The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Abstract
OBJECTIVE: A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core Diagnostic and Statistical Manual (of Mental Disorders) Fourth Edition criteria for substance dependence (dopamine dysregulation syndrome [DDS]). We aimed to evaluate levodopa-induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients. METHODS: We used a two-scan positron emission tomography protocol to calculate the percentage change in (11)C-raclopride binding potential from a baseline withdrawal (off drug) state to the binding potential after an oral dose of levodopa. We related the subjective effects of levodopa to the effects on endogenous dopamine release of a pharmacological challenge with levodopa in eight control PD patients and eight patients with DDS. RESULTS: PD patients with DDS exhibited enhanced levodopa-induced ventral striatal dopamine release compared with levodopa-treated patients with PD not compulsively taking dopaminergic drugs. The sensitized ventral striatal dopamine neurotransmission produced by levodopa in these individuals correlated with self-reported compulsive drug "wanting" but not "liking" and was related to heightened psychomotor activation (punding). INTERPRETATION: This provides evidence that links sensitization of ventral striatal circuitry in humans to compulsive drug use.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Evans et al., 2006
In the citing paper
“Dopamine surges in nucleus accumbens evoked by addictive amphetamine or by L-DOPA correlate poorly with human subjective liking ratings of the drug - but do control their subjective wanting ratings to take more of that drug (Leyton et al., 2002; Evans et al., 2006).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Evans et al., 2006
In the citing paper
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Evans et al., 2006
Citations
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Carver, C. S., & White, T. L. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.2.319 · Cited by 7,306
A psychobiological model of temperament and character
Cloninger, C. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820240059008 · Cited by 5,458
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
(1994) · Cited by 2,675
Recent Developments in Parkinson's Disease
Hurtig, H. I. (1987) · Neurology · doi:10.1212/wnl.37.5.893 · Cited by 1,925
Behavioral expressions and biosocial bases of sensation seeking
Corr, P. J. (1995) · Personality and Individual Differences · doi:10.1016/0191-8869(95)90059-4 · Cited by 1,525
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Cited by
Sorted by citations
Items 401–473 of 473
DOPAMINE DYSREGULATION SYNDROME IN PARKINSON’S DISEASE AND APPROACHES TO ITS CORRECTION WITH DRUGS
Omarova, S. M., & Федорова, Н. В. (2017) · The Clinician · doi:10.17650/1818-8338-2016-10-4-81-85
Smart, K. A. (2013) · TSpace (University of Toronto)
Arulkadacham, L. (2017) · Figshare
Balasubramani, P. P., Chakravarthy, V. S., Ravindran, B., & Moustafa, A. A. (2018) · Cognitive science and technology · doi:10.1007/978-981-10-8494-2_13
Neill, V. (2018) · Digital Commons (Liberty University)
Divergent Temporal Courses for Liking vs. Wanting in Response to PersuasionPreprint
Joo, M., Liu, W. J., & Wilbur, K. C. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3240533
The Importance of the Temporal Pattern of Drug Use in Addiction
Kawa, A. (2018) · Deep Blue (University of Michigan)
Thobois, S., & Broussolle, E. (2011) · Elsevier eBooks · doi:10.1016/b978-2-294-71153-4.00011-1
이지영 (2014) · Seoul National University Open Repository (Seoul National University)
Fugariu, V. (2018) · TSpace (University of Toronto)
Compton, W. M., & Blanco, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.001
Novel Psychoactive Substances: A New Challenge for Prevention and Treatment
Kapitány‐Fövény, M., Corazza, O., Marrinan, S., & Demetrovics, Z. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.032
Human Laboratory Paradigms in Addictions Research
Morris, V. L., Arshad, F., Balodis, I. M., Reed, D. D., MacKillop, J. M., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.010
Anhedonia in Addictive Behaviors
Dyer, W. G., Leventhal, A. M., Goldenson, N. I., & Bello, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.039
American Legal Issues in Addiction Treatment and Research
Willick, D. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.041
Strack, R. W., Orsini, M. M., Ewald, D. R., & Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.019
Psychiatric Disorders, Personality, and Developmental Factors
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.009
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.015
Use Disorders of Cocaine and Methamphetamine
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.014
Tranquilizers and Sedative Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.016
Nikolova, Y. S. (2014) · DukeSpace (Duke University)
Briand, L. A. (2007) · Deep Blue (University of Michigan)
Barbosa, P., & Lees, A. J. (2021) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2021-e011
Self-citationSchnitzler, A., & Pollok, B. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2768957.2434055
Brooks, D. J. (2013) · Informa Healthcare eBooks · doi:10.3109/9781841849096.011
Self-citationClinical and Research Methods in the Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.008
PET and SPECT in Psychiatric Complications of Parkinson’s Disease
Kaasinen, V. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_8
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.018
