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Genetic variants implicated in personality: A review of the more promising candidates
Abstract
Alleles of the serotonin transporter gene ( SERT ) and the dopamine 4 receptor gene ( DRD4 ) were first associated with anxiety‐related and novelty‐seeking personality traits, respectively, in 1996. These early successes precipitated a flood of research into the genetic basis of personality; a quest that has yet to yield decisive answers. Here, both the theoretical and the empirical evidence implicating specific loci—in particular SERT and DRD4—in the development of personality is evaluated. Despite a paucity of statistically significant results following post‐hoc analysis, and an excess of positive results derived from studies with small sample sizes, the existence of a genuine effect is argued for: a gene‐personality relationship rendered periodically latent through genetic epistasis, gene–environment interactions, variation in genetic background, and the presence of other confounding variables. © 2004 Wiley‐Liss, Inc.
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“a single nucleotide polymorphism in the gene coding for the dopamine-4 receptor has been associated with individual variation in novelty seeking and behavioural inhibition in humans and animals”
From Coping styles and behavioural flexibility: towards underlying mechanisms (2010) · cites this paper as Savitz & Ramesar 2004
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Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
Henry, M. A. (1995) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1995.0108 · Cited by 3,416
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Depue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046
Darwin's dangerous idea : evolution and the meanings of life
Dennett, D. C. (1995) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,998
Temperament and personality: Origins and outcomes.
Rothbart, M. K., Ahadi, S. A., & Evans, D. E. (2000) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.78.1.122 · Cited by 1,829
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996) · Nature Genetics · doi:10.1038/ng0196-78 · Cited by 1,475
Population stratification and spurious allelic association
Cardon, L. R., & Palmer, L. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12520-2 · Cited by 1,204
Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996) · Nature Genetics · doi:10.1038/ng0196-81 · Cited by 1,194
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,179
Genes, evolution, and personality
Bouchard, T. J., & Loehlin, J. C. (2001) · Behavior Genetics · doi:10.1023/a:1012294324713 · Cited by 1,085
Heritability of the Big Five Personality Dimensions and Their Facets: A Twin Study
Jang, K. L., Livesley, W. J., & Vemon, P. A. (1996) · Journal of Personality · doi:10.1111/j.1467-6494.1996.tb00522.x · Cited by 939
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031157.x · Cited by 858
Genes and environment in personality development
Loehlin, J. C. (1992) · DigitalGeorgetown (Georgetown University Library) · Cited by 799
Vallée, M., Mayo, W., Dellu-Hagedorn, F., Moal, M. L., Simon, H., & Maccari, S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02626.1997 · Cited by 787
Four ways five factors are not basic
Eysenck, H. J. (1992) · Personality and Individual Differences · doi:10.1016/0191-8869(92)90237-j · Cited by 751
Selective Alteration of Personality and Social Behavior by Serotonergic Intervention
Knutson, B., Wolkowitz, O. M., Cole, S. W., Chan, T., Moore, E. A., Johnson, R. C., Terpstra, J., Turner, R. A., & Reus, V. I. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.3.373 · Cited by 500
Evidence of positive selection acting at the human dopamine receptor D4 gene locus
Ding, Y.-C., Chi, H.-C., Grady, D. L., Morishima, A., Kidd, J. R., Kidd, K. K., Flodman, P., Spence, M. A., Schuck, S., Swanson, J. M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012464099 · Cited by 498
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00162-1 · Cited by 488
de Lima, A. D., Bloom, F. E., & Morrison, J. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740211 · Cited by 459
Riemann, R., Angleitner, A., & Strelau, J. (1997) · Journal of Personality · doi:10.1111/j.1467-6494.1997.tb00324.x · Cited by 457
Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli
Dulawa, S. C., Grandy, D. K., Low, M. J., Paulus, M. P., & Geyer, M. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09550.1999 · Cited by 431
Little, K. Y., McLaughlin, D. P., Zhang, L., Livermore, C. S., Dalack, G. W., McFinton, P. R., DelProposto, Z., Hill, E. M., Cassin, B. J., Watson, S. J., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.2.207 · Cited by 382
