Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men
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Objective: Skeletal muscle fat infiltration (known as myosteatosis) is greater in African compared with European ancestry men and may play an important role in the development of type 2 diabetes (T2D). However, prospective studies examining the magnitude of changes in myosteatosis with aging and their metabolic consequences are sparse. Methods: Longitudinal changes in peripheral quantitative computed tomography measured calf myosteatosis [intermuscular fat (mm 2 ) and skeletal muscle density as a measure of intramuscular fat (mg/cm 3 )] were examined in 1515 Afro‐Caribbean men aged 40+ years recruited without regard to their health status. Results: During an average of 6.2 years of follow‐up, an age‐related increase in intermuscular fat and a decrease in skeletal muscle density were observed (all P < 0.0001), which remained significant in those who lost weight, gained weight, or remained weight stable (all P < 0.0001). In addition, muscle density loss accelerated with increasing age ( P < 0.0001). Increased intermuscular fat during follow‐up was associated with an increased incident risk of T2D independent of factors known to be associated with T2D (odds ratios per 1‐SD increase in intermuscular fat = 1.29; 95% CI = 1.08‐1.53). Conclusions: Our findings suggest that both inter‐ and intramuscular fat increase with advancing age and that intermuscular fat contributes to development of T2D among African ancestry men.
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Evidence shows that skeletal muscle fat infiltration accelerates with increasing age amongst middle aged and older men.
“Evidence shows that skeletal muscle fat infiltration accelerates with increasing age amongst middle aged and older men.[ 38 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [38]
Myosteatosis increases with aging.
“Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Miljkovic et al., 2016
In the Tobago Bone Health Study, older African-Caribbean men had almost the same rate of change in myosteatosis as older African-American men.
“These findings were replicated in the Tobago Bone Health Study where older African-Caribbean men had almost the same rate of change in myosteatosis as older African-American men (Miljkovic et al., 2016)”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Miljkovic et al., 2016
Myosteatosis accelerates with increasing age among middle aged and older African-Caribbean men.
“in addition, it was reported for the first time that myosteatosis accelerates with increasing age among middle aged and older African-Caribbean men.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Miljkovic et al., 2016
Studies suggest that increased intermuscular fat with aging correlates with the onset of T2DM, raising the possibility that intermuscular fat could serve as an independent predictor of T2DM in males of African descent.
“Studies suggest that increased intermuscular fat with aging correlates with the onset of T2DM, raising the possibility that intermuscular fat could serve as an independent predictor of T2DM in males of African descent.60”
From Imaging of Sarcopenia in Type 2 Diabetes Mellitus (2024) · cites this paper as [60]
pQCT offers advantages over standard CT, including reduced radiation exposure, shorter scan times, and lower costs.
“pQCT offers advantages over standard CT, including reduced radiation exposure, shorter scan times, and lower costs.60”
From Imaging of Sarcopenia in Type 2 Diabetes Mellitus (2024) · cites this paper as [60]
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Cites
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Longitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446 · see citing works
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population
Cowie, C. C., Rust, K. F., Byrd-Holt, D. D., Eberhardt, M. S., Flegal, K. M., Engelgau, M. M., Saydah, S. H., Williams, D. E., Geiss, L. S., & Gregg, E. W. (2006) · Diabetes Care · doi:10.2337/dc06-0062 · Cited by 1,210 · see citing works
Goodpaster, B. H., Kelley, D. E., Thaete, F. L., He, J., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.104 · Cited by 956 · see citing works
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877 · see citing works
Lipid oxidation is reduced in obese human skeletal muscle
Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works
Goodpaster, B. H., Krishnaswami, S., Resnick, H., Kelley, D. E., Haggerty, C., Harris, T. B., Schwartz, A. V., Kritchevsky, S., & Newman, A. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.372 · Cited by 619 · see citing works
Haffner, S. M., Ralph, D., Saad, M. F., Rewers, M., Mykkänen, L., Selby, J., Howard, G., Savage, P. J., Hamman, R. F., Wegenknecht, L. E., et al. (1996) · Diabetes · doi:10.2337/diab.45.6.742 · Cited by 536 · see citing works
Incident Type 2 Diabetes Mellitus in African American and White Adults
Brancati, F. L., Kao, W. H. L., Folsom, A. R., Watson, R. L., & Szklo, M. (2000) · JAMA · doi:10.1001/jama.283.17.2253 · Cited by 502 · see citing works
Failure of adipocyte differentiation causes type II diabetes mellitus?
