Depression and suicide attempt as risk factors for incident unprovoked seizures

Hesdorffer, Dale C.; Hauser, W. Allen; Olafsson, Elias; Ludvigsson, Petur; Kjartansson, Olafur

doi:10.1002/ana.20685

Cited by 524Epilepsy research and treatmentSuicide and Self-Harm StudiesElectroconvulsive Therapy Studies

Depression and suicide attempt as risk factors for incident unprovoked seizures

Hesdorffer, Dale C., Hauser, W. Allen, Olafsson, Elias, Ludvigsson, Petur, Kjartansson, Olafur·2006·Annals of Neurology

DOI 10.1002/ana.20685

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Abstract

Major depression has been shown to increase the risk for development of epilepsy, but prior studies have not evaluated whether this is due to specific symptoms of depression. We conducted a population‐based case–control study of all newly diagnosed unprovoked seizures among Icelandic children and adults aged 10 years and older to test the hypothesis that major depression is a risk factor for developing unprovoked seizure and epilepsy, and to address whether specific symptoms of depression account for this increased risk. Cases were matched to the next two same sex births from the population registry. Using standardized interviews, we ascertained symptoms of major depression to make a Diagnostic and Statistical Manual, Fourth Edition (DSM‐IV) diagnosis. A history of major depression was 1.7‐fold more common among cases than among controls (95% confidence interval, 1.1–2.7). A history of attempted suicide was 5.1‐fold more common among cases than among controls (95% confidence interval, 2.2–11.5). Attempted suicide increased seizure risk even after adjusting for age, sex, cumulative alcohol intake, and major depression or number of symptoms of depression. Major depression and attempted suicide independently increase the risk for unprovoked seizure. These data suggest that depression and suicide attempt may be due to different underlying neurochemical pathways, each of which is important in the development of epilepsy. Ann Neurol 2005

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Both population-based and experimental studies in human and animal models have demonstrated a robust relationship between seizures and psychiatric disorders.
“Both population-based and experimental studies in human and animal models have demonstrated a robust relationship between seizures and psychiatric disorders.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [12]

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Authors: Hesdorffer, D. C., Hauser, W. A., Olafsson, E., Ludvigsson, P., & Kjartansson, O.
Affiliations: Columbia University (US)
Corresponding author: Hesdorffer, Dale C.
ORCID: Hesdorffer, Dale C.
Hauser, W. Allen
Venue: Annals of Neurology
Publisher: Wiley
Published: 2005-12-22
Volume: 59
Issue: 1
Pages: 35-41
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.20685
OpenAlex: W1991938716
Cited by: 524
References: 37
Citations by year: 2026: 10 · 2025: 4 · 2024: 29 · 2023: 14 · 2022: 19 · 2021: 28 · 2020: 18 · 2019: 20 · 2018: 23 · 2017: 32 · 2016: 29 · 2015: 31 · 2014: 41 · 2013: 33 · 2012: 38
FWCI: 12.03
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Hirsla (Landspítali University Hospital) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS032663, 5R01 NS 32663)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords: major depressive disorder, suicide attempts, unprovoked seizures, epilepsy, seizure risk factors, depressive symptoms, neurochemical pathways, alcohol consumption
MeSH terms: Adolescent, Adult, Child, Depression, Epilepsy, Female, Humans, Iceland, Male, Middle Aged, Risk Factors, Seizures, Suicide, Attempted

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Depression and suicide attempt as risk factors for incident unprovoked seizures

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