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Interventions for enhancing medication adherence
Open accessAbstract
BACKGROUND: People who are prescribed self administered medications typically take only about half their prescribed doses. Efforts to assist patients with adherence to medications might improve the benefits of prescribed medications. OBJECTIVES: The primary objective of this review is to assess the effects of interventions intended to enhance patient adherence to prescribed medications for medical conditions, on both medication adherence and clinical outcomes. SEARCH METHODS: We updated searches of The Cochrane Library, including CENTRAL (via http://onlinelibrary.wiley.com/cochranelibrary/search/), MEDLINE, EMBASE, PsycINFO (all via Ovid), CINAHL (via EBSCO), and Sociological Abstracts (via ProQuest) on 11 January 2013 with no language restriction. We also reviewed bibliographies in articles on patient adherence, and contacted authors of relevant original and review articles. SELECTION CRITERIA: We included unconfounded RCTs of interventions to improve adherence with prescribed medications, measuring both medication adherence and clinical outcome, with at least 80% follow-up of each group studied and, for long-term treatments, at least six months follow-up for studies with positive findings at earlier time points. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted all data and a third author resolved disagreements. The studies differed widely according to medical condition, patient population, intervention, measures of adherence, and clinical outcomes. Pooling results according to one of these characteristics still leaves highly heterogeneous groups, and we could not justify meta-analysis. Instead, we conducted a qualitative analysis with a focus on the RCTs with the lowest risk of bias for study design and the primary clinical outcome. MAIN RESULTS: The present update included 109 new RCTs published since the previous update in January 2007, bringing the total number of RCTs to 182; we found five RCTs from the previous update to be ineligible and excluded them. Studies were heterogeneous for patients, medical problems, treatment regimens, adherence interventions, and adherence and clinical outcome measurements, and most had high risk of bias. The main changes in comparison with the previous update include that we now: 1) report a lack of convincing evidence also specifically among the studies with the lowest risk of bias; 2) do not try to classify studies according to intervention type any more, due to the large heterogeneity; 3) make our database available for collaboration on sub-analyses, in acknowledgement of the need to make collective advancement in this difficult field of research. Of all 182 RCTs, 17 had the lowest risk of bias for study design features and their primary clinical outcome, 11 from the present update and six from the previous update. The RCTs at lowest risk of bias generally involved complex interventions with multiple components, trying to overcome barriers to adherence by means of tailored ongoing support from allied health professionals such as pharmacists, who often delivered intense education, counseling (including motivational interviewing or cognitive behavioral therapy by professionals) or daily treatment support (or both), and sometimes additional support from family or peers. Only five of these RCTs reported improvements in both adherence and clinical outcomes, and no common intervention characteristics were apparent. Even the most effective interventions did not lead to large improvements in adherence or clinical outcomes. AUTHORS' CONCLUSIONS: Across the body of evidence, effects were inconsistent from study to study, and only a minority of lowest risk of bias RCTs improved both adherence and clinical outcomes. Current methods of improving medication adherence for chronic health problems are mostly complex and not very effective, so that the full benefits of treatment cannot be realized. The research in this field needs advances, including improved design of feasible long-term interventions, objective adherence measures, and sufficient study power to detect improvements in patient-important clinical outcomes. By making our comprehensive database available for sharing we hope to contribute to achieving these advances.
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“Although there is a wealth of controlled trials on interventions to improve adherence, current methods of improving medication adherence for chronic health problems are mostly complex and not effective [2,3,4].”
From Factors Contributing to Medication Adherence in Patients with a Chronic Condition: A Scoping Review of Qualitative Research (2021) · cites this paper as [3]
In the citing paper
“This review is in agreement with other, CF-related reviews and general adherence reviews, which have highlighted the limitations of many included trials in terms of having small sample sizes and being underpowered to detect a meaningful difference in adherence (Goldbeck 2014; Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Previous Cochrane Reviews on adherence (Nieuwlaat 2014) and CF-specific reviews (Goldbeck 2014; Savage 2014) have not used a coding framework, so this review has improved on existing methodologies.”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Given the complexity of many adherence interventions tested to date (Nieuwlaat 2014), and the way in which complex interventions are reported or described in the literature, it is o en difficult to determine the content, or the 'active ingredients', of effective interventions that bring about change (Michie 2009).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Understanding the 'active ingredients' of promising interventions will make it easier to replicate effective interventions; will reduce the potential waste of time and resources on trials of ineffective techniques (Michie 2009); and will inform adherence research in the future (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“A previous Cochrane Review highlighted likely inclusion bias in adherence trials, with participants having higher than average adherence at baseline (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Underpowered trials are more likely to miss a meaningful difference in adherence, even when improving adherence substantially, and showing an effect on clinical outcomes is likely even harder (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
In the citing paper
“Interventions that specifically aim to improve adherence to prescribed medications vary widely (Nieuwlaat 2014).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Nieuwlaat 2014
Citations
Cites
1 retracted
Zolfaghari, M., Mousavifar, S. A., Razi, S. P., & Haghani, H. (2012) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2011.03951.x · Cited by 102
RetractedDeveloping and evaluating complex interventions: the new Medical Research Council guidance
Craig, P., Dieppe, P., Macintyre, S., Michie, S., Nazareth, I., & Petticrew, M. (2008) · BMJ · doi:10.1136/bmj.a1655 · Cited by 10,995
(2008) · Cited by 3,790
Update on Key Emerging Challenges in Cystic Fibrosis
Jennings, M. T., Riekert, K. A., & Boyle, M. (2014) · Medical Principles and Practice · doi:10.1159/000357646 · Cited by 3,671
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
Publication bias in clinical research
Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109
Unützer, J., Katon, W., Callahan, C. M., Williams, Jr., Hunkeler, E., Harpole, L., Hoffing, M., Della Penna, R. D., Noël, P. H., Lin, E. H. B., et al. (2002) · JAMA · doi:10.1001/jama.288.22.2836 · Cited by 2,405
(1980) · Postgraduate Medical Journal · doi:10.1136/pgmj.56.657.530 · Cited by 1,829
Statistical Methods for Rates and Proportions.
