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Cited by 174Genetics and Neurodevelopmental DisordersAttention Deficit Hyperactivity DisorderAutism Spectrum Disorder Research

ADHD symptoms in children with FXS

Sullivan, Kelly, Hatton, Deborah, Hammer, Julie, Sideris, John, Hooper, Stephen, Ornstein, Peter, Bailey, Donald·2006·American Journal of Medical Genetics Part A
DOI 10.1002/ajmg.a.31388
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Abstract

Parent‐ and teacher‐report of attention‐deficit/hyperactivity disorder (ADHD) symptoms were examined using problem behavior and DSM‐IV symptom inventory questionnaires for 63 children with full mutation fragile X syndrome (FXS) and 56 children without disabilities matched on mental age (MA). Prevalence rates of ADHD symptoms varied depending on type of measure (problem behavior or DSM‐IV criteria), subscale (ADHD‐inattentive or ADHD‐hyperactive), scoring method (continuous T‐scores or categorical scores based on DSM‐IV algorithm), and rater (parent or teacher). Overall, 54–59% of boys with FXS met diagnostic behavioral criteria for either ADHD‐inattentive type only, ADHD‐hyperactive type only, or ADHD‐combined type based on parent or teacher report. Boys with FXS were rated as having clinically high scores or met diagnostic criteria at higher rates than expected for the general population and had higher raw scores than their MA‐matched peers. Parent ratings of boys with FXS resulted in higher ADHD‐inattentive type and ADHD‐hyperactive type T‐scores than teachers. Boys who were rated as meeting DSM‐IV criteria were more likely to be taking psychotropic medication and to have younger mental ages. Parents were substantially more likely than teachers to rate boys as meeting DSM‐IV criteria for ADHD‐inattentive type, while teachers were only slightly more likely than parents to rate boys as meeting DSM‐IV criteria for ADHD‐hyperactive type. Teachers were more likely than parents to rate boys as meeting DSM‐IV criteria for ADHD when boys had lower levels of FMRP. © 2006 Wiley‐Liss, Inc.

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  • Boys with fragile X syndrome typically show ADHD with impulsivity and anxiety, repetitive language, hand biting, hand stereotypies, rocking, and sometimes head banging.

    “The behavior of boys with FXS typically includes attention deficit hyperactivity disorder (ADHD), with significant impulsivity and anxiety, as well as behaviors that include repetitive language, hand biting, hand stereotypies, rocking, and sometimes head banging (24,25).”

    From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [25]

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Authors
Sullivan, K., Hatton, D., Hammer, J., Sideris, J., Hooper, S., Ornstein, P., & Bailey, D.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Hatton, Deborah
ORCID
Venue
American Journal of Medical Genetics Part A
Publisher
Wiley
Published
2006-10-04
Volume
140A
Issue
21
Pages
2275-2288
ISSN
  • 1552-4825 (ISSN-L)
  • 1552-4833
DOI
10.1002/ajmg.a.31388
OpenAlex
W2035631323
Cited by
174
References
59
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 12 · 2013: 9 · 2012: 8
FWCI
4.35
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • American Journal of Medical Genetics Part A (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (1-R01-HD40602-01, R01HD040602)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, fragile X syndrome, full mutation, inattentive subtype, combined type, parent report, teacher reports, rater differences, DSM-IV diagnostic criteria, FMRP, psychotropic drugs, behavioral problems, prevalence, boys
MeSH terms
Adolescent, Adolescent Behavior, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Biometry, Child, Child Behavior, Faculty, Fragile X Syndrome, Humans, Male, Parents, Surveys and Questionnaires, Case-Control Studies

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