Danforth, E. (2000) · Nature Genetics · doi:10.1038/79111 · Cited by 487 · see citing works
Newman, A. B., Lee, J. S., Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Nevitt, M., & Harris, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.872 · Cited by 445 · see citing works
Kelley, D. E., & Goodpaster, B. H. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.933 · Cited by 406 · see citing works
Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue
Gallagher, D., Kuznia, P., Heshka, S., Albu, J., Heymsfield, S. B., Goodpaster, B., Visser, M., & Harris, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.903 · Cited by 354 · see citing works
Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women
Song, M.-Y., Ruts, E., Kim, J., Janumala, I., Heymsfield, S., & Gallagher, D. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.874 · Cited by 324 · see citing works
Intramuscular and Liver Triglycerides Are Increased in the Elderly
Cree‐Green, M., Newcomer, B. R., Katsanos, C. S., Sheffield‐Moore, M., Chinkes, D. L., Aarsland, A. A., Urban, R. J., & Wolfe, R. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031986 · Cited by 273 · see citing works
The origin of intermuscular adipose tissue and its pathophysiological implications
Vettor, R., Milan, G., Franzin, C., Sanna, M., Coppi, P. D., Rizzuto, R., & Federspil, G. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00229.2009 · Cited by 263 · see citing works
Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle
Brehm, A., Krssak, M., Schmid, A. I., Nowotny, P., Waldhäusl, W., & Roden, M. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1286 · Cited by 239 · see citing works
Miljkovic, I., & Zmuda, J. M. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328337d826 · Cited by 236 · see citing works
Self-citationZoico, E., Rossi, A. P., Francesco, V. D., Sepe, A., Olioso, D., Pizzini, F. B., Fantin, F., Bosello, O., Cominacini, L., Harris, T. B., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp155 · Cited by 216 · see citing works
Boettcher, M., Machann, J., Stefan, N., Thamer, C., Häring, H., Claussen, C. D., Fritsche, A., & Schick, F. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21754 · Cited by 214 · see citing works
Adipose tissue distribution is different in type 2 diabetes
Gallagher, D., Kelley, D. E., Yim, J., Spence, N., Albu, J., Boxt, L. M., Pi‐Sunyer, F. X., & Heshka, S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26955 · Cited by 201 · see citing works
Comparing Diabetes Prevalence Between African Americans and Whites of Similar Socioeconomic Status
Signorello, L. B., Schlundt, D. G., Cohen, S. S., Steinwandel, M. D., Buchowski, M. S., McLaughlin, J. K., Hargreaves, M. K., & Blot, W. J. (2007) · American Journal of Public Health · doi:10.2105/ajph.2006.094482 · Cited by 181 · see citing works
Albu, J., Kovera, A. J., Allen, L., Wainwright, M., Berk, E. S., Raja-Khan, N. T., Janumala, I., Burkey, B. F., Heshka, S., & Gallagher, D. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1210 · Cited by 181 · see citing works
Bunker, C. H., Patrick, A. L., Konety, B. R., Dhir, R., Brufsky, A., Vivas, C., Becich, M. J., Trump, D. L., & Kuller, L. H. (2002) · PubMed · Cited by 172 · see citing works
Self-citationHegarty, B. D., Cooney, G. J., Kraegen, E. W., & Furler, S. M. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1477 · Cited by 166 · see citing works
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 137 · see citing works