Plewis, I., & Fleiss, J. L. (1982) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2982107 · Cited by 1,753
Winearls, C., Pippard, M. J., Downing, M. R., Oliver, D., Reid, C. D. L., & Cotes, P. M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92192-6 · Cited by 1,401
A meta-analysis of the association between adherence to drug therapy and mortality
Simpson, S. H., Eurich, D. T., Majumdar, S. R., Padwal, R. S., Tsuyuki, R. T., Varney, J., & Johnson, J. A. (2006) · BMJ · doi:10.1136/bmj.38875.675486.55 · Cited by 1,353
Lester, R. T., Ritvo, P., Mills, E. J., Kariri, A., Karanja, S., Chung, M. H., Jack, W., Habyarimana, J., Sadatsafavi, M., Najafzadeh, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61997-6 · Cited by 1,278
Crow, R. A., Gage, H., Hampson, S., Hart, J., Kimber, A., Storey, L., & Thomas, H. (2002) · Health Technology Assessment · doi:10.3310/hta6320 · Cited by 1,267
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244
Self-citationInterventions to Enhance Patient Adherence to Medication Prescriptions: Scientific Review
McDonald, H. P., Garg, A. X., & Haynes, R. B. (2002) · JAMA · doi:10.1001/jama.288.22.2868 · Cited by 1,176
Self-citationFixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis
Bangalore, S., Kamalakkannan, G., Parkar, S., & Messerli, F. H. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.08.033 · Cited by 1,075
Pop-Eleches, C., Thirumurthy, H., Habyarimana, J. P., Zivin, J. G., Goldstein, M. P., de Walque, D., MacKeen, L., Haberer, J., Kimaiyo, S., Sidle, J., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834380c1 · Cited by 982
Specifying and reporting complex behaviour change interventions: the need for a scientific method
Michie, S., Fixsen, D., Grimshaw, J. M., & Eccles, M. P. (2009) · Implementation Science · doi:10.1186/1748-5908-4-40 · Cited by 976
Factors Influencing Publication of Research Results
Dickersin, K. (1992) · JAMA · doi:10.1001/jama.1992.03480030052036 · Cited by 931
Interventions for helping patients to follow prescriptions for medications
Haynes, R., McDonald, H., Garg, A., & Montague, P. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011 · Cited by 911
Self-citationResisting medicines: a synthesis of qualitative studies of medicine taking
Pound, P., Britten, N., Morgan, M., Yardley, L., Pope, C., Daker-White, G., & Campbell, R. (2005) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.11.063 · Cited by 868
Adherence to Drugs That Prevent Cardiovascular Disease: Meta-analysis on 376,162 Patients
Naderi, S. H., Bestwick, J. P., & Wald, D. S. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.12.013 · Cited by 863
The Effects of Parathyroid Hormone, Alendronate, or Both in Men with Osteoporosis
Finkelstein, J. S., Hayes, A.-M., Hunzelman, J. L., Wyland, J. J., Lee, H., & Neer, R. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035725 · Cited by 823
Determinants of patient adherence: a review of systematic reviews
Kardas, P., Lewek, P., & Matyjaszczyk, M. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00091 · Cited by 809
Lee, J. K., Grace, K. A., & Taylor, A. J. (2006) · JAMA · doi:10.1001/jama.296.21.joc60162 · Cited by 807
Kato, P. M., Cole, S. W., Bradlyn, A. S., & Pollock, B. H. (2008) · Pediatrics · doi:10.1542/peds.2007-3134 · Cited by 802
Full Coverage for Preventive Medications after Myocardial Infarction
Choudhry, N. K., Avorn, J., Glynn, R. J., Antman, E. M., Schneeweiß, S., Toscano, M., Reisman, L., Fernandes, J. F., Spettell, C. M., Lee, J. L.-Y., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmsa1107913 · Cited by 745
Katon (2004) · doi:10.1001/archpsyc.61.10.1042 · Cited by 737
Shared Treatment Decision Making Improves Adherence and Outcomes in Poorly Controlled Asthma
Wilson, S. R., Strub, P., Buist, A. S., Knowles, S. B., Lavori, P. W., Lapidus, J., & Vollmer, W. M. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200906-0907oc · Cited by 685
Miklowitz, D. J., George, E. L., Richards, J. A., Simoneau, T. L., & Suddath, R. L. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.904 · Cited by 646
Haynes, R. B., McKibbon, K. A., & Kanani, R. S. (1996) · The Lancet · doi:10.1016/s0140-6736(96)01073-2 · Cited by 643
Self-citationCompliance therapy in psychotic patients: randomised controlled trial
Kemp, R., Hayward, P., Applewhaite, G., Everitt, B. J., & David, A. S. (1996) · BMJ · doi:10.1136/bmj.312.7027.345 · Cited by 633
Patient adherence to medical treatment: a review of reviews
van Dulmen, S., Sluijs, E., van Dijk, L., de Ridder, D., Heerdink, R., & Bensing, J. (2007) · BMC Health Services Research · doi:10.1186/1472-6963-7-55 · Cited by 627
Family Management in the Prevention of Morbidity of Schizophrenia
Falloon, I. R. H. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790320059008 · Cited by 587
Multiple-Family Groups and Psychoeducation in the Treatment of Schizophrenia
McFarlane, W. R. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950200069016 · Cited by 559
Haubrich, R., Little, S. J., Currier, J. S., Forthal, D. N., Kemper, C. A., Beall, G. N., Johnson, D., Dubé, M. P., Hwanga, J. Y., & McCutchan, J. A. (1999) · AIDS · doi:10.1097/00002030-199906180-00014 · Cited by 531
Self-help interventions for smoking cessation.
Lancaster, T., & Stead, L. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001118.pub2 · Cited by 526
Randomised controlled trial of compliance therapy
Kemp, R., Kirov, G., Everitt, B. J., Hayward, P., & David, A. S. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.5.413 · Cited by 525
IMPROVEMENT OF MEDICATION COMPLIANCE IN UNCONTROLLED HYPERTENSION
Haynes, R. B., Gibson, E., Hackett, B. C., Sackett, D., Taylor, D. W., Roberts, R., & Johnson, A. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91737-2 · Cited by 513
Self-citationInterventions for enhancing medication adherence
Haynes, R. B., Yao, X., Degani, A., Kripalani, S. B., Garg, A. X., & McDonald, H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub2 · Cited by 512
Self-citationCan simple clinical measurements detect patient noncompliance?
