Cited by 206Dementia and Cognitive Impairment ResearchMemory and Neural MechanismsMemory Processes and Influences

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Imaging hippocampal function across the human life span: Is memory decline normal or not?

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Small, Scott A., Tsai, Wei Yann, DeLaPaz, Robert, Mayeux, Richard, Stern, Yaakov·2002·Annals of Neurology

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Abstract

Memory function commonly declines in later life. Whether memory decline represents a disease process or whether it is part of normal aging remains unknown. Here we answer this question by assessing the function of multiple subregions that make up the hippocampal circuit across the human life span. A newly developed MRI approach—designed to detect functional changes in individual hippocampal subregions—was used to assess the hippocampal circuit in 70 subjects between 20 and 88 years of age. Using strict parametric criteria, analysis revealed that function in two hippocampal subregions—the subiculum and the dentate gyrus—decline normally with age. In contrast, function in the entorhinal cortex declines pathologically. Single‐subject analysis revealed that hippocampal dysfunction, found in 60% of elders was selectively correlated with memory decline. These results show that memory decline is caused by different mechanisms and suggests how memory decline should be approached clinically.

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A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields
Ogawa, S., Lee, T., Nayak, A. S., & Glynn, P. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140108 · Cited by 2,269
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180
Evaluating storage, retention, and retrieval in disordered memory and learning
Buschke, H., & Fuld, P. (1974) · Neurology · doi:10.1212/wnl.24.11.1019 · Cited by 1,614
Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field
Thulborn, K. R., Waterton, J. C., Matthews, P. M., & Radda, G. K. (1982) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(82)90333-6 · Cited by 1,134
On the role of the hippocampus in learning and memory in the rat.
Jarrard, L. E. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90664-4 · Cited by 1,125
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Evolution of the neuropathology of Alzheimer's disease
Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
Rapp, P. R., & Gallagher, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9926 · Cited by 658

Show all 27 references

Research works printed but not linked: 3

Amaral DG, The human nervous system
Wechsler D, 1981, WAIS‐R manual
Benton AL, 1967, FAS test. Neurosensory Center comprehensive examination for aphasia

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Ranney, A., & Petro, M. S. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832f0193 · Cited by 43
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Hanert, A., Rave, J., Granert, O., Ziegler, M., Pedersen, A., Jan Born, A., Finke, C., & Bartsch, T. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.046 · Cited by 38
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Benarroch, E. E. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a9a156 · Cited by 40
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Fjell, A. M., Walhovd, K. B., Reinvang, I., Lundervold, A., Dale, A. M., Quinn, B. T., Makris, N., & Fischl, B. R. (2005) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617705050046 · Cited by 33
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Authors: Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., & Stern, Y.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Small, Scott A.
ORCID: Small, Scott A.
Mayeux, Richard
Stern, Yaakov
Venue: Annals of Neurology
Publisher: Wiley
Published: 2002-02-28
Volume: 51
Issue: 3
Pages: 290-295
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.10105
OpenAlex: W2107406220
Cited by: 205
References: 27
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 13
FWCI: 7.49
Type: journal article
Language: en
Open access: green
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Columbia Academic Commons (Columbia University)
Funders: National Institute on Aging (AG08702, AG 00949, P50AG008702)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: hippocampal function, memory decline, normal aging, hippocampal subfields, subiculum, dentate gyrus, entorhinal cortex, hippocampal circuitry
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Memory Disorders, Middle Aged, Reference Values, Entorhinal Cortex, Dentate Gyrus

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Imaging hippocampal function across the human life span: Is memory decline normal or not?

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