The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery
Open accessAbstract
Biocompatible and bioresponsive microneedles (MNs) are emerging technology platforms for sustained drug release with a potential to be a key player in transdermal delivery of therapeutics. In this paper, an innovative biodegradable MNs patch for the sustained delivery of drugs using a polymer patch, which can adjust delivery rates based on its crosslinking degree, is reported. Gelatin methacryloyl (GelMA) is used as the base for engineering biodegradable MNs. The anticancer drug doxorubicin (DOX) is loaded into GelMA MNs using the one molding step. The GelMA MNs can efficiently penetrate the stratum corneum layer of a mouse cadaver skin. Mechanical properties and drug release behavior of the GelMA MNs can be adjusted by tuning the degree of crosslinking. The efficacy of the DOX released from the GelMA MNs is tested and the anticancer efficacy of the released drugs against melanoma cell line A375 is demonstrated. Since GelMA is a versatile material in engineering tissue scaffolds, it is expected that the GelMA MNs can be used as a platform for the delivery of various therapeutics.
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Cites
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
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Self-citationFunctional and bioactive properties of collagen and gelatin from alternative sources: A review
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Microneedles for drug and vaccine delivery
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Current status and future potential of transdermal drug delivery
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Dissolving microneedles for transdermal drug delivery
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Dissolving polymer microneedle patches for influenza vaccination
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Self-citationPhotocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering
Zhao, X., Lang, Q., Yildirimer, L., Lin, Z. Y., Cui, W., Annabi, N., Ng, K. W., Dokmeci, M. R., Ghaemmaghami, A. M., & Khademhosseini, A. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500005 · Cited by 832
Self-citationEnhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody
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Self-citationCoated microneedles for transdermal delivery
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Cited by
Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques
Vigata, M., Meinert, C., Hutmacher, D. W., & Bock, N. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121188 · Cited by 544
Makvandi, P., Kirkby, M., Hutton, A. R. J., Shabani, M., Yiu, C. K. Y., Baghbantaraghdari, Z., Jamaledin, R., Carlotti, M., Mazzolai, B., Mattoli, V., et al. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00611-9 · Cited by 455
Current trends in polymer microneedle for transdermal drug delivery
Ahmed Saeed AL-Japairai, K., Mahmood, S., Hamed Almurisi, S., Reddy Venugopal, J., Rebhi Hilles, A., Azmana, M., & Raman, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119673 · Cited by 448
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3D‐Printed Hydrogel‐Filled Microneedle Arrays
Barnum, L., Quint, J., Derakhshandeh, H., Samandari, M., Aghabaglou, F., Farzin, A., Abbasi, L., Bencherif, S., Memic, A., Mostafalu, P., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001922 · Cited by 89
Metadata
- Authors
- Luo, Z., Sun, W., Fang, J., Lee, K., Li, S., Gu, Z., Dokmeci, M. R., & Khademhosseini, A.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2018-12-19
- Volume
- 8
- Issue
- 3
- Pages
- e1801054-e1801054
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2905326325
- Cited by
- 294
- References
- 41
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Luo, Z., Sun, W., Fang, J., Lee, K., Li, S., Gu, Z., Dokmeci, M. R., & Khademhosseini, A. (2019). Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201801054
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
