.019 · Cited by 148

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

Shimoda, A., Ueda, K., Nishiumi, S., Murata‐Kamiya, N., Mukai, S., Sawada, S., Azuma, T., Hatakeyama, M., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep18346 · Cited by 147

MicroRNAs in extracellular vesicles: potential cancer biomarkers

Kinoshita, T., Yip, K. W., Spence, T., & Liu, F. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2016.87 · Cited by 152

Extracellular Vesicles in Cardiovascular Theranostics

Bei, Y., Das, S., Rodosthenous, R. S., Holvoet, P., Vanhaverbeke, M., Monteiro, M. C., Monteiro, V. S., Radošinská, J., Barteková, M., Jansen, F., et al. (2017) · Theranostics · doi:10.7150/thno.21274 · Cited by 149

Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni

Samoil, V., Dagenais, M., Ganapathy, V., Aldridge, J. R., Glebov, A., Jardim, A., & Ribeiro, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-21587-4 · Cited by 148

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Henriques-Antunes, H., Cardoso, R. M. S., Zonari, A. A. C., Simões‐Correia, J., Leal, E. C., Jiménez‐Balsa, A., Lino, M. M., Barradas, A. M. C., Kostić, I., Gomes, C. M. F., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00376 · Cited by 147

A Comprehensive Review on Intracellular Delivery

Rad, D. M., Rad, M. A., Bazaz, S. R., Kashaninejad, N., Jin, D., & Warkiani, M. E. (2021) · Advanced Materials · doi:10.1002/adma.202005363 · Cited by 155

Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

Xitong, D., & Xiaorong, Z. (2015) · Gene · doi:10.1016/j.gene.2015.08.067 · Cited by 148

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

Plouffe, V., Mohamed, N., Rivest‐McGraw, J., Bertrand, J., Lauzon, M., & Leclerc, N. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036873 · Cited by 159

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

Vyas, N., Walvekar, A., Tate, D., Lakshmanan, V., Bansal, D., Cicero, A. L., Raposo, G., Palakodeti, D., & Dhawan, J. (2014) · Scientific Reports · doi:10.1038/srep07357 · Cited by 152

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells

Pasquier, J., Galas, L., Boulangé-Lecomte, C., Rioult, D., Bultelle, F., Magal, P., Webb, G. F., & Foll, F. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312157 · Cited by 152

Influence of storage condition on exosome recovery

Lee, M., Ban, J.-J., Im, W., & Kim, M. (2016) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-015-0781-x · Cited by 149

Placenta-derived exosomes: potential biomarkers of preeclampsia

Pillay, P., Moodley, K., Moodley, J., & Mackraj, I. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s142732 · Cited by 150

Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma

Mead, B., Amaral, J., & Tomarev, S. I. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22855 · Cited by 149

Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis

Pieragostino, D., Lanuti, P., Cicalini, I., Cufaro, M. C., Ciccocioppo, F., Ronci, M., Simeone, P., ONOFRJ, M. C., van der Pol, E., Fontana, A., et al. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103403 · Cited by 149

Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation

Zhao, Y., Gan, Y., Xu, G., Hua, K., & Liu, D. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118403 · Cited by 134

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Schneider, E., Winzer, R., Rissiek, A., Ricklefs, I., Meyer‐Schwesinger, C., Ricklefs, F. L., Bauche, A., Behrends, J., Reimer, R., Brenna, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26134-w · Cited by 151

The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes

Tolosa, J. M., Schjenken, J. E., Clifton, V. L., Vargas, A., Barbeau, B., Lowry, P., Maiti, K., & Smith, R. (2012) · Placenta · doi:10.1016/j.placenta.2012.08.004 · Cited by 142

Exosomes Mediate Epithelium–Mesenchyme Crosstalk in Organ Development

Jiang, N., Xiang, L., He, L., Yang, G., Zheng, J., Wang, C., Zhang, Y., Wang, S., Zhou, Y., Sheu, T.-J., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01087 · Cited by 142

Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

Garnier, D., Meehan, B., Kislinger, T., Daniel, P. M., Sinha, A., Abdulkarim, B., Nakano, I., & Rak, J. W. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox142 · Cited by 147

TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles

Ibáñez, F., Montesinos, J., Ureña‐Peralta, J. R., Guerri, C., & Pascual, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1529-x · Cited by 144

Combinatorial treatment of acute myocardial infarction using stem cells and their derived exosomes resulted in improved heart performance

Huang, P., Wang, L., Li, Q., Xu, J., Xu, J., Xiong, Y., Chen, G., Qian, H., Chen, J., Yuan, Y. J., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1353-3 · Cited by 145

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells

Lugini, L., Valtieri, M., Federici, C., Cecchetti, S., Meschini, S., Condello, M., Signore, M., & Fais, S. (2016) · Oncotarget · doi:10.18632/oncotarget.10574 · Cited by 148

Novel insights into MSC-EVs therapy for immune diseases

Lai, P., Weng, J., Guo, L., Chen, X., & Du, X. (2019) · Biomarker Research · doi:10.1186/s40364-019-0156-0 · Cited by 151

Exosomes from tendon stem cells promote injury tendon healing through balancing synthesis and degradation of the tendon extracellular matrix

Wang, Y., He, G., Guo, Y., Tang, H., Shi, Y., Bian, X., Zhu, M., Kang, X., Zhou, M., Lyu, J., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14430 · Cited by 147

Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

Dang, X. T. T., Jayasinghe, M. K., Zhang, D. X., Pirisinu, M., & Le, M. T. N. (2020) · Cells · doi:10.3390/cells9102191 · Cited by 154

Foetal bovine serum influence on in vitro extracellular vesicle analyses

Lehrich, B. M., Liang, Y., & Fiandaca, M. S. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12061 · Cited by 142

Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

Tian, S., Zhou, X., Zhang, M., Cui, L., Li, B., Liu, Y., Su, R., Sun, K., Hu, Y., Yang, F., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03010-y · Cited by 144

Bacterial Membrane Vesicles Mediate the Release of Mycobacterium tuberculosis Lipoglycans and Lipoproteins from Infected Macrophages

Athman, J. J., Wang, Y., McDonald, D. J., Boom, W. H., Harding, C. V., & Wearsch, P. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402894 · Cited by 145

Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

Han, K., Tran, J. A., Chang, J.-H., Azar, D. T., & Zieske, J. D. (2017) · Scientific Reports · doi:10.1038/srep40548 · Cited by 143

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

Bian, X., Ma, K., Zhang, C., & Fu, X. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1276-z · Cited by 145

Electrical and Label-Free Quantification of Exosomes with a Reduced Graphene Oxide Field Effect Transistor Biosensor

Yu, Y., Li, Y., Jin, D., Yang, F., Wu, D. C., Xiao, M., Zhang, H., Zhang, Z., & Zhang, G. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b01950 · Cited by 141

miR-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury

Pan, Q., Kuang, X., Cai, S., Wang, X., Du, D., Wang, J., Wang, Y., Chen, Y., Bihl, J. C., Chen, Y., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01761-0 · Cited by 143

Exosomes: Extracellular organelles important in intercellular communication

Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,581

Exosomes Isolation, Purification, and Characterization

Ranjan, P., & Verma, S. K. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3995-5_16 · Cited by 5

The ins-and-outs of exosome biogenesis, secretion, and internalization

Arya, S. B., Collie, S. P., & Parent, C. A. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.06.006 · Cited by 427

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,979

A Protocol for Isolation, Purification, Characterization, and Functional Dissection of Exosomes.

Rai, A., Fang, H., Fatmous, M., Claridge, B., Poh, Q. H., Simpson, R. J., & Greening, D. W. (2021) · La Trobe University · doi:10.26181/13606028