Updates on the psychological and psychiatric aspects of the Ehlers–Danlos syndromes and hypermobility spectrum disorders
Abstract
The field of the psychiatric and psychological aspects of Ehlers–Danlos syndromes (EDS) has been understudied and neglected for many years. People with EDS are often classified as “somatizers” by untrained clinicians. However, research on the biological basis of EDS is improving our understanding of the physiology and psychopathology of the disorder. In this article, we consider the literature on the psychopathological dimensions associated with EDS as well as the EDS symptoms in psychiatric conditions since our review in 2017. Literature confirms that psychological processes (i.e., fear, emotional distress, or negative emotions) in EDS have a significant impact on the outcomes of EDS. Common systemic associations are found between anxiety disorders and EDS as well as significant correlations with neurodevelopmental, eating, mood, and sleep disorders. There is limited but increasing evidence of an association between EDS and suicidal thoughts and behaviors, which should be further explored. The broad spectrum of human anxiety and associated somatic symptoms (beyond anxiety disorders) appears to be the core of the psychopathology in EDS and therefore, detecting and assessing EDS might be a new opportunity for psychiatric nosology to develop more inclusive phenotypes like the Neuroconnective Phenotype that include both somatic and psychological manifestations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is a high prevalence of psychiatric disorders and heightened psychological distress among individuals with EDS and HSD.
“the high prevalence of psychiatric disorders among individuals with EDS and HSD, which is becoming increasingly evident [54, 55].”
From Psychological interventions for individuals with Ehlers-Danlos syndrome and hypermobility spectrum disorder: a scoping review (2023) · cites this paper as [55]
Because ESSENCE problems are believed to be prevalent within the joint hypermobility spectrum, GJH may serve as an additional clinical clue during health check-ups.
“Because ESSENCE problems are believed to be prevalent within the joint hypermobility spectrum, 24,33 GJH may serve as an additional clinical clue during health check-ups.”
From No association between joint hypermobility, musculoskeletal pain and neurodevelopmental problems in a school-based sample of 11-year-old children (2025) · cites this paper as [33]
Cites
Aguirre Velasco, A., Cruz, I. S. S., Billings, J., Jimenez, M., & Rowe, S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02659-0 · Cited by 736 · see citing works
The Somatosensory Amplification Scale and its relationship to hypochondriasis
BARSKY, A. J., Wyshak, G., & Klerman, G. L. (1990) · Journal of Psychiatric Research · doi:10.1016/0022-3956(90)90004-a · Cited by 630 · see citing works
A framework for the classification of joint hypermobility and related conditions
Castori, M., Tinkle, B., Levy, H., Grahame, R., Malfait, F., & Hakim, A. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31539 · Cited by 602 · see citing works
Tinkle, B., Castori, M., Berglund, B., Cohen, H., Grahame, R., Kazkaz, H., & Levy, H. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31538 · Cited by 499 · see citing works
Soloff, P. H., Lynch, K. G., Kelly, T. M., Malone, K. M., & Mann, J. J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.601 · Cited by 456 · see citing works
Fisher, M., Rosen, D. S., Ornstein, R. M., Mammel, K. A., Katzman, D. K., Rome, E. S., Callahan, S. T., Malizio, J. B., Kearney, S., & Walsh, B. T. (2014) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.11.013 · Cited by 443 · see citing works
Reynolds, K., Pietrzak, R. H., El-Gabalawy, R. M., Mackenzie, C. S., & Sareen, J. (2015) · World Psychiatry · doi:10.1002/wps.20193 · Cited by 411 · see citing works