Haynes, R. B., Taylor, D. W., Sackett, D. L., Gibson, E., Bernholz, C. D., & Mukherjee, J. (1980) · Hypertension · doi:10.1161/01.hyp.2.6.757 · Cited by 512
Self-citationMannheimer, S., Friedland, G. H., Matts, J. P., Child, C. C., & Chesney, M. A. (2002) · Clinical Infectious Diseases · doi:10.1086/339074 · Cited by 512
Friedman, R. H. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00353-3 · Cited by 507
RANDOMISED CLINICAL TRIAL OF STRATEGIES FOR IMPROVING MEDICATION COMPLIANCE IN PRIMARY HYPERTENSION
Sackett, D., Gibson, E., Taylor, D. W., Haynes, R. B., Hackett, B. C., Roberts, R., & Johnson, A. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92192-3 · Cited by 502
Self-citationThe Multilevel Compliance Challenge: Recommendations for a Call to Action
Miller, N. H., Hill, M. N., Kottke, T. E., & Ockene, I. S. (1997) · Circulation · doi:10.1161/01.cir.95.4.1085 · Cited by 493
Educational video game for juvenile diabetes: results of a controlled trial
Brown, S. J., Lieberman, D. A., Gemeny, B. A., Fan, Y. C., Wilson, D. M., & Pasta, D. J. (1997) · Medical Informatics · doi:10.3109/14639239709089835 · Cited by 477
Pharmacist Intervention to Improve Medication Adherence in Heart Failure
Murray, M. D., Young, J., Hoke, S., Tu, W., Weiner, M., Morrow, D. G., Stroupe, K. T., Wu, J., Clark, D. O., Smith, F. E., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-10-200705150-00005 · Cited by 471
Miklowitz, D. J., Simoneau, T. L., George, E. L., Richards, J. A., Kalbag, A. S., Sachs‐Ericsson, N., & Suddath, R. L. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00931-8 · Cited by 448
Safren, S. A., O’Cleirigh, C. M., Tan, J. Y., Raminani, S. R., Reilly, L. C., Otto, M. W., & Mayer, K. H. (2009) · Health Psychology · doi:10.1037/a0012715 · Cited by 404
Assessment of Group Versus Individual Diabetes Education
Rickheim, P., Weaver, T. W., Flader, J. L., & Kendall, D. M. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.269 · Cited by 400
Treatment of Reflux Oesophagitis
COLE, P. V. (1988) · Inpharma Weekly · doi:10.1007/bf03308057 · Cited by 391
Is This Patient Taking the Treatment as Prescribed?
Stephenson, B. (1993) · JAMA · doi:10.1001/jama.269.21.2779 · Cited by 381
Coaching patients On Achieving Cardiovascular Health (COACH)
Vale, M. J., Jelinek, M. V., Best, J. D., Dart, A. M., Grigg, L., Hare, D. L., Ho, B. P., Newman, R. W., & McNeil, J. J. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2775 · Cited by 379
An Overview of Interventions to Improve Compliance With Appointment Keeping for Medical Services
Macharia, W. (1992) · JAMA · doi:10.1001/jama.1992.03480130129038 · Cited by 369
Stress Management Improves Long-Term Glycemic Control in Type 2 Diabetes
Surwit, R. S., van Tilburg, M. A. L., Zucker, N. L., McCaskill, C. C., Parekh, P. I., Feinglos, M. N., Edwards, C. L., Williams, P., & Lane, J. D. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.30 · Cited by 366
Diabetes Control With Reciprocal Peer Support Versus Nurse Care Management: A Randomized Trial
Heisler, M., Vijan, S., Makki, F., & Piette, J. D. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-8-201010190-00007 · Cited by 366
Druss, B. G., Zhao, L., von Esenwein, S. A., Bona, J. R., Fricks, L., Jenkins-Tucker, S., Sterling, E., DiClemente, R., & Lorig, K. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.01.026 · Cited by 363
Sawicki, P. T. (1999) · JAMA · doi:10.1001/jama.281.2.145 · Cited by 353
Five-year blood pressure control and mortality following health education for hypertensive patients.
Morisky, D. E., Levine, D. M., Green, L. W., Shapiro, S., Russell, R. P., & Smith, C. R. (1983) · American Journal of Public Health · doi:10.2105/ajph.73.2.153 · Cited by 353
Piette, J. D., Weinberger, M., Kraemer, F. B., & McPhee, S. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.202 · Cited by 346
Family-Based Intervention for Schizophrenic Patients in China: A Randomised Controlled Trial
Xiong, W., Phillips, M. R., Hu, X., Wang, R., Dai, Q., Kleinman, J., & Kleinman, A. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.165.2.239 · Cited by 341
Clowes, J. A., Peel, N. F. A., & Eastell, R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030501 · Cited by 334
Cost-effectiveness of Practice-Initiated Quality Improvement for Depression
Schoenbaum, M., Unützer, J., Sherbourne, C. D., Duan, N., Rubenstein, L. V., Miranda, J. M., Meredith, L. S., Carney, M. F., & Wells, K. B. (2001) · JAMA · doi:10.1001/jama.286.11.1325 · Cited by 330
for the ABC project team, Demonceau, J., Ruppar, T. M., Kristanto, P., Hughes, D. A., Fargher, E., Kardas, P., Geest, S. D., Dobbels, F., Lewek, P., et al. (2013) · Drugs · doi:10.1007/s40265-013-0041-3 · Cited by 321
Limited (information only) patient education programs for adults with asthma
Gibson, P. G., Powell, H. A., Wilson, A., Hensley, M., Abramson, M. J., Bauman, A. E., Walters, E. H., & Roberts, J. J. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001005 · Cited by 320
Integrative Health Coaching for Patients With Type 2 Diabetes
Wolever, R. Q., Dreusicke, M., Fikkan, J., Hawkins, T. V., Yeung, S., Wakefield, J., Duda, L., Flowers, P., Cook, C., & Skinner, E. (2010) · The Diabetes Educator · doi:10.1177/0145721710371523 · Cited by 317
A randomized trial of telemedicine-based collaborative care for depression
Fortney, J. C., Pyne, J. M., Edlund, M. J., Williams, D. K., Robinson, D. E., Mittal, D., & Henderson, K. L. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0201-9 · Cited by 315
Laffel, L. M. B., Vangsness, L., Connell, A., Goebel-Fabbri, A., Butler, D., & Anderson, B. J. (2003) · The Journal of Pediatrics · doi:10.1067/mpd.2003.138 · Cited by 314
Evers, A. W. M., Kraaimaat, F. W., van Riel, P. L. C. M., & de Jong, A. J. L. (2002) · Pain · doi:10.1016/s0304-3959(02)00274-9 · Cited by 301
Ulcer Prevention in Long-term Users of Nonsteroidal Anti-inflammatory Drugs
Graham, D. Y., Agrawal, N. M., Campbell, D. R., Haber, M. M., Collis, C., Lukasik, N. L., & Huang, B. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.2.169 · Cited by 299
Rueda, S., Park‐Wyllie, L. Y., Bayoumi, A. M., Tynan, A., Antoniou, T., Rourke, S. B., & Glazier, R. H. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001442.pub2 · Cited by 299
Schroeder, K., Fahey, T. P., & Ebrahim, S. B. J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004804 · Cited by 298
Shared decision making for in‐patients with schizophrenia
