The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration
Open accessAbstract
The cytokines released by immune cells are considered important factors to induce bone tissue regeneration. However, the pathway of those bone‐targeting macrophage cytokines induced by biomaterial surface under tissue microenvironment is rarely reported. In this study, the immunomodulatory capability of zinc ions on macrophage polarization and its effects on osteogenic differentiation are investigated. Hence, a layer of zinc ions are incorporated on sulfonated polyetheretherketone (SPEEK) biomaterials by using a customized magnetron sputtering technique. The results reveal that the microenvironment on Zn‐coated SPEEK can modulate nonactivated macrophage polarization to an anti‐inflammatory phenotype and induce the secretion of anti‐inflammatory and osteogenic cytokines. The osteogenic differentiation capability of bone marrow stromal cells (BMSCs) is therefore enhanced, leading to improved osteointegration between the zinc‐coated SPEEK and bone tissue. This study verifies that zinc ion is a promising additive in the osteoimmunomodulation process and provides knowledge that may pave the way to develop the next generation of immunomodulatory biomaterials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100
Spiller, K. L., Nassiri, S., Witherel, C. E., Anfang, R. R., Ng, J., Nakazawa, K. R., Yu, T., & Vunjak-Novakovic, G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.017 · Cited by 773
The roles of vascular endothelial growth factor in bone repair and regeneration
Hu, K., & Olsen, B. R. (2016) · Bone · doi:10.1016/j.bone.2016.06.013 · Cited by 678
Macrophage phenotypes during tissue repair
Novak, M. L., & Koh, T. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012512 · Cited by 658
Characterization of topographical effects on macrophage behavior in a foreign body response model
Chen, S., Jones, J. A., Xu, Y., Low, H.-Y., Anderson, J. M., & Leong, K. W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.074 · Cited by 389
ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB
Liu, M.-J., Bao, S., Gálvez-Peralta, M., Pyle, C. J., Rudawsky, A. C., Pavlovicz, R. E., Killilea, D. W., Li, C., Nebert, D. W., Wewers, M. D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.009 · Cited by 367
Bai, L., Du, Z., Du, J., Yao, W., Zhang, J., Weng, Z., Liu, S., Zhao, Y., Liu, Y., Zhang, X., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.010 · Cited by 265
Self-citationUnraveling macrophage contributions to bone repair
Wu, A. C., Raggatt, L. J., Alexander, K. A., & Pettit, A. R. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.107 · Cited by 256
Cited by
Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration
Zhu, L., Luo, D., & Liu, Y. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0073-y · Cited by 458
Tailoring Materials for Modulation of Macrophage Fate
Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 403
Self-citationScaffolds for bone-tissue engineering
Lee, S. S., Du, X., Kim, I., & Ferguson, S. J. (2022) · Matter · doi:10.1016/j.matt.2022.06.003 · Cited by 375
On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook
Montoya, C., Du, Y., Gianforcaro, A. L., Orrego, S., Yang, M., & Lelkes, P. I. (2021) · Bone Research · doi:10.1038/s41413-020-00131-z · Cited by 298
Wang, T., Bai, J., Lu, M., Huang, C., Geng, D., Chen, G., Wang, L., Qi, J., Cui, W., & Deng, L. (2022) · Nature Communications · doi:10.1038/s41467-021-27816-1 · Cited by 221
Metadata
- Authors
- Liu, W., Li, J., Cheng, M., Wang, Q., Yeung, K. W. K., Chu, P. K., & Zhang, X.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2018-08-07
- Volume
- 5
- Issue
- 10
- Pages
- 1800749-1800749
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W2885316173
- Cited by
- 301
- References
- 10
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration. https://app.cochat.ai/papers/10.1002/advs.201800749
- The paper
- Liu, W., Li, J., Cheng, M., Wang, Q., Yeung, K. W. K., Chu, P. K., & Zhang, X. (2018). Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration. Advanced Science. https://doi.org/10.1002/advs.201800749
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