Miljkovic-Gacic, I., Gordon, C. L., Goodpaster, B. H., Bunker, C. H., Patrick, A. L., Kuller, L. H., Wheeler, V. W., Evans, R. W., & Zmuda, J. M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1590 · Cited by 122 · see citing works
Self-citationSimonsick, E. M., Maffeo, C. E., Rogers, S. K., Skinner, E. A., Davis, D., Guralnik, J. M., & Fried, L. P. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.5.m264 · Cited by 115 · see citing works
Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
Larson‐Meyer, D. E., Smith, S. R., Heilbronn, L. K., Kelley, D. E., Ravussin, E., Newcomer, B. R., & The Look AHEAD Adipose Research Group (2006) · Obesity · doi:10.1038/oby.2006.10 · Cited by 111 · see citing works
Miljkovic, I., Cauley, J. A., Wang, P. Y., Holton, K. F., Lee, C. G., Sheu, Y., Barrett-Connor, E. L., Hoffman, A. R., Lewis, C. E., ORWOLL, E. S., et al. (2013) · Obesity · doi:10.1002/oby.20346 · Cited by 107 · see citing works
Self-citationGreater adipose tissue infiltration in skeletal muscle among older men of African ancestry
Miljkovic, I., Cauley, J. A., Petit, M. A., Ensrud, K. E., Strotmeyer, E., Sheu, Y., Gordon, C. L., Goodpaster, B. H., Bunker, C. H., Patrick, A. L., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2541 · Cited by 79 · see citing works
Self-citationBeattie, K. A., MacIntyre, N. J., Ramadan, K., Inglis, D., & Maly, M. R. (2012) · Arthritis Care & Research · doi:10.1002/acr.20628 · Cited by 65 · see citing works
Origins of metabolic complications in obesity
Carobbio, S., Rodríguez‐Cuenca, S., & Vidal‐Puig, A. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834ad966 · Cited by 64 · see citing works
Kovalik, J., Slentz, D. H., Stevens, R. D., Kraus, W. E., Houmard, J. A., Nicoll, J. B., Lea-Currie, Y. R., Everingham, K., Kien, C. L., Buehrer, B. M., et al. (2011) · Diabetes · doi:10.2337/db10-0427 · Cited by 50 · see citing works
Sinanan, A., Buxton, P., & Lewis, M. P. (2006) · Biology of the Cell · doi:10.1042/bc20050050 · Cited by 42 · see citing works
Correlates of Trabecular and Cortical Volumetric BMD in Men of African Ancestry
Sheu, Y., Cauley, J. A., Bunker, C. H., Wheeler, V. W., Patrick, A. L., Gordon, C. L., Kammerer, C. M., & Zmuda, J. M. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090522 · Cited by 23 · see citing works
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Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626 · see citing works
Correa-de-Araujo, R., Addison, O., Miljkovic, I., Goodpaster, B. H., Bergman, B. C., Clark, R. V., Elena, J. W., Esser, K. A., Ferrucci, L., Harris-Love, M. O., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00963 · Cited by 468 · see citing works
Self-citationMyosteatosis and prognosis in cancer: Systematic review and meta-analysis
Aleixo, G. F. P., Shachar, S. S., Nyrop, K. A., Muss, H. B., Malpica, L., & Williams, G. R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102839 · Cited by 347 · see citing works
Correa‐de‐Araujo, R., Harris‐Love, M. O., Miljkovic, I., Fragala, M. S., Anthony, B., & Manini, T. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00087 · Cited by 267 · see citing works
Self-citationAdvances in muscle health and nutrition: A toolkit for healthcare professionals
Prado, C. M., Landi, F., Chew, S. T. H., Atherton, P. J., Molinger, J., Ruck, T., & Gonzalez, M. C. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.07.041 · Cited by 237 · see citing works
