Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder
Abstract
Attention deficit hyperactivity disorder (ADHD) is a highly heritable disorder. Although the causes of ADHD are unknown, dopaminergic, serotonergic and nor‐adrenergic pathways have been strongly implicated. Monoamine Oxidase A (MAOA) is involved in the degradation of all three of these neurotransmitters and therefore has been suggested as a strong candidate gene for ADHD. Animal and human studies have implicated MAOA and 5‐HT in impulsive and aggressive behavior. We therefore additionally postulated that MAOA might be associated with a subtype of ADHD where aggressive and impulsive features are especially prominent. We have tested this hypothesis by genotyping two polymorphisms (the 30‐bp VNTR in the promoter and the Fnu4HI 941T→G) in MAOA that are associated with altered MAOA function. Our sample consisted of 171 British Caucasian children 6–16 years of age fulfilling DSM‐III R, DSM‐IV or ICD‐10 criteria for ADHD/Hyperkinetic Disorder. Using case control analysis and then the TDT, no association was found between these two MAOA polymorphisms and ADHD. Case control analysis of the VNTR showed an association with a subgroup of children with comorbid conduct problems (OR = 2.0, 95% CI = 1.09, 3.5), and TDT analysis indicated a statistical trend toward association. Our findings highlight the importance of phenotype definition and the need for the MAOA VNTR to be further examined. © 2003 Wiley‐Liss, Inc.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The first study investigating MAOA-uVNTR and childhood aggressive behavior in the context of ADHD reported that low transcription (3 R only) alleles were associated with higher aggression among children with ADHD.
“The first study that investigated the association between MAOA-uVNTR and childhood aggressive behavior in the context of ADHD reported that low transcription (3 R only) alleles of MAOA-uVNTR was associated with higher aggression among children with ADHD [43].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [43]
Cites
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.5.564 · Cited by 1,738 · see citing works
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644 · see citing works
BARKLEY, R. A., FISCHER, M., EDELBROCK, C. S., & SMALLISH, L. (1990) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199007000-00007 · Cited by 1,507 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
MONOAMINE OXIDASE: From Genes to Behavior
Shih, J. C., Chen, K., & Ridd, M. J. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.197 · Cited by 1,211 · see citing works
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079 · see citing works
The Child and Adolescent Psychiatric Assessment (CAPA)
Angold, A., Prendergast, M., Cox, A., Harrington, R., Simonoff, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s003329170003498x · Cited by 968 · see citing works
The TDT and other family-based tests for linkage disequilibrium and association.
(1996) · PubMed Central · Cited by 901 · see citing works
Comorbidity in ADHD: implications for research, practice, and DSM-V.
Jensen, P., Martin, D., & Cantwell, D. (1997) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199708000-00014 · Cited by 839 · see citing works
Structure and function of dopamine receptors
Vallone, D., Picetti, R., & Borrelli, E. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00063-9 · Cited by 821 · see citing works
Neurobiology of attention-deficit hyperactivity disorder
Faraone, S. V., & Biederman, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00240-6 · Cited by 811 · see citing works
Faraone, S., Doyle, A., Mick, E., & Biederman, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1052 · Cited by 740 · see citing works
Attention-Deficit Hyperactivity Disorder
Barkley, R. A. (1998) · Scientific American · doi:10.1038/scientificamerican0998-66 · Cited by 688 · see citing works
Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677 · see citing works
An extended transmission/disequilibrium test (TDT) for multi‐allele marker loci
Sham, P. C., & Curtis, D. (1995) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1995.tb00751.x · Cited by 609 · see citing works
Deckert, J., Catalano, M., Syagailo, Y. V., Bosi, M., Okladnova, O., Di Bella, D., Nothen, M. M., Maffei, P., Franke, P., Fritze, J., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.621 · Cited by 582 · see citing works
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00162-1 · Cited by 486 · see citing works
Genetic basis of attention deficit and hyperactivity
Thapar, A., Holmes, J., Poulton, K., & Harrington, R. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.174.2.105 · Cited by 399 · see citing works
Self-citationATTENTION-DEFICIT/HYPERACTIVITY DISORDER AND COMORBIDITY
Spencer, T. J., Biederman, J., & Wilens, T. (1999) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70163-2 · Cited by 271 · see citing works
Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design
Thapar, A., Harrington, R., & McGuffin, P. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.3.224 · Cited by 266 · see citing works
Self-citationHuman monoamine oxidase A gene determines levels of enzyme activity.
