Advances in redox-responsive drug delivery systems of tumor microenvironment
Open accessAbstract
With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed by redox-responsive delivery can be much stable when in circulation. In addition, redox-responsive vectors can respond to the high intracellular level of glutathione and release the loaded cargoes rapidly, only if they reach the site of tumor tissue or targeted cells. Moreover, redox-responsive delivery systems are often applied to significantly improve drug concentrations in targeted cells, increase the therapeutic efficiency and reduce side effects or toxicity of primary drugs. In this review, we focused on the structures and types of current redox-responsive delivery systems and provided a comprehensive overview of relevant researches, in which the disulfide bond containing delivery systems are of the utmost discussion.
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The currently constructed smart delivery system mainly contains redox stimulants such as disulfide bonds, diselenide bonds, succinimide-thioether bonds and trimethyl-locked benzoquinone.
“The currently constructed smart delivery system mainly contains redox stimulants such as disulfide bonds, diselenide bonds, succinimide-thioether bonds and “trimethyl-locked” benzoquinone.165”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [165]
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Cites
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works
Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842 · see citing works
Future perspectives and recent advances in stimuli-responsive materials
Roy, D., Cambre, J. N., & Sumerlin, B. S. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.008 · Cited by 1,484 · see citing works
Lü, Y., Aimetti, A. A., Langer, R., & Gu, Z. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.75 · Cited by 1,432 · see citing works
Reduction-sensitive polymers and bioconjugates for biomedical applications
Meng, F., Hennink, W. E., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.026 · Cited by 1,132 · see citing works
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 917 · see citing works
Nanomedicine therapeutic approaches to overcome cancer drug resistance
Markman, J. L., Rekechenetskiy, A., Holler, E., & Ljubimova, J. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.019 · Cited by 733 · cited 2× · see citing works
“ATNDDS can improve the solubility and stability of drugs, enhance the targeting ability, reduce potential toxicity, achieve the co-delivery of drugs and genes, and realize the collaborative treatment [3].”
BackgroundMulti-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies
Klaikherd, A., Nagamani, C., & Thayumanavan, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809475a · Cited by 594 · see citing works
Redox-responsive polymers for drug delivery: from molecular design to applications
Huo, M., Yuan, J., Tao, L., & Wei, Y. (2014) · Polym. Chem. · doi:10.1039/c3py01192e · Cited by 561 · see citing works
Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Ryu, J., Chacko, R. T., Jiwpanich, S., Bickerton, S., Babu, R. P., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1069932 · Cited by 555 · see citing works
Li, J., Huo, M., Wang, J., Zhou, J., Mohammad, J. M., Zhang, Y., Zhu, Q., Waddad, A. Y., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.022 · Cited by 468 · see citing works
Enzyme-responsive materials: a new class of smart biomaterials
Ulijn, R. V. (2006) · Journal of Materials Chemistry · doi:10.1039/b601776m · Cited by 468 · see citing works
Stimuli-Responsive Polymersomes for Biomedical Applications
Hu, X., Zhang, Y., Xie, Z., Jing, X., Bellotti, A., & Gu, Z. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.6b01704 · Cited by 396 · see citing works
Koo, A. N., Lee, H. J., Kim, S. E., Chang, J. H., Park, C., Kim, C., Park, J. H., & Lee, S. C. (2008) · Chemical Communications · doi:10.1039/b815918a · Cited by 395 · see citing works