Ahn, H., Kim, D. W., Ko, Y., Ha, J., Shin, Y. B., Lee, J., Sung, Y. S., & Kim, K. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101398 · Cited by 221 · see citing works
Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism
Wang, L., Valencak, T. G., & Shan, T. (2024) · iScience · doi:10.1016/j.isci.2024.109221 · Cited by 149 · see citing works
Lee, C., & Kang, J. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12575 · Cited by 128 · see citing works
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Rezuş, E., Burlui, A., Cardoneanu, A., Rezuș, C., Codreanu, C., Parvu, M., Zota, G. R., & Tamba, B.-I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020592 · Cited by 117 · see citing works
Kim, H.-K., & Kim, C.-H. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1348 · Cited by 85 · see citing works
Nachit, M., De Rudder, M., Thissen, J., Schakman, O., Bouzin, C., Horsmans, Y., Vande Velde, G., & Leclercq, I. A. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12646 · Cited by 82 · see citing works
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Armani, A., Berry, A., Cirulli, F., & Caprio, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601125rrr · Cited by 73 · see citing works
Srpčič, M., Jordan, T., Popuri, K., & Sok, M. (2020) · Radiology and Oncology · doi:10.2478/raon-2020-0016 · Cited by 70 · see citing works
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Larsen, B. A., Bellettiere, J., Allison, M., McClelland, R. L., Miljkovic, I., Vella, C. A., Ouyang, P., Guzman, K. R. D., Criqui, M. H., & Unkart, J. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154321 · Cited by 62 · see citing works
Self-citationXie, L., Jiang, J., Fu, H., Zhang, W., Yang, L. Y., & Yang, M. J. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.11.025 · Cited by 53 · see citing works
Dubin, R. L., Heymsfield, S. B., Ravussin, E., & Greenway, F. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15913 · Cited by 47 · see citing works
Nachit, M., Lanthier, N., Rodriguez, J., Neyrinck, A. M., Cani, P. D., Bindels, L. B., Hiel, S., Pachikian, B. D., Tréfois, P., Thissen, J., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100323 · Cited by 46 · see citing works
Frank-Wilson, A. W., Chalhoub, D., Figueiredo, P., Jónsson, P. V., Siggeirsdóttir, K., Sigurdsson, S., Eiriksdottir, G., Guðnason, V., Launer, L., Harris, T. B., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx262 · Cited by 37 · see citing works
Morel, A., Ouamri, Y., Canouï‐Poitrine, F., Mulé, S., Champy, C. M., Ingels, A., Audard, V., Luciani, A., Grimbert, P., Matignon, M., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12853 · Cited by 37 · see citing works
Wei, M., Meng, D., Guo, H., He, S., Tian, Z., Wang, Z., Yang, G., & Wang, Z. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169952 · Cited by 37 · see citing works
Kiefer, L. S., Fabian, J., Lorbeer, R., Machann, J., Storz, C., Kraus, M. S., Wintermeyer, E., Schlett, C. L., Roemer, F. W., Nikolaou, K., et al. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180019 · Cited by 35 · see citing works
D'Angelo, G. F., de Mello, A. A. F., Schorr, F., Gebrim, E. M. M. S., Fernandes, M. D., Lima, G. F., Grad, G. F., Yanagimori, M., Lorenzi‐Filho, G., & Genta, P. R. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.02.011 · Cited by 33 · see citing works
Farsijani, S., Santanasto, A. J., Miljkovic, I., Boudreau, R. M., Goodpaster, B. H., Kritchevsky, S. B., & Newman, A. B. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa161 · Cited by 33 · see citing works
