Biomaterial‐Based Implantable Devices for Cancer Therapy
Open accessAbstract
This review article focuses on the current local therapies mediated by implanted macroscaled biomaterials available or proposed for fighting cancer and also highlights the upcoming research in this field. Several authoritative review articles have collected and discussed the state‐of‐the‐art as well as the advancements in using biomaterial‐based micro‐ and nano‐particle systems for drug delivery in cancer therapy. On the other hand, implantable biomaterial devices are emerging as highly versatile therapeutic platforms, which deserve an increased attention by the healthcare scientific community, as they are able to offer innovative, more effective and creative strategies against tumors. This review summarizes the current approaches which exploit biomaterial‐based devices as implantable tools for locally administrating drugs and describes their specific medical applications, which mainly target resected brain tumors or brain metastases for the inaccessibility of conventional chemotherapies. Moreover, a special focus in this review is given to innovative approaches, such as combined delivery therapies, as well as to alternative approaches, such as scaffolds for gene therapy, cancer immunotherapy and metastatic cell capture, the later as promising future trends in implantable biomaterials for cancer applications.
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- Authors
- Chew, S. A., & Danti, S.
- Affiliations
- The University of Texas Rio Grande Valley (US)
- University of Pisa (IT)
- Corresponding author
- Chew, Sue Anne
- Danti, Serena
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2016-11-25
- Volume
- 6
- Issue
- 2
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2551684048
- Cited by
- 121
- References
- 153
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 14 · 2023: 14 · 2022: 17 · 2021: 14 · 2020: 15 · 2019: 14 · 2018: 5 · 2017: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- cancer therapy, local drug delivery, brain tumors, brain metastases, cancer immunotherapy, resected tumors
- MeSH terms
- Animals, Biocompatible Materials, Drug Implants, Humans, Immunotherapy, Neoplasms, Genetic Therapy, Implants, Experimental
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