Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo
Abstract
Mesoporous silica nanoparticles (MSNs) functionalized with redox‐sensitive or pH‐sensitive nanovalves for doxorubicin delivery and release by using recombinant human H chain ferritin (HFn) as a cap have been designed and fabricated. In both cases, transmission electron microscope observatory, dynamic light scattering change, Fourier transform infrared spectra examination, thermogravimetric analysis show that HFn can be chemically bonded to MSNs while retaining its ability to target transferrin receptor 1 (TfR1). Cargo loading and release studies demonstrate that HFn is an efficient capping agent, blocking the pores of MSN preventing cargo molecules from diffusing out, and is responsive to redox stimuli or pH changes. More importantly, HFn can not only cap the MSNs, but also enables targeted cargo delivery to malignant cells by binding to the TfR1 that has been overexpressed in various tumors, which can be reflected by the cell viability and fluorescence microscope analysis results comparing with cyclodextrin as the capping agent and TfR1 blocking assay. The in vivo study reveals the excellent efficacy of doxorubicin loaded and HFn capped MSNs on suppression of tumor growth. The new developed drug delivery system features mutually benefit and mutually support, providing strategy for achieving specific‐site therapeutics delivery systems.
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Mesoporous silica nanoparticles can have their surface altered for active targeting by adding peptides, folate, mannose, and transferrin.
“Mesoporous silica nanoparticles can have their surface altered for active targeting by adding peptides, folate, mannose, and transferrin.75–77”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [76]
Cites
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667 · see citing works
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,932 · see citing works
Self-citationMesoporous silica nanoparticles in biomedical applications
Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., & Zink, J. I. (2012) · Chemical Society Reviews · doi:10.1039/c1cs15246g · Cited by 1,911 · see citing works
Self-citationSmart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works
pH-Sensitive nano-systems for drug delivery in cancer therapy
Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121 · see citing works
Lu, J., Liong, M., Li, Z., Zink, J. I., & Tamanoi, F. (2010) · Small · doi:10.1002/smll.201000538 · Cited by 1,075 · see citing works
Self-citationMesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility
Tarn, D., Ashley, C. E., Xue, M., Carnes, E. C., Zink, J. I., & Brinker, C. J. (2013) · Accounts of Chemical Research · doi:10.1021/ar3000986 · Cited by 950 · see citing works
Self-citationMultifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Argyo, C., Weiß, V., Bräuchle, C., & Bein, T. (2013) · Chemistry of Materials · doi:10.1021/cm402592t · Cited by 903 · see citing works
Ferritins: A family of molecules for iron storage, antioxidation and more
Arosio, P., Ingrassia, R., & Cavadini, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.004 · Cited by 886 · see citing works
Mesoporous silica nanoparticles in target drug delivery system: A review
Bharti, C., Gulati, N., Nagaich, U., & Pal, A. (2015) · International Journal of Pharmaceutical Investigation · doi:10.4103/2230-973x.160844 · Cited by 818 · see citing works
Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts
Lawson, D. M., Artymiuk, P. J., Yewdall, S. J., Smith, J. M. A., Livingstone, J. C., Treffry, A., Luzzago, A., Levi, S., Arosio, P., Cesareni, G., et al. (1991) · Nature · doi:10.1038/349541a0 · Cited by 777 · see citing works
Magnetoferritin nanoparticles for targeting and visualizing tumour tissues