Self-citationBannangkoon, K., Hongsakul, K., Tubtawee, T., Ina, ์., & Chichareon, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-31184-9 · Cited by 31 · see citing works
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Self-citationBream, K. D. W., Breyre, A., Garcia, K. M., Calgua, E., Chuc, J. M., & Taylor, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200434 · Cited by 27 · see citing works
Jing, X., Tan, L., Fu, H., Yang, L. Y., & Yang, M. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.743698 · Cited by 26 · see citing works
Figueiredo, P., Marques, E. A., Gudnason, V. G., Lang, T., Sigurdsson, S. O., Jónsson, P. V., Aspelund, T., Siggeirsdóttir, K., Launer, L. J., Eiríksdóttir, G., et al. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111306 · Cited by 25 · see citing works
Kim, E. H., Kim, H., Lee, M. J., Bae, S., Kim, K. W., & Choe, J. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3513 · Cited by 25 · see citing works
Adeva‐Andany, M. M., Domínguez-Montero, A., Adeva-Contreras, L., Fernández‐Fernández, C., Carneiro-Freire, N., & González-Lucán, M. (2023) · Current Diabetes Reviews · doi:10.2174/1573399820666230816111624 · Cited by 24 · see citing works
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Self-citationMurea, M., Lenchik, L., Register, T. C., Russell, G. B., Xu, J., Smith, S. C., Bowden, D. W., Divers, J., & Freedman, B. I. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.03.004 · Cited by 22 · see citing works
Keramidaki, K., Tsagari, A., Hiona, M., & Risvas, G. (2019) · Journal of Frailty Sarcopenia and Falls · doi:10.22540/jfsf-04-091 · Cited by 22 · see citing works
Chan, D. L. H., Clarke, S. J., Engel, A. F., Diakos, C. I., Pavlakis, N., ROACH, P. J., Bailey, D. L., Bauer, J. D., & Findlay, M. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00915-4 · Cited by 19 · see citing works
Santanasto, A. J., Zmuda, J. M., Cvejkus, R., Gordon, C. L., Nair, S., Carr, J. J., Terry, J. G., Wheeler, V. W., & Miljkovic, I. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac124 · Cited by 19 · see citing works
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MacCormick, A. P., Streeter, A., Puckett, M., & Aroori, S. (2022) · Annals of The Royal College of Surgeons of England · doi:10.1308/rcsann.2021.0290 · Cited by 18 · see citing works
Guo, H., Cao, J., He, S., Wei, M., Meng, D., Yu, I., Wang, Z., Chang, X., Yang, G., & Wang, Z. (2024) · JMIR Aging · doi:10.2196/58175 · Cited by 17 · see citing works
Miljkovic, I., Kuipers, A. L., Cvejkus, R., Carr, J. J., Terry, J. G., Thyagarajan, B., Wheeler, V. W., Nair, S., & Zmuda, J. M. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0097 · Cited by 17 · see citing works
Self-citationInflammation‐associated intramyocellular lipid alterations in human pancreatic cancer cachexia
Deng, M., Cao, J., van der Kroft, G., van Dijk, D. P. J., Aberle, M. R., Grgic, A., Neumann, U. P., Wiltberger, G. J., Balluff, B., Schaap, F. G., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13474 · Cited by 15 · see citing works
Chasapi, A., Balampanis, K., Kourea, E. P., Kalfarentzos, F., Lambadiari, V., Lambrou, G. Ι., Melachrinou, M., & Sotiropoulou‐Bonikou, G. (2018) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances
Zhang, Y., Jo, Y., Wei, S., Kim, Y., Park, W., Jeong, S.-J., Xue, Y., Lee, S. H., Kim, B., Oh, C., et al. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00676-2 · Cited by 14 · see citing works
