Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes
Open accessAbstract
Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM). The photosensitive molecule changes from a ring-closed, for photoacoustic imaging, to a ring-opened state for fluorescence and photodynamic effects upon an external light trigger. The nanoparticles’ photoacoustic and fluorescence imaging properties demonstrate the advantage of the switch. The use of the nanoparticles improves the outcomes of in vivo cancer surgery using preoperative photoacoustic imaging and intraoperative fluorescent visualization/photodynamic therapy of residual tumours to ensure total tumour removal.
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- Authors
- Qi, J., Chen, C., Zhang, X., Hu, X., Ji, S., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Nankai University (CN)
- Corresponding author
- Ding, Dan
- Tang, Ben Zhong
- ORCID
- Venue
- Nature Communications
- Published
- 2018-05-10
- Volume
- 9
- Issue
- 1
- Pages
- 1848-1848
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5945617
- OpenAlex
- W2802852094
- Cited by
- 350
- References
- 56
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 38 · 2023: 29 · 2022: 58 · 2021: 41 · 2020: 58 · 2019: 75 · 2018: 22
- FWCI
- 19.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (ITCPD/17-9, N_HKUST604/14, AoE/P-03/08, 16301614, ITC-CNERC14SC01, IRT13023, 21 788 102, 16305015, 51622305)
- Innovation and Technology Commission (ITC PD/17-9, RE:ITCPD/17‐9, CNERC14SC01, ITC- CNERC-14SC01)
- Guangdong Province Introduction of Innovative R&D Team (201101C0105067115)
- National Key Research and Development Program of China (2015CB856503, IRT13023, 21788102)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Keywords
- dithienylethene, photoacoustic imaging, fluorescence imaging, photodynamic therapy, organic nanoparticles, photoisomerization, cancer surgery
- MeSH terms
- Animals, Antineoplastic Agents, Female, Humans, Intraoperative Period, Male, Mice, Inbred BALB C, Neoplasms, Photochemotherapy, Temperature, Survival Rate, Treatment Outcome, Chemotherapy, Adjuvant, Rats, Sprague-Dawley, Photosensitizing Agents, Xenograft Model Antitumor Assays, Cell Line, Tumor, Mice, Rats, Nanoparticles, Preoperative Period, Photoacoustic Techniques, Optical Imaging
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