The DOI matches its Crossref record; 640 of the 645 references it cites were found in a registry or an index.
Interventions for enhancing medication adherence
Open accessAbstract
BACKGROUND: People who are prescribed self administered medications typically take only about half their prescribed doses. Efforts to assist patients with adherence to medications might improve the benefits of prescribed medications. OBJECTIVES: The primary objective of this review is to assess the effects of interventions intended to enhance patient adherence to prescribed medications for medical conditions, on both medication adherence and clinical outcomes. SEARCH METHODS: We updated searches of The Cochrane Library, including CENTRAL (via http://onlinelibrary.wiley.com/cochranelibrary/search/), MEDLINE, EMBASE, PsycINFO (all via Ovid), CINAHL (via EBSCO), and Sociological Abstracts (via ProQuest) on 11 January 2013 with no language restriction. We also reviewed bibliographies in articles on patient adherence, and contacted authors of relevant original and review articles. SELECTION CRITERIA: We included unconfounded RCTs of interventions to improve adherence with prescribed medications, measuring both medication adherence and clinical outcome, with at least 80% follow-up of each group studied and, for long-term treatments, at least six months follow-up for studies with positive findings at earlier time points. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted all data and a third author resolved disagreements. The studies differed widely according to medical condition, patient population, intervention, measures of adherence, and clinical outcomes. Pooling results according to one of these characteristics still leaves highly heterogeneous groups, and we could not justify meta-analysis. Instead, we conducted a qualitative analysis with a focus on the RCTs with the lowest risk of bias for study design and the primary clinical outcome. MAIN RESULTS: The present update included 109 new RCTs published since the previous update in January 2007, bringing the total number of RCTs to 182; we found five RCTs from the previous update to be ineligible and excluded them. Studies were heterogeneous for patients, medical problems, treatment regimens, adherence interventions, and adherence and clinical outcome measurements, and most had high risk of bias. The main changes in comparison with the previous update include that we now: 1) report a lack of convincing evidence also specifically among the studies with the lowest risk of bias; 2) do not try to classify studies according to intervention type any more, due to the large heterogeneity; 3) make our database available for collaboration on sub-analyses, in acknowledgement of the need to make collective advancement in this difficult field of research. Of all 182 RCTs, 17 had the lowest risk of bias for study design features and their primary clinical outcome, 11 from the present update and six from the previous update. The RCTs at lowest risk of bias generally involved complex interventions with multiple components, trying to overcome barriers to adherence by means of tailored ongoing support from allied health professionals such as pharmacists, who often delivered intense education, counseling (including motivational interviewing or cognitive behavioral therapy by professionals) or daily treatment support (or both), and sometimes additional support from family or peers. Only five of these RCTs reported improvements in both adherence and clinical outcomes, and no common intervention characteristics were apparent. Even the most effective interventions did not lead to large improvements in adherence or clinical outcomes. AUTHORS' CONCLUSIONS: Across the body of evidence, effects were inconsistent from study to study, and only a minority of lowest risk of bias RCTs improved both adherence and clinical outcomes. Current methods of improving medication adherence for chronic health problems are mostly complex and not very effective, so that the full benefits of treatment cannot be realized. The research in this field needs advances, including improved design of feasible long-term interventions, objective adherence measures, and sufficient study power to detect improvements in patient-important clinical outcomes. By making our comprehensive database available for sharing we hope to contribute to achieving these advances.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although there is a wealth of controlled trials on interventions to improve adherence, current methods of improving medication adherence for chronic health problems are mostly complex and not effective [2,3,4].”
From Factors Contributing to Medication Adherence in Patients with a Chronic Condition: A Scoping Review of Qualitative Research (2021) · cites this paper as [3]
In the citing paper
“This review is in agreement with other, CF-related reviews and general adherence reviews, which have highlighted the limitations of many included trials in terms of having small sample sizes and being underpowered to detect a meaningful difference in adherence (Goldbeck 2014; Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Previous Cochrane Reviews on adherence (Nieuwlaat 2014) and CF-specific reviews (Goldbeck 2014; Savage 2014) have not used a coding framework, so this review has improved on existing methodologies.”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Given the complexity of many adherence interventions tested to date (Nieuwlaat 2014), and the way in which complex interventions are reported or described in the literature, it is o en difficult to determine the content, or the 'active ingredients', of effective interventions that bring about change (Michie 2009).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Understanding the 'active ingredients' of promising interventions will make it easier to replicate effective interventions; will reduce the potential waste of time and resources on trials of ineffective techniques (Michie 2009); and will inform adherence research in the future (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“A previous Cochrane Review highlighted likely inclusion bias in adherence trials, with participants having higher than average adherence at baseline (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Underpowered trials are more likely to miss a meaningful difference in adherence, even when improving adherence substantially, and showing an effect on clinical outcomes is likely even harder (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Interventions that specifically aim to improve adherence to prescribed medications vary widely (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
Citations
Cites
1 retracted
Zolfaghari, M., Mousavifar, S. A., Razi, S. P., & Haghani, H. (2012) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2011.03951.x · Cited by 102
RetractedDeveloping and evaluating complex interventions: the new Medical Research Council guidance
Craig, P., Dieppe, P., Macintyre, S., Michie, S., Nazareth, I., & Petticrew, M. (2008) · BMJ · doi:10.1136/bmj.a1655 · Cited by 10,995
(2008) · Cited by 3,790
Update on Key Emerging Challenges in Cystic Fibrosis
Jennings, M. T., Riekert, K. A., & Boyle, M. (2014) · Medical Principles and Practice · doi:10.1159/000357646 · Cited by 3,671
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
Publication bias in clinical research
Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109
Unützer, J., Katon, W., Callahan, C. M., Williams, Jr., Hunkeler, E., Harpole, L., Hoffing, M., Della Penna, R. D., Noël, P. H., Lin, E. H. B., et al. (2002) · JAMA · doi:10.1001/jama.288.22.2836 · Cited by 2,405
(1980) · Postgraduate Medical Journal · doi:10.1136/pgmj.56.657.530 · Cited by 1,829
Statistical Methods for Rates and Proportions.