Hotamışlıgil, G. S., & Breakefield, X. O. (1991) · PubMed · Cited by 264 · see citing works
The Epidemiology of Childhood Hyperactivity
Garralda, M. E. (1992) · Archives of Disease in Childhood · doi:10.1136/adc.67.8.1060-b · Cited by 217 · see citing works
Impact of Comorbid Oppositional or Conduct Problems on Attention-Deficit Hyperactivity Disorder
KUHNE, M., SCHACHAR, R., & TANNOCK, R. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199712000-00020 · Cited by 209 · see citing works
Lahey, B. B., Applegate, B. E., Barkley, R. A., Garfinkel, B. D., McBurnett, K., KERDYK, L., Greenhill, L. L., Hynd, G. W., Frick, P. J., & Newcorn, J. H. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1163 · Cited by 189 · see citing works
The neurobiology of attention-deficit/hyperactivity disorder.
Zametkin, A. J., & Liotta, W. (1998) · PubMed · Cited by 173 · see citing works
Payton, A., Holmes, J., Barrett, J., Hever, T., Fitzpatrick, H., Trumper, A., Harrington, R., McGuffin, P., O'DONOVAN, M., Owen, M., et al. (2001) · American journal of medical genetics · doi:10.1002/ajmg.1407 · Cited by 132 · see citing works
Self-citationSeeger, G., Schloss, P. D., & Schmidt, M. H. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000820 · Cited by 124 · see citing works
Faraone, S. V., Biederman, J., Mennin, D. S., Russell, R. L., & Tsuang, M. T. (1998) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00407 · Cited by 108 · see citing works
Association of DRD4 in children with ADHD and comorbid conduct problems
Holmes, J., Payton, A., Barrett, J. H., Harrington, R., McGuffin, P., Owen, M. J., Ollier, W., Worthington, J., Gill, M., Kirley, A., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10149 · Cited by 101 · see citing works
Self-citationFurlong, R. A., Ho, L. W., Rubinsztein, J. S., Walsh, C., Paykel, E. S., & Rubinsztein, D. C. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 100 · see citing works
Lajard, A.-M., Bou, C., Monteau, R., & Hilaire, G. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)01012-x · Cited by 24 · see citing works
No evidence of linkage or association between ADHD and DXS7 locus in Irish population
Lowe, N., Hawi, Z., Fitzgerald, M., & Gill, M. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1357 · Cited by 10 · see citing works
Donnelly, S. L., Wolpert, C. M., Menold, M. M., Bass, M. P., Gilbert, J. R., Cuccaro, M. L., Delong, G. R., & Pericak-Vance, M. A. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20000612)96:3
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
Genetics of attention deficit hyperactivity disorder
Faraone, S. V., & Larsson, H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0070-0 · Cited by 1,338 · see citing works
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020 · see citing works
Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Aneey, R., Franke, B., Gill, M., Ebstein, R., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001869 · Cited by 533 · see citing works
Mayes, S. D., & Calhoun, S. L. (2007) · Child Neuropsychology · doi:10.1080/09297040601112773 · Cited by 420 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · see citing works
Attention-Deficit Hyperactivity Disorder (ADHD)
Voeller, K. K. S. (2004) · Journal of Child Neurology · doi:10.1177/08830738040190100901 · Cited by 289 · see citing works
Two Genes Predict Voter Turnout
Fowler, J., & Dawes, C. T. (2008) · Journal of Politics · doi:10.1017/s0022381608080638 · Cited by 271 · see citing works
Newman, T. K., Syagailo, Y. V., Barr, C. S., Wendland, J. R., Champoux, M., Grässle, M., Suomi, S. J., Higley, J. D., & Lesch, K. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.012 · Cited by 257 · see citing works
Genetics of Attention Deficit Hyperactivity Disorder
Mick, E. O., & Faraone, S. V. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.11.011 · Cited by 230 · see citing works
Social conflict models: Can they inform us about human psychopathology?
