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Cited by 531Nanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems

pH-responsive polymer nanoparticles for drug delivery

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Deirram, Nayeleh, Zhang, Changhe, Kermaniyan, Sarah S., Johnston, Angus P. R., Such, Georgina K.·2019·Macromolecular Rapid Communications
DOI 10.1002/marc.201800917
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Abstract

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.

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  • The ionic interaction can dissolve in response to pH changes, causing the drug to be released from the polymer backbone.

    “The ionic interaction can dissolve in response to pH changes, causing the drug to be released from the polymer backbone (Pang et al., 2016; Deirram et al., 2019).”

    From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Deirram et al., 2019

    The Introduction describes pH-driven nanoparticle disassembly, and section 3.7 describes drug release following cleavage of pH-sensitive linkages in polymer backbones. Neither passage says that an ionic interaction dissolves to release a drug from the backbone; the specific mechanism attributed to this source is unsupported. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • These ionizable groups can achieve a targeted and regulated drug discharge in reaction to local pH alterations by experiencing conformational, solubility changes or transitioning between swelling and deswelling states.

    “These ionizable groups can achieve a targeted and regulated drug discharge in reaction to local pH alterations by experiencing conformational, solubility changes or transitioning between swelling and deswelling states (Kocak et al., 2016; Deirram et al., 2019).”

    From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Deirram et al., 2019

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Authors
Deirram, N., Zhang, C., Kermaniyan, S. S., Johnston, A. P. R., & Such, G. K.
Affiliations
  • The University of Melbourne (AU)
  • Monash University (AU)
Corresponding author
Such, Georgina K.
ORCID
Venue
Macromolecular Rapid Communications
Publisher
Wiley
Published
2019-03-05
Volume
40
Issue
10
Pages
e1800917-e1800917
ISSN
  • 1022-1336 (ISSN-L)
  • 1521-3927
DOI
10.1002/marc.201800917
OpenAlex
W2921117033
Cited by
531
References
152
Citations by year
2026: 58 · 2025: 78 · 2024: 78 · 2023: 101 · 2022: 84 · 2021: 76 · 2020: 53 · 2019: 3
FWCI
3.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Macromolecular Rapid Communications (publishedVersion)
  • PubMed (publishedVersion)
  • Monash University Research Portal (Monash University) (submittedVersion, other-oa)
  • Minerva Access (University of Melbourne) (submittedVersion)
Funders
  • Australian Research Council (DP180100844)
  • National Health and Medical Research Council (APP1129672)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
pH-responsive nanoparticles, stimuli-responsive drug delivery, crosslinking, tumor acidosis, endosomal acidification, targeted drug release, polymeric nanoparticles
MeSH terms
Humans, Hydrogen-Ion Concentration, Polymers, Drug Delivery Systems, Nanoparticles, Drug Liberation

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