MacKenzie, A., & Quinn, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15251 · Cited by 374
Greenberg, B. D., Li, Q., Lucas, F. R., Hu, S., Sirota, L. A., Benjamin, J., Lesch, K., Hamer, D. H., & Murphy, D. L. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000403)96:2<202::aid-ajmg16>3.0.co;2-j · Cited by 354
Prenatal stress and cognitive development and temperament in infants
Buitelaar, J. K., Huizink, A. C., Mulder, E. J. H., de Medina, P. R., & Visser, G. H. A. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00050-2 · Cited by 348
Lesch, K., & Mößner, R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00121-8 · Cited by 338
BENSON, D. F. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.10.1400-a · Cited by 329
D2 and D4 dopamine receptor polymorphisms and personality
Noble, E. P., Ozkaragoz, T. Z., Ritchie, T. L., Zhang, X., Belin, T. R., & Sparkes, R. S. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980508)81:3<257::aid-ajmg10>3.0.co;2-e · Cited by 294
A meta-analysis of the association between DRD4 polymorphism and novelty seeking
Kluger, A. N., Siegfried, Z., & Ebstein, R. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001082 · Cited by 283
Downey, K. K., Stelson, F., Pomerleau, O., & Giordani, B. (1997) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-199701000-00006 · Cited by 262
Fiskerstrand, C. E., Lovejoy, E. A., & Quinn, J. P. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01150-3 · Cited by 256
Dopamine‐related personality traits in Parkinson's disease
Menza, M. A., Golbe, L. I., Cody, R., & Forman, N. (1993) · Neurology · doi:10.1212/wnl.43.3_part_1.505 · Cited by 247
Role of the Serotonin Transporter Promoter Polymorphism in Anxiety-Related Traits
Mazzanti, C. M., Lappalainen, J., Long, J. C., Bengel, D., Naukkarinen, H., Eggert, M., Virkkunen, M. E., Linnoila, M., & Goldman, D. A. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.10.936 · Cited by 247
DRD4 and novelty seeking: Results of meta‐analyses
Schinka, J. A., Letsch, E. A., & Crawford, F. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10649 · Cited by 234
Malhotra, A. K., Virkkunen, M. E., Rooney, W., Eggert, M., Linnoila, M., & Goldman, D. A. (1996) · PubMed · Cited by 230
D2 dopamine receptors and personality traits
Farde, L., Gustavsson, P. J., & Jönsson, E. G. (1997) · Nature · doi:10.1038/385590a0 · Cited by 217
McCrae, R. R., Jang, K. L., Livesley, W. J., Riemann, R., & Angleitner, A. (2001) · Journal of Personality · doi:10.1111/1467-6494.694154 · Cited by 214
Emergenesis: Genetic traits that may not run in families.
Lykken, D. T., McGue, M. K., Tellegen, A., & Bouchard, T. J. (1992) · American Psychologist · doi:10.1037/0003-066x.47.12.1565 · Cited by 211
The human serotonin transporter gene polymorphism-basic research and clinical implications
Heils, A., M��ner, R., & Lesch, K. (1997) · Journal of Neural Transmission · doi:10.1007/bf01273314 · Cited by 209
Auerbach, J. G., Geller, V., Lezer, S., Shinwell, E. S., Belmaker, R. H., Levine, J., & Ebstein, R. P. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000531 · Cited by 206
Arbelle, S., Benjamin, J., Golin, M., Kremer, I., Belmaker, R. H., & Ebstein, R. P. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.671 · Cited by 205
Temperament predicts clomipramine and desipramine response in major depression
Joyce, P. R., Mulder, R., & Cloninger, C. R. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90149-x · Cited by 204
Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament
Ebstein, R. P., Levine, J., Geller, V., Auerbach, J. G., Gritsenko, I., & Belmaker, R. H. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000363 · Cited by 200
Auerbach, J. G., Faroy, M., Ebstein, R. P., Kahana, M., & Levine, J. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00774 · Cited by 200
Association between serotonin transporter gene polymorphism and anxiety-related traits
Katsuragi, S., Kunugi, H., Sano, A., Tsutsumi, T., Isogawa, K., Nanko, S., & Akiyoshi, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00090-0 · Cited by 197
Benjamin, J., Osher, Y., Kotler, M., Gritsenko, I., Nemanov, L., Belmaker, R. H., & Ebstein, R. P. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000640 · Cited by 196
Herbst, J. H., Zonderman, A. B., McCrae, R. R., & Costa, P. T. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1285 · Cited by 194
Gelernter, J. E., Kranzler, H. R., Coccaro, E. F., Siever, L. J., New, A. S., & Mulgrew, C. L. (1997) · The American Journal of Human Genetics · doi:10.1086/301595 · Cited by 188
Molecular genetics of shyness and aggression in preschoolers
Schmidt, L. A., Fox, N. A., Rubin, K. H., Hu, S., & Hamer, D. H. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(01)00147-7 · Cited by 185
How Common Is Resistance to Treatment in Recurrent, Nonpsychotic Geriatric Depression?