Huhman, K. L. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.022 · Cited by 243 · see citing works
Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)
Cai, Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2040 · Cited by 216 · see citing works
Molecular genetic studies of ADHD: 1991 to 2004
Bobb, A. J., Castellanos, F. X., Addington, A. M., & Rapoport, J. L. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30086 · Cited by 188 · see citing works
Ficks, C. A., & Waldman, I. D. (2014) · Behavior Genetics · doi:10.1007/s10519-014-9661-y · Cited by 182 · see citing works
The genetics of attention deficit hyperactivity disorder
Waldman, I. D., & Gizer, I. R. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.01.007 · Cited by 149 · see citing works
Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update
Tripathi, R. K. P., & Ayyannan, S. R. (2019) · Medicinal Research Reviews · doi:10.1002/med.21561 · Cited by 136 · see citing works
Biological correlates of intimate partner violence perpetration
Pinto, L. A., Sullivan, E. L., Rosenbaum, A., Wyngarden, N., Umhau, J. C., Miller, M. W., & Taft, C. T. (2010) · Aggression and Violent Behavior · doi:10.1016/j.avb.2010.07.001 · Cited by 123 · see citing works
Pinsonneault, J. K., Papp, A. C., & Sadée, W. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl192 · Cited by 114 · see citing works
Contini, V., Marques, F. Z., Garcia, C. E. D., Hutz, M. H., & Bau, C. H. D. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30290 · Cited by 110 · see citing works
Regulation of monoamine oxidase A by the SRY gene on the Y chromosome
Wu, J. B., Chen, K., Li, Y., Lau, Y. C., & Shih, J. C. (2009) · The FASEB Journal · doi:10.1096/fj.09-139097 · Cited by 110 · see citing works
Guan, L., Wang, B., Chen, Y., Yang, L., Li, J., Qian, Q., Wang, Z., Faraone, S. V., & Wang, Y.-T. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002139 · Cited by 105 · see citing works
Hessl, D. R., Tassone, F., Cordeiro, L., Koldewyn, K., McCormick, C. E. B., Green, C. C., Wegelin, J. A., Yuhas, J. M., & Hagerman, R. J. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0365-5 · Cited by 105 · see citing works
The importance of stress and genetic variation in human aggression
Craig, I. (2007) · BioEssays · doi:10.1002/bies.20538 · Cited by 104 · see citing works
Role of the serotonin system in ADHD: treatment implications
Oades, R. D. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.10.1357 · Cited by 92 · see citing works
Genetic and Environmental Overlap between Low Self-Control and Delinquency
Boisvert, D. L., WRIGHT, J. P., Knopik, V. S., & Vaske, J. C. (2011) · Journal of Quantitative Criminology · doi:10.1007/s10940-011-9150-x · Cited by 82 · see citing works
Domschke, K., Sheehan, K., Lowe, N., Kirley, A., Mullins, C., O’Sullivan, R. J., Freitag, C., Becker, T., Conroy, J., Fitzgerald, M., et al. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30158 · Cited by 89 · see citing works
Monoamine oxidase A gene is associated with borderline personality disorder
Ni, X., Sicard, T., Bulgin, N., Bismil, R., Chan, K., McMain, S., & Kennedy, J. L. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328016831c · Cited by 79 · see citing works
Ducci, F., Newman, T. K., Funt, S. A., Brown, G. L., Virkkunen, M. E., & Goldman, D. A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001856 · Cited by 66 · see citing works
Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene
