The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Thiol–Ene Clickable Gelatin: A Platform Bioink for Multiple 3D Biofabrication Technologies
Abstract
Bioprinting can be defined as the art of combining materials and cells to fabricate designed, hierarchical 3D hybrid constructs. Suitable materials, so called bioinks, have to comply with challenging rheological processing demands and rapidly form a stable hydrogel postprinting in a cytocompatible manner. Gelatin is often adopted for this purpose, usually modified with (meth‐)acryloyl functionalities for postfabrication curing by free radical photopolymerization, resulting in a hydrogel that is cross‐linked via nondegradable polymer chains of uncontrolled length. The application of allylated gelatin (GelAGE) as a thiol–ene clickable bioink for distinct biofabrication applications is reported. Curing of this system occurs via dimerization and yields a network with flexible properties that offer a wider biofabrication window than (meth‐)acryloyl chemistry, and without additional nondegradable components. An in‐depth analysis of GelAGE synthesis is conducted, and standard UV‐initiation is further compared with a recently described visible‐light‐initiator system for GelAGE hydrogel formation. It is demonstrated that GelAGE may serve as a platform bioink for several biofabrication technologies by fabricating constructs with high shape fidelity via lithography‐based (digital light processing) 3D printing and extrusion‐based 3D bioprinting, the latter supporting long‐term viability postprinting of encapsulated chondrocytes.
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Cites
Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,182
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146
UV-induced DNA damage and repair: a review
Sinha, R. P., & Häder, D.-P. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b201230h · Cited by 1,978
Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels
Van Den Bulcke, A. I., Bogdanov, B., De Rooze, N., Schacht, E. H., Cornelissen, M., & Berghmans, H. (2000) · Biomacromolecules · doi:10.1021/bm990017d · Cited by 1,536
Fairbanks, B. D., Schwartz, M. P., Bowman, C. N., & Anseth, K. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.055 · Cited by 1,200
Bioink properties before, during and after 3D bioprinting
Hölzl, K., Lin, S., Tytgat, L., Van Vlierberghe, S., Gu, L., & Ovsianikov, A. (2016) · Biofabrication · doi:10.1088/1758-5090/8/3/032002 · Cited by 1,070
Williams, C. G., Malik, A. N., Kim, T. K., Manson, P. N., & Elisseeff, J. H. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.024 · Cited by 899
The power of thiol‐ene chemistry
Kade, M. J., Burke, D. J., & Hawker, C. J. (2010) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.23824 · Cited by 853
Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair
Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J., & Melchels, F. P. W. (2016) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.01.002 · Cited by 846
Bryant, S. J., Nuttelman, C. R., & Anseth, K. S. (2000) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856200743805 · Cited by 774
Cited by
Printability and shape fidelity of bioinks in 3D bioprinting
Schwab, A., Levato, R., D’Este, M., Piluso, S., Eglin, D., & Malda, J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00084 · Cited by 1,359
Biofabrication strategies for 3D in vitro models and regenerative medicine
Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753
Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies
Chimene, D., Kaunas, R., & Gaharwar, A. K. (2020) · Advanced Materials · doi:10.1002/adma.201902026 · Cited by 600
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
Ashammakhi, N., Ahadian, S., Xu, C., Montazerian, H., Ko, H., Nasiri, R., Barros, N., & Khademhosseini, A. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100008 · Cited by 549
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Metadata
- Authors
- Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., Tessmar, J., Hooper, G. J., Woodfield, T. B. F., & Groll, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-10-17
- Volume
- 29
- Issue
- 44
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2765595220
- Cited by
- 331
- References
- 30
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., Tessmar, J., Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol–Ene Clickable Gelatin: A Platform Bioink for Multiple 3D Biofabrication Technologies. Advanced Materials. https://doi.org/10.1002/adma.201703404
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