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Semiconducting Polymer Nanoparticles for Centimeters‐Deep Photoacoustic Imaging in the Second Near‐Infrared Window

Wu, Jiayingzi, You, Liyan, Lan, Lu, Lee, Hyeon Jeong, Chaudhry, Saadia T., Li, Rui, Cheng, Ji‐Xin, Mei, Jianguo·2017·Advanced Materials

Abstract

Thienoisoindigo‐based semiconducting polymer with a strong near‐infrared absorbance is synthesized and its water‐dispersed nanoparticles (TSPNs) are investigated as a contrast agent for photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1350 nm). The TSPNs generate a strong PA signal in the NIR‐II optical window, where background signals from endogenous contrast agents, including blood and lipid, are at the local minima. By embedding a TSPN‐containing tube in chicken‐breast tissue, an imaging depth of more than 5 cm at 1064 nm excitation is achieved with a contrast‐agent concentration as low as 40 µg mL−1. The TSPNs under the skin or in the tumor are clearly visualized at 1100 and 1300 nm, with negligible interference from the tissue background. TSPN as a PA contrast in the NIR‐II window opens new opportunities for biomedical imaging of deep tissues with improved contrast.

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Metadata

Authors
Wu, J., You, L., Lan, L., Lee, H. J., Chaudhry, S. T., Li, R., Cheng, J., & Mei, J.
Venue
Advanced Materials
Publisher
Wiley
Published
2017-09-18
Volume
29
Issue
41
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2754873054
Cited by
160
References
5
FWCI
8.50
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Semiconducting Polymer Nanoparticles for Centimeters‐Deep Photoacoustic Imaging in the Second Near‐Infrared Window. https://app.cochat.ai/papers/10.1002/adma.201703403
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Wu, J., You, L., Lan, L., Lee, H. J., Chaudhry, S. T., Li, R., Cheng, J., & Mei, J. (2017). Semiconducting Polymer Nanoparticles for Centimeters‐Deep Photoacoustic Imaging in the Second Near‐Infrared Window. Advanced Materials. https://doi.org/10.1002/adma.201703403

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