The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nanoceria‐Triggered Synergetic Drug Release Based on CeO2‐Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2
Abstract
Herein, a pH stimuli‐responsive vehicle for intracellular drug delivery using CeO 2 capped mesoporous silica nanoparticles (MSN) is reported. β‐Cyclodextrin‐modified CeO 2 nanoparticles could cap onto ferrocene‐functionalized mesoporous silica through host–guest interactions. After internalization into A549 cells by a lysosomal pathway, the ferrocenyl moieties are oxidized to ferrocenium ions by CeO 2 lids, which could trigger the uncapping of the CeO 2 and cause the drugs release. Because of the pH‐dependent toxicity, the CeO 2 here behaves as a multi‐purpose entity that not only acts as a lid but also exhibits a synergistic antitumor effect on cancer cells. Meanwhile, the cell protective effect of CeO 2 nanoparticles alone is demonstrated, which ensures that the dissolved CeO 2 nanoparticles can be non‐toxic to normal cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
Ruoslahti, E. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.697 · Cited by 3,191
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds
HEIDELBERGER, C., CHAUDHURI, N. K., DANNEBERG, P., MOOREN, D., GRIESBACH, L., DUSCHINSKY, R., SCHNITZER, R. J., PLEVEN, E., & SCHEINER, J. (1957) · Nature · doi:10.1038/179663a0 · Cited by 1,603
Stabilization and Size Control of Gold Nanoparticles during Laser Ablation in Aqueous Cyclodextrins
Sylvestre, J.-P., Kabashin, A. V., Sacher, E., Meunier, M., & Luong, J. H. T. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048678s · Cited by 369
Cited by
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Fundamentals and Catalytic Applications of CeO 2 -Based Materials
Montini, T., Melchionna, M., Monai, M., & Fornasiero, P. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00603 · Cited by 2,766
Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes
Lin, Y., Ren, J., & Qu, X. (2014) · Accounts of Chemical Research · doi:10.1021/ar400250z · Cited by 1,252
Self-citationYang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights
Vallet-Regí, M., Colilla, M., Izquierdo-Barba, I., & Manzano, M. (2017) · Molecules · doi:10.3390/molecules23010047 · Cited by 538
Metadata
- Authors
- Xu, C., Lin, Y., Wang, J., Wu, L., Wei, W., Ren, J., & Qu, X.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2013-04-30
- Volume
- 2
- Issue
- 12
- Pages
- 1591-1599
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W1986265174
- Cited by
- 200
- References
- 6
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nanoceria‐Triggered Synergetic Drug Release Based on CeO2‐Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2. https://app.cochat.ai/papers/10.1002/adhm.201200464
- The paper
- Xu, C., Lin, Y., Wang, J., Wu, L., Wei, W., Ren, J., & Qu, X. (2013). Nanoceria‐Triggered Synergetic Drug Release Based on CeO2‐Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201200464
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