Fan, K., Cao, C., Pan, Y., Lü, D., Yang, D., Feng, J., Song, L., Liang, M., & Yan, X. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.90 · Cited by 756 · see citing works
Self-citationMeng, H., Xue, M., Xia, T., Zhao, Y., Tamanoi, F., Stoddart, J. F., Zink, J. I., & Nel, A. E. (2010) · Journal of the American Chemical Society · doi:10.1021/ja104501a · Cited by 596 · see citing works
Self-citationEnzyme-Responsive Snap-Top Covered Silica Nanocontainers
Patel, K., Angelos, S., Dichtel, W. R., Coşkun, A., Yang, Y., Zink, J. I., & Stoddart, J. F. (2008) · Journal of the American Chemical Society · doi:10.1021/ja0772086 · Cited by 573 · see citing works
Self-citationBinding and uptake of H-ferritin are mediated by human transferrin receptor-1
Li, L., Fang, C. J., Ryan, J. C., Niemi, E. C., Lebrón, J. A., Björkman, P. J., Arase, H., Torti, F. M., Torti, S. V., Nakamura, M. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913192107 · Cited by 558 · see citing works
Liang, M., Fan, K., Zhou, M., Duan, D., Zheng, J., Yang, D., Feng, J., & Yan, X. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407808111 · Cited by 507 · see citing works
Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems
Wen, J., Yang, K., Liu, F., Li, H., Xu, Y., & Sun, S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00219j · Cited by 477 · see citing works
Synthesis of inorganic nanophase materials in supramolecular protein cages
Meldrum, F. C., Wade, V. J., Nimmo, D. L., Heywood, B. R., & Mann, S. (1991) · Nature · doi:10.1038/349684a0 · Cited by 465 · see citing works
Chemical Protein Modification through Cysteine
Gunnoo, S. B., & Madder, A. (2016) · ChemBioChem · doi:10.1002/cbic.201500667 · Cited by 409 · see citing works
Ferritin: A Versatile Building Block for Bionanotechnology
Jutz, G., van Rijn, P., de Miranda, B. S., & Böker, A. (2015) · Chemical Reviews · doi:10.1021/cr400011b · Cited by 407 · see citing works
Yu, M., Jambhrunkar, S., Thorn, P., Chen, J., Gu, W., & Yu, C. (2012) · Nanoscale · doi:10.1039/c2nr32145a · Cited by 336 · see citing works
Ferritin nanocages: A biological platform for drug delivery, imaging and theranostics in cancer
Truffi, M., Fiandra, L., Sorrentino, L., Monieri, M., Corsi, F., & Mazzucchelli, S. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.002 · Cited by 277 · see citing works
Zhen, Z., Tang, W., Guo, C., Chen, H., Lin, X., Liu, G., Fei, B., Chen, X. S., Xu, B., & Xie, J. (2013) · ACS Nano · doi:10.1021/nn402199g · Cited by 273 · see citing works
Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery
Baeza, A., Colilla, M., & Vallet‐Regí, M. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.953051 · Cited by 270 · see citing works
Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery
Chen, W., Glackin, C. A., Horwitz, M. A., & Zink, J. I. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00116 · Cited by 265 · see citing works
Self-citationThe ferritin superfamily: Supramolecular templates for materials synthesis
Uchida, M., Kang, S., Reichhardt, C., Harlen, K. M., & Douglas, T. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.12.005 · Cited by 264 · see citing works
Chimeric Ferritin Nanocages for Multiple Function Loading and Multimodal Imaging
Lin, X., Xie, J., Niu, G., Zhang, F., Gao, H., Yang, M., Quan, Q., Aronova, M. A., Zhang, G., Lee, S., et al. (2011) · Nano Letters · doi:10.1021/nl104141g · Cited by 263 · see citing works
Cheng, Y.-J., Luo, G., Zhu, J., Xu, X., Zeng, X., Cheng, D., Li, Y., Wu, Y., Zhang, X., Zhuo, R., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b00752 · Cited by 253 · see citing works
Chemical methods for mapping cysteine oxidation
Alcock, L. J., Perkins, M. V., & Chalker, J. M. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00607a · Cited by 252 · see citing works
Zhao, Q., Liu, J., Zhu, W., Sun, C., Di, D., Zhang, Y., Wang, P., Wang, Z., & Wang, S. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.05.010 · Cited by 231 · see citing works