Davis, L. K., Hazlett, H. C., Librant, A. L., Nopoulos, P., Sheffield, V. C., Piven, J., & Wassink, T. H. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30738 · Cited by 66 · see citing works
Das, M., Das Bhowmik, A., Sinha, S., Chattopadhyay, A., Chaudhuri, K., Singh, M., & Mukhopadhyay, K. (2006) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30385 · Cited by 63 · see citing works
Xu, X.-H., Brookes, K., Chen, C.-K., Huang, Y.-S., Wu, Y., & Asherson, P. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-10 · Cited by 30 · see citing works
Genetic associations with reflexive visual attention in infancy and childhood
Lundwall, R. A., Dannemiller, J. L., & Goldsmith, H. H. (2015) · Developmental Science · doi:10.1111/desc.12371 · Cited by 54 · see citing works
Heiser, P., Dempfle, A., Friedel, S., Konrad, K., Hinney, A., Kiefl, H., Walitza, S., Bettecken, T., Saar, K., Linder, M., et al. (2006) · Journal of neural transmission · doi:10.1007/s00702-006-0584-5 · Cited by 54 · see citing works
Malmberg, K., Wargelius, H., Lichtenstein, P., Oreland, L., & Larsson, J. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-28 · Cited by 58 · see citing works
Organization of MAO A and MAO B Promoters and Regulation of Gene Expression
Chen, K. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(03)00113-x · Cited by 50 · see citing works
Roohi, J., DeVincent, C. J., Hatchwell, E., & Gadow, K. D. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0600-8 · Cited by 48 · see citing works
Kanarik, M., Grimm, O., Mota, N. R., Reif, A., & Harro, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104757 · Cited by 48 · see citing works
Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.
Das, M., Bhowmik, A. D., Bhaduri, N., Sarkar, K., Ghosh, P., Sinha, S., Ray, A., Chatterjee, A., & Mukhopadhyay, K. (2011) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.027 · Cited by 47 · see citing works
Parent-of-origin effects in attention-deficit hyperactivity disorder
Goos, L. M., Ezzatian, P., & Schachar, R. J. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2006.08.006 · Cited by 40 · see citing works
Li, J. J., & Lee, S. S. (2012) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-011-9553-z · Cited by 38 · see citing works
Liu, L., Guan, L., Chen, Y., Ji, N., Li, H.-M., Li, Z.-H., Qian, Q., Yang, L., Glatt, S., Faraone, S., et al. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31217 · Cited by 40 · see citing works
Li, J., Wang, Y.-F., Zhou, R., Zhang, H.-B., Yang, L., Wang, B., & Faraone, S. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.022 · Cited by 36 · see citing works
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
Qian, Q., Liu, J., Wang, Y.-F., Yang, L., Guan, L., & Faraone, S. (2009) · Behavioral and Brain Functions · doi:10.1186/1744-9081-5-8 · Cited by 86 · see citing works
A genetic study of ADHD and activity level in infancy
Ilott, N. E., Saudino, K. J., Wood, A. C., & Asherson, P. J. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00560.x · Cited by 33 · see citing works
Wendland, J. R., Hampe, M., Newman, T. K., Syagailo, Y. V., Meyer, J., Schempp, W., Timme, A., Suomi, S. J., & Lesch, K. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00130.x · Cited by 32 · see citing works
The monoamine oxidase B gene exhibits significant association to ADHD
Li, J., Wang, Y., Hu, S., Zhou, R., Yu, X., Wang, B., Guan, L., Yang, L., Zhang, F., & Faraone, S. V. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30606 · Cited by 29 · see citing works