Hamann, J., Langer, B., Winkler, V., Busch, R., Cohen, R., Leucht, S., & Kissling, W. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00798.x · Cited by 296
Rich, M. W., Gray, D. B., Beckham, V., Wittenberg, C., & Luther, P. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00172-6 · Cited by 296
A Randomized Trial of Relapse Prevention of Depression in Primary Care
Katon, W. J., Rutter, C. M., Ludman, E. J., Korff, M. V., Lin, E. H. B., Simon, G., Bush, T. M., Walker, E., & Unützer, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.241 · Cited by 292
Dyke, R. B. V., Lee, S., Johnson, G. M., WIZNIA, A. A., Mohan, K. M., Stanley, K., Morse, E. V., Krogstad, P. A., & Nachman, S. (2002) · PEDIATRICS · doi:10.1542/peds.109.4.e61 · Cited by 291
Analysis and Reporting of Factorial Trials
McAlister, F. A., Straus, S. E., Sackett, D. L., & Altman, D. G. (2003) · JAMA · doi:10.1001/jama.289.19.2545 · Cited by 287
Compliance with cardiovascular disease prevention strategies: A review of the research
Burke, L. E., Dunbar-Jacob, J. M., & Hill, M. N. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02892289 · Cited by 286
The Diabetes Mellitus Medication Choice Decision Aid
Mullan, R. J., Montori, V. M., Shah, N. D., Christianson, T. J. H., Bryant, S. C., Guyatt, G. H., Perestelo‐Pérez, L., Stroebel, R. J., Yawn, B. P., Yapuncich, V. P., et al. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.293 · Cited by 282
A Randomized Trial to Improve Self-Management Practices of Adults With Asthma
Bailey, W. C. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00040031664013 · Cited by 281
Ross, S. E., Moore, L. A., Earnest, M. A., Wittevrongel, L., & Lin, C. (2004) · Journal of Medical Internet Research · doi:10.2196/jmir.6.2.e12 · Cited by 280
Psychoeducation Efficacy in Bipolar Disorders
Colom, F., Vieta, E., Reinares, M., Martínez‐Arán, A., Torrent, C., Goikolea, J. M., & Gastó, C. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0917 · Cited by 276
Ryan, R. E., Santesso, N., Lowe, D., Hill, S., Grimshaw, J. M., Prictor, M., Kaufman, C., Cowie, G., & Taylor, M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007768.pub3 · Cited by 273
The Diabetes Education Study: A Controlled Trial of the Effects of Diabetes Patient Education
Mazzuca, S. A., Moorman, N., Wheeler, M. L., Norton, J. A., Fineberg, N. S., Vinicor, F., Cohen, S. J., & Clark, C. M. (1986) · Diabetes Care · doi:10.2337/diacare.9.1.1 · Cited by 266
Preventing medical noncompliance in the outpatient treatment of bipolar affective disorders.
Cochran, S. D. (1984) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.52.5.873 · Cited by 264
Long-term Effectiveness and Cost of a Systematic Care Program for Bipolar Disorder
Simon, G. E., Ludman, E. J., Bauer, M. S., Unützer, J., & Operskalski, B. H. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.500 · Cited by 263
A Randomized Trial of A.C.T. (Asthma Care Training) for Kids
Lewis, C. E., Rachelefsky, G. S., Lewis, M. A., de la Sota, A., & Kaplan, M. (1984) · PEDIATRICS · doi:10.1542/peds.74.4.478 · Cited by 261
Pharmacy Asthma Care Program (PACP) improves outcomes for patients in the community
Armour, C. L., Bosnic-Anticevich, S. Z., Brillant, M., Burton, D., Emmerton, L., Krass, I., Saini, B., Smith, L. D., & Stewart, K. (2007) · Thorax · doi:10.1136/thx.2006.064709 · Cited by 260
Peveler, R., George, C., Kinmonth, A. L., Campbell, M. J., & Thompson, C. (1999) · BMJ · doi:10.1136/bmj.319.7210.612 · Cited by 255
GRuttenfor the ADDITION Study Group, Lauritzen, T., Griffin, S. J., Borch‐Johnsen, K., Wareham, N., & Wolffenbuttel, B. H. R. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801420 · Cited by 247
Preventing medical noncompliance in the outpatient treatment of bipolar affective disorders.
Cochran, S. D. (1984) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.52.5.873 · Cited by 247
Combining psychotherapy and antidepressants in the treatment of depression
de Jonghe, F., Kool, S., van Aalst, G., Dekker, J., & Peen, J. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00259-7 · Cited by 245
Tuldrà, A., Fumaz, C. R., Ferrer, M. J., Bayés, R., Arnó, A., Balagué, M., Bonjoch, A., Jou, A., Negredo, E., Paredes, R., et al. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200011010-00003 · Cited by 244
Couple-focused support to improve HIV medication adherence: a randomized controlled trial
Remien, R. H., Stirratt, M. J., Dolezal, C. L., Dognin, J. S., Wagner, G. J., Carballo‐Diéguez, A., El‐Bassel, N., & Jung, T. (2005) · AIDS · doi:10.1097/01.aids.0000168975.44219.45 · Cited by 244
Case Management in a Heterogeneous Congestive Heart Failure Population
Laramee, A. S., Levinsky, S. K., Sargent, J. Q., Ross, R., & CALLAS, P. W. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.7.809 · Cited by 241
Gallefoss, F., Bakke, P. S., & RSGAARD, P. K. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.3.9804047 · Cited by 235
Parsons, J. T., Golub, S. A., Rosof, E., & Holder, C. A. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318158a461 · Cited by 233
Ogedegbe, G. O. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.1307 · Cited by 230
Walley, J. D., Khan, M. A., Newell, J. N., & Khan, M. H. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04129-5 · Cited by 230
A Patient Education Program to Improve Adherence Rates with Antituberculosis Drug Regimens
Morisky, D. E., Malotte, C. K., Choi, P., Davidson, P. T., Rigler, S., Sugland, B. W., & Langer, M. (1990) · Health Education Quarterly · doi:10.1177/109019819001700303 · Cited by 224
Treatment, expressed emotion and relapse in recent onset schizophrenic disorders
Linszen, D. H., Dingemans, P. M. A. J., van der Does, W. A. J., Nugter, A., Scholte, P., Lenior, R., Vanier, C., & Goldstein, M. J. (1996) · Psychological Medicine · doi:10.1017/s0033291700034723 · Cited by 223
The Alendronate Once-Weekly Study Group, & Rizzoli, R. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.1988 · Cited by 222
Five-Year Impact of Quality Improvement for Depression
Wells, K. B., Sherbourne, C. D., Schoenbaum, M., Ettner, S. L., Duan, N., Miranda, J. M., Unützer, J., & Rubenstein, L. V. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.4.378 · Cited by 221
Wu, J. Y. F., Leung, W. Y. S., Chang, S., Lee, B., Zee, B. C.-Y., Tong, P. C. Y., & Chan, J. C. N. (2006) · BMJ · doi:10.1136/bmj.38905.447118.2f · Cited by 220
Compliance therapy: a randomised controlled trial in schizophrenia
O’Donnell, C. P., Donohoe, G. J., Sharkey, L., Owens, N., Migone, M., Harries, R., Kinsella, A., Larkin, C., & O'Callaghan, E. (2003) · BMJ · doi:10.1136/bmj.327.7419.834 · Cited by 219