Little, J. T., Reynolds, C. F., Dew, M. A., Frank, E., Begley, A. E., Miller, M. D., Cornes, C. L., Mazumdar, S., Perel, J. M., & Kupfer, D. J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1035 · Cited by 184
Heritability and biological explanation.
Turkheimer, E. N. (1998) · Psychological Review · doi:10.1037/0033-295x.105.4.782-791 · Cited by 177
Okuyama, Y., Ishiguro, H., Nankai, M., Shibuya, H., Watanabe, A., & Arinami, T. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000563 · Cited by 172
Gelernter, J. E., Kranzler, H. R., Coccaro, E. F., Siever, L. J., & New, A. S. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1332 · Cited by 168
Shioe, K., Ichimiya, T., Suhara, T., Takano, A., Sudo, Y., Yasuno, F., Hirano, M., Shinohara, M., Kagami, M., Okubo, Y., et al. (2003) · Synapse · doi:10.1002/syn.10204 · Cited by 168
Dopamine D4 Receptor Gene Novelty or Nonsense?
Paterson, A. D. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00115-8 · Cited by 163
Ebstein, R. P., Gritsenko, I., Nemanov, L., Frisch, A., Osher, Y., & Belmaker, R. H. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000275 · Cited by 157
Ebstein, R. P., Segman, R. H., Benjamin, J., Osher, Y., Nemanov, L., & Belmaker, R. H. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970221)74:1<65::aid-ajmg15>3.0.co;2-p · Cited by 157
The DRD2 gene in psychiatric and neurological disorders and its phenotypes
Noble, E. P. (2000) · Pharmacogenomics · doi:10.1517/14622416.1.3.309 · Cited by 150
Anxiety proneness linked to epistatic loci in genome scan of human personality traits
Cloninger, C. R., Eerdewegh, P. V., Goate, A., Edenberg, H. J., Blangero, J., HESSELBROCK, V. M., Reich, T., Nürnberger, J. I., Schuckit, M. A., Bernice Porjesz, A., et al. (1998) · American Journal of Medical Genetics · Cited by 145
Stoltenberg, S. F., Twitchell, G. R., Hanna, G. L., Cook, E. H., Fitzgerald, H. E., Zucker, R. A., & Little, K. Y. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10187 · Cited by 143
Ebstein, R. P., Nemanov, L., Klotz, I., Gritsenko, I., & Belmaker, R. H. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000333 · Cited by 143
Comings, D. E., Gade‐Andavolu, R., Gonzalez, N., Wu, S., Muhleman, D. R., Blake, H., Mann, M. B., Dietz, G., Saucier, G., & MacMurray, J. P. (2000) · Clinical Genetics · doi:10.1034/j.1399-0004.2000.580508.x · Cited by 143
Methylenetetrahydrofolate reductase variant and schizophrenia/depression
Arinami, T., Yamada, N., Yamakawa‐Kobayashi, K., Hamaguchi, H., & Toru, M. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970919)74:5<483::aid-ajmg5>3.0.co;2-p · Cited by 141
Melke, J., Landén, M., Baghei, F., Rosmond, R., Holm, G., Björntorp, P. A., Westberg, L., Hellstrand, M., & Eriksson, E. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1434 · Cited by 139
Ono, Y., Manki, H., Yoshimura, K., Muramatsu, T., Mizushima, H., Higuchi, S., Yagi, G., Kanba, S., & Asai, M. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970919)74:5<501::aid-ajmg9>3.0.co;2-q · Cited by 134
Jorm, A. F., Henderson, A. S., Jacomb, P. A., Christensen, H. M., Korten, A. E., Rodgers, B., Tan, X., & Easteal, S. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000424 · Cited by 132
The serotonin transporter gene and peer-rated neuroticism
