The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Magnetofluorescent Carbon Dot Assembly as an Acidic H2O2‐Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy
Abstract
Recent studies indicate that carbon dots (CDs) can efficiently generate singlet oxygen (1 O 2) for photodynamic therapy (PDT) of cancer. However, the hypoxic tumor microenvironment and rapid consumption of oxygen in the PDT process will severely limit therapeutic effects of CDs due to the oxygen‐dependent PDT. Thus, it is becoming particularly important to develop a novel CD as an in situ tumor oxygenerator for overcoming hypoxia and substantially enhancing the PDT efficacy. Herein, for the first time, magnetofluorescent Mn‐CDs are successfully prepared using manganese(II) phthalocyanine as a precursor. After cooperative self‐assembly with DSPE‐PEG, the obtained Mn‐CD assembly can be applied as a smart contrast agent for both near‐infrared fluorescence (FL) (maximum peak at 745 nm) and T1‐weighted magnetic resonance (MR) (relaxivity value of 6.97 mM−1 s−1) imaging. More interestingly, the Mn‐CD assembly can not only effectively produce 1 O 2 (quantum yield of 0.40) but also highly catalyze H 2 O 2 to generate oxygen. These collective properties of the Mn‐CD assembly enable it to be utilized as an acidic H 2 O 2‐driven oxygenerator to increase the oxygen concentration in hypoxic solid tumors for simultaneous bimodal FL/MR imaging and enhanced PDT. This work explores a new biomedical use of CDs and provides a versatile carbon nanomaterial candidate for multifunctional nanotheranostic applications.
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Cited by
Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications
Liu, J., Li, R., & Yang, B. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c01306 · Cited by 1,936
Evolution and Synthesis of Carbon Dots: From Carbon Dots to Carbonized Polymer Dots
Xia, C., Zhu, S., Feng, T., Yang, M., & Yang, B. (2019) · Advanced Science · doi:10.1002/advs.201901316 · Cited by 1,508
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Self-citationConquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 521
Metadata
- Authors
- Jia, Q., Ge, J., Liu, W., Zheng, X., Chen, S., Wen, Y., Zhang, H., & Wang, P.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-02-13
- Volume
- 30
- Issue
- 13
- Pages
- e1706090-e1706090
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2789450843
- Cited by
- 509
- References
- 5
- FWCI
- 26.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jia, Q., Ge, J., Liu, W., Zheng, X., Chen, S., Wen, Y., Zhang, H., & Wang, P. (2018). A Magnetofluorescent Carbon Dot Assembly as an Acidic H2O2‐Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy. Advanced Materials. https://doi.org/10.1002/adma.201706090
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