Pishgar, F., Shabani, M., Quinaglia, T., Bluemke, D. A., Budoff, M. J., Barr, R. G., Allison, M., Bertoni, A. G., Post, W. S., Lima, J. A. C., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003700 · Cited by 13 · see citing works
Comportamentos sedentários e sua relação com os componentes da síndrome metabólica em quilombolas
de Almeida, C. B., Nunes, L. A., Mussi, R. F. D. F., & Casotti, C. A. (2022) · Research Society and Development · doi:10.33448/rsd-v11i1.25001 · Cited by 13 · see citing works
Rosano, C., Newman, A. B., Santanasto, A. J., Zhu, X., Goodpaster, B. H., & Miljkovic, I. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18419 · Cited by 13 · see citing works
Self-citationTucker, B. M., Hsu, F., Register, T. C., Xu, J., Smith, S. C., Murea, M., Bowden, D. W., Freedman, B. I., & Lenchik, L. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.5 · Cited by 13 · see citing works
Skeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women
Acevedo-Fontánez, A. I., Cvejkus, R., Zmuda, J. M., Kuipers, A. L., Barinas‐Mitchell, E., Sekikawa, A. M., Wheeler, V. W., Rosano, C., & Miljkovic, I. (2023) · Obesity · doi:10.1002/oby.23816 · Cited by 12 · see citing works
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Santanasto, A. J., Miljkovic, I., Cvejkus, R., Gordon, C. L., Bunker, C. H., Patrick, A. L., Wheeler, V. W., & Zmuda, J. M. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly067 · Cited by 12 · see citing works
Self-citationImaging of Sarcopenia in Type 2 Diabetes Mellitus
Wang, D., Zhang, G., Yu, Y., & Zhang, Z. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s443572 · Cited by 11 · see citing works
Pelvic muscle size and myosteatosis: Relationship with age, gender, and obesity
Pacicco, T., Ratner, S., Xi, Y., Yokoo, T., Fetzer, D. T., Öz, O. K., Rubin, C. D., & Chhabra, A. B. (2019) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.4103/ijri.ijri_414_18 · Cited by 11 · see citing works
Rosano, C., Karikari, T. K., Cvejkus, R., Bellaver, B., Ferreira, P. C. L., Zmuda, J. M., Wheeler, V. W., Pascoal, T. A., & Miljkovic, I. (2024) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12460 · Cited by 10 · see citing works
Self-citationJung, M., Rieder, H., Reisert, M., Rospleszcz, S., Nattenmüller, J., Peters, A., Schlett, C. L., Bamberg, F., & Weiß, J. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13527 · Cited by 10 · see citing works
Santanasto, A. J., Miljkovic, I., Cvejkus, R., Wheeler, V. W., & Zmuda, J. M. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz233 · Cited by 10 · see citing works
Self-citationTilves, C., Zmuda, J. M., Kuipers, A. L., Carr, J. J., Terry, J. G., Wheeler, V. W., Peddada, S., Nair, S., & Miljkovic, I. (2019) · Obesity · doi:10.1002/oby.22695 · Cited by 10 · see citing works
Self-citationKuipers, A. L., Zmuda, J. M., Carr, J. J., Terry, J. G., Nair, S., Cvejkus, R., Bunker, C. H., Patrick, A. L., Wassel, C. L., & Miljkovic, I. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.030 · Cited by 10 · see citing works
Self-citationShen, Z.-L., Chen, W., Liu, Z., Yu, D., Chen, W., Zang, W., Zhang, P., Yan, X., & Yu, Z. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112244 · Cited by 9 · see citing works
Petrič, M., Jordan, T., Karteek, P., Ličen, S., Trotovšek, B., & Tomažič, A. (2023) · Radiology and Oncology · doi:10.2478/raon-2023-0025 · Cited by 7 · see citing works
Sarcopenia in type 2 diabetes mellitus: an imaging review
