The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Light‐Up Probe for Targeted and Activatable Photodynamic Therapy with Real‐Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses
Open accessAbstract
Integrated systems that offer traceable cancer therapy are highly desirable for personalized medicine. Herein, a probe is reported that is composed of a red‐emissive photosensitizer (PS) with aggregation‐induced emission characteristics and a built‐in apoptosis sensor with activatable green emission for targeted cancer cell ablation and real‐time monitoring of PS activation and therapeutic response. The probe is nonemissive in aqueous media and can be selectively uptaken by αvβ3 integrin overexpressed cancer cells. Cleavage of the probe by intracellular glutathione leads to release of the apoptosis sensor and red fluorescence turn‐on to report the PS activation. Upon light irradiation, the PS can generate reactive oxygen species to induce cell apoptosis and activate caspase‐3/‐7, which will cleave the apoptosis sensor to yield intense green fluorescence. Both the red and green emission can be obtained through a single wavelength excitation, which makes the probe very convenient for therapeutic protocol development.
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Cites
Role of reactive oxygen species (ROS) in apoptosis induction
Simon, H.-U., Haj-Yehia, A., & Levi-Schaffer, F. (2000) · Apoptosis · doi:10.1023/a:1009616228304 · Cited by 2,774
BODIPY dyes in photodynamic therapy
Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35216h · Cited by 2,104
Definition of type I and type II photosensitized oxidation
Foote, C. S. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02071.x · Cited by 1,248
Xue, X., Zhao, Y., Dai, L., Zhang, X., Hao, X., Zhang, C., Huo, S., Liu, J., Liu, C., Kumar, A., et al. (2014) · Advanced Materials · doi:10.1002/adma.201302365 · Cited by 206
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Cited by
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Liu, H.-W., Chen, L., Xu, C., Li, Z., Zhang, H., Zhang, X.-B., & Tan, W. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00862g · Cited by 948
Activatable Photosensitizers: Agents for Selective Photodynamic Therapy
Li, X., Kolemen, S., Yoon, J., & Akkaya, E. U. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201604053 · Cited by 544
Wu, W., Mao, D., Hu, F., Xu, S., Chen, C., Zhang, C., Cheng, X., Yuan, Y., Ding, D., Kong, D., et al. (2017) · Advanced Materials · doi:10.1002/adma.201700548 · Cited by 462
Self-citationProgress and Trends in AIE-Based Bioprobes: A Brief Overview
Mei, J., Huang, Y., & Tian, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14343 · Cited by 384
The fast-growing field of photo-driven theranostics based on aggregation-induced emission
Zhang, Z., Kang, M., Tan, H., Song, N., Li, M., Xiao, P., Yan, D., Zhang, L., Wang, D., & Tang, B. Z. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01138c · Cited by 374
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Metadata
- Authors
- Yuan, Y., Zhang, C., Kwok, R. T. K., Xu, S., Zhang, R., Wu, J., Tang, B. Z., & Liu, B.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2015-10-08
- Volume
- 25
- Issue
- 42
- Pages
- 6586-6595
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2172816737
- Cited by
- 167
- References
- 4
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yuan, Y., Zhang, C., Kwok, R. T. K., Xu, S., Zhang, R., Wu, J., Tang, B. Z., & Liu, B. (2015). Light‐Up Probe for Targeted and Activatable Photodynamic Therapy with Real‐Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses. Advanced Functional Materials. https://doi.org/10.1002/adfm.201502728
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