Cited by 42Schizophrenia research and treatmentMedication Adherence and CompliancePsychotherapy Techniques and Applications

Modeling Determinants of Medication Attitudes and Poor Adherence in Early Nonaffective Psychosis: Implications for Intervention

Open access
Drake, Richard J., Nordentoft, Merete, Haddock, Gillian, Arango, Celso, Fleischhacker, W. Wolfgang, Glenthøj, Birte, Leboyer, Marion, Leucht, Stefan +7 more·2015·Schizophrenia Bulletin

Abstract

We aimed to design a multimodal intervention to improve adherence following first episode psychosis, consistent with current evidence. Existing literature identified medication attitudes, insight, and characteristics of support as important determinants of adherence to medication: we examined medication attitudes, self-esteem, and insight in an early psychosis cohort better to understand their relationships. Existing longitudinal data from 309 patients with early Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, nonaffective psychosis (83% first episode) were analyzed to test the hypothesis that medication attitudes, while meaningfully different from "insight," correlated with insight and self-esteem, and change in each influenced the others. Rosenberg Self-Esteem Scale, Birchwood Insight Scale, and Positive and Negative Syndrome Scale insight were assessed at presentation, after 6 weeks and 3 and 18 months. Drug Attitudes Inventory (DAI) and treatment satisfaction were rated from 6 weeks onward. Structural equation models of their relationships were compared. Insight measures' and DAI's predictive validity were compared against relapse, readmission, and remission. Analysis found five latent constructs best fitted the data: medication attitudes, self-esteem, accepting need for treatment, self-rated insight, and objective insight. All were related and each affected the others as it changed, except self-esteem and medication attitudes. Low self-reported insight at presentation predicted readmission. Good 6-week insight (unlike drug attitudes) predicted remission. Literature review and data modeling indicated that a multimodal intervention using motivational interviewing, online psychoeducation, and SMS text medication reminders to enhance adherence without damaging self-concept was feasible and appropriate.

Integrity signals

Registry

Crossref · 10.1093/schbul/sbv015

Cites

133 of 133 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Drake, R. J., Nordentoft, M., Haddock, G., Arango, C., Fleischhacker, W. W., Glenthøj, B., Leboyer, M., Leucht, S., Leweke, M., McGuire, P., Meyer-Lindenberg, A., Rujescu, D., Sommer, I. E., Kahn, R. S., & Lewis, S. W.
Affiliations
  • Manchester Academic Health Science Centre (GB)
  • University of Copenhagen (DK)
  • Universidad Complutense de Madrid (ES)
  • Innsbruck Medical University (AT)
  • Inserm (FR)
  • Technical University of Munich (DE)
  • Martin Luther University Halle-Wittenberg (DE)
  • University Medical Center Utrecht (NL)
Corresponding author
Drake, Richard J.
Venue
Schizophrenia Bulletin
Published
2015-03-05
Volume
41
Issue
3
Pages
584-596
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
OpenAlex
W2127158799
Cited by
42
References
133
Citations by year
2026: 4 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3
FWCI
4.05
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
Lundbeckfonden (R155-2013-16337, R155-2014-1724)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
medication adherence, attitudes toward medication
MeSH terms
Adult, Awareness, Humans, Health Knowledge, Attitudes, Practice, Longitudinal Studies, Psychotic Disorders, Self Concept, Models, Statistical, Medication Adherence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review