Plewis, I., & Fleiss, J. L. (1982) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2982107 · Cited by 1,753
Winearls, C., Pippard, M. J., Downing, M. R., Oliver, D., Reid, C. D. L., & Cotes, P. M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92192-6 · Cited by 1,401
Research works printed but not linked: 33
- Chamorro, 2011, Effect of pharmacist involvement in adherence to medications in patients with high to moderate cardiovascular risk (Study EMDADER-CV-INCUMPLIMIENTO), Atencion Primaria, 43, 245
- Marquez Contreras, 2004, Efficacy of an intervention to improve treatment compliance in hyperlipidemias, Atencion Primaria, 33, 443
- Marquez Contreras, 2007, Therapy compliance in cases of hyperlipaemia, as measured through electronic monitors. Is a reminder calendar to avoid forgetfulness effective?, Atencion Primaria, 39, 661
- Strang, 1981, The effects of family therapy on treatment compliance in schizophrenia, Psychopharmacology Bulletin, 17, 87
- Yopp, 2004, The Impact of Family Functioning on Treatment Adherence and Metabolic Control for Adolescents with Poorly Controlled T1DM [dissertation]
- Barcelo, 2001, An intervention to improve diabetes control in Chile, Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 10, 328
- Binstock, 1986, Therapeutic adherence programme improves compliance and lowers blood pressure, Journal of Hypertension, 4 Suppl, 375
- Birrer, 1984, Hypertension: a double-blind study of compliance in an urban community, Family Practice Research Journal, 3, 251
- Bonner, 2002, An individualized intervention to improve asthma management among urban Latino and African-American families, Journal of Asthma, 39, 167, 10.1081/JAS-120002198 · DOI
- Bouvy, 2003, Guidance improves compliance. Pharmacist stimulates proper use of loop diuretics in patient with heart failure, Pharmaceutisch Weekblad, 138, 1432
- Celik, 1997, Comparison of the clinical efficacy of azithromycin and cerufoxime axetile in the treatment of patients with acute otitis media, Mikrobiyoloji Bulteni, 31, 253
- Edworthy, 1999, Improving medication adherence through patients education distinguishing between appropriate and inappropriate utilization, Journal of Rheumatology, 26, 1793
- Kelly, 1991, Medication compliance and health education among outpatients with chronic mental disorders [erratum], Medical Care, 29, 889
- Leal, 2004, Written information on the use of aerosols in COPD patients. Can we improve their use? [see comment], Atencion Primaria, 33, 6
- Levesque, 1983, Comparative efficacy of two dosage regimens of cimetidine in the treatment of symptomatic duodenal ulcer: results of a multicenter clinical trial, Current Therapeutic Research, Clinical and Experimental, 33, 70
- Marquez Contreras, 2004, Effectiveness of an intervention to provide information to patients with hypertension as short text messages and reminders sent to their mobile phone (HTA-Alert), Atencion Primaria, 34, 399
- Ogedegbe, 2007, An RCT of the effect of motivational interviewing on medication adherence in hypertensive African Americans: rationale and design, Contemporary Clinical Trials, 28, 169, 10.1016/j.cct.2006.04.002 · DOI
- Phan, 1995, Enhancing client adherence to psychotropic medication regimens: a psychosocial nursing approach, International Journal of Psychiatric Nursing Research, 2, 146
- Purcell, 2004, Interventions for seropositive injectors-research and evaluation: an integrated behavioral intervention with HIV-positive injection drug users to address medical care, adherence, and risk reduction, Journal of Acquired Immune Deficiency Syndromes, 37, S110, 10.1097/01.qai.0000140609.44016.c4 · DOI
- Razali, 1997, Health education and drug counseling for schizophrenia, International Medical Journal, 4, 187
- Rickheim, 2002, Assessment of group versus individual diabetes education: a randomized study, Diabetes Care, 25, 269, 10.2337/diacare.25.2.269 · DOI
- Rodriguez, 2003, Effectiveness of a group educational intervention in patients with chronic obstructive pulmonary disease, Enfermeria Clinica, 13, 131
- Sanchez, 2002, Treatment of latent tuberculosis infection in injecting drug users co-infected by HIV, Enfermedades Emergentes, 4, 62
