The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Imaging hippocampal function across the human life span: Is memory decline normal or not?
Open accessAbstract
Memory function commonly declines in later life. Whether memory decline represents a disease process or whether it is part of normal aging remains unknown. Here we answer this question by assessing the function of multiple subregions that make up the hippocampal circuit across the human life span. A newly developed MRI approach—designed to detect functional changes in individual hippocampal subregions—was used to assess the hippocampal circuit in 70 subjects between 20 and 88 years of age. Using strict parametric criteria, analysis revealed that function in two hippocampal subregions—the subiculum and the dentate gyrus—decline normally with age. In contrast, function in the entorhinal cortex declines pathologically. Single‐subject analysis revealed that hippocampal dysfunction, found in 60% of elders was selectively correlated with memory decline. These results show that memory decline is caused by different mechanisms and suggests how memory decline should be approached clinically.
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“Normal ageing is associated with reduced metabolic activity in the subiculum and the dentate gyrus, whereas reduced activity in the entorhinal cortex may be an early indicator of Alzheimer’s disease (14).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [14]
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A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields
Ogawa, S., Lee, T., Nayak, A. S., & Glynn, P. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140108 · Cited by 2,269
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180
Evaluating storage, retention, and retrieval in disordered memory and learning
Buschke, H., & Fuld, P. (1974) · Neurology · doi:10.1212/wnl.24.11.1019 · Cited by 1,614
Thulborn, K. R., Waterton, J. C., Matthews, P. M., & Radda, G. K. (1982) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(82)90333-6 · Cited by 1,134
On the role of the hippocampus in learning and memory in the rat.
Jarrard, L. E. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90664-4 · Cited by 1,125
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Evolution of the neuropathology of Alzheimer's disease
Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
Rapp, P. R., & Gallagher, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9926 · Cited by 658
Flagged first, then by citations
Research works printed but not linked: 3
- Amaral DG, The human nervous system
- Wechsler D, 1981, WAIS‐R manual
- Benton AL, 1967, FAS test. Neurosensory Center comprehensive examination for aphasia
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Bernardo, J. A. (2022) · theses.fr (ABES) · doi:10.70675/389ded6dz4486z434cz8806ze1df16edb36c
Antonenko, D., Thams, F., Flöel, A., & Hayek, D. (2019) · OSF Preprints (OSF Preprints)
Impact of aging on neck vasculature and brain biochemistry in female mice
Jones, A. W., Jarrahi, A., Karpowich, K., Moody, E., Renner, L., Brown, L. P., Tressler, C. M., & Crouch, A. C. (2026) · Physiological Reports · doi:10.14814/phy2.71059
Differential Retrieval of Contextual Fear‐Conditioned Memory in Adolescent and Adult Rats
Jha, V. M., & Jha, S. K. (2026) · Behavioural Processes · doi:10.1016/j.beproc.2026.105434
Associative and Error-Driven Learning in Younger and Older Adults
Groves, C. B. T. (2011) · TopSCHOLAR (Western Kentucky University)
Metadata
- Authors
- Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., & Stern, Y.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Small, Scott A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2002-02-28
- Volume
- 51
- Issue
- 3
- Pages
- 290-295
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2107406220
- Cited by
- 205
- References
- 27
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 13
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (AG08702, AG 00949, P50AG008702)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampal function, memory decline, normal aging, hippocampal subfields, subiculum, dentate gyrus, entorhinal cortex, hippocampal circuitry
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Memory Disorders, Middle Aged, Reference Values, Entorhinal Cortex, Dentate Gyrus
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