Li, H., Tan, L., Jia, P., Li, Q., Sun, Y., Zhang, J., Ning, Y., Yu, J., & Yang, Y. (2014) · Chemical Science · doi:10.1039/c4sc00198b · Cited by 227 · see citing works
Lu, J., Li, Z., Zink, J. I., & Tamanoi, F. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.06.002 · Cited by 224 · see citing works
Self-citationLuo, Z. Y., Ding, X., Hu, Y., Wu, S., Xiang, Y., Zeng, Y., Zhang, B., Yan, H., Zhang, H., Zhu, L., et al. (2013) · ACS Nano · doi:10.1021/nn404676w · Cited by 221 · see citing works
Ferris, D. P., Lu, J., Gothard, C. M., Yanes, R. E., Thomas, C. R., Olsen, J., Stoddart, J. F., Tamanoi, F., & Zink, J. I. (2011) · Small · doi:10.1002/smll.201002300 · Cited by 219 · see citing works
Self-citationCryo-EM structure of the human ferritin–transferrin receptor 1 complex
Montemiglio, L. C., Testi, C., Ceci, P., Falvo, E., Pitea, M., Savino, C., Arcovito, A., Peruzzi, G., Baiocco, P., Mancia, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09098-w · Cited by 179 · see citing works
Zhang, B., Luo, Z. Y., Liu, J., Ding, X., Li, J., & Cai, K. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.037 · Cited by 152 · see citing works
Niedermayer, S., Weiß, V., Herrmann, A., Schmidt, A., Datz, S., Müller, K., Wagner, E., Bein, T., & Bräuchle, C. (2015) · Nanoscale · doi:10.1039/c4nr07245f · Cited by 151 · see citing works
Li, Z., Hu, J., Xu, Q., Chen, S., Jia, H.-Z., Sun, Y., Zhuo, R., & Zhang, X. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01533a · Cited by 149 · see citing works
Activation of Snap-Top Capped Mesoporous Silica Nanocontainers Using Two Near-Infrared Photons
Guardado‐Alvarez, T. M., Devi, L. S., Russell, M. M., Schwartz, B. J., & Zink, J. I. (2013) · Journal of the American Chemical Society · doi:10.1021/ja407331n · Cited by 145 · see citing works
Self-citationTransferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery
Chen, X., Sun, H. Q., Hu, J., Han, X., Liu, H., & Hu, Y. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.01.010 · Cited by 136 · see citing works
Renoux, B., Raes, F., Legigan, T., Péraudeau, E., Eddhif, B., Poinot, P., Tranoy‐Opalinski, I., Alsarraf, J., Koniev, O., Kolodych, S., et al. (2017) · Chemical Science · doi:10.1039/c7sc00472a · Cited by 134 · see citing works
Protein nanocages that penetrate airway mucus and tumor tissue
Huang, X., Chisholm, J., Zhuang, J., Xiao, Y., Duncan, G., Chen, X., Suk, J. S., & Hanes, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705407114 · Cited by 131 · see citing works
Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release
Hu, J., Dong, X., & Zhang, X. (2016) · Small · doi:10.1002/smll.201600325 · Cited by 130 · see citing works
Spatial, Temporal, and Dose Control of Drug Delivery using Noninvasive Magnetic Stimulation
Chen, W., Cheng, C., & Zink, J. I. (2019) · ACS Nano · doi:10.1021/acsnano.8b06655 · Cited by 125 · see citing works
Self-citationSaint‐Cricq, P., Deshayes, S., Zink, J. I., & Kasko, A. M. (2015) · Nanoscale · doi:10.1039/c5nr03777h · Cited by 124 · see citing works
Self-citationLi, Z., Clemens, D. L., Lee, B., Dillon, B. J., Horwitz, M. A., & Zink, J. I. (2015) · ACS Nano · doi:10.1021/acsnano.5b04306 · Cited by 123 · see citing works
Self-citationHainfeld, J. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11064 · Cited by 122 · see citing works
Falvo, E., Tremante, E., Arcovito, A., Papi, M., Elad, N., Boffi, A., Morea, V., Conti, G., Toffoli, G., Fracasso, G., et al. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01446 · Cited by 118 · see citing works
Cheng, C., Deng, T., Lin, F.-C., Cai, Y., & Zink, J. I. (2019) · Theranostics · doi:10.7150/thno.34576 · Cited by 118 · see citing works
Self-citationAmbrogio, M. W., Pecorelli, T. A., Patel, K., Khashab, N. M., Trabolsi, A., Khatib, H. A., Botros, Y. Y., Zink, J. I., & Stoddart, J. F. (2010) · Organic Letters · doi:10.1021/ol101286a · Cited by 117 · see citing works