Ball, D., Hill, L., Freeman, B., Eley, T. C., Strelau, J., Riemann, R., Spinath, F. M., Angleitner, A., & Plomin, R. J. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00048 · Cited by 131
Relationship between serotonin and the Temperament and Character Inventory
Peirson, A. R., Heuchert, J., Thomala, L., Berk, M., Plein, H., & Cloninger, C. R. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00079-7 · Cited by 130
Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism
Flory, J. D., Manuck, S. B., Ferrell, R. E., Dent, K. M., Peters, D. G., & Muldoon, M. F. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000466 · Cited by 128
Poltyrev, T., Keshet, G. I., Kay, G., & Weinstock, M. (1996) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199607)29:5<453::aid-dev4>3.0.co;2-n · Cited by 128
Osher, Y., Hamer, D. H., & Benjamin, J. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000660 · Cited by 127
Does fluoxetine influence major depression by modifying five-factor personality traits?
Du, L., Bakish, D., Ravindran, A. V., & Hrdina, P. D. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00370-6 · Cited by 124
Jönsson, E. G., Nöthen, M. M., Gustavsson, P. J., Neidt, H., Brené, S., Tylec, A., Propping, P., & Sedvall, G. C. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.697 · Cited by 123
Strobel, A., Wehr, A., Michel, A., & Brocke, B. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000535 · Cited by 121
Lakatos, K., Nemoda, Z., Tóth, I., Rónai, Z., Ney, K., Szekely, M. S., & Gervai, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000986 · Cited by 121
Lakatos, K., Nemoda, Z., Birkas, E., Ronai, Z., Kovacs, E., Ney, K., Toth, I., Sasvari-Szekely, M., & Gervai, J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001212 · Cited by 120
Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects
Breier, A. F., Kestler, L. J., Adler, C. M., Elman, I., Wiesenfeld, N., Malhotra, A. K., & Pickar, D. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1440 · Cited by 119
Ekelund, J., Lichtermann, D., Järvelin, M., & Peltonen, L. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1453 · Cited by 118
Du, L., Bakish, D., & Hrdina, P. D. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010040-00002 · Cited by 115
Murakami, F., Shimomura, T., Kotani, K., Ikawa, S., Nanba, E., & Adachi, K. (1999) · Journal of Human Genetics · doi:10.1007/s100380050098 · Cited by 115
Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine
Rao, P. A. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110072009 · Cited by 112
Pogue‐Geile, M. F., Ferrell, R. E., Deka, R., Debski, T. T., & Manuck, S. B. (1998) · PubMed · Cited by 110
Schneider, M. L. (1992) · Infant Behavior and Development · doi:10.1016/0163-6383(92)80009-j · Cited by 109
Lusher, J. M., Chandler, C., & Ball, D. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000918 · Cited by 105
Tome, M. B., Cloninger, C. R., Watson, J. P., & Isaac, M. T. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00030-x · Cited by 104
Imaging of the 5-HT2A system: age-, gender-, and Alzheimer’s disease-related findings
Versijpt, J., Van Laere, K. J., Dumont, F., Decoo, D., Vandecapelle, M., Santens, P., Goethals, I., Audenaert, K., Slegers, G., Dierckx, R. A., et al. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00137-9 · Cited by 102
