Superwetting injectable hydrogel with ultrastrong and fast tissue adhesion for minimally invasive hemostasis
Abstract
Injectable hydrogels have recently emerged as alternatives to sutures for various clinical indications. However, existing injectable hydrogels are unsuitable for hemostasis in minimally invasive surgery because of their weak interfacial adhesion and complex/prolonged processing. Herein, a superwetting injectable hydrogel composed of oppositely charged polysaccharides is developed. The spontaneous spreading of the injectable hydrogel on the surfaces achieves complete wetting and forms tight interfacial contact by absorbing the interfacial water. The superwetting ability and subsequent covalent crosslinking perform fast and ultrastrong wet adhesion (140 kPa) on the tissue surface. Ex vivo porcine and in vivo rat models show that the hydrogel successfully leads to the aggregation of erythrocytes for targeted hemostasis (in less than 12 s) without requiring external adjuncts, and no postsurgical adhesions to the peripheral tissues. This further demonstrates that hydrogel can act as an effective hemostasis agent in laparoscopic surgery in a rabbit model. Overall, the strong wet adhesion, antibacterial properties, and easy operability make this injectable hydrogel a promising candidate for hemostasis applications, as it can successfully combine clinical efficacy and transformation opportunities for minimally invasive surgery.
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Injectable hydrogel-based tissue adhesives, with shape adaptability and minimally invasive characteristics, have become promising alternatives for hemorrhage control.
“Injectable hydrogel-based tissue adhesives, with their shape adaptability and minimally invasive characteristics, have become promising alternatives for hemorrhage control [116].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [116]
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- Authors
- Wei, C., Shi, W., Zhao, C., Yang, S., Zheng, J., Zhong, J., Zhao, T., Kong, S., Gong, X., & Liu, M.
- Affiliations
- Beihang University (CN)
- Peking University Third Hospital (CN)
- Corresponding author
- Gong, Xi
- Liu, Mingjie
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2022-11-14
- Volume
- 12
- Issue
- 3
- Pages
- e2201799-e2201799
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W4308257874
- Cited by
- 38
- References
- 60
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 15 · 2023: 7
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (22161142021, 81902208)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- injectable hydrogel, superwetting, tissue adhesion, hemostasis, minimally invasive surgery, covalent cross-linking, erythrocyte aggregation, laparoscopic surgery, antibacterial hydrogel, postoperative adhesions
- MeSH terms
- Tissue Adhesions, Animals, Hemostasis, Polysaccharides, Rabbits, Swine, Hydrogels, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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