Self-citationLi, Y., Zhi, X., Lin, J., You, X., & Yuan, J. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.12.067 · Cited by 116 · see citing works
Lei, Y., Hamada, Y., Li, J., Cong, L., Wang, N., Li, Y., Zheng, W., & Jiang, X. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.023 · Cited by 115 · see citing works
Toussaint, L., Bertrand, L., Hue, L., Crichton, R. R., & Declercq, J.-P. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.010 · Cited by 113 · see citing works
Dong, X., Jia, H.-Z., Ma, N., Zhuo, R., & Zhang, X. (2015) · Nanoscale · doi:10.1039/c5nr02247a · Cited by 103 · see citing works
Cheng, C., Chen, W., Zhang, L., Wu, H. H., & Zink, J. I. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b07591 · Cited by 101 · see citing works
Self-citationUltrasound responsive mesoporous silica nanoparticles for biomedical applications
Manzano, M., & Vallet‐Regí, M. (2019) · Chemical Communications · doi:10.1039/c8cc09389j · Cited by 100 · see citing works
Cao, C., Wang, X., Cai, Y., Sun, L., Tian, L., Wu, H., He, X., Lei, H. C., Liu, W., Chen, G., et al. (2014) · Advanced Materials · doi:10.1002/adma.201304544 · Cited by 97 · see citing works
Self-citationShahin, S. A., Wang, R., Simargi, S. I., Contreras, A., Parra, L. E., Qu, L., Wen, W. X., Dellinger, T. H., Unternaehrer, J., Tamanoi, F., et al. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.04.008 · Cited by 97 · see citing works
Self-citationMartínez‐Carmona, M., Baeza, A., Rodríguez-Milla, M. Á., Garcı́a-Castro, J., & Vallet‐Regí, M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00304k · Cited by 87 · see citing works
Lee, B., Li, Z., Clemens, D. L., Dillon, B. J., Hwang, A., Zink, J. I., & Horwitz, M. A. (2016) · Small · doi:10.1002/smll.201600892 · Cited by 87 · see citing works
Self-citationDisulfide vibrational spectra in the sulfur-sulfur and carbon-sulfur stretching region
Bastian, E. J., & Martin, R. B. (1973) · The Journal of Physical Chemistry · doi:10.1021/j100628a010 · Cited by 83 · see citing works
Dai, L., Li, J., Zhang, B., Liu, J., Luo, Z. Y., & Cai, K. (2014) · Langmuir · doi:10.1021/la501924p · Cited by 83 · see citing works
Lv, Y., Cao, Y., Li, P., Liu, J., Chen, H., Hu, W., & Zhang, L. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700354 · Cited by 83 · see citing works
Hwang, A., Lu, J., Tamanoi, F., & Zink, J. I. (2014) · Small · doi:10.1002/smll.201400765 · Cited by 71 · see citing works
Self-citationPolymer‐Mediated Synthesis of Ferritin‐Encapsulated Inorganic Nanoparticles
Li, M., Viravaidya, C., & Mann, S. (2007) · Small · doi:10.1002/smll.200700199 · Cited by 68 · see citing works
Chen, W., Cheng, C., Lee, B., Clemens, D. L., Huang, W.-Y., Horwitz, M. A., & Zink, J. I. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b09069 · Cited by 65 · see citing works
Self-citationSelf-assembly of ferritin nanocages into linear chains induced by poly(α, l -lysine)
Yang, R., Chen, L., Zhang, T., Yang, S., Leng, X., & Zhao, G. (2013) · Chemical Communications · doi:10.1039/c3cc47847e · Cited by 58 · see citing works
Yu, F., Wu, H., Tang, Y., Xu, Y. F., Qian, X. H., & Zhu, W. P. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.025 · Cited by 57 · see citing works
Novel Method for Making Nanodot Arrays Using a Cage-like Protein
Hikono, T., Uraoka, Y., Fuyuki, T., & Yamashita, I. (2003) · Japanese Journal of Applied Physics · doi:10.1143/jjap.42.l398 · Cited by 56 · see citing works
H‐Chain Ferritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector
Zhang, L., Li, L., di Penta, A., Carmona, U., Yang, F., Schöps, R., Brandsch, M., Zugaza, J. L., & Knez, M. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500226 · Cited by 53 · see citing works
Emmenegger, U., & Kerbel, R. S. (2010) · Nature · doi:10.1038/468637a · Cited by 53 · see citing works
The structure and function of ferritin