Fetal behaviour : developmental and perinatal aspects
Nijhuis, J. G. (1992) · Oxford University Press eBooks · Cited by 98
Fragile States of Mind: Neuroticism, Vulnerability and the Long-Term Outcome of Depression
Surtees, P. G., & Wainwright, N. W. J. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.169.3.338 · Cited by 98
Kumakiri, C., Kodama, K., Shimizu, E., Yamanouchi, N., Okada, S., Noda, S., Okamoto, H., Sato, T., & Shirasawa, H. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00098-1 · Cited by 96
Benefits and pitfalls encountered in psychiatric genetic association studies
Malhotra, A. K., & Goldman, D. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00365-5 · Cited by 95
Pogue‐Geile, M. F., Ferrell, R. E., Deka, R., Debski, T. T., & Manuck, S. B. (1998) · American Journal of Medical Genetics · Cited by 94
Ricketts, M., Hamer, R. M., Sage, J. I., Manowitz, P., Feng, F., & Menza, M. A. (1998) · Psychiatric Genetics · doi:10.1097/00041444-199800820-00001 · Cited by 92
Neuroticism and polymorphisms in the serotonin transporter gene
Deary, I. J., Battersby, S., Whiteman, M., CONNOR, J. M., Fowkes, F. G. R., & Harmar, A. J. (1999) · Psychological Medicine · doi:10.1017/s0033291798007557 · Cited by 92
Rónai, Z., Székely, A., Nemoda, Z., Lakatos, K., Gervai, J., Staub, M., & Sasvári‐Székely, M. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000832 · Cited by 90
Further evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study
Hansenne, M., Pinto, E., Pitchot, W., Reggers, J., Scantamburlo, G., Moor, M., & Ansseau, M. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(01)00205-7 · Cited by 89
Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese
Nakamura, T., Muramatsu, T., Ono, Y., Matsushita, S., Higuchi, S., Mizushima, H., Yoshimura, K., Kanba, S., & Asai, M. (1997) · American Journal of Medical Genetics · Cited by 89
Molecular and cellular genetics of fragile X syndrome
Kaufmann, W. E., & Reiss, A. L. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990205)88:1<83::aid-ajmg15>3.0.co;2-0 · Cited by 88
Retz, W., Thome, J., Blocher, D., Baader, M., & Rösler, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02575-7 · Cited by 88
Patkar, A. A., Berrettini, W. H., Hoehe, M. R., Thornton, C. C., Gottheil, E., Hill, K. P., & Weinstein, S. P. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00098-7 · Cited by 87
Kaiser, R., Müller-Oerlinghausen, B., Filler, D., Tremblay, P., Berghöfer, A., Roots, I., & Brockmöller, J. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10119 · Cited by 87
K�hn, K.-U., Meyer, K., Nöthen, M. M., Gänsicke, M., Papassotiropoulos, A., & Maier, W. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990416)88:2<168::aid-ajmg14>3.3.co;2-g · Cited by 86
Samochowiec, J., Rybakowski, F., Czerski, P. M., Zakrzewska, M., Stȩpień, G., Pełka-Wysiecka, J., Horodnicki, J., RYBAKOWSKI, J. K., & Hauser, J. (2001) · Neuropsychobiology · doi:10.1159/000054898 · Cited by 85
Sullivan, P. F., Fifield, W. J., Kennedy, M. A., Mulder, R. T., Sellman, J. D., & Joyce, P. R. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.98 · Cited by 85
Tomitaka, M., Tomitaka, S., Otuka, Y., Kim, K., Matuki, H., Sakamoto, K., & Tanaka, A. (1999) · American Journal of Medical Genetics · Cited by 81
Association between alcoholism and the dopamine D4 receptor gene.
