One Step Creation of Multifunctional 3D Architectured Hydrogels Inducing Bone Regeneration
Open accessAbstract
Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.
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The above two features differ notably from common shape memory hydrogels for which shape changing kinetics is strongly affected by device dimension due to inside-and-out water diffusion.
“The above two features differ notably from common shape memory hydrogels 21-24 for which the shape changing kinetics is strongly affected by the device dimension due to the inside-and-out water diffusion 25 .”
From Shape memory polymer with programmable recovery onset (2023) · cites this paper as [23]
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Shape memory polymer with programmable recovery onset
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Self-citation
- Authors
- Neffe, A. T., Pierce, B. F., Tronci, G., Ma, N., Pittermann, E., Gebauer, T., Frank, O., Schossig, M., Xu, X., Willie, B. M., Forner, M., Ellinghaus, A., Lienau, J., Duda, G. N., & Lendlein, A.
- Affiliations
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- University of Leeds (GB)
- University of Rostock (DE)
- Helmholtz-Zentrum Hereon (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Corresponding author
- Lendlein, Andreas
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2015-01-20
- Volume
- 27
- Issue
- 10
- Pages
- 1738-1744
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2161626383
- Cited by
- 113
- References
- 41
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 6 · 2021: 22 · 2020: 13 · 2019: 10 · 2018: 13 · 2017: 5 · 2016: 21 · 2015: 6
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advanced Materials (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Helmholtz-Zentrum Geesthacht Zentrum für Materialforschung und kustenforschung (The Helmholtz Center Geesthacht) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- 3D hydrogels, bone regeneration, porous scaffolds, cell adhesion, cell differentiation, hydrogel degradation, form stability, elastic properties, biomaterials, one-step fabrication
- MeSH terms
- Animals, Biocompatible Materials, Bone Regeneration, Bony Callus, Cell Adhesion, Cell Differentiation, Cell Line, Cell Survival, Cells, Cultured, Elasticity, Female, Femur, Fibroblasts, Gelatin, Humans, Materials Testing, Physical Stimulation, Porosity, Rats, Sprague-Dawley, Hydrogels, Absorbable Implants, Mesenchymal Stem Cells
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