Redox-optimized ROS balance: A unifying hypothesis
Aon, M. A., Cortassa, S. C., & O'Rourke, B. P. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.016 · Cited by 376 · see citing works
Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment
Chen, B., Dai, W., He, B., Zhang, H., Wang, X., Wang, Y., & Zhang, Q. (2017) · Theranostics · doi:10.7150/thno.16684 · Cited by 347 · see citing works
Dynamic Diselenide Bonds: Exchange Reaction Induced by Visible Light without Catalysis
Ji, S., Cao, W., Yu, Y., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403442 · Cited by 336 · see citing works
Synthesis of Reversible Shell Cross-Linked Micelles for Controlled Release of Bioactive Agents
Li, Y., Lokitz, B. S., Armes, S. P., & McCormick, C. L. (2006) · Macromolecules · doi:10.1021/ma0604035 · Cited by 277 · see citing works
Intracellular drug release nanosystems
Meng, F., Cheng, R., Deng, C., & Zhong, Z. (2012) · Materials Today · doi:10.1016/s1369-7021(12)70195-5 · Cited by 250 · see citing works
Zhai, S., Hu, X., Hu, Y. J., Wu, B., & Xing, D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.002 · Cited by 228 · see citing works
Poly(amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery
Kurtoglu, Y. E., Navath, R. S., Wang, B., Kannan, S., Romero, R. J., & Kannan, R. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.054 · Cited by 224 · see citing works
Interfacing Materials Science and Biology for Drug Carrier Design
Such, G. K., Yan, Y., Johnston, A. P. R., Gunawan, S. T., & Caruso, F. (2015) · Advanced Materials · doi:10.1002/adma.201405084 · Cited by 219 · see citing works
Redox-Triggered Contents Release from Liposomes
Ong, W., Yang, Y., Cruciano, A. C., & McCarley, R. L. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8050469 · Cited by 216 · see citing works
Hu, Y., Du, Y., Liu, N., Liu, X., Meng, T., Cheng, B., He, J., You, J., Yuan, H., & Hu, F. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.018 · Cited by 205 · see citing works
Enzyme-triggered nanomedicine: Drug release strategies in cancer therapy (Invited Review)
Andresen, T. L., Thompson, D. H., & Kaasgaard, T. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.515950 · Cited by 202 · see citing works
Wu, J., Zhao, L., Xu, X., Bertrand, N., Choi, W. I., Yameen, B., Shi, J., Shah, V., Mulvale, M., MacLean, J. L., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201503863 · Cited by 193 · see citing works
Baldwin, A. D., & Kiick, K. L. (2012) · Polymer Chemistry · doi:10.1039/c2py20576a · Cited by 178 · see citing works
Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy
Barar, J., & Omidi, Y. (2013) · Europe PMC (PubMed Central) · doi:10.5681/bi.2013.036 · Cited by 177 · see citing works
Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy
Cheng, R., Meng, F., Deng, C., & Zhong, Z. (2015) · Nano Today · doi:10.1016/j.nantod.2015.09.005 · Cited by 165 · see citing works
Zhang, L., Liu, W., Lin, L., Chen, D., & Stenzel, M. H. (2008) · Biomacromolecules · doi:10.1021/bm800867n · Cited by 163 · see citing works
Zhang, Q., Shen, C., Zhao, N., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201606229 · Cited by 160 · see citing works
Strategies to overcome the polycation dilemma in drug delivery
Bernkop‐Schnürch, A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.017 · Cited by 155 · see citing works
Selenoglutathione: Efficient Oxidative Protein Folding by a Diselenide
Beld, J., Woycechowsky, K. J., & Hilvert, D. (2007) · Biochemistry · doi:10.1021/bi700124p · Cited by 154 · see citing works
Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology
Levine, M. N., & Raines, R. T. (2012) · Chemical Science · doi:10.1039/c2sc20536j · Cited by 141 · see citing works
Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery
Chen, X., Sun, H. Q., Hu, J., Han, X., Liu, H., & Hu, Y. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.01.010 · Cited by 136 · see citing works