Muramatsu, T., Higuchi, S., Murayama, M., Matsushita, S., & Hayashida, M. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.2.113 · Cited by 78
Mitsuyasu, H., Hirata, N., Sakai, Y., Shibata, H., Takeda, Y., Ninomiya, H., Kawasaki, H., Tashiro, N., & Fukumaki, Y. (2001) · Journal of Human Genetics · doi:10.1007/s100380170120 · Cited by 78
Association of the HLA-DQA1∗0501 allele in multiple racial groups with juvenile dermatomyositis
Reed, A. M., & Stirling, J. D. (1995) · Human Immunology · doi:10.1016/0198-8859(95)00035-6 · Cited by 77
Parkinson's disease, personality, and dopamine
Menza, M. A., Forman, N., Goldstein, H. S., & Golbe, L. I. (1990) · Journal of Neuropsychiatry · doi:10.1176/jnp.2.3.282 · Cited by 73
Jorm, A. F., Prior, M., Sanson, A. V., Smart, D., Zhang, Y., & Easteal, S. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000782 · Cited by 73
Akiskal, H. S., & Pinto, O. (2000) · Springer eBooks · doi:10.1007/0-306-47521-9_2 · Cited by 71
No association between serotonin transporter gene polymorphisms and personality traits
Gustavsson, P. J., Nöthen, M. M., Jönsson, E. G., Neidt, H., Forslund, K., Rylander, G., Mattila‐Evenden, M., Sedvall, G., Propping, P., & �sberg, M. (1999) · American Journal of Medical Genetics · Cited by 68
Vandenbergh, D. J., Rodriguez, L. A., Hivert, E., Schiller, J. H., Villareal, G., Pugh, E. W., Lachman, H. M., & Uhl, G. R. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20001009)96:5<678::aid-ajmg15>3.0.co;2-8 · Cited by 62
Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals
Gebhardt, C., Leisch, F., SCHÜSSLER, P., Fuchs, K., Stompe, T., Sieghart, W., Hornik, K., Kasper, S. F., & Aschauer, H. N. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010030-00005 · Cited by 59
Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign
Glatt, C. E., & Freimer, N. B. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02670-7 · Cited by 59
Behavioural-Genetic Perspectives on Personality Function
Jang, K. L., Vernon, P. A., & Livesley, W. J. (2001) · The Canadian Journal of Psychiatry · doi:10.1177/070674370104600303 · Cited by 56
Strobel, A., Lesch, K., Jatzke, S., Paetzold, F., & Brocke, B. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001253 · Cited by 54
Zohar, A. H., Dina, C., Rosolio, N., Osher, Y., Gritsenko, I., Bachner‐Melman, R., Benjamin, J., Belmaker, R. H., & Ebstein, R. P. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10029 · Cited by 54
Jorm, A. F., Henderson, A. S., Jacomb, P. A., Christensen, H. M., Korten, A. E., Rodgers, B., Tan, X., & Easteal, S. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010020-00006 · Cited by 52
DRD4 promoter SNPs and gender effects on Extraversion in African Americans
Bookman, E., Taylor, R. E., Adams-Campbell, L. L., & Kittles, R. A. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001075 · Cited by 51
D2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking
Berman, S. M., Ozkaragoz, T. Z., Young, R. M., & Noble, E. P. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(01)00197-0 · Cited by 50
Evans, J., Battersby, S., Ogilvie, A. D., Smith, C., Harmar, A. J., Nutt, D., & Goodwin, G. M. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00027-0 · Cited by 50
Gestel, S. V., Forsgren, T., Claes, S. J., Del‐Favero, J., van Duijn, C. M., Sluijs, S., Nilsson, L.-G., Adolfsson, R., & Broeckhoven, C. V. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001005 · Cited by 49
Wiesbeck, G. A., Mauerer, C., Thome, J., et al. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00014-3 · Cited by 48
Jönsson, E. G., Cichon, S., Gustavsson, P. J., Grünhage, F., Forslund, K., Mattila‐Evenden, M., Rylander, G., Åsberg, M., Farde, L., Propping, P., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01732-8 · Cited by 47
Lack of association between dopamine D4 receptor gene and personality traits
Jönsson, E. G., Nöthen, M. M., Gustavsson, P. J., et al. (1998) · Psychological Medicine · doi:10.1017/s0033291798006837 · Cited by 47
Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese
Tsai, S., Hong, C., & Cheng, C. (2002) · Psychiatric Genetics · doi:10.1097/00041444-200209000-00008 · Cited by 47
Kusumi, I., Suzuki, K., Sasaki, Y., Kameda, K., Sasaki, T., & Koyama, T. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00324-4 · Cited by 43
Luca, A. D., Rizzardi, M., Buccino, A., Alessandroni, R., Salvioli, G. P., Filograsso, N., Novelli, G., & Dallapiccola, B. (2003) · Neurogenetics · doi:10.1007/s10048-003-0146-z · Cited by 43
NOTCH4 and the frontal lobe in schizophrenia
