The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sample
Open accessAbstract
In this letter we describe novel, preliminary work, examining a possible mechanism of the Gene-environment interactions thought to moderate the response of individuals to stressful life events. The molecular mechanisms through which this moderation may be accomplished are currently unknown but some have suggested DNA methylation (Lui and others, 1997; McGowan and others 2009). In order to test this hypothesis, we analyzed the relationship of child abuse to methylation of cytosine residues in the promoter region of the serotonin transporter gene in DNA from 96 male and 96 female subjects from the Iowa Adoptee Studies using a principal components analysis. The results from this preliminary work suggest a lasting effect of child abuse on overall methylation levels in both males and females.
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Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
The neurobiology of stress and development.
Gunnar, M., & Quevedo, K. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085605 · Cited by 2,011 · cited 1×
“Because early maltreatment within a family environment may be particularly important in producing long-term epigenetic change [Gunnar and Quevedo, 2007] and early experience has been linked to epigenetic change via CpG methylation in animal models [Kaffman and Meaney, 2007], we focused our…”
BackgroundHeim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070
Strategy for Investigating Interactions Between Measured Genes and Measured Environments
Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784
Weiss, E. L., Longhurst, J. G., & Mazure, C. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.816 · Cited by 517
Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder
Surtees, P. G., Wainwright, N. W. J., Willis-Owen, S. A. G., Luben, R., Day, N. E., & Flint, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.014 · Cited by 265
Research works printed but not linked: 17
- 10.1038/sj.ejhg.5201979 · DOI · Paper page
- 10.1097/01.mpa.0000179730.69081.64 · DOI
- 10.1038/sj.mp.4001459 · DOI
- 10.1002/ajmg.b.30132 · DOI · Paper page
- 10.1016/0022-3956(93)90010-Y · DOI
- 10.1016/S0006-3223(01)01157-X · DOI · Paper page
- 10.1111/j.1469-7610.2007.01730.x · DOI · Paper page
- 10.1001/archpsyc.62.5.529 · DOI · Paper page
- 10.1126/science.274.5292.1527 · DOI · Paper page
- 10.1097/00041444-200409000-00001 · DOI · Paper page
- 10.1176/appi.ajp.158.11.1878 · DOI · Paper page
- 10.1016/0145-2134(95)00112-3 · DOI · Paper page
- 10.1002/ajmg.b.30747 · DOI
- 10.1038/mp.2008.108 · DOI
- 10.1002/ajmg.b.30414 · DOI · Paper page
- 10.1002/ajmg.10187 · DOI
- 10.1006/meth.1999.0883 · DOI
Cited by
Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000611 · Cited by 1,564
Brain mechanisms of insomnia: new perspectives on causes and consequences
Van Someren, E. J. W. (2021) · Physiological Reviews · doi:10.1152/physrev.00046.2019 · Cited by 543
Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder
Smith, A. K., Conneely, K. N., Kilaru, V., Mercer, K. B., Weiss, T. E., Bradley, B., Tang, Y., Gillespie, C. F., Cubells, J. F., & Ressler, K. J. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31212 · Cited by 355
Telomere length and early severe social deprivation: linking early adversity and cellular aging
Drury, S. S., Theall, K., Gleason, M. M., Smyke, A. T., De Vivo, I., Wong, J. Y. Y., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.53 · Cited by 316
The role of DNA methylation in stress-related psychiatric disorders
Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309
Metadata
- Authors
- Beach, S. R. H., Brody, G. H., Todorov, A. A., Gunter, T. D., & Philibert, R. A.
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2010-02-18
- Volume
- 153B
- Issue
- 2
- Pages
- 710-713
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2167163188
- Cited by
- 229
- References
- 9
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- green
- Funders
- National Institutes of Health (DA 015789, DA010923, DA02173603)
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- CoChat. (2026). Citation check: Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sample. https://app.cochat.ai/papers/10.1002/ajmg.b.31028
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- Beach, S. R. H., Brody, G. H., Todorov, A. A., Gunter, T. D., & Philibert, R. A. (2010). Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. https://doi.org/10.1002/ajmg.b.31028
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