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Cited by 818Parkinson's Disease Mechanisms and TreatmentsCoffee research and impactsNuclear Receptors and Signaling

The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.

A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

Hernán, Miguel A., Takkouche, Bahi, Caamaño‐Isorna, Francisco, Gestal‐Otero, Juan J.·2002·Annals of Neurology
DOI 10.1002/ana.10277
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Abstract

We conducted a systematic review to summarize the epidemiological evidence on the association between cigarette smoking, coffee drinking, and the risk of Parkinson's disease. Case–control and cohort studies that reported the relative risk of physician‐confirmed Parkinson's disease by cigarette smoking or coffee drinking status were included. Study‐specific log relative risks were weighted by the inverse of their variances to obtain a pooled relative risk and its 95% confidence interval (CI). Results for smoking were based on 44 case–control and 4 cohort studies, and for coffee 8 case–control and 5 cohort studies. Compared with never smokers, the relative risk of Parkinson's disease was 0.59 (95% CI, 0.54–0.63) for ever smokers, 0.80 (95% CI, 0.69–0.93) for past smokers, and 0.39 (95% CI, 0.32–0.47) for current smokers. The relative risk per 10 additional pack‐years was 0.84 (95% CI, 0.81–0.88) in case–control studies and 0.78 (95% CI, 0.73–0.84) in cohort studies. Compared with non–coffee drinkers, relative risk of Parkinson's disease was 0.69 (95% CI, 0.59–0.80) for coffee drinkers. The relative risk per three additional cups of coffee per day was 0.75 (95% CI, 0.64–0.86) in case–control studies and 0.68 (95% CI, 0.46–1.00) in cohort studies. This meta‐analysis shows that there is strong epidemiological evidence that smokers and coffee drinkers have a lower risk of Parkinson's disease. Further research is required on the biological mechanisms underlying this potentially protective effect.

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Citations

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Research works printed but not linked: 4

  1. Zuber M, 1991, Smoking and Parkinson's disease: differences according to age at disease onset, Neuroepidemiology, 10, 103
  2. Willems‐Giesbergen PCLM, 2001, Smoking, alcohol, and coffee consumption and the risk of PD: results from the Rotterdam Study, Neurology, 54, A347
  3. Wolf PA, 1991, Precursors and natural history of Parkinson's disease: the Framingham Study, Neurology, 41, 371
  4. Fink JS, 2001, Caffeine intake and the risk of incident Parkinson's disease: the Framingham Study [abstract], Mov Disord, 16, 984

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Metadata

Authors
Hernán, M. A., Takkouche, B., Caamaño‐Isorna, F., & Gestal‐Otero, J. J.
Affiliations
Universidade de Santiago de Compostela (ES)
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2002-05-29
Volume
52
Issue
3
Pages
276-284
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.10277
OpenAlex
W2053969387
Cited by
818
References
62
Citations by year
2026: 21 · 2025: 28 · 2024: 24 · 2023: 35 · 2022: 28 · 2021: 48 · 2020: 41 · 2019: 36 · 2018: 31 · 2017: 43 · 2016: 36 · 2015: 44 · 2014: 43 · 2013: 40 · 2012: 35
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, coffee consumption, cigarette smoking, pack-years, disease risk, protective factors, neurodegeneration
MeSH terms
Coffee, Humans, Parkinson Disease, Risk Factors, Smoking, Cohort Studies, Case-Control Studies

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