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Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

Open access
Klotz, Barbara J., Gawlitta, Debby, Rosenberg, Antoine J.W.P., Malda, Jos, Melchels, Ferry P.W.·2016·Trends in Biotechnology

Abstract

Research over the past decade on the cell-biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GelMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GelMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.

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Crossref · 10.1016/j.tibtech.2016.01.002

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Metadata

Authors
Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J., & Melchels, F. P. W.
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2016-05
Volume
34
Issue
5
Pages
394-407
ISSN
0167-7799 (ISSN-L)
OpenAlex
W2263512280
Cited by
846
References
9
FWCI
4.78
Type
journal article
Language
en
Open access
hybrid

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Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J., & Melchels, F. P. W. (2016). Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2016.01.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.