Specialised care for early psychosis: Symptoms, social functioning and patient satisfaction
Garety, P. A., Craig, T., Dunn, G., Fornells‐Ambrojo, M., Colbert, S., Rahaman, N., Reed, J., & Power, P. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.104.007286 · Cited by 219
Randomised trial of telephone intervention in chronic heart failure: DIAL trial
GESICA Investigators (2005) · BMJ · doi:10.1136/bmj.38516.398067.e0 · Cited by 218
Ellis, D. A., Frey, M. A., Naar‐King, S., Templin, T., Cunningham, P. B., & Çakan, N. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1604 · Cited by 216
Effectiveness of Pharmacist Care for Patients With Reactive Airways Disease
Weinberger, M., Murray, M. D., Marrero, D. G., Brewer, N., Lykens, M., Harris, L. E., SESHADRI, R. M., Caffrey, H., Roesner, J. F., Smith, F. E., et al. (2002) · JAMA · doi:10.1001/jama.288.13.1594 · Cited by 214
Medication compliance feedback and monitoring in a clinical trial: predictors and outcomes
Cramer, J., Rosenheck, R., Kirk, G., Krol, W., & Krystal, J. (2003) · Value in Health · doi:10.1046/j.1524-4733.2003.65269.x · Cited by 212
Cue-dose training with monetary reinforcement
Rigsby, M. O., Rosen, M. I., Beauvais, J. E., Cramer, J. A., Rainey, P. M., O’Malley, S. S., Dieckhaus, K. D., & Rounsaville, B. J. (2000) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2000.00127.x · Cited by 211
Health Education for Hypertensive Patients
Levine, D. M. (1979) · JAMA · doi:10.1001/jama.1979.03290420026019 · Cited by 211
Predicting medication adherence in severe mental disorders
Adams, J. M., & Scott, J. L. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.90061.x · Cited by 208
The value of inpatient pharmaceutical counselling to elderly patients prior to discharge
Alrashed, S. A., Wright, D. J., Roebuck, N., Sunter, W., & Chrystyn, H. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01707.x · Cited by 206
A Practice-Based Trial of Motivational Interviewing and Adherence in Hypertensive African Americans
Ogedegbe, G. G., Chaplin, W. F., Schoenthaler, A., Statman, D., Berger, D. B., Richardson, T., Phillips, E. L., Spencer, J., & Allegrante, J. P. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.240 · Cited by 202
Hammond, A., & Freeman, K. (2004) · Clinical Rehabilitation · doi:10.1191/0269215504cr766oa · Cited by 202
A Randomized Controlled Trial of Cognitive Therapy for Bipolar Disorder
Ball, J. R. B., Mitchell, P. B., Corry, J., Skillecorn, A., Smith, M., & Malhi, G. S. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0215 · Cited by 199
Browne, G., Steiner, M., Roberts, J., Gafni, A., Byrne, C., Dunn, E., Bell, B., Mills, M., Chalklin, L., Wallik, D., et al. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00343-3 · Cited by 199
Coté, J., Cartier, A., Robichaud, P., Boutin, H., Malo, J., Rouleau, M., Fillion, A., Lavallee, M., Krusky, M., & Boulet, L. P. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.5.9154850 · Cited by 196
Ran, M., Xiang, M., Chan, C., Leff, J., Simpson, P., Huang, M., Shan, Y.-H., & Li, S. (2003) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-003-0601-z · Cited by 195
de Lusignan, S., Wells, S., Johnson, P., Meredith, K., & Leatham, E. (2001) · European Journal of Heart Failure · doi:10.1016/s1388-9842(01)00190-8 · Cited by 195
Individualized asthma self-management improves medication adherence and markers of asthma control
Janson, S. L., McGrath, K. W., Covington, J. K., Cheng, S., & Boushey, H. A. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.01.053 · Cited by 195
Bouvy, M. L., Heerdink, E. R., Urquhart, J., Grobbee, D. E., Hoe, A. W., & Leufkens, H. G. M. (2003) · Journal of Cardiac Failure · doi:10.1054/s1071-9164(03)00130-1 · Cited by 194
Chan, D. S., Callahan, C. W., Hatch-Pigott, V. B., Lawless, A., Proffitt, H. L., Manning, N. E., Schweikert, M. P., & Malone, F. J. (2007) · PEDIATRICS · doi:10.1542/peds.2006-1884 · Cited by 194
Adherence therapy for people with schizophrenia
Gray, R. J., Leese, M., Bindman, J. P., Becker, T. M., Burti, L., David, A. S., Gournay, K., Kikkert, M., Koeter, M. W. J., Puschner, B., et al. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.019489 · Cited by 194
Clarkin, J. F., Carpenter, D., Hull, J. W., Wilner, P. J., & Glick, I. D. (1998) · Psychiatric Services · doi:10.1176/ps.49.4.531 · Cited by 194
Improving Blood Pressure Control in a Pharmacist‐Managed Hypertension Clinic
Vivian, E. (2002) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.22.17.1533.34127 · Cited by 194
Self-management Counseling in Patients With Heart Failure
Powell, L. H., Calvin, J. E., Richardson, D., Janssen, İ., de Leon, C. F. M., Flynn, K. J., Grady, K. L., Rucker-Whitaker, C. S., Eaton, C., Avery, E., et al. (2010) · JAMA · doi:10.1001/jama.2010.1362 · Cited by 192
Behavior Therapy for Families of Adolescents With Diabetes
Wysocki, T., Greco, P., Harris, M. A., Bubb, J., & White, N. H. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.441 · Cited by 191
A pharmacy discharge plan for hospitalized elderly patients—a randomized controlled trial
Nazareth, I., Burton, A., Shulman, S., Smith, P., Haines, A., & Timberall, H. (2001) · Age and Ageing · doi:10.1093/ageing/30.1.33 · Cited by 189
Medication adherence: Factors influencing compliance with prescribed medication plans
Vlasnik, J. J., Aliotta, S. L., & DeLor, B. (2005) · The Case Manager · doi:10.1016/j.casemgr.2005.01.009 · Cited by 187
Gallefoss, F., & Bakke, P. S. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9901028 · Cited by 187
Chang, L. W., Kagaayi, J., Arem, H., Nakigozi, G., Ssempijja, V., Serwadda, D., Quinn, T. C., Gray, R. H., Bollinger, R. C., & Reynolds, S. J. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-9995-x · Cited by 184
Shared Decision Making and Long-Term Outcome in Schizophrenia Treatment
Hamann, J., Cohen, R., Leucht, S., Busch, R. M., & Kissling, W. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0703 · Cited by 184
Katon, W. J., Russo, J. E., Korff, M. V., Lin, E. H. B., Simon, G., Bush, T. M., Ludman, E. J., & Walker, E. A. (2002) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2002.11051.x · Cited by 182
Gensichen, J., von Korff, M., Peitz, M., Muth, C., Beyer, M., Güthlin, C., Torge, M., Petersen, J. J., Rosemann, T., König, J., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-6-200909150-00001 · Cited by 181
Influence of pharmaceutical care on health outcomes in patients with Type 2 diabetes mellitus