Demmler, J. C., Atkinson, M. D., Reinhold, E. J., Choy, E., Lyons, R. A., & Brophy, S. T. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031365 · Cited by 271 · see citing works
Patients Who Amplify Bodily Sensations
BARSKY, A. J. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-1-63 · Cited by 239 · see citing works
Ehlers Danlos syndrome and gastrointestinal manifestations: a 20‐year experience at Mayo Clinic
Nelson, A. D., Mouchli, M. A., Valentin, N., Deyle, D., Pichurin, P., Acosta, A., & Camilleri, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12665 · Cited by 182 · see citing works
Fatigue Is a Frequent and Clinically Relevant Problem in Ehlers-Danlos Syndrome
Voermans, N. C., Knoop, H., van de Kamp, N., Hamel, B. C. J., Bleijenberg, G., & van Engelen, B. G. M. (2009) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2009.08.003 · Cited by 171 · see citing works
Psychiatric and psychological aspects in the Ehlers–Danlos syndromes
Bulbena, A., Baeza‐Velasco, C., Bulbena‐Cabré, A., Pailhez, G., Critchley, H., Chopra, P., Mallorquí‐Bagué, N., Frank, C., & Porges, S. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31544 · Cited by 149 · see citing works
Self-citationHakim, A. J. (2004) · Rheumatology · doi:10.1093/rheumatology/keh279 · Cited by 147 · see citing works
Chronic fatigue in Ehlers–Danlos syndrome—Hypermobile type
Hakim, A. J., Wandele, I. D., O'Callaghan, C., Pocinki, A. G., & Rowe, P. C. (2017) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31542 · Cited by 146 · see citing works
Cederlöf, M., Larsson, H., Lichtenstein, P., Almqvist, C., Serlachius, E., & Ludvigsson, J. F. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0922-6 · Cited by 142 · see citing works
Smith, T. O., Easton, V., Bacon, H., Jerman, E., Armon, K., Poland, F., & Macgregor, A. J. (2014) · Rheumatology · doi:10.1093/rheumatology/ket317 · Cited by 130 · see citing works
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders
Casanova, E. L., Baeza-Velasco, C., Buchanan, C. B., & Casanova, M. F. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040260 · Cited by 109 · see citing works
Self-citationEating Disorders and Gastrointestinal Diseases
Santonicola, A., Gagliardi, M., Guarino, M. P. L., Siniscalchi, M., Ciacci, C., & Iovino, P. (2019) · Nutrients · doi:10.3390/nu11123038 · Cited by 107 · see citing works
Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain
Csecs, J. L. L., Iodice, V., Rae, C. L., Brooke, A., Simmons, R., Quadt, L., Savage, G. K., Dowell, N. G., Prowse, F., Themelis, K., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.786916 · Cited by 98 · see citing works
Castori, M., Morlino, S., Pascolini, G., Blundo, C., & Grammatico, P. (2015) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31431 · Cited by 98 · see citing works
Evaluation for sleep apnea in patients with Ehlers–Danlos syndrome and Marfan: a questionnaire study
Verbraecken, J. A., Declerck, A. C., de Heyning, P. V., Backer, W. D., & Wouters, E. F. �. (2001) · Clinical Genetics · doi:10.1034/j.1399-0004.2001.600507.x · Cited by 94 · see citing works
Hershenfeld, S. A., Wasim, S., McNiven, V., Parikh, M., Majewski, P., Faghfoury, H., & So, J. (2016) · Rheumatology International · doi:10.1007/s00296-015-3375-1 · Cited by 81 · see citing works
Lam, C. Y., Palsson, O. S., Whitehead, W. E., Sperber, A. D., Tornblom, H., Simren, M., & Aziz, I. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.02.034 · Cited by 71 · see citing works
Sleep-Disordered Breathing in Ehlers-Danlos Syndrome
Guilleminault, C., Primeau, M., Chiu, H.-Y., Yuen, K. M., Leger, D., & Metlaine, A. (2013) · Chest · doi:10.1378/chest.13-0174 · Cited by 68 · see citing works
Bulbena, A., Pailhez, G., Bulbena-Cabré, A., Mallorquí-Bagué, N., & Baeza-Velasco, C. (2015) · Advances in Psychosomatic Medicine · doi:10.1159/000369113 · Cited by 60 · see citing works