He, L., Luo, G., Jiang, H., Zhang, L., Li, Y., Gu, W., Zeng, Q., Zhu, J., Liu, J., Lei, H., et al. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1637499 · Cited by 6 · see citing works
Acevedo-Fontánez, A. I., Rosano, C., Yaffe, K. S., Carr, J. J., Terry, J. G., Nair, S., Barinas‐Mitchell, E., Cvejkus, R., & Miljkovic, I. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70846 · Cited by 6 · see citing works
Self-citationHwang, J. J., Zmuda, J. M., Kuipers, A. L., Bunker, C. H., Santanasto, A. J., Wheeler, V. W., & Miljkovic, I. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2018.40 · Cited by 6 · see citing works
Self-citationYang, M., Zhou, F., Wang, C., sun, T., zhao, W., Liu, L., Meng, Y., & tian, L. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00473.2025 · Cited by 5 · see citing works
Park, S., Widmer, A., Swartz, A. Z., Koethe, J. R., & Silver, H. J. (2025) · Nutrition and Diabetes · doi:10.1038/s41387-025-00381-y · Cited by 5 · see citing works
Myosteatosis and Type 2 Diabetes Mellitus
de Oliveira, L. B., Silva, V. D. O. E., Jucá, Í. C. L., Torres, J. V. G. D. S., Torres, M. R. D. S., Moura, F., & Bandeira, F. A. F. (2025) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2025.17 · Cited by 4 · see citing works
Vella, C. A., Miljkovic, I., Price, C. A., & Allison, M. (2022) · Journal of Physical Activity and Health · doi:10.1123/jpah.2021-0409 · Cited by 4 · see citing works
Self-citationTilves, C., Zmuda, J. M., Kuipers, A. L., Nair, S., Carr, J., Terry, J., Peddada, S., Wheeler, V. W., & Miljkovic, I. (2021) · Obesity Science & Practice · doi:10.1002/osp4.529 · Cited by 2 · see citing works
Self-citationLyadov, V. K., Dikova, T. S., Zatsepina, A., & Ivashchenko, D. V. (2022) · Journal of Modern Oncology · doi:10.26442/18151434.2022.2.201710 · Cited by 3 · see citing works
Jung, H. N., Cho, Y. K., Kim, H. S., Kim, E. H., Lee, M. J., Park, J., Lee, W. J., Kim, H.-K., & Jung, C. H. (2022) · Clinical Imaging · doi:10.1016/j.clinimag.2022.10.009 · Cited by 3 · see citing works
Organ fat, not general obesity, defines risk for diabetes, inflammation, and comorbiditiesPreprint
Ennis, M., Yamazaki, H., Tauchi, S., Nakamura, F., Dohke, M., Hanawa, N., Wagner, R., & Heni, M. (2025) · medRxiv · doi:10.64898/2025.12.22.25342850 · Cited by 3 · see citing works
Acute Sarcopenia: Definition and Actual Issues
Welch, C. (2021) · Practical issues in geriatrics · doi:10.1007/978-3-030-80038-3_10 · Cited by 2 · see citing works
Farsijani, S., Marron, M. M., Miljkovic, I., Baugh, M. E., Kritchevsky, S. B., & Newman, A. B. (2021) · Metabolites · doi:10.3390/metabo11040224 · Cited by 2 · see citing works
Self-citationAge-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men
Roe, L. S., Cvejkus, R., Wheeler, V. W., Gordon, C. L., Kenkre, T. S., Zmuda, J. M., & Miljkovic, I. (2025) · GeroScience · doi:10.1007/s11357-025-02023-8 · Cited by 1 · see citing works
Self-citationİpek, O. M., Dinçer, E., Aydıner, Ö., Sevinç, A. H., HANCI, B., & Aras, E. (2026) · Medicina · doi:10.3390/medicina62061155 · Cited by 1 · see citing works
Muscle in fat trouble: The rise of IMAT in metabolic and musculoskeletal disease
Weik, V., Birkenfeld, A., Peter, A., Weigert, C., & Dreher, S. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102424
Bannangkoon, K., Hongsakul, K., Tubtawee, T., & Ina, ์. (2024) · Cancers · doi:10.3390/cancers16203503 · Cited by 1 · see citing works
Sato, S., Nakayama, S., & Shinohara, H. (2025) · Surgery Today · doi:10.1007/s00595-025-03049-3 · Cited by 1 · see citing works