Mazrouei, N. A., Kamal, M. M., Ghabash, N. M., Yacout, T. A., Kole, P. L., & McElnay, J. C. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03391.x · Cited by 178
Improved Adherence with Contingency Management
Rosen, M. I., Dieckhaus, K. D., McMahon, T. J., Valdes, B., Petry, N. M., Cramer, J. A., & Rounsaville, B. J. (2007) · AIDS Patient Care and STDs · doi:10.1089/apc.2006.0028 · Cited by 176
Hou, M. Y., Hurwitz, S., Kavanagh, E., Fortin, J., & Goldberg, A. B. (2010) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181eb6b0f · Cited by 176
Chisholm, M. A., Mulloy, L. L., Jagadeesan, M., & DiPiro, J. T. (2001) · Clinical Transplantation · doi:10.1034/j.1399-0012.2001.150505.x · Cited by 176
Wakefield, B. J., Holman, J. E., Ray, A. L., Scherubel, M., Adams, M. R., Hillis, S. L., & Rosenthal, G. E. (2011) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2010.0176 · Cited by 174
Impact of telemonitoring at home on the management of elderly patients with congestive heart failure
Antonicelli, R., Testarmata, P., Spazzafumo, L., Gagliardi, C., Bilo, G., Valentini, M., Olivieri, F., & Parati, G. (2008) · Journal of Telemedicine and Telecare · doi:10.1258/jtt.2008.071213 · Cited by 174
Simoni, J. M., Huh, D., Frick, P. A., Pearson, C. R., Andrasik, M. P., Dunbar, P. J., & Hooton, T. M. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181b9300c · Cited by 174
Simoni, J. M., Pantalone, D. W., Plummer, M. D., & Huang, B. (2007) · Health Psychology · doi:10.1037/0278-6133.26.4.488 · Cited by 174
Reducing Acute Adverse Outcomes in Youths With Type 1 Diabetes: A Randomized, Controlled Trial
Svoren, B. M., Butler, D. A., Levine, B.-S., Anderson, B. J., & Laffel, L. M. (2003) · PEDIATRICS · doi:10.1542/peds.112.4.914 · Cited by 174
Holland, R., Brooksby, I. A. B., Lenaghan, E., Ashton, K. E., Hay, L., Smith, R., Shepstone, L., Lipp, A., Daly, C., Howe, A. C., et al. (2007) · BMJ · doi:10.1136/bmj.39164.568183.ae · Cited by 174
Zhang, M., Wang, M., Li, J., & Phillips, M. R. (1994) · PubMed · Cited by 172
Jarab, A. S., Alqudah, S., Mukattash, T. L., Shattat, G. F., & Al‐Qirim, T. M. (2012) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2012.18.7.516 · Cited by 170
Simon, J. A., Lewiecki, E. M., Smith, M. E., Petruschke, R. A., Wang, L., & Palmisano, J. J. (2002) · Clinical Therapeutics · doi:10.1016/s0149-2918(02)80085-6 · Cited by 170
An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma
Charles, T., Quinn, D., Weatherall, M., Aldington, S., Beasley, R. W., & Holt, S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.11.700 · Cited by 169
Velligan, D. I., Diamond, P. M., Mintz, J., Maples, N. J., Li, X., Zeber, J. E., Ereshefsky, L., Lam, Y.-W. F., Castillo, D., & Miller, A. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm111 · Cited by 168
Antoni, M. H., Carrico, A. W., Durán, R. E., Spitzer, S. B., Penedo, F. J., Ironson, G. H., FLETCHER, M. A., Klimas, N. G., & Schneiderman, N. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195749.60049.63 · Cited by 167
Effect of Peer Health Workers on AIDS Care in Rakai, Uganda: A Cluster-Randomized Trial
Chang, L. W., Kagaayi, J., Nakigozi, G. F., Ssempijja, V., Packer, A. H., Serwadda, D., Quinn, T. C., Gray, R. H., Bollinger, R. C., & Reynolds, S. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010923 · Cited by 167
Assessment of a Community Pharmacy‐Based Program for Patients with Asthma
Cordina, M., & McElnay, J. C. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.15.1196.33894 · Cited by 166
Nurse management for hypertensionA systems approach
Rudd, P., Miller, N. H., KAUFMAN, J., KRAEMER, H. C., Bandura, A., Greenwald, G., & DeBusk, R. F. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.06.006 · Cited by 166
Results of a Successful Telephonic Intervention to Improve Diabetes Control in Urban Adults
Walker, E. A., Shmukler, C., Ullman, R., Blanco, E., Scollan‐Koliopoulos, M., & Cohen, H. W. (2010) · Diabetes Care · doi:10.2337/dc10-1005 · Cited by 164
Hill, J., Bird, H. A., & Johnson, S. (2001) · Annals of the Rheumatic Diseases · doi:10.1016/s0003-4967(24)43387-6 · Cited by 163
DiIorio, C. K., McCarty, F., Resnicow, K., Holstad, M. M., Soet, J. E., Yeager, K. A., Sharma, S., Morisky, D. E., & Lundberg, B. E. (2008) · AIDS Care · doi:10.1080/09540120701593489 · Cited by 163
Sorensen, J. L., Haug, N. A., Delucchi, K., Gruber, V. A., Kletter, E., Batki, S. L., Tulsky, J. P., Barnett, P. G., & Hall, S. M. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.09.019 · Cited by 163
The impact of a pharmacist intervention on 6-month outcomes in depressed primary care patients
Adler, D. A., Bungay, K. M., Wilson, I. B., Pei, Y., Supran, S. E., Peckham, E., Cynn, D. J., & Rogers, W. H. (2004) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2003.08.005 · Cited by 163
Finley, P. R., Rens, H. R., Pont, J. T., Gess, S. L., Louie, C., Bull, S. A., Lee, J. Y., & Bero, L. A. (2003) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.23.10.1175.32760 · Cited by 162
Adherence to Preventive Medications
Walker, E. A., Molitch, M., Kramer, M. K., Kahn, S., Ma, Y., Edelstein, S., Smith, K., Johnson, M. K., Kitabchi, A., Crandall, J., et al. (2006) · Diabetes Care · doi:10.2337/dc06-0454 · Cited by 161
Katelaris, P., Forbes, G. M., Talley, N. J., & Crotty, B. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.37051 · Cited by 160
Contreras, E. M., Claros, N. M., Gil-Guillén, V. F., Wichmann, M. D. L. F.-V., Casado-Martínez, J. J., Pablos, J. L. M.-D., Figueras, M., Galera, J., & Serra, A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000198023.53859.a2 · Cited by 159
Okeke, C. O., Quigley, H. A., JAMPEL, H. D., Ying, G., Plyler, R. J., Jiang, Y., & Friedman, D. S. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.05.026 · Cited by 159
A Randomized Trial of High-Dose Compared with Low-Dose Omega-3 Fatty Acids in Severe IgA Nephropathy
Donadío, J. V., Larson, T. S., Bergstralh, E. J., & Grande, J. P. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v124791 · Cited by 159
Breslin, M., Mullan, R. J., & Montori, V. M. (2008) · Patient Education and Counseling · doi:10.1016/j.pec.2008.07.024 · Cited by 158
Lemstra, M., Stewart, B., & Olszynski, W. P. (2002) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2002.02202.x · Cited by 158
Roy-Byrne, P. P., Katon, W., Cowley, D. S., & Russo, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.9.869 · Cited by 158
The benefits of prescription information leaflets (1).