McDermott, R., Dawes, C., Prom‐Wormley, E. C., Eaves, L. J., & Hatemi, P. (2012) · Journal of Conflict Resolution · doi:10.1177/0022002712457746 · Cited by 26 · see citing works
The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4
Su, S.-Y., Chen, J. J.-H., Lai, C., Chen, C., & Tsai, F. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0213-6 · Cited by 25 · see citing works
The Role of Serotonin in Attention-Deficit Hyperactivity Disorder (ADHD)
Oades, R. D. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70101-6 · Cited by 23 · see citing works
Méta-analyse des gènes candidats dans le trouble déficit attentionnel avec hyperactivité (TDAH)
Wohl, M., Purper‐Ouakil, D., Mouren, M., Adès, J., & Gorwood, P. A. P. M. (2005) · L Encéphale · doi:10.1016/s0013-7006(05)82405-4 · Cited by 23 · see citing works
Stressful life events and adolescent drug use: Moderating influences of the MAOA gene
Stogner, J. M., & Gibson, C. L. (2013) · Journal of Criminal Justice · doi:10.1016/j.jcrimjus.2013.06.003 · Cited by 22 · see citing works
Eusebi, P. G., Sevane, N., Cortés, O., Contreras, E., Cañon, J., & Dunner, S. (2020) · Animal Genetics · doi:10.1111/age.12867 · Cited by 21 · see citing works
Is there a genetic susceptibility to engage in criminal acts
Morley, K. I., & Hall, W. (2003) · DigitalGeorgetown (Georgetown University Library) · Cited by 21 · see citing works
Fluorescent Peptide-PNA Chimeras for Imaging Monoamine Oxidase A mRNA in Neuronal Cells
Sethi, D., Chen, C.-P., Jing, R.-Y., Thakur, M., & Wickstrom, E. (2012) · Bioconjugate chemistry · doi:10.1021/bc2004507 · Cited by 18 · see citing works
Xu, X.-H., Brookes, K., Sun, B., Ilott, N., & Asherson, P. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-71 · Cited by 19 · see citing works
A Twin Study of Sex Differences in Self-Control
Boisvert, D. L., WRIGHT, J. P., Knopik, V. S., & Vaske, J. C. (2011) · Justice Quarterly · doi:10.1080/07418825.2011.610762 · Cited by 19 · see citing works
Eo, J., Lee, H.-E., Nam, G.-H., Kwon, Y., Choi, Y., Choi, B., Huh, J., Kim, M., Lee, S.-E., Seo, B., et al. (2016) · Gene · doi:10.1016/j.gene.2016.01.022 · Cited by 18 · see citing works
Ilott, N., Saudino, K., & Asherson, P. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-102 · Cited by 20 · see citing works
Biochemical markers and genetic research of ADHD.
Paclt, I., Koudelová, J., Křepelová, A., Uhlíková, P., Gazdíková, M., & Bauer, P. O. (2005) · PubMed · Cited by 18 · see citing works
Karmakar, A., Maitra, S., Verma, D., Chakraborti, B., Goswami, R., Ghosh, P., Sinha, S., Mohanakumar, K. P., Usha, R., & Mukhopadhyay, K. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1276-4 · Cited by 15 · see citing works
Chappell, G. A., Britt, J. K., & Borghoff, S. J. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111310 · Cited by 16 · see citing works
The MAOA Gene Predicts Credit Card DebtPreprint
Jan-emmanuel De Neve, A., & Fowler, J. H. (2010) · SSRN Electronic Journal · doi:10.2139/ssrn.1457224 · Cited by 15 · see citing works
Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese
Lin, Y.-M. J., Davamani, F. A., Yang, W.-C., Lai, T., & Sun, H. S. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-21 · Cited by 14 · see citing works
Wargelius, H., Malmberg, K., Larsson, J., & Oreland, L. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328347c1ab · Cited by 14 · see citing works
