The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Interfacing Materials Science and Biology for Drug Carrier Design
Open accessAbstract
Over the last ten years, there has been considerable research interest in the development of polymeric carriers for biomedicine. Such delivery systems have the potential to significantly reduce side effects and increase the bioavailability of poorly soluble therapeutics. The design of carriers has relied on harnessing specific variations in biological conditions, such as pH or redox potential, and more recently, by incorporating specific peptide cleavage sites for enzymatic hydrolysis. Although much progress has been made in this field, the specificity of polymeric carriers is still limited when compared with their biological counterparts. To synthesize the next generation of carriers, it is important to consider the biological rationale for materials design. This requires a detailed understanding of the cellular microenvironments and how these can be harnessed for specific applications. In this review, several important physiological cues in the cellular microenvironments are outlined, with a focus on changes in pH, redox potential, and the types of enzymes present in specific regions. Furthermore, recent studies that use such biologically inspired triggers to design polymeric carriers are highlighted, focusing on applications in the field of therapeutic delivery.
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Self-citationpH-responsive polymer nanoparticles for drug delivery
Deirram, N., Zhang, C., Kermaniyan, S. S., Johnston, A. P. R., & Such, G. K. (2019) · Macromolecular Rapid Communications · doi:10.1002/marc.201800917 · Cited by 531
Self-citationAdvances in redox-responsive drug delivery systems of tumor microenvironment
Guo, X., Cheng, Y., Zhao, X., Luo, Y., Chen, J., & Yuan, W.-E. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0398-2 · Cited by 459
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald
Zhao, S., Caruso, F., Dähne, L., Decher, G., De Geest, B. G., Fan, J., Feliu, N., Gogotsi, Y., Hammond, P. T., Hersam, M. C., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03326 · Cited by 283
Self-citationJia, X., Zhang, Y., Zou, Y., Wang, Y., Niu, D., He, Q., Huang, Z., Zhu, W., Tian, H., Shi, J., et al. (2018) · Advanced Materials · doi:10.1002/adma.201704490 · Cited by 232
Metadata
- Authors
- Such, G. K., Yan, Y., Johnston, A. P. R., Gunawan, S. T., & Caruso, F.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2015-02-26
- Volume
- 27
- Issue
- 14
- Pages
- 2278-2297
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2167263245
- Cited by
- 220
- References
- 15
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Such, G. K., Yan, Y., Johnston, A. P. R., Gunawan, S. T., & Caruso, F. (2015). Interfacing Materials Science and Biology for Drug Carrier Design. Advanced Materials. https://doi.org/10.1002/adma.201405084
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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