Trigger responsive polymeric nanocarriers for cancer therapy
Kaur, S., Prasad, C., Balakrishnan, B., & Banerjee, R. (2015) · Biomaterials Science · doi:10.1039/c5bm00002e · Cited by 132 · see citing works
Li, R., & Xie, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.020 · Cited by 127 · see citing works
Asgharzadeh, M. R., Barar, J., Pourseif, M. M., Eskandani, M., Niya, M. J., Mashayekhi, M. R., & Omidi, Y. (2017) · Bioimpacts · doi:10.15171/bi.2017.15 · Cited by 117 · see citing works
Redox-sensitive polymeric nanoparticles for drug delivery
Cho, H., Bae, J., Garripelli, V. K., Anderson, J. M., Jun, H., & Jo, S. (2012) · Chemical Communications · doi:10.1039/c2cc31463k · Cited by 111 · see citing works
Zhou, Y., Wen, H., Gu, L., et al. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0316-z · Cited by 106 · see citing works
Li, X., Zhao, W., Liu, X., et al. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.036 · Cited by 99 · see citing works
Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors
Manickam, D. S., Li, J., Putt, D. A., Zhou, Q.-H., Wu, C., Lash, L. H., & Oupický, D. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.08.022 · Cited by 97 · see citing works
Vachutinsky, Y., Oba, M., Miyata, K., Hiki, S., Kano, M. R., Nishiyama, N., Koyama, H., Miyazono, K., & Kataoka, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.002 · Cited by 88 · see citing works
Smart Drug Delivery Systems in Cancer Therapy
Ünsoy, G., & Gündüz, U. (2016) · Current Drug Targets · doi:10.2174/1389450117666160401124624 · Cited by 83 · see citing works
Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system
Schmitz, T., Bravo‐Osuna, I., Vauthier, C., et al. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.017 · Cited by 80 · see citing works
CXCR4-Targeted and Redox Responsive Dextrin Nanogel for Metastatic Breast Cancer Therapy
Zhang, F., Gong, S., Wu, J., Li, H., Oupický, D., & Sun, M. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00208 · Cited by 75 · see citing works
Cheng, B., He, H., Huang, T., Berr, S. S., He, J., Fan, D., Zhang, J., & Xu, P. (2016) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2016.2195 · Cited by 72 · see citing works
Zhao, S., Xu, M., Cao, C., Yu, Q., Zhou, Y., & Liu, J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00613f · Cited by 72 · see citing works
Ghorbani, M., & Hamishehkar, H. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.02.008 · Cited by 69 · see citing works
Gu, Z. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s32961 · Cited by 66 · see citing works
Liu, L., & Liu, P. (2015) · Frontiers of Materials Science · doi:10.1007/s11706-015-0283-y · Cited by 66 · see citing works
Lin, J., Du, J., Yang, Y.-Q., Li, L., Zhang, D., Liang, C.-L., Wang, J., Mei, J., & Wang, G.-H. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.08.036 · Cited by 62 · see citing works
Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery
Qiu, L., Zhao, L., Xing, C., et al. (2017) · Chinese Chemical Letters · doi:10.1016/j.cclet.2017.09.048 · Cited by 56 · see citing works
Zhou, Y., Jie, K., & Huang, F. (2017) · Chemical Communications · doi:10.1039/c7cc04779g · Cited by 54 · see citing works
Zhou, Y., Wang, S., Ying, X., Wang, Y., Geng, P., Deng, A., & Yu, Z. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s141229 · Cited by 53 · see citing works
A pH and redox dual stimuli-responsive poly(amino acid) derivative for controlled drug release
Gong, C., Shan, M., Li, B., & Wu, G. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.06.038 · Cited by 51 · see citing works
mPEGylated solanesol micelles as redox-responsive nanocarriers with synergistic anticancer effect
Qin, B., Liu, L., Wu, X., Liang, F., Hou, T., Pan, Y., & Song, S. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.09.040 · Cited by 40 · see citing works
John, J. V., Uthaman, S., Augustine, R., Lekshmi, K. M., Park, I., & Kim, I. (2017) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28602 · Cited by 39 · see citing works