Gibbs, S., Waters, W. E., & George, C. (1989) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1989.tb03434.x · Cited by 158
Impact of a Patient Education Program on Adherence to HIV Medication
Goujard, C. C., Bernard, N., Sohier, N., Peyramond, D., on, F. L., Chwalow, J., Arnould, B., & Delfraissy, J.-F. O. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200310010-00009 · Cited by 155
Fumaz, C. R., Tuldrà, A., Ferrer, M. J., Paredes, R., Bonjoch, A., Jou, T., Negredo, E., Romeu, J., Sirera, G., Tural, C., et al. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200203010-00004 · Cited by 154
Pharmacist intervention program to enhance hypertension control: a randomised controlled trial
Morgado, M., Rolo, S., & Castelo-Branco, M. (2011) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-010-9474-x · Cited by 152
Cetina, T. E. C. D., Canto, P., & Luna, M. O. (2001) · Contraception · doi:10.1016/s0010-7824(01)00181-0 · Cited by 150
Uptake of Self-Management Strategies in a Heart Failure Management Programme
Wright, S. P., Walsh, H. J., Ingley, K. M., Muncaster, S. A., Gamble, G. D., Pearl, A., WHALLEY, G. A., Sharpe, N., & Doughty, R. N. (2003) · European Journal of Heart Failure · doi:10.1016/s1388-9842(03)00039-4 · Cited by 150
Integrating Medical Management With Diabetes Self-Management Training
Polonsky, W. H., Earles, J. E., Smith, S., Pease, D. J., Macmillan, M., Christensen, R. S., Taylor, T., Dickert, J., & Jackson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3048 · Cited by 149
WORK-SITE TREATMENT OF HYPERTENSION BY SPECIALLY TRAINED NURSES
Logan, A., Achber, C., Milne, B. J., Campbell, W., & Haynes, R. B. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92397-3 · Cited by 148
Self-citationLong-term Effectiveness of Disseminating Quality Improvement for Depression in Primary Care
Sherbourne, C. D., Wells, K. B., Duan, N., Miranda, J. M., Unützer, J., Jaycox, L. H., Schoenbaum, M., Meredith, L. S., & Rubenstein, L. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.7.696 · Cited by 147
Schwartz, R. H. (1981) · JAMA · doi:10.1001/jama.246.16.1790 · Cited by 147
Huguelet, P., Mohr, S., Betrisey, C., Borras, L., Gillieron, C., Marie, A. M., Rieben, I., Perroud, N., & Brandt, P.-Y. (2011) · Psychiatric Services · doi:10.1176/ps.62.1.pss6201_0079 · Cited by 147
Hammond, A., & Freeman, K. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.9.1044 · Cited by 147
Randomised-Control Trial of Family Intervention for 78 First-Episode Male Schizophrenic Patients
Zhang, M., Wang, M., Li, J., & Phillips, M. R. (1994) · The British Journal of Psychiatry · doi:10.1192/s0007125000293045 · Cited by 147
Improving Inhaler Adherence in a Clinical Trial Through the Use of the Nebulizer Chronolog
Nides, M. A., Tashkin, D. P., Simmons, M. S., Wise, R. A., Li, V. C., & Rand, C. S. (1993) · CHEST Journal · doi:10.1378/chest.104.2.501 · Cited by 146
Zarnke, K. B. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00305-6 · Cited by 145
Better medication adherence results in greater improvement in severity of psoriasis
Carroll, C. L., Feldman, S. R., CAMACHO, F. T., & Balkrishnan, R. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06174.x · Cited by 145
Clinical pharmacy‐led disease and medicine management programme for patients with COPD
Khdour, M. R., Kidney, J. C., Smyth, B. M., & McElnay, J. C. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03493.x · Cited by 144
Measuring Adherence in a Hypertension Clinical Trial
Hamilton, G. A. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00058-6 · Cited by 144
Côté, J., BOWIE, D. M., Robichaud, P., PARENT, J.-G., Battisti, L., & Boulet, L. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.6.2006069 · Cited by 143
Haynes, R. B., & Wilczynski, N. L. (2010) · Implementation Science · doi:10.1186/1748-5908-5-12 · Cited by 142
Self-citationRandomized trial of pharmacist interventions to improve depression care and outcomes in primary care
Capoccia, K. L., Boudreau, D. M., Blough, D. K., Ellsworth, A. J., Clark, D., Stevens, N. G., Katon, W. J., & Sullivan, S. D. (2004) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/61.4.364 · Cited by 141
Long-Term Results After a Telephone Intervention in Chronic Heart Failure
Ferrante, D., Varini, S. D., Macchia, A., Soifer, S., Badra, R., Nul, D. R., Grancelli, H., & Doval, H. C. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.049 · Cited by 140
Ludman, E. J., Katon, W. J., Bush, T. M., Rutter, C. M., Lin, E. H. B., Simon, G. E., Korff, M. V., & WALKER, E. (2003) · Psychological Medicine · doi:10.1017/s003329170300816x · Cited by 140
Integration of Depression and Hypertension Treatment: A Pilot, Randomized Controlled Trial
Bogner, H. R., & de Vries, H. F. (2008) · The Annals of Family Medicine · doi:10.1370/afm.843 · Cited by 140
Mehuys, E., Van Bortel, L., De Bolle, L., Van Tongelen, I., Annemans, L., Remon, J.-P., & Giri, M. (2011) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2010.01218.x · Cited by 139
Medication Compliance and Health Education Among Outpatients With Chronic Mental Disorders
Kelly, G. R., & Scott, J. E. (1990) · Medical Care · doi:10.1097/00005650-199012000-00006 · Cited by 139
Case management for patients with poorly controlled diabetes: a randomized trial
Krein, S. L., Klamerus, M. L., Vijan, S. S., Lee, J. L., Fitzgerald, J. T., Pawlow, A., Reeves, P. J., & Hayward, R. A. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.11.028 · Cited by 138
Insull, W., Toth, P. D., Mullican, W. S., Hunninghake, D. B., Burke, S. K., Donovan, J. M., & Davidson, M. H. (2001) · Mayo Clinic Proceedings · doi:10.4065/76.10.971 · Cited by 138
Patient compliance and the conduct and interpretation of therapeutic trials
Haynes, R. B., & Dantes, R. B. (1987) · Controlled Clinical Trials · doi:10.1016/0197-2456(87)90021-3 · Cited by 138
Self-citation
Research works printed but not linked: 33
- Chamorro, 2011, Effect of pharmacist involvement in adherence to medications in patients with high to moderate cardiovascular risk (Study EMDADER-CV-INCUMPLIMIENTO), Atencion Primaria, 43, 245
- Marquez Contreras, 2004, Efficacy of an intervention to improve treatment compliance in hyperlipidemias, Atencion Primaria, 33, 443