Self-citationSimmonds, J. V., Herbland, A., Hakim, A., Ninis, N., Lever, W., Aziz, Q., & Cairns, M. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1398278 · Cited by 60 · see citing works
Kindgren, E., Quiñones Perez, A., & Knez, R. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s290494 · Cited by 56 · see citing works
Eccles, J. A., Thompson, B., Themelis, K., Amato, M. L., Stocks, R., Pound, A., Jones, A.-M., Cipinova, Z., Shah-Goodwin, L., Timeyin, J., et al. (2021) · Clinical Medicine · doi:10.7861/clinmed.2020-0743 · Cited by 55 · see citing works
Pain in hypermobile Ehlers‐Danlos syndrome: New insights using new criteria
Bénistan, K., & Martinez, V. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61175 · Cited by 53 · see citing works
Cañas, L., Palma, C., Molano, A. M., Domene, L., Carulla‐Roig, M., Cecilia‐Costa, R., Dolz, M., & Serrano‐Troncoso, E. (2020) · European Eating Disorders Review · doi:10.1002/erv.2815 · Cited by 52 · see citing works
Baeza-Velasco, C., Bulbena, A., Polanco-Carrasco, R., & Jaussaud, R. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1419294 · Cited by 51 · see citing works
Self-citationObstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: a parallel cohort study
Gaisl, T., Giunta, C., Bratton, D. J., Sutherland, K., Schlatzer, C., Sievi, N., Franzen, D., Cistulli, P. A., Rohrbach, M., & Kohler, M. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-209560 · Cited by 47 · see citing works
Baeza-Velasco, C., Sinibaldi, L., & Castori, M. (2018) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-018-0252-2 · Cited by 44 · see citing works
Self-citationSedky, K., Gaisl, T., & Bennett, D. S. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7636 · Cited by 44 · see citing works
Wasim, S., Suddaby, J. S., Parikh, M., Leylachian, S., Ho, B., Guerin, A., & So, J. (2019) · Rheumatology International · doi:10.1007/s00296-019-04293-w · Cited by 44 · see citing works
Freyler, A., Kőhegyi, Z., Köteles, F. G., Kökönyei, G., & Bárdos, G. (2013) · Journal of Health Psychology · doi:10.1177/1359105313479629 · Cited by 41 · see citing works
Köteles, F. G., & Doering, B. K. (2015) · Journal of Health Psychology · doi:10.1177/1359105315588216 · Cited by 40 · see citing works
Baeza-Velasco, C., Van den Bossche, T., Grossin, D., & Hamonet, C. (2016) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-015-0232-x · Cited by 39 · see citing works
Self-citationWynne-Davies, R. (1971) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591577106400649 · Cited by 37 · see citing works
Köteles, F., & Simor, P. (2014) · European Journal of Mental Health · doi:10.5708/ejmh.9.2014.1.2 · Cited by 34 · see citing works
Olfactory functioning in panic disorder
Burón, E., Bulbena, A., & Bulbena‐Cabré, A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.049 · Cited by 33 · see citing works
Self-citationDomany, K. A., Hantragool, S., Smith, D. F., Xu, Y., Hossain, M., & Simakajornboon, N. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7058 · Cited by 29 · see citing works
Chiarelli, N., Zoppi, N., Ritelli, M., Venturini, M., Capitanio, D., Gelfi, C., & Colombi, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166051 · Cited by 27 · see citing works
Gastrointestinal and eating problems in women with Ehlers–Danlos syndromes
Baeza-Velasco, C., Lorente, S., Tasa-Vinyals, E., Guillaume, S., Mora, M. S., & Espinoza, P. (2021) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-021-01146-z · Cited by 25 · see citing works
Self-citationMesdom, P., Colle, R., Lebigot, É., Trabado, S., Deflesselle, É., Fève, B., Becquemont, L., Corruble, E., & Verstuyft, C. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191021141057 · Cited by 24 · see citing works
Obstructive Sleep Apnoea in Children and Adolescents with Ehlers-Danlos Syndrome