- Tapanya S A biopsychosocial intervention program to improve medical regimen adherence and glycemic control in type II diabetic patients Dissertation Abstracts International: Section B: the Sciences and Engineering 1997
- Vander Stichele, 1992, Measuring patient compliance with electronic monitoring: lisinopril versus atenolol in essential hypertension, Post Market Surveillance, 6, 77
- Vetter, 1999, Efficacy and safety of once-daily and twice-daily clarithromycin formulations in the treatment of acute exacerbations of chronic bronchitis, Advances in Therapy, 16, 13
- Andres Rodriguez, 2007, Assessment of knowledge/compliance in a drug therapy follow-up program involving type 2 diabetic patients in community pharmacy: a randomized study, Pharmaceutical Care Espana, 9, 2
- Marquez Contreras, 2000, Therapeutic compliance in hypertension. Trial of two-year health education intervention, Atencion Primaria, 26, 5
- Marquez Contreras, 2009, Non-pharmacological intervention as a strategy to improve antihypertensive treatment compliance, Atencion Primaria, 41, 501
- Gordis, 1979, Conceptual and methodologic problems in measuring compliance, 23
- Haynes, 1979, Determinants of compliance: the disease and the mechanics of treatment, 49
- Sackett, 1979, The magnitude of adherence and nonadherence, 11
- Stephenson, 1993, Is this patient taking their medication?, JAMA, 269, 2779, 10.1001/jama.1993.03500210079036 · DOI
Cited by
Sorted by citations
Items 701–800 of 1,018
Psychosocial Factors in Severe Pediatric Asthma
Booster, G. D., Oland, A. A., & Bender, B. G. (2016) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2016.03.012 · Cited by 46
Morrissey, E. C., Durand, H., Nieuwlaat, R., Navarro, T., Haynes, R. B., Walsh, J. C., & Molloy, G. J. (2017) · Psychology and Health · doi:10.1080/08870446.2016.1273356 · Cited by 46
Self-citationChallenges in secondary prevention after acute myocardial infarction: A call for action
Piepoli, M. F., Corrà, U., Dendale, P., Frederix, I., Prescott, E., Schmid, J. P., Cupples, M., Deaton, C., Doherty, P., Giannuzzi, P., et al. (2017) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872616689773 · Cited by 52
The Effect of Different Types of Monitoring Strategies on Weight Loss: A Randomized Controlled Trial
Jospe, M. R., Roy, M., Brown, R. C., Williams, S., Osborne, H., Meredith-Jones, K. A., McArthur, J., Fleming, E., & Taylor, R. W. (2017) · Obesity · doi:10.1002/oby.21898 · Cited by 46
“Adherence is a challenge even for the arguably simpler behaviors of taking medications, which can have nonadherence rates of around 50% (38).”
BackgroundAllemann, S. S., Nieuwlaat, R., Navarro, T., Haynes, B. R., Hersberger, K. E., & Arnet, I. (2017) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.07.011 · Cited by 46
Self-citationLipid Testing and Statin Dosing After Acute Myocardial Infarction
Wang, W. T., Hellkamp, A. S., Doll, J. A., Thomas, L. E., Návar, A. M., Fonarow, G. C., Julien, H. M., Peterson, E. D., & Wang, T. Y. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.006460 · Cited by 47
“However, prior studies have shown that patients are more likely to be adherent to therapies when these therapies are prescribed at discharge.(25) Some clinicians view the current guidelines as a sledgehammer approach to a nuanced problem.”
BackgroundWang, Z., Zhu, Y., Cui, L., & Qu, B. (2019) · JMIR mhealth and uhealth · doi:10.2196/14404 · Cited by 48
“Previous studies suggested that patients with chronic diseases may develop negative emotions during long-term medication and believe that their illnesses are incurable so that lacks the motivation to adhere to medication [12].”
Kim, C., Sung, J., Lee, J. H., Kim, W., Lee, G. J., Jee, S., Jung, I., Rah, U. W., Kim, B. O., Choi, K. H., et al. (2019) · Korean Circulation Journal · doi:10.4070/kcj.2019.0194 · Cited by 48
Zhai, P., Hayat, K., Ji, W., Li, Q., Shi, L., Atif, N., Xu, S., Li, P., Du, Q., & Fang, Y. (2020) · Journal of Medical Internet Research · doi:10.2196/16019 · Cited by 49
“A large number of interventions and strategies have been proposed to improve adherence to the treatment plan among patients despite inconsistent results [18].”