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.001
The Biopsychosocial Perspective and Research Methods for Investigation of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.002
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.010
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.004
Genetic Influence on Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.007
Levels of Analysis and Etiology
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.014
Brain Function and Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.006
Tobacco Use and Nicotine Addiction
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.012
Ongoing and Future Research Directions
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.030
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.002
Behavioral, Cognitive, and Social Factors Promoting SUD
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.008
Srivastava, A. B., & Gold, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.033
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.005
Diagnosis of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.003
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.011
Treatment of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.017
Impulse Control Disorders and the Dopamine Dysregulation Syndrome
Djamshidian, A., Pagnier, G. J., Frank, M. J., & Friedman, J. H. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009039291.021
Stoessl, A. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0434-1.00038-4
Management of treatment-related behavioral disturbances in Parkinson's disease
Pandya, M. A., Nacopoulos, D. A., & Khokhar, N. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781107284210.014
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.042
Szarpak, J., Drożak, P., Piwoński, M., Wróblewski, H., & Morylowska-Topolska, J. (2022) · Current Problems of Psychiatry · doi:10.2478/cpp-2022-0021
Modulação da atividade encefálica pelo canabidiol em camundongos tratados com cocaína
Spelta, L. E. W. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2022.tde-01122022-181624
Determining the Frequency of Restless Legs Syndrome in the Adult Population
Kıskaç, N., & Zorlu, M. (2023) · Bezmialem Science · doi:10.14235/bas.galenos.2023.36036
Case Reports in Movement Disorders - volume III - 2023
(2024) · Frontiers research topics · doi:10.3389/978-2-8325-4678-9
Frucht, S. J., & Termsarasab, P. (2024) · Springer eBooks · doi:10.1007/978-3-031-52573-5_2
Clinical management model for impulse control disorders in Parkinson’s disease
Li, H., Yang, Y., Yang, L., & Xie, A. (2024) · CNS Spectrums · doi:10.1017/s1092852924000403
The Effect and Mechanism of Magnesium Valproate on Methamphetamine‐Addicted Rats
Li, Y., Wang, L., Sun, Y., & Wang, X. (2025) · Addiction Biology · doi:10.1111/adb.70084
PET and SPECT in Psychiatric Complications of Parkinson’s Disease
Kaasinen, V. (2014) · Springer eBooks · doi:10.1007/978-3-642-40384-2_10
Attention and novelty processing in stroke and Parkinson's disease
Singh‐Curry, V. (2011) · UCL Discovery (University College London)
Étude moléculaire et comportementale de la variabilité de réponse à la cocaïne
Martinez, L. A. A. (2021) · theses.fr (ABES) · doi:10.70675/c394f299z9930z4d9fzb9ecz074185fe9fee
Neumane, S. (2011) · theses.fr (ABES) · doi:10.70675/4cb9b747z6b13z46eazb3cbzb58a8bffabf2
Bases génétiques des troubles du contrôle des impulsions dans la maladie de Parkinson
Bekadar, S. (2021) · theses.fr (ABES) · doi:10.70675/2479c7b7zf902z4f82zb884z73019fdf9661
Goutaudier, R. (2022) · theses.fr (ABES) · doi:10.70675/6619b466z54bfz41e3z8a90zf0967825d579
Fleury, V., Pirondini, E., Benis, D., Corbet, T., Thorens, G., Lüscher, C., & Krack, P. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70118
Understanding Neuropsychiatric Fluctuations in Parkinson's Disease: From Mechanisms to Management
Sousa, M., Amstutz, D., Natera‐Villalba, E., Krack, P., & Martínez‐Fernández, R. (2026) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.70771
Substance-related visual cues alter sensory gating in adults who regularly use methamphetamine
Huang, P., Arif, Y., Schantell, M. D., Glesinger, R. J., Horne, L. K., Coutant, A. T., Okelberry, H. J., Ende, G. C., Garrison, G. M., Luca, K. R. D., et al. (2026) · Psychological Medicine · doi:10.1017/s0033291726105686
Park, J. H. (2026) · Brain Sciences · doi:10.3390/brainsci16101081
Chugani, B. (2012) · TSpace (University of Toronto)
Metadata
- Authors
- Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Hammersmith Hospital (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- Corresponding author
- Piccini, Paola
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2006-03-23
- Volume
- 59
- Issue
- 5
- Pages
- 852-858
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2115622614
- Cited by
- 473
- References
- 52
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 15 · 2021: 17 · 2020: 76 · 2019: 10 · 2018: 25 · 2017: 20 · 2016: 17 · 2015: 30 · 2014: 23 · 2013: 30 · 2012: 30
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- dopamine dysregulation syndrome, compulsive drug use, Parkinson's disease, ventral striatum, dopamine signaling, levodopa challenge, dopamine release, punding, drug liking, substance dependence
- MeSH terms
- Aged, Brain Mapping, Dopamine, Exploratory Behavior, Female, Humans, Levodopa, Male, Middle Aged, Synaptic Transmission, Psychological Tests, Dopamine Agents, Neostriatum, Receptors, Dopamine D2, Dopamine Antagonists, Substance-Related Disorders, Raclopride, Positron-Emission Tomography, Receptors, Dopamine D3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