Hou, B.-W., Zheng, R., Li, Y., Zhang, J., Chu, Y., Gharaibeh, N. M., & Li, W. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i9.110183 · Cited by 1 · see citing works
DE-OLIVEIRA, G. J. M., Hacke, L., Rodrigues, E. V., Gomes, A. R. S., Gallo, L. H., Rabito, E. I., Silva, C. T. D. S., Hauser, A. B., Sokulski, J. S., & Schieferdecker, M. E. M. (2022) · Geriatrics Gerontology and Aging · doi:10.53886/gga.e0220028 · Cited by 1 · see citing works
Zhang, H., Du, H., Zhao, Y., Li, Z., Liu, K., Wang, X., Manafe, H., & Sun, K. (2024) · Research Square · doi:10.21203/rs.3.rs-4738380/v1 · Cited by 1 · see citing works
Giuliani, H. K. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/f2dv-nf45
Petrič, M., Jordan, T., Popuri, K., Ličen, S., Trotovšek, B., & Tomažič, A. (2022) · Journal of Liver Transplantation · doi:10.1016/j.liver.2022.100106
RetractedFan, J., Zuo, L., Hou, M., Wang, B., An, Y., Hao, B., & Yu, D. (2023) · Academic Radiology · doi:10.1016/j.acra.2023.01.033
Assessment of myosteatosis and functionality in pretreatment gynecological cancer patients
da Silva, R. C., Chaves, G. V., Bergmann, A. K., & Frajácomo, F. T. T. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08558-4
Hou, S., Li, M., Cao, J., Wang, Y., Yang, M., Tian, L., Ni, Y.-H., Yang, B.-X., Hao, L.-R., Hao, J., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1687179
Yang, F., Zhang, S., Liu, S., Zhang, J., Yang, J., Zhayier, D., Ruihan, G., Pu, F., Xu, M., Zhu, B., et al. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-14025-8
Gluteus Maximus Shape Reveals Sex‐Specific Associations Between Morphology and Metabolic Dysfunction
Thanaj, M., Whitcher, B. J., Raza, H., Bell-Bradford, C., Niglas, M., Bell, J. D., Amiras, D., & Thomas, E. L. (2026) · JCSM Communications · doi:10.1002/rco2.70046
Myosteatosis: an emerging biomarker of aging
Roe, L. S., Zmuda, J. M., & Miljkovic, I. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1868010
Self-citationWu, W., Wang, R., Wang, D., Ren, Q., Wang, L., Duan, F., Yang, G., Yu, R., Wang, Y., Zhang, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.77648
- Authors
- Miljkovic, I., Kuipers, A. L., Cvejkus, R., Bunker, C. H., Patrick, A. L., Gordon, C. L., & Zmuda, J. M.
- Affiliations
- University of Pittsburgh (US)
- Tobago Health Studies Office Scarborough Tobago, Trinidad and Tobago West Indies
- McMaster University (CA)
- Corresponding author
- Miljkovic, Iva
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-12-23
- Volume
- 24
- Issue
- 2
- Pages
- 476-482
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC4731257
- OpenAlex
- W2198241880
- Cited by
- 89
- References
- 40
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 4
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K01HL125658)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK083029, R01DK097084)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049747)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myosteatosis, skeletal muscle fat infiltration, intermuscular fat, intramuscular fat, skeletal muscle density, aging, type 2 diabetes, new-onset diabetes, Afro-Caribbean men, peripheral quantitative computed tomography, weight change
- MeSH terms
- Adipose Tissue, Adult, Aged, Aging, Body Weight, Diabetes Mellitus, Type 2, Humans, Leg, Longitudinal Studies, Male, Middle Aged, Muscular Diseases, Prospective Studies, Muscle, Skeletal, Black People, White People
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