BackgroundNewman-Casey, P. A., Niziol, L. M., Lee, P. P., Musch, D. C., Resnicow, K., & Heisler, M. (2020) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2020.04.013 · Cited by 46
Gasse, B., Baroux, N., Rouchon, B., Meunier, J., de Frémicourt, I., & D’Ortenzio, É. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-131 · Cited by 46
Strategies to Measure and Improve Patient Adherence in Clinical Trials
Matsui, D. (2009) · Pharmaceutical Medicine · doi:10.1007/bf03256784 · Cited by 40
mHealth intervention to support asthma self-management in adolescents: the ADAPT study
Kosse, R. C., Bouvy, M., de Vries, T., Kaptein, A., Geers, H. C. J., van Dijk, L., & Koster, E. (2017) · Patient Preference and Adherence · doi:10.2147/ppa.s124615 · Cited by 45
“16 Interventions tailored to individual’s needs are suggested to be more effective, because every individual might need a different approach to tackle his or her specific intentional and unintentional barriers affecting adherence.”
Cole, T., Robinson, L., Romero, L., & O’Brien, L. (2017) · Journal of Hand Therapy · doi:10.1016/j.jht.2017.11.040 · Cited by 45
Alfian, S. D., van Boven, J. F. M., Abdulah, R., Sukandar, H., Denig, P., & Hak, E. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14610 · Cited by 46
“In addition, many interventions showing promising results have not been widely adopted given the substantial human resources required to maintain them.(8) Nonadherence may be more efficiently improved if only patients who need it are targeted and interventions are tailored to patients' individual adherence barriers.”
BackgroundBar, L., Brandis, S. J., & Marks, D. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s323766 · Cited by 50
“In a medical context, these terms indicate the extent to which patients follow the instructions they are given for treatment.(19) In the context of compression wear, the term”
BackgroundMancia, G., Cappuccio, F. P., Burnier, M., Coca, A., Persu, A., Borghi, C., Kreutz, R. H., & Sanner, B. M. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13678 · Cited by 55
Insel, K. C., Einstein, G. O., Morrow, D. G., & Hepworth, J. T. (2012) · Contemporary Clinical Trials · doi:10.1016/j.cct.2012.09.005 · Cited by 47
Jeffery, R. A., Navarro, T., Wilczynski, N. L., Iserman, E. C., Keepanasseril, A., Sivaramalingam, B., Agoritsas, T., & Haynes, R. B. (2014) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.06.008 · Cited by 45
Self-citationA population-based study of dosing and persistence with anti-dementia medications
Brewer, L., Bennett, K., McGreevy, C., & Williams, D. J. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-013-1483-y · Cited by 45
Counseling African Americans to Control Hypertension (CAATCH) Trial
Ogedegbe, G. G., Tobin, J. N., Fernandez, S., Gerin, W., Diaz-Gloster, M., Cassells, A. N., Khalida, C., Pickering, T. G., Schoenthaler, A., & Ravenell, J. E. (2009) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.109.849976 · Cited by 46
Bengtsson, U., Kasperowski, D., Ring, L., & Kjellgren, K. (2014) · Blood Pressure · doi:10.3109/08037051.2014.883203 · Cited by 44
Opportunities for cystic fibrosis care teams to support treatment adherence
Riekert, K. A., Eakin, M. N., Bilderback, A. L., Ridge, A. K., & Marshall, B. C. (2014) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2014.10.003 · Cited by 47
Impact of Appointment-Based Medication Synchronization on Existing Users of Chronic Medications
Holdford, D. A., & Saxena, K. (2015) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2015.21.8.662 · Cited by 45
“Nonadherence to medications is a complex and multifactorial problem that is not easily resolved by simple solutions.(1,12,13) The causes of nonadherence vary depending on individual characteristics (e.”
BackgroundInfluentialWilcox, L. G., Woollen, J., Prey, J. E., Restaino, S. W., Henry, S. B., Feiner, S., Sackeim, A., & Vawdrey, D. K. (2016) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocv160 · Cited by 45
Advances in Audio-Based Systems to Monitor Patient Adherence and Inhaler Drug Delivery
Taylor, T. E., Zigel, Y., Looze, C. D., Sulaiman, I., Costello, R. W., & Reilly, R. B. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.08.1162 · Cited by 46
Lauffenburger, J. C., Franklin, J. M., Krumme, A. A., Shrank, W. H., Matlin, O. S., Spettell, C. M., Brill, G. E., & Choudhry, N. K. (2018) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2018.24.5.469 · Cited by 47
Gijón‐Conde, T., Gorostidi, M., Camafort, M., Abad-Cardiel, M., Martín-Rioboó, E., Morales‐Olivas, F. J., Vinyoles, E., Armario, P., Banegas, J. R., Coca, A., et al. (2018) · Hipertensión y Riesgo Vascular · doi:10.1016/j.hipert.2018.04.001 · Cited by 65
Ayorinde, A., Williams, I., Mannion, R., Song, F., Skrybant, M., Lilford, R. J., & Chen, Y. (2020) · BMC Medical Research Methodology · doi:10.1186/s12874-020-01010-1 · Cited by 45
“For instance, a Cochrane review of the effectiveness of interventions to enhance medication adherence included 182 RCTs and judged eight and 32 RCTs to be of high and low risk for outcome reporting bias respectively, but the remaining 142 RCTs were judged to be of unclear risk, primarily due to unavailability of proto…”
BackgroundNovel electronic adherence monitoring devices in children with asthma: a mixed-methods study
Makhecha, S., Chan, A. H. Y., Pearce, C. J., Jamalzadeh, A., & Fleming, L. (2020) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2020-000589 · Cited by 46
Holbrook, A. M., Wang, M., Lee, M., Chen, Z., Garcia, M. C., Nguyen, L. N., Ford, A., Manji, S., & Law, M. R. (2021) · Systematic Reviews · doi:10.1186/s13643-020-01558-5 · Cited by 45
“(17) Randomized trials show that interventions to improve adherence do so only modestly and do not seem to improve patient outcomes.(61) Two recent randomized controlled trials (RCTs) in the United States directly address whether removing medication cost improves clinical outcomes.”