Wassink, T. H., Nopoulos, P., Pietila, J., Crowe, R., & Andreasen, N. C. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10071 · Cited by 42
Validity of PCR with emphasis on variable number of tandem repeat analysis
Kaiser, R., Tremblay, P., Roots, I., & Brockmöller, J. (2002) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00273-4 · Cited by 40
Lee, H., Lee, H. S., Kim, Y., Kim, S. H., Kim, L., Lee, M. S., Joe, S.-H., Jung, I., Suh, K., & Kim, S. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10047 · Cited by 40
Ozkaragoz, T. Z., & Noble, E. P. (2000) · Alcohol · doi:10.1016/s0741-8329(00)00112-9 · Cited by 39
Dopamine D4 receptor gene and personality dimensions in Brazilian male alcoholics
Bau, C. H. D., Roman, T., Almeida, S., et al. (1999) · Psychiatric Genetics · doi:10.1097/00041444-199909000-00005 · Cited by 39
Persson, M.-L., Wasserman, D., Jönsson, E. G., Bergman, H., Terenius, L. Y., Gyllander, A., Neiman, J., & Geijer, T. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00160-8 · Cited by 38
No association of the −521 C/T polymorphism in the promoter of DRD4 with novelty seeking
Ekelund, J., Suhonen, J., Järvelin, M., Peltonen, L., & Lichtermann, D. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000943 · Cited by 37
Soyka, M., Preuss, U. W., Koller, G., Zill, P., & Bondy, B. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00049-3 · Cited by 36
Strobel, A., Lesch, K., Hohenberger, K., Jatzke, S., Gutzeit, H. O., Anacker, K., & Brocke, B. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001027 · Cited by 36
Brummett, B. H., Siegler, I. C., McQuoid, D. R., Svenson, I. K., Marchuk, D. A., & Steffens, D. C. (2003) · Psychiatric Genetics · doi:10.1097/00041444-200303000-00002 · Cited by 36
Katsuragi, S., Kiyota, A., Tsutsumi, T., et al. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00331-6 · Cited by 34
Luca, A. D., Rizzardi, M., Torrente, I., Alessandroni, R., Salvioli, G. P., Filograsso, N., Dallapiccola, B., & Novelli, G. (2001) · Neurogenetics · doi:10.1007/s100480100106 · Cited by 33
Lack of Association between Polymorphisms of the Dopamine D4 Receptor Gene and Personality
Strobel, A., Spinath, F. M., Angleitner, A., Riemann, R., & Lesch, K. (2003) · Neuropsychobiology · doi:10.1159/000068876 · Cited by 32
No association between dopamine D4 receptor gene variants and Novelty Seeking
Jönsson, E. G., Ivo, R., Gustavsson, P. J., Geijer, T., Forslund, K., Mattila‐Evenden, M., Rylander, G., Cichon, S., Propping, P., Bergman, H., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000950 · Cited by 28
Umekage, T., Tochigi, M., Marui, T., Kato, C., Hibino, H., Otani, T., Kohda, K., Kato, N., & Sasaki, T. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01291-0 · Cited by 28
Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers
Persson, M.-L., Wassermann, D., Geijer, T., Frisch, A., Rockah, R., Michaelovsky, E., Apter, A. S., Weizman, A., Jönsson, E. G., & Bergmann, H. (2000) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060070025 · Cited by 28
Pleiotropy of the serotonin transporter gene for seasonality and neuroticism
Sher, L., Greenberg, B. D., Murphy, D. L., Rosenthal, N. E., Sirota, L. A., & Hamer, D. H. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010030-00004 · Cited by 26
Serotonin transporter gene polymorphisms and affective disorder-related phenotypes
Bellivier, F., Roy, I., & Leboyer, M. (2002) · Current Opinion in Psychiatry · doi:10.1097/00001504-200201000-00009 · Cited by 23
5HTR2A gene polymorphism and personality traits in patients with major psychoses
Голимбет, В. Е., Алфимова, М. В., Manandyan, K. K., Mitushina, N. G., Abramova, L. I., Каледа, В. Г., Oleichik, I. V., Yurov, Y. B., & Трубников, В. И. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00623-5 · Cited by 22
An examination of the association between DRD4 and DRD2 polymorphisms and personality traits
Burt, S. A., McGue, M. K., Iacono, W. G., Comings, D. E., & MacMurray, J. P. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(01)00194-5 · Cited by 19
No association between serotonin 2A receptor gene variants and personality traits
Jönsson, E. G., Nöthen, M. M., Gustavsson, P. J., et al. (2001) · Psychiatric Genetics · doi:10.1097/00041444-200103000-00003 · Cited by 17
Guo, W., Mourad, W. M., Charron, D. J., & Al‐Daccak, R. (1999) · Human Immunology · doi:10.1016/s0198-8859(98)00131-1 · Cited by 16
de Brettes, B., Berlin, I., Laurent‐Levinson, C., Lépine, J., Mallet, J. J., & Puech, A. J. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80692-0 · Cited by 15
The dopamine receptor DRD4 gene: are duplications distracting?