- Marquez Contreras, 2007, Therapy compliance in cases of hyperlipaemia, as measured through electronic monitors. Is a reminder calendar to avoid forgetfulness effective?, Atencion Primaria, 39, 661
- Strang, 1981, The effects of family therapy on treatment compliance in schizophrenia, Psychopharmacology Bulletin, 17, 87
- Yopp, 2004, The Impact of Family Functioning on Treatment Adherence and Metabolic Control for Adolescents with Poorly Controlled T1DM [dissertation]
- Barcelo, 2001, An intervention to improve diabetes control in Chile, Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 10, 328
- Binstock, 1986, Therapeutic adherence programme improves compliance and lowers blood pressure, Journal of Hypertension, 4 Suppl, 375
- Birrer, 1984, Hypertension: a double-blind study of compliance in an urban community, Family Practice Research Journal, 3, 251
- Bonner, 2002, An individualized intervention to improve asthma management among urban Latino and African-American families, Journal of Asthma, 39, 167, 10.1081/JAS-120002198 · DOI
- Bouvy, 2003, Guidance improves compliance. Pharmacist stimulates proper use of loop diuretics in patient with heart failure, Pharmaceutisch Weekblad, 138, 1432
- Celik, 1997, Comparison of the clinical efficacy of azithromycin and cerufoxime axetile in the treatment of patients with acute otitis media, Mikrobiyoloji Bulteni, 31, 253
- Edworthy, 1999, Improving medication adherence through patients education distinguishing between appropriate and inappropriate utilization, Journal of Rheumatology, 26, 1793
- Kelly, 1991, Medication compliance and health education among outpatients with chronic mental disorders [erratum], Medical Care, 29, 889
- Leal, 2004, Written information on the use of aerosols in COPD patients. Can we improve their use? [see comment], Atencion Primaria, 33, 6
- Levesque, 1983, Comparative efficacy of two dosage regimens of cimetidine in the treatment of symptomatic duodenal ulcer: results of a multicenter clinical trial, Current Therapeutic Research, Clinical and Experimental, 33, 70
- Marquez Contreras, 2004, Effectiveness of an intervention to provide information to patients with hypertension as short text messages and reminders sent to their mobile phone (HTA-Alert), Atencion Primaria, 34, 399
- Ogedegbe, 2007, An RCT of the effect of motivational interviewing on medication adherence in hypertensive African Americans: rationale and design, Contemporary Clinical Trials, 28, 169, 10.1016/j.cct.2006.04.002 · DOI
- Phan, 1995, Enhancing client adherence to psychotropic medication regimens: a psychosocial nursing approach, International Journal of Psychiatric Nursing Research, 2, 146
- Purcell, 2004, Interventions for seropositive injectors-research and evaluation: an integrated behavioral intervention with HIV-positive injection drug users to address medical care, adherence, and risk reduction, Journal of Acquired Immune Deficiency Syndromes, 37, S110, 10.1097/01.qai.0000140609.44016.c4 · DOI
- Razali, 1997, Health education and drug counseling for schizophrenia, International Medical Journal, 4, 187
- Rickheim, 2002, Assessment of group versus individual diabetes education: a randomized study, Diabetes Care, 25, 269, 10.2337/diacare.25.2.269 · DOI
- Rodriguez, 2003, Effectiveness of a group educational intervention in patients with chronic obstructive pulmonary disease, Enfermeria Clinica, 13, 131
- Sanchez, 2002, Treatment of latent tuberculosis infection in injecting drug users co-infected by HIV, Enfermedades Emergentes, 4, 62
- Tapanya S A biopsychosocial intervention program to improve medical regimen adherence and glycemic control in type II diabetic patients Dissertation Abstracts International: Section B: the Sciences and Engineering 1997
- Vander Stichele, 1992, Measuring patient compliance with electronic monitoring: lisinopril versus atenolol in essential hypertension, Post Market Surveillance, 6, 77
- Vetter, 1999, Efficacy and safety of once-daily and twice-daily clarithromycin formulations in the treatment of acute exacerbations of chronic bronchitis, Advances in Therapy, 16, 13
- Andres Rodriguez, 2007, Assessment of knowledge/compliance in a drug therapy follow-up program involving type 2 diabetic patients in community pharmacy: a randomized study, Pharmaceutical Care Espana, 9, 2
- Marquez Contreras, 2000, Therapeutic compliance in hypertension. Trial of two-year health education intervention, Atencion Primaria, 26, 5
- Marquez Contreras, 2009, Non-pharmacological intervention as a strategy to improve antihypertensive treatment compliance, Atencion Primaria, 41, 501
- Gordis, 1979, Conceptual and methodologic problems in measuring compliance, 23
- Haynes, 1979, Determinants of compliance: the disease and the mechanics of treatment, 49
- Sackett, 1979, The magnitude of adherence and nonadherence, 11
- Stephenson, 1993, Is this patient taking their medication?, JAMA, 269, 2779, 10.1001/jama.1993.03500210079036 · DOI
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Metadata
- Authors
- Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., Sivaramalingam, B., Iserman, E., Mustafa, R. A., Jedraszewski, D., Cotoi, C., & Haynes, R. B.
- Affiliations
- Hamilton General Hospital (CA)
- McMaster University (CA)
- St. Michael's Hospital (CA)
- University of Guelph (CA)
- ORCID
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2014-11-20
- Volume
- 2014
- Issue
- 11
- Pages
- CD000011-CD000011
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC7263418
- OpenAlex
- W1594567624
- Cited by
- 2,945
- References
- 645
- Citations by year
- 2026: 64 · 2025: 119 · 2024: 108 · 2023: 147 · 2022: 157 · 2021: 177 · 2020: 200 · 2019: 190 · 2018: 209 · 2017: 244 · 2016: 224 · 2015: 191 · 2014: 214
- FWCI
- 37.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Patient Safety and Medication Errors
- Keywords
- medication adherence, adherence interventions, self-administered medication, clinical outcomes, risk of bias, quality of evidence, pill organizers, pharmacists
- MeSH terms
- Drug Therapy, Humans, Patient Education as Topic, Self Administration, Randomized Controlled Trials as Topic, Publication Bias, Medication Adherence
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