Lang-Stöberl, A. S., Gaisl, T., Giunta, C., Sievi, N. A., Singer, F., Mœller, A., Rohrbach, M., & Kohler, M. (2018) · Respiration · doi:10.1159/000494328 · Cited by 22 · see citing works
Csecs, J. L. L., lodice, V., Rae, C. L., et al. (2020) · medRxiv · doi:10.1101/2020.09.14.20194118 · Cited by 19 · see citing works
Pain and sleep quality in children with non‐vascular Ehlers–Danlos syndromes
Muriello, M. J., Clemens, J. L., Mu, W., Tran, P. T., Rowe, P. C., Smith, C. H., Francomano, C. A., Bodurtha, J. N., & Kline, A. D. (2018) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.40371 · Cited by 18 · see citing works
Bowen, J., Fatjó, J., Serpell, J. A., Bulbena-Cabré, A., Leighton, E., & Bulbena, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-45096-0 · Cited by 17 · see citing works
Both anxiety and joint laxity determine the olfactory features in panic disorder
Burón, E., Bulbena, A., Bulbena-Cabré, A., Rosado, S., & Pailhez, G. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.018 · Cited by 14 · see citing works
Self-citationSuicidal Behaviors in Women With the Hypermobile Ehlers–Danlos Syndrome
Baeza‐Velasco, C., Hamonet, C., Montalescot, L., & Courtet, P. (2021) · Archives of Suicide Research · doi:10.1080/13811118.2021.1885538 · Cited by 14 · see citing works
Self-citationJoint Hypermobility Classes in 9-Year-Old Children from the General Population and Anxiety Symptoms
Ezpeleta, L., Navarro, J. B., Osa, N. D. L., Penelo, E., & Bulbena, A. (2018) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000577 · Cited by 13 · see citing works
Self-citationCasanova, M., Sharp, J. L., Edelson, S. M., Kelly, D. P., Sokhadze, E. M., & Casanova, M. F. (2019) · Journal for ReAttach Therapy and Developmental Diversities · doi:10.26407/2019jrtdd.1.20 · Cited by 13 · see citing works
La hiperlaxitud articular como marcador de ansiedad en niños
Bulbena-Cabre, A., Duñó, L., Almeda, S., Batlle, S., Camprodon-Rosanas, E., Martín-Lopez, L. M., & Bulbena, A. (2019) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2019.01.004 · Cited by 12 · see citing works
Self-citationJoint hypermobility is also associated with anxiety disorders in the elderly population
Bulbena‐Cabré, A., Rojo, C., Pailhez, G., Buron Maso, E., Martín‐Lopez, L. M., & Bulbena, A. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4733 · Cited by 10 · see citing works
Self-citationProblems with diagnosing Conversion Disorder in response to variable and unusual symptoms
Barnum, R. (2014) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s57486 · Cited by 9 · see citing works
Body perception in a sample of nonclinical youngsters with joint hypermobility
Bulbena‐Cabré, A., Pailhez, G., Cabrera, A., Baeza‐Velasco, C., Porges, S. W., & Bulbena, A. (2017) · Ansiedad y Estrés · doi:10.1016/j.anyes.2017.07.002 · Cited by 8 · see citing works
Self-citationCasanova, M., Sharp, J. L., Edelson, S. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/670661 · Cited by 8 · see citing works
Schizophrenia and anxiety: yes, they are relatives not just neighbours
Bulbena‐Cabré, A., & Bulbena, A. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.126 · Cited by 4 · see citing works
Self-citationDissociative experiences in fibromyalgia are mediated by symptoms of autonomic dysfunctionPreprint
Aslanyan, D., Iodice, V., Davies, K. A., Critchley, H., & Eccles, J. (2019) · medRxiv · doi:10.1101/19006320 · Cited by 4 · see citing works
Eccles, J., Thompson, B. H., Themelis, K., et al. (2020) · medRxiv · doi:10.1101/2020.02.21.20025072 · Cited by 4 · see citing works
Parvaneh, V. J., Shahvaladi, H., Rahmani, K., Yekta, S. J., Gorji, F. A., Shiari, R., & Abdollahimajd, F. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03264-8 · Cited by 4 · see citing works
Ehlers-Danlos Syndrome and Narcolepsy: An Incidental Relationship?