BackgroundMultilevel factors predict medication adherence in rheumatoid arthritis: a 6-month cohort study
Balsa, A., de Yébenes, M. J. G., Carmona, L., Courel, L. G., Mendizábal, J., Restrepo, J., Fábregas, D., de Buruaga, J. A. S., Etxebarrieta, J. D., Zavaleta, N. R., et al. (2021) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221163 · Cited by 45
Validation of EHR medication fill data obtained through electronic linkage with pharmacies
Blecker, S., Adhikari, S., Zhang, H., Dodson, J. A., Desai, S. M., Anzisi, L., Pazand, L., Schoenthaler, A. M., & Mann, D. M. (2021) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2021.27.10.1482 · Cited by 44
Kooij, J. J. S., Rösler, M., Philipsen, A., Wächter, S., Dejonckheere, J., van der Kolk, A., van Agthoven, M., & Schäuble, B. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-36 · Cited by 44
A systematic review of interventions to enhance adherence and persistence with ADHD pharmacotherapy
Parkin, R., McNicholas, F., & Hayden, J. C. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.05.044 · Cited by 47
Ahmad, A., Hugtenburg, J. G., Welschen, L. M. C., Dekker, J. M., & Nijpels, G. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-133 · Cited by 44
Oberjé, E. J. M., de Kinderen, R. J. A., Evers, S., van Woerkum, C. M. J., & de Bruin, M. (2013) · PharmacoEconomics · doi:10.1007/s40273-013-0108-8 · Cited by 44
Comparative effectiveness of asthma interventions within a practice based research network
Tapp, H., Hebert, L., & Dulin, M. (2011) · BMC Health Services Research · doi:10.1186/1472-6963-11-188 · Cited by 44
Anderson, K. R., Chambers, C. R., Lam, N., Yau, P., Cusano, F. L., Savoie, M. L., & Sheikh, N. (2014) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155213520261 · Cited by 44
Kjeldsen, L. J., Bjerrum, L., Dam, P., Larsen, B. O., Rossing, C., Søndergaard, B., & Herborg, H. (2014) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2014.03.003 · Cited by 44
Paterson, M., Kinnear, M., Bond, C. M., & McKinstry, B. (2016) · International Journal of Pharmacy Practice · doi:10.1111/ijpp.12242 · Cited by 44
“A recent Cochrane review([14]) of interventions to improve adherence found that while almost all of the effective interventions were complex these did not lead to large improvements in adherence and treatment outcomes.”
BackgroundShen, Y., Peng, X., Wang, M., Zheng, X., Xu, G., Lü, L., Xu, K., Burström, B., Burström, K., & Wang, J. (2016) · Journal of Human Hypertension · doi:10.1038/jhh.2016.8 · Cited by 44
Lawson, A. J., Shipman, K. E., George, S., & Dasgupta, I. (2015) · Journal of Analytical Toxicology · doi:10.1093/jat/bkv102 · Cited by 44
Rash, J. A., Campbell, D. J. T., Tonelli, M. A., & Campbell, T. S. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.07.006 · Cited by 46
Timmers, L., Boons, C. C. L. M., Verbrugghe, M., van den Bemt, B. J. F., Hecke, A. V., & Hugtenburg, J. G. (2017) · BMC Cancer · doi:10.1186/s12885-017-3110-2 · Cited by 44
“Patient education is often used in interventions to enhance medication adherence [22, 23].”
BackgroundMedication adherence: staying within the boundaries of safety
Mickelson, R. S., & Holden, R. J. (2017) · Ergonomics · doi:10.1080/00140139.2017.1301574 · Cited by 43
“currently for treatment of multiple chronic conditions, can reduce the risk of non-adherence and ADEs (Hajjar, Cafiero, and Hanlon 2007; Nieuwlaat et al. 2014; Rossi et al. 2007; Scott et al. 2015).”
