Cited by 65Nutrition and Health in AgingOsteoarthritis Treatment and MechanismsBody Composition Measurement Techniques

Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis

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Beattie, Karen A., MacIntyre, Norma J., Ramadan, Khaled, Inglis, Dean, Maly, Monica R.·2012·Arthritis Care & Research

Abstract

Objective: To quantify rates of change in quadriceps muscle (QM) and intermuscular fat (IMF) volumes over 2 years in women in the Osteoarthritis Initiative (OAI) study and examine group differences between those with radiographic osteoarthritis (ROA) and those without ROA. Methods: The OAI database was queried for women ≥50 years of age in the incident and progression cohorts with and without ROA at baseline. Midthigh magnetic resonance imaging scans (15 contiguous slices, 5 mm slice thickness) of eligible women were randomly selected and anonymized. Image pairs were registered. QM and IMF were segmented in the 12 most proximal matching slices with the segmenter blinded to image time point. Age‐adjusted differences in QM and IMF volume changes between groups were tested using analysis of covariance. Results: Forty‐one women without ROA (mean ± SD age 60.7 ± 7.6 years) and 45 women with ROA (mean ± SD age 64.5 ± 6.7 years) were included. Mean ± SD QM and IMF volume changes in the non‐ROA group were −4.1 ± 11.1 cm 3 and 3.4 ± 7.1 cm 3 , respectively, and −5.4 ± 13.5 cm 3 and 3.1 ± 7.4 cm 3 in the ROA group, respectively. Age‐adjusted between‐group differences in QM and IMF changes were not significant ( P > 0.05). Conclusion: Two‐year changes in QM and IMF volumes appear consistent with aging and do not seem to be related to OA status. Direct comparison with a control cohort without OA risk factors could confirm this. Since group assignment was based on baseline data, there may have been women in the non‐ROA group who developed ROA over followup, resulting in some overlap between groups.

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Authors
Beattie, K. A., MacIntyre, N. J., Ramadan, K., Inglis, D., & Maly, M. R.
Affiliations
McMaster University (CA)
Corresponding author
Beattie, Karen A.
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2011-12-28
Volume
64
Issue
1
Pages
22-29
ISSN
  • 0893-7524 (ISSN-L)
  • 2151-464X
  • 2151-4658
OpenAlex
W2072412536
Cited by
65
References
39
Citations by year
2026: 5 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 11 · 2013: 6 · 2012: 5
FWCI
4.80
Type
journal article
Language
en
Open access
Locations
  • Arthritis Care & Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01ar22260-13-0-1, n01ar22258-16-0-1, n01ar22259-12-0-1, n01ar22262-12-0-1, n01ar22261-13-0-1)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01 ‐ AR ‐ 2 ‐ 2261, N01‐AR‐2‐2260, N01 AR022262, N01 AR022260, N01 ‐ AR ‐ 2 ‐ 2258, N01 AR022261, N01-AR-2- 2262, N01 AR022259, N01 AR022258, N01AR22259)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
Keywords
knee osteoarthritis, intermuscular fat, thigh muscle volume, longitudinal change, women, aging, radiographic osteoarthritis, Osteoarthritis Initiative, magnetic resonance imaging, muscle atrophy
MeSH terms
Age Factors, Aged, Aging, Analysis of Variance, Canada, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Middle Aged, Organ Size, Radiography, Sex Factors, Time Factors, Case-Control Studies, Disease Progression, Osteoarthritis, Knee, Adiposity, Quadriceps Muscle

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