3D printed anatomical nerve regeneration pathways
Open accessAbstract
A 3D printing methodology for the design, optimization, and fabrication of a custom nerve repair technology for the regeneration of complex peripheral nerve injuries containing bifurcating sensory and motor nerve pathways is introduced. The custom scaffolds are deterministically fabricated via a microextrusion printing principle using 3D models, which are reverse engineered from patient anatomies by 3D scanning. The bifurcating pathways are augmented with 3D printed biomimetic physical cues (microgrooves) and path‐specific biochemical cues (spatially controlled multicomponent gradients). In vitro studies reveal that 3D printed physical and biochemical cues provide axonal guidance and chemotractant/chemokinetic functionality. In vivo studies examining the regeneration of bifurcated injuries across a 10 mm complex nerve gap in rats showed that the 3D printed scaffolds achieved successful regeneration of complex nerve injuries, resulting in enhanced functional return of the regenerated nerve. This approach suggests the potential of 3D printing toward advancing tissue regeneration in terms of: (1) the customization of scaffold geometries to match inherent tissue anatomies; (2) the integration of biomanufacturing approaches with computational modeling for design, analysis, and optimization; and (3) the enhancement of device properties with spatially controlled physical and biochemical functionalities, all enabled by the same 3D printing process.
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Nerves can be scanned and reconstructed in three dimensions in order to later 3D print cuffs perfectly adapted to their anatomy.
“Nerves can be scanned in reconstructed in three dimensions in order to later 3D print cuffs perfectly adapted to their anatomy (Johnson et al., 2015), potentially minimizing mechanical trauma and FBR at the nerve-implant interface.”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Johnson et al., 2015
Section 3 describes scanning a nerve, reconstructing its 3D geometry, and printing a geometrically matching nerve-regeneration pathway. It does not describe printing nerve cuffs; the device in this paper is a nerve guide for repairing a gap, so the claim changes the type of device. (LLM, conf=0.86)
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Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
Carnicer-Lombarte, A., Chen, S.-T., Malliaras, G. G., & Barone, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.622524 · Cited by 454 · see citing works
“PDMS is now the material of choice for most nerve cuffs in clinical practice, including those for vagus nerve (BenMenachem et al., 2015) and sacral nerve stimulation (Brindley et al., 1982; Johnston et al., 2005).”
Background3D Bioprinted in vitro metastatic models via reconstruction of tumor microenvironments
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Self-citationA shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles
Zheng, H., Zhang, Z., Jiang, S., Yan, B., Shi, X., Xie, Y., Huang, X., Yu, Z., Liu, H., Weng, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10418-3 · Cited by 58 · see citing works
- Authors
- Johnson, B. N., Lancaster, K. Z., Zhen, G., He, J., Gupta, M. K., Kong, Y. L., Engel, E. A., Krick, K. D., Ju, A., Meng, F., Enquist, L. W., Jia, X., & McAlpine, M. C.
- Affiliations
- Princeton University (US)
- Johns Hopkins University (US)
- University of Maryland, Baltimore (US)
- University of Minnesota (US)
- Corresponding author
- Jia, Xiaofeng
- McAlpine, Michael C.
- ORCID
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2015-09-18
- Volume
- 25
- Issue
- 39
- Pages
- 6205-6217
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- PMC
- PMC4765385
- OpenAlex
- W1768356346
- Cited by
- 293
- References
- 74
- Citations by year
- 2026: 6 · 2025: 23 · 2024: 25 · 2023: 24 · 2022: 21 · 2021: 35 · 2020: 38 · 2019: 36 · 2018: 38 · 2017: 34 · 2016: 11 · 2015: 1 · 2014: 1
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Functional Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (NSF) Materials Research Science and Engineering Centers (MRSEC) Program (DMR-0819860)
- National Institutes of Health (R01NS033506, R01NS060699, R01HL118084)
- Maryland Stem Cell Research Fund (2013-MSCRFE-146-00)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- peripheral nerve regeneration, microgrooves, axon guidance, chemotaxis, nerve repair
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