BackgroundDima, A. L., Allemann, S. S., Dunbar‐Jacob, J. M., Hughes, D. A., Vrijens, B., & Wilson, I. B. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14659 · Cited by 47
Ryan, R. E., Kaufman, C. A., & Hill, S. (2009) · BMC Medical Research Methodology · doi:10.1186/1471-2288-9-16 · Cited by 44
O’Carroll, R. E., Dennis, M. S., Johnston, M., & Sudlow, C. L. M. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-15 · Cited by 43
Panel, O. T. E. E., Brouwers, M. C., Garcia, K., Makarski, J., & Daraz, L. (2011) · Implementation Science · doi:10.1186/1748-5908-6-130 · Cited by 44
Calip, G. S., Elmore, J. G., & Boudreau, D. M. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-4043-1 · Cited by 44
Unravelling adherence to prophylaxis in haemophilia: a patients’ perspective
Schrijvers, L. H., Kars, M. C., Beijlevelt, M., Peters, M., Schuurmans, M. J., & Fischer, K. (2015) · Haemophilia · doi:10.1111/hae.12660 · Cited by 44
High-Dose Statin Therapy in Patients With Stable Coronary Artery Disease
Dorresteijn, J. A. N., Boekholdt, S. M., van der Graaf, Y., Kastelein, J. J. P., LaRosa, J. C., Pedersen, T. R., DeMicco, D. A., Ridker, P. M., Cook, N. R., & Visseren, F. L. J. (2013) · Circulation · doi:10.1161/circulationaha.112.000712 · Cited by 43
Axelsson, M., Lötvall, J. O., Cliffordson, C., Lundgren, J., & Brink, E. (2012) · Quality of Life Research · doi:10.1007/s11136-012-0181-z · Cited by 43
Buus, N., Johannessen, H., & Stage, K. B. (2012) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2012.04.012 · Cited by 41
Aspects of Patient and Clinician Language Predict Adherence to Antidepressant Medication
Kaplan, J. E., Keeley, R. D., Engel, M., Emsermann, C. B., & Brody, D. S. (2013) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2013.04.120201 · Cited by 43
Buhse, S., hlhauser, I. M. X. F., Heller, T., Kuniß, N., ller, U. A. M., Kasper, J., Lehmann, T. N., & Lenz, M. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009116 · Cited by 44
Schrijvers, L. H., Schuurmans, M. J., & Fischer, K. (2016) · Haemophilia · doi:10.1111/hae.12904 · Cited by 43
Improving adherence to medication for secondary cardiovascular disease prevention
Keenan, J. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317708145 · Cited by 43
Detection of Cases of Noncompliance to Drug Treatment in Patient Forum Posts: Topic Model Approach
Abdellaoui, R., Foulquié, P., Texier, N., Faviez, C., Burgun, A., & Schück, S. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9222 · Cited by 40
“Several meta-analyses showed that current methods of improving medication adherence for chronic diseases were mostly complex and not very effective [2,3].”
Barnett, P. G., Sorensen, J. L., Wong, W., Haug, N. A., & Hall, S. M. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.09.017 · Cited by 43
Adisa, R., & Fakeye, T. O. (2014) · African Health Sciences · doi:10.4314/ahs.v14i1.2 · Cited by 43
Interventions to improve adherence to lipid-lowering medication
van Driel, M. L., Morledge, M. D., Ulep, R., Shaffer, J. P., Davies, P., & Deichmann, R. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004371.pub4 · Cited by 333
Pratiwi, H., Kristina, S. A., Widayanti, A. W., Prabandari, Y. S., & Kusuma, I. Y. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010803 · Cited by 42
“Several strategies have been developed to improve or maintain patient medication adherence [13].”
BackgroundAnghel, L., Ciubară, A., Pătraș, D., & Ciubară, A. B. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14061809 · Cited by 48
Torresan, M. M., Garrino, L., Borraccino, A., Macchi, G., Luca, A. D., & Dimonte, V. (2015) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2015.01.001 · Cited by 42
“Adherence to therapy can be maximized when doctors, patients and their family agree on goals of pain treatment and the medication plan (Haynes et al., 2008) that foster the patient's self-responsibility, identity, active collaboration and empowerment (Aujoulat et al.”
BackgroundFlodmark, C., Lilja, K., Woehling, H., & Järvholm, K. (2013) · Biologics in Therapy · doi:10.1007/s13554-013-0011-z · Cited by 42
Pharmacoeconomic aspects of poor adherence: can better adherence reduce healthcare costs?
Golay, A. (2011) · Journal of Medical Economics · doi:10.3111/13696998.2011.597808 · Cited by 45
Larsen, J. T., Støvring, H., Kragstrup, J., & Hansen, D. G. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-145 · Cited by 42
Improving medication adherence in stroke survivors: Mediators and moderators of treatment effects.
