The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy
Abstract
Development of single near‐infrared (NIR) laser triggered phototheranostics for multimodal imaging guided combination therapy is highly desirable but is still a big challenge. Herein, a novel small‐molecule dye DPP‐BT is designed and synthesized, which shows strong absorption in the first NIR window (NIR‐I) and fluorescence emission in the second NIR region (NIR‐II). Such a dye not only acts as a dual‐modal contrast agent for NIR‐II fluorescence and photoacoustic (PA) imaging, but also serves as a combined therapeutic agent for photothermal therapy (PTT) and photodynamic therapy (PDT). The single NIR laser triggered all‐in‐one phototheranostic nanoparticles are constructed by encapsulating the dye DPP‐BT, chemotherapy drug DOX, and natural phase‐change materials with a folic acid functionalized amphiphile. Notably, under NIR laser irradiation, DOX can effectively release from such nanoparticles via NIR‐induced hyperthermia of DPP‐BT. By intravenous injection of such nanoparticles into Hela tumor‐bearing mice, the tumor size and location can be accurately observed via NIR‐II fluorescence/PA dual‐modal imaging. From in vitro and in vivo therapy results, such nanoparticles simultaneously present remarkable antitumor efficacy by PTT/PDT/chemo combination therapy, which is triggered by a single NIR laser. Overall, this work provides an innovative strategy to design and construct all‐in‐one nanoplatforms for clinical phototheranostics.
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Cites
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Cited by
Perfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394
NIR-II light in clinical oncology: opportunities and challenges
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NIR-II bioimaging of small organic molecule
Su, Y., Yu, B., Wang, S., Cong, H., & Shen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120717 · Cited by 251
Advanced multifunctional composite phase change materials based on photo-responsive materials
Tang, Z., Gao, H., Chen, X., Zhang, Y., Li, A., & Wang, G. (2021) · Nano Energy · doi:10.1016/j.nanoen.2020.105454 · Cited by 240
Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm
Li, Y., Liu, Y., Li, Q., Zeng, X., Tian, T., Zhou, W., Cui, Y., Wang, X., Cheng, X., Ding, Q., et al. (2020) · Chemical Science · doi:10.1039/c9sc06567a · Cited by 177
Metadata
- Authors
- Wang, Q., Dai, Y., Xu, J., Cai, J., Niu, X., Zhang, L., Chen, R., Shen, Q., Huang, W., & Fan, Q.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2019-05-23
- Volume
- 29
- Issue
- 31
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2946538408
- Cited by
- 369
- References
- 70
- FWCI
- 19.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Q., Dai, Y., Xu, J., Cai, J., Niu, X., Zhang, L., Chen, R., Shen, Q., Huang, W., & Fan, Q. (2019). All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy. Advanced Functional Materials. https://doi.org/10.1002/adfm.201901480
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