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Semiconducting Polymer Nanoparticles for Centimeters‐Deep Photoacoustic Imaging in the Second Near‐Infrared Window
Abstract
Thienoisoindigo‐based semiconducting polymer with a strong near‐infrared absorbance is synthesized and its water‐dispersed nanoparticles (TSPNs) are investigated as a contrast agent for photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1350 nm). The TSPNs generate a strong PA signal in the NIR‐II optical window, where background signals from endogenous contrast agents, including blood and lipid, are at the local minima. By embedding a TSPN‐containing tube in chicken‐breast tissue, an imaging depth of more than 5 cm at 1064 nm excitation is achieved with a contrast‐agent concentration as low as 40 µg mL−1. The TSPNs under the skin or in the tumor are clearly visualized at 1100 and 1300 nm, with negligible interference from the tissue background. TSPN as a PA contrast in the NIR‐II window opens new opportunities for biomedical imaging of deep tissues with improved contrast.
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Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
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Deep optical imaging of tissue using the second and third near-infrared spectral windows
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Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
Wei, D., Sun, Y., Zhu, H., & Fu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.3c06019 · Cited by 303
Wen, K., Tan, H., Peng, Q., Chen, H., Ma, H., Wang, L., Peng, A., Shi, Q., Cai, X., & Huang, H. (2022) · Advanced Materials · doi:10.1002/adma.202108146 · Cited by 298
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
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Metadata
- Authors
- Wu, J., You, L., Lan, L., Lee, H. J., Chaudhry, S. T., Li, R., Cheng, J., & Mei, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-09-18
- Volume
- 29
- Issue
- 41
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2754873054
- Cited by
- 160
- References
- 5
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
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