Harrison, P. M. (1986) · Biochemical Education · doi:10.1016/0307-4412(86)90203-7 · Cited by 52 · see citing works
A molecular nanocap activated by superparamagnetic heating for externally stimulated cargo release
Rühle, B., Datz, S., Argyo, C., Bein, T., & Zink, J. I. (2015) · Chemical Communications · doi:10.1039/c5cc08636a · Cited by 47 · see citing works
Self-citationDisulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
Zang, J., Chen, H., Zhang, X., Zhang, C., Guo, J., Du, M., & Zhao, G. (2019) · Nature Communications · doi:10.1038/s41467-019-08788-9 · Cited by 47 · see citing works
Song, Z., Shi, J., Zhang, Z., Qi, Z., Han, S., & Cao, S. (2018) · Journal of Materials Science · doi:10.1007/s10853-018-2117-7 · Cited by 45 · see citing works
The role of cysteine residues in the oxidation of ferritin
Welch, K. D., Reilly, C. A., & Aust, S. D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00915-2 · Cited by 33 · see citing works
Ferritin Nanocages: Great Potential as Clinically Translatable Drug Delivery Vehicles?
Todd, T., Zhen, Z., & Xie, J. (2013) · Nanomedicine · doi:10.2217/nnm.13.141 · Cited by 27 · see citing works
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Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Zhou, S., Zhong, Q., Wang, Y., Hu, P., Zhong, W. H., Huang, C., Yu, Z., Ding, C., Liu, H., & Fu, J. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214309 · Cited by 156 · see citing works
Kankala, R. K., Han, Y., Xia, H., Wang, S., & Chen, A. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01315-x · Cited by 147 · see citing works
Chen, L., Zhang, S., Duan, Y., Song, X., Chang, M., Feng, W., & Chen, Y. (2024) · Chemical Society Reviews · doi:10.1039/d1cs01022k · Cited by 150 · see citing works
Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment
Isa, E. D. M., Ahmad, H., Rahman, M. B. A., & Gill, M. R. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020152 · Cited by 136 · see citing works
Porous nanomaterials: Main vein of agricultural nanotechnology
Sharma, S., Sahu, B. K., Cao, L., Bindra, P., Kaur, K., Chandel, M., Koratkar, N. A., Huang, Q., & Shanmugam, V. (2021) · Progress in Materials Science · doi:10.1016/j.pmatsci.2021.100812 · Cited by 95 · see citing works
Mesoporous silica/organosilica nanoparticles for cancer immunotherapy
Theivendran, S., Lazarev, S., & Yu, C. (2023) · Exploration · doi:10.1002/exp.20220086 · Cited by 79 · see citing works
Targeting the tumor microenvironment with biomaterials for enhanced immunotherapeutic efficacy
Feng, Y., Tang, Q., Wang, B., Yang, Q., Zhang, Y., Lei, L., & Li, S. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03005-2 · Cited by 73 · see citing works
Shi, Y., Zhou, M., Zhang, Y., Wang, Y., & Cheng, J. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.12.053 · Cited by 69 · see citing works
Pore-engineered nanoarchitectonics for cancer therapy
Sutrisno, L., & Ariga, K. (2023) · NPG Asia Materials · doi:10.1038/s41427-023-00469-w · Cited by 62 · see citing works
Advances in targeted therapy for tumor with nanocarriers: A review
Cheng, H., Liao, J., Ma, Y., Sarwar, M. T., & Yang, H. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101583 · Cited by 64 · see citing works
The recent progress of inorganic‐based intelligent responsive nanoplatform for tumor theranostics
Yang, Z., & Chen, H. (2022) · Open Research (University of Surrey) · doi:10.1002/viw.20220009 · Cited by 57 · see citing works
Advances in intelligent-responsive nanocarriers for cancer therapy
Tian, M., Xin, X., Wu, R., Guan, W., & Zhou, W. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106184 · Cited by 56 · see citing works
Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates
Gisbert-Garzarán, M., & Vallet‐Regí, M. (2021) · Nanomaterials · doi:10.3390/nano11092222 · Cited by 55 · see citing works
Emerging natural polymer-based architectured nanotherapeutics for the treatment of cancer.
