The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Highly Efficient Photosensitizers with Far‐Red/Near‐Infrared Aggregation‐Induced Emission for In Vitro and In Vivo Cancer Theranostics
Abstract
Fluorescence‐imaging‐guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such a theranostic material for simultaneously achieving bright emission with long wavelength, high‐performance reactive oxygen species (ROS) generation, and good targeting‐specificity of cancer cells, is highly desirable but remains challenging. In this study, a novel type of far‐red/near‐infrared‐emissive fluorescent molecules with aggregation‐induced emission (AIE) characteristics is synthesized through a few steps reaction. These AIE luminogens (AIEgens) possess simple structures, excellent photostabilities, large Stokes shifts, bright emission, and good biocompatibilities. Meanwhile, their ROS generation is extremely efficient with up to 90.7% of ROS quantum yield, which is far superior to that of some popularly used photosensitizers. Importantly, these AIEgens are able to selectively target and ablate cancer cells over normal cells without the aid of any extra targeting ligands. Rather than using laser light, one of the presented AIEgens (MeTTPy) shows a remarkable tumor‐targeting photodynamic therapeutic effect by using an ultralow‐power lamp light (18 mW cm−2). This study thus not only extends the applications scope of AIEgens, but also offers useful insights into designing a new generation of cancer theranostics.
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Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Self-citationAggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationPhotodynamic therapy for cancer
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Self-citationPhotodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
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Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014) · Advanced Materials · doi:10.1002/adma.201401356 · Cited by 3,381
Self-citationThe Fluorescent Toolbox for Assessing Protein Location and Function
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Photodynamic therapy and anti-tumour immunity
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Functional Nanomaterials for Phototherapies of Cancer
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
Li, J., Wang, J., Li, H., Song, N., Wang, D., & Tang, B. Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00495e · Cited by 741
Self-citationAggregate Science: From Structures to Properties
Zhang, H., Zhao, Z., Turley, A. T., Wang, L., McGonigal, P. R., Tu, Y., Li, Y., Wang, Z., Kwok, R. T. K., Lam, J. W. Y., et al. (2020) · Advanced Materials · doi:10.1002/adma.202001457 · Cited by 518
Self-citationAggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Self-citationZhang, Z., Xu, W., Kang, M., Wen, H., Guo, H., Zhang, P., Xi, L., Li, K., Wang, L., Wang, D., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003210 · Cited by 436
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Metadata
- Authors
- Wang, D., Lee, M. M. S., Shan, G., Kwok, R. T. K., Lam, J. W. Y., Su, H., Cai, Y., & Tang, B. Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-08-22
- Volume
- 30
- Issue
- 39
- Pages
- e1802105-e1802105
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2888586602
- Cited by
- 365
- References
- 44
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, D., Lee, M. M. S., Shan, G., Kwok, R. T. K., Lam, J. W. Y., Su, H., Cai, Y., & Tang, B. Z. (2018). Highly Efficient Photosensitizers with Far‐Red/Near‐Infrared Aggregation‐Induced Emission for In Vitro and In Vivo Cancer Theranostics. Advanced Materials. https://doi.org/10.1002/adma.201802105
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