Milliken, L., & Sedky, K. (2019) · Journal of Sleep And Sleep Disorder Research · doi:10.14302/issn.2574-4518.jsdr-18-2511 · Cited by 2 · see citing works
過剰運動スペクトル障害または過可動性Ehlers-Danlos症候群患者におけるローマIV機能性胃腸障害と健康障害【JST・京大機械翻訳】
Ching, Y. L., Olafur, S. P., William, E. W., Ami, D. S., Hans, T., Simrén, M., & Aziz, I. (2021) · Clinical Gastroenterology and Hepatology · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hypermobility spectrum disorders: A review
Carroll, M. B. (2023) · Rheumatology and Immunology Research · doi:10.2478/rir-2023-0010 · Cited by 45 · see citing works
Blajwajs, L., Williams, J., Timmons, W., & Sproule, J. (2023) · Rheumatology International · doi:10.1007/s00296-023-05338-x · Cited by 35 · see citing works
Ritelli, M., Chiarelli, N., Cinquina, V., Vezzoli, M., Venturini, M., & Colombi, M. (2023) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.63426 · Cited by 22 · see citing works
Pezaro, S., Brock, I., Buckley, M., Callaway, S., Demirdas, S., Hakim, A. J., Harris, C. L., Gross, C. H., Karanfil, M., Ray, I. L., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302401 · Cited by 12 · see citing works
Collins, M., Liang, E., Fuster, E., & Blitshteyn, S. (2025) · Autonomic Neuroscience · doi:10.1016/j.autneu.2025.103356 · Cited by 10 · see citing works
Fletcher, E. K. S., Fischer, A. L., & Manocha, R. H. K. (2025) · Rheumatology International · doi:10.1007/s00296-025-05869-5 · Cited by 9 · see citing works
“There has been increasing recognition that psychological conditions commonly co-occur in HSD/hEDS [3].”
Gender dysphoria in adolescents with Ehlers–Danlos syndrome
Jones, J. T., Black, W. R., Moser, C. N., Rush, E. T., & Malloy-Walton, L. E. (2022) · SAGE Open Medicine · doi:10.1177/20503121221146074 · Cited by 10 · see citing works
“Gender-affirming hormone therapy 10 (36) Anxiolytic 6 (21) Antidepressant 16 (57) Other psychiatric medication 2 (7) Antihistamine 17 (61) Nonsteroid anti-inflammatory drug 11 (39) Sleep aid medication 7 (25)”
BackgroundSong, J. Z., Luong, D., Feldman, E. C. H., Tran, S., Perrier, L., Eubanks, K., Bayley, M., Kastner, M., Slepian, M., & Munce, S. E. P. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02799-y · Cited by 9 · see citing works
“This is especially problematic because of the high prevalence of psychiatric disorders among individuals with EDS and HSD, which is becoming increasingly evident [54, 55].”
BackgroundTudini, F. T., Levine, D. F., Healy, M., Jordon, M., & Chui, K. K. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1089748 · Cited by 6 · see citing works
“Finally, the WOSI was the only measure that specifically inquired about instability and the emotional impact of shoulder pain and disability on the individual, which may be profound (30).”
BackgroundTrudgian, R., & Flood, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0307574 · Cited by 5 · see citing works
Ahimaz, P. R., Kramer, T., Swaroop, P., Mitchell, M., Hernan, R., Anyane‐Yeboa, K., & Pereira, E. M. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62945 · Cited by 5 · see citing works
“Research by Bulbena-Cabre et al. (2021) indicates that there are multiple domains to the psychological presentation of patients with hEDS which is varied and complex enough to warrant the consideration of a separate neurocognitive subtype.”
BackgroundAlsakarneh, S., Ta’ani, O. A., Madi, M. Y., Syn, W., Ruffle, J. K., Aziz, Q., & Farmer, A. D. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70506 · Cited by 4 · see citing works
“These psychological manifestations may result from chronic pain, functional limitations, and autonomic dysfunction, creating a complex interplay between physical and psychological symptoms [42].”
Guedry, S. E., Langley, B. O., Schaefer, K., & Hanes, D. A. (2024) · Disability and Rehabilitation · doi:10.1080/09638288.2024.2314713 · Cited by 3 · see citing works
“The erroneous and harmful misclassification of patients with HSD and EDS as “somatizers” (due to the lack of pathophysiological explanation for their symptoms) leads to misdiagnosis and or delayed diagnosis [65].”