Le, C. M. Q., Thi, H. H. P., Cao, X. T., Kim, G., Oh, C., & Lim, K. T. (2016) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28271 · Cited by 38 · see citing works
Fabrication of degradable lemon-like porous silica nanospheres for pH/redox-responsive drug release
Zhang, X., Zhao, Y., Cao, L., et al. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.10.104 · Cited by 38 · see citing works
Huang, Y., Sun, R., Luo, Q., Wang, Y., Zhang, K., Deng, X., Zhu, W., Li, X., & Shen, Z. (2015) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.27778 · Cited by 31 · see citing works
Yuan, F., Li, J.-L., Cheng, H. L., et al. (2017) · Biomaterials Science · doi:10.1039/c7bm00793k · Cited by 30 · see citing works
Polythiolactone-Based Redox-Responsive Layers for the Reversible Release of Functional Molecules
Belbekhouche, S., Reinicke, S., Espeel, P., Prez, F. D., Eloy, P., Dupont‐Gillain, C. C., Jonas, A. M., Demoustier‐Champagne, S., & Glinel, K. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am506489j · Cited by 25 · see citing works
Wang, Z., Liu, H., Shu, X., et al. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.09.010 · Cited by 24 · see citing works
Zhang, L., Li, Y., Yu, J. C., & Chan, K. M. (2016) · RSC Advances · doi:10.1039/c6ra16578h · Cited by 19 · see citing works
Zhao, C., Shao, L., Lu, J., Zhao, C., Wei, Y., Junxing, L., Li, M., & Wu, Y. F. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600295 · Cited by 17 · see citing works
Hu, Y., Liu, N., Cheng, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13083 · Cited by 13 · see citing works
Bioreducible polyspermine as less toxic and efficient gene carrier
Park, H., Nichols, J. W., Kang, H. C., & Bae, Y. H. (2014) · Polymers for Advanced Technologies · doi:10.1002/pat.3269 · Cited by 12 · see citing works
Mavuso, S., Marimuthu, T., Kumar, P., et al. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.11.011 · Cited by 12 · see citing works
Ren, G., Chen, P. C., Tang, J., et al. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1405435 · Cited by 11 · see citing works
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- [71]Zhang Q Shen CN Zhao N Xu FJ Redox-responsive and drug-embedded silica nanoparticles with unique self-destruction features for efficient gene/drug codelivery Adv Funct Mater 2017 27 1606229 10.1002/adfm.201606229 · DOI
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- Authors
- Guo, X., Cheng, Y., Zhao, X., Luo, Y., Chen, J., & Yuan, W.-E.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Southern Medical University (CN)
- Corresponding author
- Chen, Jianjun
- Venue
- Journal of Nanobiotechnology
- Published
- 2018-09-22
- Volume
- 16
- Issue
- 1
- Pages
- 74-74
- ISSN
- 1477-3155 (ISSN-L)
- PMC
- PMC6151045
- OpenAlex
- W2890063360
- Cited by
- 459
- References
- 71
- Citations by year
- 2026: 59 · 2025: 88 · 2024: 50 · 2023: 63 · 2022: 70 · 2021: 62 · 2020: 48 · 2019: 19
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Nanobiotechnology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (YG2015QN12, 81602099, 81570992)
- Shanghai Jiao Tong University (YG2016QN22, YG2015QN12, 2018ZX09711003-008-002, YG2017MS22, YG2017QN56)
- Southern Medical University (C1034335)
- Shanghai University of Medicine and Health Sciences
- Organization Department of the Central Committee of the Communist Party of China (C1080094)
- Thousand Young Talents Program of China (C1080094, C1034335)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- redox-responsive drug delivery, tumor microenvironment, glutathione, disulfide bonds, nanocarriers, targeted drug delivery, intracellular drug release, nanomaterials
- MeSH terms
- Animals, Antineoplastic Agents, Delayed-Action Preparations, Disulfides, Glutathione, Humans, Neoplasms, Oxidation-Reduction, Drug Delivery Systems, Tumor Microenvironment
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