O’Carroll, R. E., Chambers, J. A., Dennis, M. S., Sudlow, C. L. M., & Johnston, M. (2014) · Health Psychology · doi:10.1037/hea0000082 · Cited by 42
Haverkamp, F., & Gasteyger, C. (2011) · Journal of Medical Economics · doi:10.3111/13696998.2011.590829 · Cited by 42
Depont, F., Berenbaum, F., Filippi, J., Maître, M. L., Nataf, H., Paul, C. F., Peyrin‐Biroulet, L., & Thibout, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145076 · Cited by 42
LeQuang, Kuusniemi, K., & Pöyhiä, R. (2016) · Journal of Pain Research · doi:10.2147/jpr.s92502 · Cited by 40
Shchelochkov, O. A., Dickinson, K., Scharschmidt, B. F., Lee, B., Marino, M., & Mons, C. L. (2016) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2016.07.003 · Cited by 42
Cukor, D., Halen, N. V., Pencille, M., Tedla, F. M., & Salifu, M. O. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000448627 · Cited by 41
Medication Management: The Macrocognitive Workflow of Older Adults With Heart Failure
Mickelson, R. S., Unertl, K. M., & Holden, R. J. (2016) · JMIR Human Factors · doi:10.2196/humanfactors.6338 · Cited by 43
“Interventions to improve medication adherence have primarily involved educating and motivating the patient, with only moderate effects on short-term and little effect on long-term medication adherence [16,17].”
BackgroundTorres-Robles, A., Wiecek, E., Tonin, F. S., Benrimoj, S. I., Fernández-Llimós, F., & García‐Cárdenas, V. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01454 · Cited by 46
“During the past 10 years there has been mounting evidence demonstrating the impact of diverse interventions onmedication adherence in a range of clinical outcomes (Nieuwlaat et al., 2014).”
BackgroundMethodResultInfluentialDoes adherence to inhaled corticosteroids predict asthma-related outcomes over time? A cohort study
Dima, A. L., Ganse, E. H. V., Stadler, G., & de Bruin, M. (2019) · European Respiratory Journal · doi:10.1183/13993003.00901-2019 · Cited by 42
McCloskey, A. P., Penson, P. E., Tse, Y., Abdelhafiz, M. A., Ahmed, S. N., & Lim, E. J. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15463 · Cited by 42
“In neither case can it be confirmed whether the patient actually took the medication or not.(33) Pill swallowing screening and interventions to assist paediatric patients are common.”
BackgroundMotivators and Barriers to Prenatal Supplement Use among Minority Women in the United States
Tessema, J., Jefferds, M. E., Cogswell, M. E., & Carlton, E. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.10.013 · Cited by 42
Gwadry-Sridhar, F. H., Manias, E., Zhang, Y., Roy, A. N., Yu-Isenberg, K. S., Hughes, D. A., & Nichol, M. B. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.02.021 · Cited by 43
Medication Literacy Is a 2-Way Street
Raynor, D. K. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.5.520 · Cited by 42
Bediang, G., Stoll, B., Elia, N., Abena, J.-L., Nolna, D., Chastonay, P., & Geissbuhler, A. (2014) · Trials · doi:10.1186/1745-6215-15-35 · Cited by 41
Drake, R. J., Nordentoft, M., Haddock, G., Arango, C., Fleischhacker, W. W., Glenthøj, B., Leboyer, M., Leucht, S., Leweke, M., McGuire, P., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv015 · Cited by 42
Riaz, H., Godman, B., Hussain, S., Malik, F., Mahmood, S., Shami, A. M., & Bashir, S. (2015) · Journal of Pharmaceutical Health Services Research · doi:10.1111/jphs.12091 · Cited by 40
“Enhancing adherence rates to medicines is also important as rates are currently low in patients with chronic asymptomatic diseases (44-46).”
BackgroundFactors affecting medication adherence in Lebanese patients with chronic diseases
Al‐Hajje, A., Awada, S., Rachidi, S., Zein, S., Bawab, W., El-Hajj, Z., Bouzeid, M., Yassine, M., & Salameh, P. (2015) · Pharmacy Practice · doi:10.18549/pharmpract.2015.03.590 · Cited by 41
“While on the contrary, patients with low HRQoL adhere less to their medications, which leads to bad outcomes, which in turn makes their quality of life even more deteriorating.(1)”
BackgroundInfluentialGlascoe, F. P., & Trimm, F. (2014) · PEDIATRICS · doi:10.1542/peds.2013-1859 · Cited by 41
Richy, F. F., Pietri, G., Moran, K. A., Senior, E., & Makaroff, L. (2013) · Applied Health Economics and Health Policy · doi:10.1007/s40258-013-0033-1 · Cited by 41
Reach, G. (2011) · Patient Preference and Adherence · doi:10.2147/ppa.s24518 · Cited by 41
Accuracy of Measures of Medication Adherence in a Cholesterol-Lowering Regimen
Dunbar‐Jacob, J. M., Sereika, S. M., Houze, M. P., Luyster, F. S., & Callan, J. A. (2012) · Western Journal of Nursing Research · doi:10.1177/0193945912439251 · Cited by 41
Nonadherence in outpatient thromboprophylaxis after major orthopedic surgery: a systematic review
Wilke, T., & Müller, S. (2010) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/erp.10.77 · Cited by 41
A Review of Breast Cancer Survivorship Issues from Survivors' Perspectives
Cho, J., Jung, S., Lee, J. E., Shim, E., Kim, N. H., Kim, Z., Sohn, G., Youn, H. J., Kim, K. S., Kim, H., et al. (2014) · Journal of Breast Cancer · doi:10.4048/jbc.2014.17.3.189 · Cited by 41
“For short-term prescriptions for diverse medical problems, several simple interventions increased adherence to medication and improved outcomes; however, for long-term treatments, no simple intervention and only a few complex interventions led to improvements in health outcomes [103].”
