The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mitochondrion‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation
Abstract
The first mitochondrion‐anchoring photosensitizer that specifically generates singlet oxygen (1 O 2) in mitochondria under white light irradiation that can serve as a highly effective radiosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation. An aggregation‐induced emission luminogen (AIEgen), namely DPA‐SCP, is rationally designed with α‐cyanostilbene as a simple building block to reveal AIE, diphenylamino (DPA) group as a strong electron donating group to benefit red emission and efficient light‐controlled 1 O 2 generation, as well as a pyridinium salt as the targeting moiety to ensure specific mitochondrial localization. The AIE signature endows DPA‐SCP with the capacity to visualize mitochondria in a fluorescence turn‐on mode. It is found that under optimized experimental condition, DPA‐SCP with white light does not lead to apoptosis/death of cancer cells, whereas provides an elevated 1 O 2 environment in the mitochondria. More importantly, increasing intracellular level of 1 O 2 originated from mitochondria is demonstrated to be a generic method to enhance the radiosensitivity of cancer cells with a supra‐additive synergistic effect of “0 + 1 > 1.” Noteworthy is that “DPA‐SCP + white light” achieves a high SER10 value of 1.62, which is much larger than that of the most popularly used radiosensitizers, gold nanoparticles (1.19), and paclitaxel (1.32).
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Aggregation-Induced Emission: Together We Shine, United We Soar!
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Self-citationMitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy
Nguyen Cao, T. G., Truong Hoang, Q., Hong, E. J., Kang, S. J., Kang, J. H., Ravichandran, V., Kang, H. C., Ko, Y. T., Rhee, W. J., & Shim, M. S. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.044 · Cited by 69
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Metadata
- Authors
- Yu, C. Y. Y., Xu, H., Ji, S., Kwok, R. T. K., Lam, J. W. Y., Li, X., Krishnan, S., Ding, D., & Tang, B. Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-02-13
- Volume
- 29
- Issue
- 15
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2588515730
- Cited by
- 272
- References
- 3
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- closed
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