Kuna, K., Baddam, S., Kalagara, S., Akkiraju, P. C., Tade, R., & Enaganti, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129434 · Cited by 38 · see citing works
Development of mesoporous silica-based nanoprobes for optical bioimaging applications
Sun, B., Xu, Z. C., & Jiang, X. (2021) · Biomaterials Science · doi:10.1039/d1bm00204j · Cited by 46 · see citing works
Optical Monitoring of <i>In Situ</i> Iron Loading into Single, Native Ferritin Proteins
Yousefi, A., Ying, C., Parmenter, C. D. J., Assadipapari, M., Sanderson, G., Zheng, Z., Xu, L., Zargarbashi, S., Hickman, G. J., Cousins, R. B., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c00042 · Cited by 37 · see citing works
Liu, Y., Zhao, M., Zhang, M., Yang, B., Qi, Y., & Fu, Q. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102223 · Cited by 36 · see citing works
Long, H., Tian, W., Jiang, S., Zhao, J., Zhou, J., He, Q., Tang, Z., Shen, W., & Wang, J. (2022) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2022.111943 · Cited by 36 · see citing works
Recent advances in biomedical applications of smart nanomaterials: a comprehensive review
Goshisht, M. K., Goshisht, A., Bajpai, A., & Bajpai, A. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00137d · Cited by 35 · see citing works
Zhu, Y., Bai, Y., He, J., & Qiu, X. (2023) · 3 Biotech · doi:10.1007/s13205-023-03651-7 · Cited by 30 · see citing works
Zhao, Y. G., Liu, S., Shi, Z., Zhu, H., Li, M., & Yu, Q. (2022) · Nano Research · doi:10.1007/s12274-022-4211-z · Cited by 23 · see citing works
Gao, R., Qiu, Q., & Dong, W. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c00607 · Cited by 21 · see citing works
Dong, Y., Yang, K., Xu, Z., Li, X., Wang, F., & Zhang, Y. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00616 · Cited by 19 · see citing works
Wang, Z., Peng, C., Zheng, Y. Z., Zhang, Y., Xu, T., Yan, J., Zhou, Y., Liu, Y., Xie, H., Wang, C., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214899 · Cited by 19 · see citing works
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics
Jin, D., Liu, M., Zhang, M., Yu, W., Yu, J., Shen, A., Cheng, J., & Liu, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114648 · Cited by 19 · see citing works
Pei, W., Li, Y., Wu, Y., Wu, Y., Cai, L., Wang, S., Wang, S., & Chen, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202308117 · Cited by 18 · see citing works
Tailoring the Inherent Properties of Biobased Nanoparticles for Nanomedicine
Zahid, A. A., Chakraborty, A., Luo, W., Coyle, A., & Paul, A. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00364 · Cited by 17 · see citing works
Yang, F. M., Wei, P., Yang, M., Chen, W., Zhao, B., Li, W., Wang, J., Qiu, L., & Chen, J. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103851 · Cited by 16 · see citing works
Bioengineering nanomaterials for tumor therapy and anti-metastasis
Cheng, J., Pan, Y., Zou, J., Zhang, M., Zhu, Y., Liu, Y., & Chen, X. S. (2024) · Progress in Materials Science · doi:10.1016/j.pmatsci.2024.101375 · Cited by 15 · see citing works
Self-citationMa, H., Xing, F., Zhou, Y., Yu, P., Luo, R., Xu, J., Xiang, Z., Rommens, P. M., Duan, X., & Ritz, U. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01008b · Cited by 14 · see citing works
Xing, J., Jin, S., Yu, Y., Chen, H., Xiao, H., Li, K., & Li, J. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.119369 · Cited by 13 · see citing works
Advances of typical mesoporous materials and the application in drug delivery
He, S., Pan, H., & Zhang, J. (2023) · Materials Research Express · doi:10.1088/2053-1591/acc82d · Cited by 13 · see citing works
Chemically Modified Silica in Sorption-Instrumental Analytical Methods
Лисичкин, Г. В., & Olenin, A. Y. (2021) · Russian Journal of General Chemistry · doi:10.1134/s1070363221050182 · Cited by 11 · see citing works