BackgroundSeal, B. S., Anderson, S. E., & Shermock, K. M. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2016.22.3.227 · Cited by 43
“Educational campaigns may raise awareness of the potential for lower adherence with oral anticancer therapy on the part of providers and might improve patients’ understanding of the importance of adherence.(1,7,18,19,22-24) Additionally, changes to benefit design, where payers cover oral anticancer medications as a me…”
BackgroundGrady, D., Weiss, M., Hernández‐Sánchez, J., & Pepke‐Żaba, J. (2017) · Pulmonary Circulation · doi:10.1177/2045893217743616 · Cited by 42
“Other authors have highlighted that participants can overestimate their adherence with self-reported tools and can suffer from poor recall of behavior.(5,6,8,9) In addition, the three-month Pulmonary Circulation Volume 8 Number 1 | 7”
BackgroundPosttransplant Medical Adherence: What Have We Learned and Can We Do Better?
Dew, M. A., Posluszny, D. M., DiMartini, A. F., Myaskovsky, L., Steel, J. L., & Dabbs, A. D. (2018) · Current Transplantation Reports · doi:10.1007/s40472-018-0195-8 · Cited by 45
Easthall, C., Taylor, N. J., & Bhattacharya, D. (2018) · International Journal of Pharmacy Practice · doi:10.1111/ijpp.12491 · Cited by 50
“highlight important considerations for medication adherence research, the most recent Cochrane review highlights that meaningful progress with adherence research is still sub-optimal.([5]) Theoretical models such as social cognitive theory, the health belief model and self-regulation model have been applied to medicat…”
BackgroundWareham, K., Brennan, M. L., & Dean, R. S. (2018) · Veterinary Record · doi:10.1136/vr.104793 · Cited by 42
Theory-Based Digital Interventions to Improve Asthma Self-Management Outcomes: Systematic Review
Lycett, H., Raebel, E. M., Wildman, E. K., Guitart, J., Kenny, T., Sherlock, J., & Cooper, V. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9666 · Cited by 46
Rijsbergen, M., der Kolk, T. N., Rijneveld, R., Pinckaers, H., Meshcheriakov, Y. V., Bavinck, J. N. B., van Doorn, M. B. A., Hogendoorn, G., Feiss, G. L., Cohen, A. F., et al. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15872 · Cited by 39
Gregoriano, C., Dieterle, T., Breitenstein, A.-L., Dürr, S., Baum, A., Giezendanner, S., Maier, S., Leuppi-Taegtmeyer, A. B., Arnet, I., Hersberger, K. E., et al. (2019) · Respiratory Research · doi:10.1186/s12931-019-1219-3 · Cited by 41
“A Cochrane systematic review which analysed randomized controlled trials to improve adherence to pharmacological regimens showed that less than 50% of the interventions reached a significant improvement of adherence and only 30% demonstrated improved clinical outcomes [38].”
Method
Metadata
- Authors
- Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., Sivaramalingam, B., Iserman, E., Mustafa, R. A., Jedraszewski, D., Cotoi, C., & Haynes, R. B.
- Affiliations
- Hamilton General Hospital (CA)
- McMaster University (CA)
- St. Michael's Hospital (CA)
- University of Guelph (CA)
- ORCID
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2014-11-20
- Volume
- 2014
- Issue
- 11
- Pages
- CD000011-CD000011
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC7263418
- OpenAlex
- W1594567624
- Cited by
- 2,945
- References
- 645
- Citations by year
- 2026: 64 · 2025: 119 · 2024: 108 · 2023: 147 · 2022: 157 · 2021: 177 · 2020: 200 · 2019: 190 · 2018: 209 · 2017: 244 · 2016: 224 · 2015: 191 · 2014: 214
- FWCI
- 37.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Patient Safety and Medication Errors
- Keywords
- medication adherence, adherence interventions, self-administered medication, clinical outcomes, risk of bias, quality of evidence, pill organizers, pharmacists
- MeSH terms
- Drug Therapy, Humans, Patient Education as Topic, Self Administration, Randomized Controlled Trials as Topic, Publication Bias, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