Todd, R. D., & O’Malley, K. L. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01612-6 · Cited by 15
Novelty seeking traits and D4 dopamine receptors
Swift, G., Larsen, B., Hawi, Z., & Gill, M. (2000) · American Journal of Medical Genetics · Cited by 13
The role of personality variables in response to chlorpromazine, dextroamphetamine and placebo
Forrest, G. L., Bortner, T. W., & Bakker, C. B. (1967) · Journal of Psychiatric Research · doi:10.1016/0022-3956(67)90016-7 · Cited by 11
Blum, K., Braverman, E. R., Cull, J. G., et al. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)88120-6 · Cited by 5
(2012) · SpringerReference · doi:10.1007/springerreference_184625 · Cited by 4
Novelty seeking and harm avoidance and dopamine 4 and serotonine 2A receptor gene polymorphisms
SCHÜSSLER, P., Gebhardt, C., Fuchs, K., Stompe, T., Sieghart, W., Kasper, S. F., Aschauer, H. N., Leisch, F., & Hornik, K. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)80562-3 · Cited by 2
Allele specific HLA-DQAI expression in B cell lines and peripheral blood mononuclear cells
(1995) · Human Immunology · doi:10.1016/0198-8859(95)92941-w · Cited by 1
Research works printed but not linked: 9
- 10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U · DOI
- 10.1002/(SICI)1096-8628(19990820)88:4<430::AID-AJMG23>3.0.CO;2-1 · DOI
- 10.1002/(SICI)1096-8628(19990416)88:2<168::AID-AJMG14>3.0.CO;2-P · DOI
- Malhotra AK, 1996, The association between dopamine (DRD4) 16 amino acid repeat and novelty seeking, Mol Psychiatry, 1, 388
- 10.1002/(SICI)1096-8628(19970919)74:5<544::AID-AJMG18>3.0.CO;2-C · DOI
- 10.1002/(SICI)1096-8628(19980207)81:1<44::AID-AJMG9>3.0.CO;2-N · DOI
- 10.1037/0022-3514.78.1.122 · DOI
- 10.1002/(SICI)1096-8628(20000403)96:2<222::AID-AJMG18>3.0.CO;2-B · DOI
- 10.1002/(SICI)1096-8628(19991015)88:5<469::AID-AJMG6>3.0.CO;2-F · DOI
Cited by
Schaller, M., & Murray, D. R. (2008) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.95.1.212 · Cited by 647
Coping styles and behavioural flexibility: towards underlying mechanisms
Coppens, C. M., de Boer, S. F., & Koolhaas, J. M. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0217 · Cited by 646
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494
Self-citationKORSTEN, P., MUELLER, J. C., HERMANNSTÄDTER, C., BOUWMAN, K. M., DINGEMANSE, N. J., DRENT, P. J., LIEDVOGEL, M., MATTHYSEN, E., Van OERS, K., Van OVERVELD, T., et al. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2009.04518.x · Cited by 123
Brezo, J., Bureau, A., Mérette, C., Jomphe, V, Barker, E. D., Vitaro, F., Hébert, M., Carbonneau, R., Tremblay, R. E., & Turecki, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.19 · Cited by 109
Metadata
- Authors
- Savitz, J. B., & Ramesar, R. S.
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2004-09-23
- Volume
- 131B
- Issue
- 1
- Pages
- 20-32
- ISSN
- 1552-4841
- 1552-485X
- Cited by
- 114
- References
- 161
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.