Yekkalam, N., Novo, M., & Wänman, A. (2024) · CRANIO® · doi:10.1080/08869634.2024.2319565 · Cited by 4 · see citing works
Udugampolage, N. S., Taurino, J., Bassotti, A., Pini, A., Caruso, R., Callus, E., Magon, A., Conte, G., Angeli, G. D., Paglione, G., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087298 · Cited by 4 · see citing works
“35 These findings align with our results, where psychological factors such as depression emerged as significant contributors to fatigue in both syndromes, with insomnia playing a particularly strong role in hEDS.”
Slepian, P. M., Axenova, K., McCarthy, M., Siegal, R., Gobin, K. C., Weinrib, A., Buryk-Iggers, S., Mina, D. S., McGillis, L., Mittal, N., et al. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03550-5 · Cited by 5 · see citing works
Knight, D. R. T., Bruno, K. A., Gehin, J. M., Lothman, K. A., Leschitz, J., Lazo, A. L., Mejia, L., Motherwell, L. S., Seymour-Sonnier, A. M., Dawson, N. L., et al. (2022) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2022.0092 · Cited by 4 · see citing works
van Die-de Vries, J., Verbunt, J., Ramaekers, S., Calders, P., & Engelbert, R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19052662 · Cited by 3 · see citing works
Llach, C.-D., Pailhez, G., Conejo-González, C., Singh, P. M., & Bulbena, A. (2024) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-024-02559-8 · Cited by 3 · see citing works
“These findings, in any case, are consistent with previous investigations report - ing a connection between anxiety disorders and a specific variant of connective tissue externally manifested by JHS, embracing what has been coined as the “neuroconnective endophenotype” [45, 46 ].”
Self-citationBulbena, A., Rosado, S., Cabaleiro, M., Martínez, M. P., Baeza‐Velasco, C., Martin, L.-M., Batlle, S., & Bulbena‐Cabré, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1039223 · Cited by 3 · see citing works
“A recent review showed the growing group of disorders associated with HSD/hEDS (12).”
BackgroundSelf-citationYekkalam, N., Novo, M., Tyrberg, M. J., & Sipilä, K. (2024) · Journal of Oral Rehabilitation · doi:10.1111/joor.13706 · Cited by 3 · see citing works
“38 Therefore, the presence of psychological component should be considered in the diagnosis process and management of TMD.”
Guinchat, V., Baeza‐Velasco, C., Bulbena, A., & Castori, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1109515 · Cited by 3 · see citing works
“, supercontrol-uncontrol and avoidanceintrusion), and (5) psychological and psychopathological dimensions (e.”
BackgroundSelf-citationEhlers-Danlos Syndrome and Fibromyalgia: Beyond Pain and Fatigue
Pimiento, D. C. N., & Vergara-García, D. (2024) · Revista Salud Bosque · doi:10.18270/rsb.4489 · Cited by 1 · see citing works
Molecular Pathogenesis of Joint Hypermobility: The Role of Intergenic Interactions
Akhiiarova, K., Tyurin, A., & Khusainova, R. (2025) · Medical Science · doi:10.3390/medsci13040223 · Cited by 2 · see citing works
“Joint hypermobility (JH) is defined as an increased range of motion in the joints beyond physiological limits [1].”
Cuenca-Gómez, J. A., Dawid-Milner, M. S., & Sánchez‐Martínez, R. (2026) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2026.502457 · Cited by 1 · see citing works
Xavier, J., Gauthier, S., Zammouri, I., Anzalone, S. M., & Cohen, D. (2022) · Case Reports in Psychiatry · doi:10.1155/2022/5819406 · Cited by 1 · see citing works
The Neural Correlates of Autonomic Interoception in a Clinical Sample: Implications for AnxietyPreprint
Grimes, P. Z., Kampoureli, C. N., Rae, C. L., Harrison, N. A., Garfinkel, S. N., Critchley, H., & Eccles, J. (2023) · medRxiv · doi:10.1101/2023.05.25.23290230 · Cited by 1 · see citing works
“Hypermobility is significantly overrepresented among people with clinical diagnoses of anxiety [25, 26] and present 59 in up to 70% of such patients [18, 27].”