Karmakar, A., Goswami, R., Saha, T., Maitra, S., Roychowdhury, A., Panda, C. K., Sinha, S., Ray, A., Mohanakumar, K. P., Rajamma, U., et al. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0469-5 · Cited by 14 · see citing works
El-Tarras, A. E., Alsulaimani, A. A., Awad, N. S., Mitwaly, N., Said, M. M., & Sabry, A. M. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2012-2 · Cited by 13 · see citing works
Misener, V. L., & Barr, C. L. (2008) · Nucleic acids and molecular biology · doi:10.1007/978-3-540-85383-1_4 · Cited by 13 · see citing works
Teramoto, S., Soeda, A., Hayashi, Y., Saito, K., & Urashima, M. (2005) · Early Human Development · doi:10.1016/j.earlhumdev.2004.12.011 · Cited by 12 · see citing works
Hwang, I. W., Lim, M. H., Kwon, H., & Jin, H. J. (2018) · Medicina · doi:10.3390/medicina54030032 · Cited by 12 · see citing works
Lung, F., Yang, P., Cheng, T.-S., & Kao, W.-T. (2006) · Neuropsychobiology · doi:10.1159/000098649 · Cited by 12 · see citing works
Gandy, K. C., Sapkota, Y., Scoggins, M., Jacola, L. M., Koscik, T. R., Hudson, M. M., Pui, C., Krull, K. R., & van der Plas, E. A. A. (2023) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkad039 · Cited by 10 · see citing works
Nishioka, S. A., Perin, E. A., Sampaio, A. S., Cordeiro, Q., Cappi, C., Mastrorosa, R. S., Morais, I. A., Reis, V. N. D. S., do Rosário, M. C., & Hounie, A. G. (2011) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832011000100008 · Cited by 10 · see citing works
Brummett, B. H., Boyle, S. H., Siegler, I. C., Zuchner, S. L., Ashley‐Koch, A. E., & Williams, R. B. (2008) · PubMed · Cited by 10 · see citing works
Rehan, W., Sandnabba, N. K., Johansson, A., Westberg, L., & Santtila, P. O. (2015) · Nordic Psychology · doi:10.1080/19012276.2015.1026922 · Cited by 9 · see citing works
Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence
Kõks, G., Prans, E., Ho, X. D., Duy, B. H., Tran, H. D., Ngo, N. B. T., Hoang, L. N. N., Tran, H. M. T., Bubb, V. J., Quinn, J. P., et al. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220916888 · Cited by 9 · see citing works
Credit card borrowing and the monoamine oxidase A (MAOA) gene
Jan-emmanuel De Neve, A., & Fowler, J. (2014) · Journal of Economic Behavior & Organization · doi:10.1016/j.jebo.2014.03.002 · Cited by 9 · see citing works
Serum level of semicarbazide-sensitive amine oxidase in children with ADHD
Roessner, V., Uebel, H., Becker, A., Beck, G., Bleich, S., & Rothenberger, A. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-5 · Cited by 9 · see citing works
The Roles of Norepinephrine and Serotonin in Attention Deficit Hyperactivity Disorder
Oades, R. D. (2005) · Contemporary clinical neuroscience · doi:10.1385/1-59259-891-9:097 · Cited by 9 · see citing works
Yang, Q., Ikemoto, K., Nishino, S., Yamaki, J., Kunii, Y., Wada, A., Homma, Y., & Niwa, S. (2012) · Open Journal of Psychiatry · doi:10.4236/ojpsych.2012.224053 · Cited by 8 · see citing works
Towards a Neurodevelopmental Model of Clinical Case Formulation
Solomon, M., Hessl, D. R., Chiu, S., Olsen, E., & Hendren, R. L. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2008.11.003 · Cited by 8 · see citing works
Gao, Q., Liu, L., Li, H.-M., Tang, Y.-L., Wu, Z.-M., Chen, Y., Wang, Y.-F., & Qian, Q. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32273 · Cited by 8 · see citing works
Dopamine System Genes and ADHD: A Review of the Evidence
Barr, C. L., & Misener, V. L. (2008) · Future Neurology · doi:10.2217/14796708.3.6.705 · Cited by 6 · see citing works
Rethinking Gottfredson and Hirschi's General Theory of Crime: A Behavioral Genetic Approach