Activation of bone tumor-eating macrophages via assembling and co-delivering 3D printed scaffold
Li, C., Ma, Z., Sun, X. S., Li, J., Liang, J., Wang, F., Deng, L., Wang, J., & Cui, W. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123495 · Cited by 9 · see citing works
Recent advances in nanoagents delivery system-based phototherapy for osteosarcoma treatment
Ji, L., Huang, J., Yu, L., Jin, H., Hu, X., Sun, Y., Yin, F., & Cai, Y. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124633 · Cited by 8 · see citing works
Self-citationBetter together: biomimetic nanomedicines for high performance tumor therapy
Mohammad, I. S., Kurşunluoğlu, G., Patel, A. K., Ishaq, H. M., Tunç, C. Ü., Kanarya, D., Rehman, M., Aydin, Ö. F., & Lifang, Y. (2025) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.16.92 · Cited by 9 · see citing works
Cu2+-Chelating Mesoporous Silica Nanoparticles for Synergistic Chemotherapy/Chemodynamic Therapy
Zhang, Y., Lou, J., Williams, G. R., Ye, Y., Ren, D., Shi, A., Wu, J., Chen, W., & Zhu, L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061200 · Cited by 8 · see citing works
Skin-Adaptive Hydrogel Patch with Antitumor Activity for Tumor Elimination
Li, D., Zhang, J., Zhang, J., Ding, J., Sun, H., Qu, X., & Zhang, J. (2025) · ACS Applied Polymer Materials · doi:10.1021/acsapm.5c00124 · Cited by 4 · see citing works
Triple-Responsive Cross-Linked Micelles for Synergistic Chemo-Photothermal Cancer Therapy
Ou, Y., Wang, Y., Chen, K., Liao, W., & Tang, Z. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01130 · Cited by 2 · see citing works
Samari, M., Kashanian, S., Zinadini, S., & Derakhshankhah, H. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107263 · Cited by 2 · see citing works
Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy
Zaidi, Z. S., Teki, S. V. N., & Katti, D. S. (2026) · Springer eBooks · doi:10.1007/978-981-95-2744-1_8 · Cited by 1 · see citing works
Recent Advances and Challenges in Targeted Drug Delivery Using Biofunctional Coatings
Bal, T., Anjrini, N., & Zeroual, M. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837675555-00041 · Cited by 1 · see citing works
Zhao, Y. G., Liu, S., Shi, Z., Zhu, H., Li, M., & Yu, Q. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3940189
Therapy-chemotherapy dual mode intelligent nano hydrogen generator for tumor treatment
Chen, X., Zhang, H., Liu, Y., Zhao, F., Li, B., Yang, R., Qian, N., Bai, Y., Zhao, L., Zheng, B., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.172135
Sun, Z. X., Liu, J., Fang, Y., Ma, L., Zhang, T., Zhang, W., & Pan, Y. (2026) · ACS Nano · doi:10.1021/acsnano.6c00407
Self-citationSelvan, S. T. (2026) · Next Materials · doi:10.1016/j.nxmate.2026.102599
Xu, H., Zhang, Y., Guo, H., Shao, Z., Zhang, S., & Cheng, Y. (2026) · Nanoscale · doi:10.1039/d6nr00974c
- Authors
- Cai, Y., Deng, T., Pan, Y., & Zink, J. I.
- Affiliations
- University of California, Los Angeles (US)
- California NanoSystems Institute (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Cai, Yao
- Zink, Jeffrey I.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2020-08-09
- Volume
- 30
- Issue
- 39
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3047902260
- Cited by
- 48
- References
- 77
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 7
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- National Natural Science Foundation of China (41621004, 41704072)
- China Postdoctoral Science Foundation (2017M610979)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- mesoporous silica nanoparticles, ferritin, doxorubicin delivery, redox-responsive drug release, pH-responsive drug release, transferrin receptor 1, targeted drug delivery, nanoparticle capping agents, tumor growth inhibition
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