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Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

Open access
Lyu, Yan, Pu, Kanyi·2017·Advanced Science

Abstract

Molecular probes that change their signals in response to the target of interest have a critical role in fundamental biology and medicine. Semiconducting polymer nanoparticles (SPNs) have recently emerged as a new generation of purely organic photonic nanoagents with desirable properties for biological applications. In particular, tunable optical properties of SPNs allow them to be developed into photoluminescence, chemiluminescence, and photoacoustic probes, wherein SPNs usually serve as the energy donor and internal reference for luminescence and photoacoustic probes, respectively. Moreover, facile surface modification and intraparticle engineering provide the versatility to make them responsive to various biologically and pathologically important substances and indexes including small‐molecule mediators, proteins, pH and temperature. This article focuses on recent advances in the development of SPN‐based activatable molecular probes for sensing and imaging. The designs and applications of these probes are discussed in details, and the present challenges to further advance them into life science are also analyzed.

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Metadata

Authors
Lyu, Y., & Pu, K.
Venue
Advanced Science
Publisher
Wiley
Published
2017-02-09
Volume
4
Issue
6
Pages
1600481-1600481
ISSN
2198-3844 (ISSN-L)
OpenAlex
W2586373994
Cited by
248
References
9
FWCI
15.13
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging. https://app.cochat.ai/papers/10.1002/advs.201600481
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Lyu, Y., & Pu, K. (2017). Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging. Advanced Science. https://doi.org/10.1002/advs.201600481

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