Silk‐Enabled Conformal Multifunctional Bioelectronics for Investigation of Spatiotemporal Epileptiform Activities and Multimodal Neural Encoding/Decoding
Open accessAbstract
Flexible electronics can serve as powerful tools for biomedical diagnosis and therapies of neurological disorders, particularly for application cases with brain–machine interfaces (BMIs). Existing conformal soft bioelectrodes are applicable for basic electrocorticogram (ECoG) collecting/monitoring. Nevertheless, as an emerging and promising approach, further multidisciplinary efforts are still demanded for in‐depth exploitations with these conformal soft electronics toward their practical neurophysiological applications in both scientific research and real‐world clinical operation. Here, clinically‐friendly silk‐supported/delivered soft bioelectronics are developed, and multiple functions and features valuable for customizable intracranial applications (e.g., biocompatible and spontaneously conformal coupling with cortical surface, spatiotemporal ECoG detecting/monitoring, electro‐neurophysiological neural stimulating/decoding, controllable loading/delivery of therapeutic molecules, and parallel optical readouts of operating states) are integrated.
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- Authors
- Shi, Z., Zheng, F., Zhou, Z., Li, M., Fan, Z., Ye, H., Zhang, S., Xiao, T., Chen, L., Tao, T. H., Sun, Y., & Mao, Y.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Chinese Academy of Sciences (CN)
- Harvard University (US)
- Shanghai Jiao Tong University (CN)
- Jilin University (CN)
- Corresponding author
- Tao, Tiger H.
- Sun, Yun‐Lu
- Mao, Ying
- ORCID
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2019-03-07
- Volume
- 6
- Issue
- 9
- Pages
- 1801617-1801617
- ISSN
- 2198-3844 (ISSN-L)
- PMC
- PMC6498121
- OpenAlex
- W2922029517
- Cited by
- 94
- References
- 4
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 22 · 2023: 12 · 2022: 15 · 2021: 12 · 2020: 9 · 2019: 3
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Advanced Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (61822406)
- Shanghai Natural Science Foundation (16ZR1442500)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- silk, electrocorticography, epileptiform activity, neural decoding, neurostimulation, brain-computer interface, biocompatible electrodes, drug delivery, optical readout, flexible electronics, neuromonitoring
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