BackgroundGlans, M. R., Aziz, A., Kindgren, E., Knez, R., Landgren, M., & Landgren, V. (2025) · BJPsych Open · doi:10.1192/bjo.2025.10881
“6,7,31 NDPs rarely present with a clear and well-defined clinical picture.”
Bulbena, A., & Bulbena‐Cabré, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95082-4.00005-0
Self-citationBulbena, A., & Bulbena‐Cabré, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95082-4.00064-5
Self-citationHypermobilität und Ehlers-Danlos-Syndrom
Grotz, W., Doll, S., & Gabriel, H. (2024) · CME · doi:10.1007/s11298-024-4007-4
Hippotherapy in the management of hypermobile Ehlers-Danlos syndrome
Viruega, H., Loriette, C., Quignon, M., & Gaviria, M. (2024) · BMJ Case Reports · doi:10.1136/bcr-2024-261605
Jaussaud, R., Pontille, F., Mohamed, S., Deibener-Kaminsky, J., Decker, P., & Moulinet, T. (2024) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2024.10.400
Renzi, A., Celletti, C., Trani, M. D., Vizzini, M. A. S., Colaboni, L., Petronelli, G., Pasquini, M., Camerota, F., & Mariani, R. (2025) · Healthcare · doi:10.3390/healthcare13060636
Sweerts, K. W. E., Mujagic, Z., Keszthelyi, D., & Conchillo, J. M. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70157
Cuenca-Gómez, J. A., Dawid-Milner, M. S., & Sánchez-Martín, R. (2026) · Revista Clínica Española · doi:10.1016/j.rce.2025.502457
Anderson, L. K. (2026) · Nursing for Women s Health · doi:10.1016/j.nwh.2025.09.006
Williams, C. M., Siegal, R., Ratnasekera, A., McCarthy, M., Flynn, M. J., Gobin, K. C., McGillis, L., Mittal, N., Buryk-Iggers, S., Renna, T. D., et al. (2026) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2026.112660
Tudini, F. T., Crews-Stowe, C., & Levine, D. F. (2026) · Healthcare · doi:10.3390/healthcare14111573
Accompagner un proche vers l’aide médicale à mourir : une étude qualitative
Baudot, C., Fréjaville, V., & Baeza‐Velasco, C. (2026) · Médecine Palliative · doi:10.1016/j.medpal.2026.05.003
Self-citationZhang, K. L., Wallon, R., Laukaitis, C. M., & Davies, C. R. (2026) · Sleep And Breathing · doi:10.1007/s11325-026-03763-3
“Psychiatric disorders, especially anxiety and depression, are highly prevalent in hEDS/HSD population; psychological processes such as fear, emotional distress, and arousal are also heightened in hEDS/HSD [23].”
- Authors
- Bulbena‐Cabré, A., Baeza‐Velasco, C., Rosado‐Figuerola, S., & Bulbena, A.
- Affiliations
- New York City Health and Hospitals Corporation (US)
- Centre National de la Recherche Scientifique (FR)
- Institut Neuropsychiatry and Addictions Parc Salut Mar, Hospital del Mar Barcelona Spain
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Bulbena, Antonio
- Venue
- American Journal of Medical Genetics Part C: Seminars in Medical Genetics
- Publisher
- Wiley
- Published
- 2021-11-22
- Volume
- 187
- Issue
- 4
- Pages
- 482-490
- ISSN
- 1552-4868 (ISSN-L)
- 1552-4876
- OpenAlex
- W3214781819
- Cited by
- 41
- References
- 63
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 7 · 2022: 6
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part C Seminars in Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- Ehlers-Danlos syndrome, hypermobility spectrum disorders, psychopathology, anxiety disorders, somatization, emotional distress, suicidal ideation, mood disorders, sleep disorders, eating disorders, neurodevelopmental disorders, psychiatric classification, somatic symptoms
- MeSH terms
- Anxiety, Anxiety Disorders, Ehlers-Danlos Syndrome, Humans, Joint Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
