The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Biomaterials to Mimic and Heal Connective Tissues
Open accessAbstract
Connective tissue is one of the four major types of animal tissue and plays essential roles throughout the human body. Genetic factors, aging, and trauma all contribute to connective tissue dysfunction and motivate the need for strategies to promote healing and regeneration. The goal here is to link a fundamental understanding of connective tissues and their multiscale properties to better inform the design and translation of novel biomaterials to promote their regeneration. Major clinical problems in adipose tissue, cartilage, dermis, and tendon are discussed that inspire the need to replace native connective tissue with biomaterials. Then, multiscale structure–function relationships in native soft connective tissues that may be used to guide material design are detailed. Several biomaterials strategies to improve healing of these tissues that incorporate biologics and are biologic‐free are reviewed. Finally, important guidance documents and standards (ASTM, FDA, and EMA) that are important to consider for translating new biomaterials into clinical practice are highligted.
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Cites
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Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
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Hydrogels with tunable stress relaxation regulate stem cell fate and activity
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Self-citationAdipose-derived stem cells for regenerative medicine
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Cited by
Nam, S., & Mooney, D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00798 · Cited by 764
Self-citationBreakthrough treatments for accelerated wound healing
Freedman, B. R., Hwang, C., Talbot, S., Hibler, B., Matoori, S., & Mooney, D. J. (2023) · Science Advances · doi:10.1126/sciadv.ade7007 · Cited by 447
Self-citationEnhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
Freedman, B. R., Kuttler, A., Beckmann, N., Nam, S., Kent, D., Schuleit, M., Ramazani, F., Accart, N., Rock, A., Li, J., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00810-0 · Cited by 298
Self-citationMultifaceted Design and Emerging Applications of Tissue Adhesives
Ma, Z., Bao, G., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202007663 · Cited by 269
Biomimetic silk fibroin and xanthan gum blended hydrogels for connective tissue regeneration
Byram, P. K., Sunka, K. C., Barik, A., Kaushal, M., Dhara, S., & Chakravorty, N. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.231 · Cited by 67
Metadata
- Authors
- Freedman, B. R., & Mooney, D. J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-03-25
- Volume
- 31
- Issue
- 19
- Pages
- e1806695-e1806695
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2924996440
- Cited by
- 226
- References
- 25
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