Boisvert, D. L. (2009) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 5 · see citing works
Genetic and Environmental Influences on Criminal Behavior
Rae, M. N. (2006) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 5 · see citing works
MAOA Influences the Trajectory of Attentional Development
Lundwall, R. A., & Rasmussen, C. G. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00424 · Cited by 5 · see citing works
Surajambika, R. R., Ramalakshmi, N., Nalini, C. N., & Amuthalakshmi, S. (2022) · RASAYAN Journal of Chemistry · doi:10.31788/rjc.2022.1547080 · Cited by 5 · see citing works
Novel variable number of tandem repeats of gibbon MAOA gene and its evolutionary significance
Choi, Y., Jung, Y.-D., Ayarpadikannan, S., Koga, A., Imai, H., Hirai, H., Roos, C., & Kim, H. (2014) · Genome · doi:10.1139/gen-2014-0065 · Cited by 4 · see citing works
Provençal, N., Shink, É., Harvey, M., Tremblay, M., & Barden, N. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.07.001 · Cited by 3 · see citing works
The role of genes and abuse in the etiology of offending
Vaske, J. C. (2009) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 3 · see citing works
Improved approaches to genotyping MAOA-uVNTR polymorphisms with novel allele discovery
Hnoonual, A., Graidist, P., & Limprasert, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-10525-w · Cited by 2 · see citing works
Beaver, K. M. (2006) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 2 · see citing works
El-Din, A. M. M. G., Ali, N. H., Swelim, H. H., Amr, K. S., & Effat, L. K. (2014) · IOSR Journal of Pharmacy and Biological Sciences · doi:10.9790/3008-09273842 · Cited by 2 · see citing works
Perry, G. M. L., & Faraone, S. V. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139035491.016 · Cited by 2 · see citing works
Hashmi, A. N., Taj, R., Agha, Z., Qamar, R., Williams, J. B., & Azam, M. (2025) · Biomedicines · doi:10.3390/biomedicines13030698 · Cited by 1 · see citing works
Wattanathorn, J., Muchimapura, S., Thukham-mee, W., & Tong-un, T. (2025) · Life · doi:10.3390/life15071093 · Cited by 1 · see citing works
Neurogenetics, Genome-Wide Association and Candidate Gene Studies
Haller, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-46331-1_3 · Cited by 1 · see citing works
Nishioka, S. A., Perin, E. A., Sampaio, A. S., Cordeiro, Q., Cappi, C., Morais, I. A., Neri, V., dos Reis, S., do Rosário, M. C., & Hounie, A. G. (2011)
Marques, F. Z. (2006) · Americanae (AECID Library)
- Authors
- Lawson, D. C., Turic, D., Langley, K., Pay, H. M., Govan, C. F., Norton, N., Hamshere, M. L., Owen, M. J., O'Donovan, M. C., & Thapar, A.
- Affiliations
- University of Wales (GB)
- Corresponding author
- Thapar, Anita
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2002-12-19
- Volume
- 116B
- Issue
- 1
- Pages
- 84-89
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2062199416
- Cited by
- 108
- References
- 34
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 9 · 2013: 2 · 2012: 4
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- attention deficit hyperactivity disorder, monoamine oxidase A, conduct problems, candidate gene association, hyperkinetic disorder, children, phenotype definition
- MeSH terms
- Adolescent, Alleles, Attention Deficit Disorder with Hyperactivity, Child, DNA, Gene Frequency, Genotype, Humans, Monoamine Oxidase, Case-Control Studies, Minisatellite Repeats, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
