The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Abstract
OBJECTIVE: A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core Diagnostic and Statistical Manual (of Mental Disorders) Fourth Edition criteria for substance dependence (dopamine dysregulation syndrome [DDS]). We aimed to evaluate levodopa-induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients. METHODS: We used a two-scan positron emission tomography protocol to calculate the percentage change in (11)C-raclopride binding potential from a baseline withdrawal (off drug) state to the binding potential after an oral dose of levodopa. We related the subjective effects of levodopa to the effects on endogenous dopamine release of a pharmacological challenge with levodopa in eight control PD patients and eight patients with DDS. RESULTS: PD patients with DDS exhibited enhanced levodopa-induced ventral striatal dopamine release compared with levodopa-treated patients with PD not compulsively taking dopaminergic drugs. The sensitized ventral striatal dopamine neurotransmission produced by levodopa in these individuals correlated with self-reported compulsive drug "wanting" but not "liking" and was related to heightened psychomotor activation (punding). INTERPRETATION: This provides evidence that links sensitization of ventral striatal circuitry in humans to compulsive drug use.
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“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Evans et al., 2006
In the citing paper
“Dopamine surges in nucleus accumbens evoked by addictive amphetamine or by L-DOPA correlate poorly with human subjective liking ratings of the drug - but do control their subjective wanting ratings to take more of that drug (Leyton et al., 2002; Evans et al., 2006).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Evans et al., 2006
In the citing paper
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Evans et al., 2006
Citations
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Carver, C. S., & White, T. L. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.2.319 · Cited by 7,306
A psychobiological model of temperament and character
Cloninger, C. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820240059008 · Cited by 5,458
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
(1994) · Cited by 2,675
Recent Developments in Parkinson's Disease
Hurtig, H. I. (1987) · Neurology · doi:10.1212/wnl.37.5.893 · Cited by 1,925
Behavioral expressions and biosocial bases of sensation seeking
Corr, P. J. (1995) · Personality and Individual Differences · doi:10.1016/0191-8869(95)90059-4 · Cited by 1,525
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,360
Conditioned place preference: what does it add to our preclinical understanding of drug reward?
Bardo, M. T., & Bevins, R. A. (2000) · Psychopharmacology · doi:10.1007/s002130000569 · Cited by 1,274
Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924
Studholme, C., Hill, D., & Hawkes, D. (1997) · Medical Physics (Lancaster) · doi:10.1118/1.598130 · Cited by 753
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
Piccini, P. P., Brooks, D. J., Björklund, A., Gunn, R. N., Grasby, P. M., Rimoldi, O. E., Brundin, P., Hagell, P., Rehncrona, S., Widner, H., et al. (1999) · Nature Neuroscience · doi:10.1038/16060 · Cited by 700
Self-citationChildhood Personality Predicts Alcohol Abuse in Young Adults
Cloninger, C. R., Sigvardsson, S., & Bohman, M. (1988) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1988.tb00232.x · Cited by 694
Psychobiology of novelty seeking and drug seeking behavior
Bardo, M. T., Donohew, R. L., & Harrington, N. G. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00203-0 · Cited by 667
Giovannoni, G. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.4.423 · Cited by 587
Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward?
Bechara, A., Dolan, S., & Hindes, A. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00016-7 · Cited by 580
Pathological Gambling Caused by Drugs Used to Treat Parkinson Disease
Dodd, M. L., Klos, K. J., Bower, J. H., Geda, Y. E., Josephs, K. A., & Ahlskog, J. E. (2005) · Archives of Neurology · doi:10.1001/archneur.62.9.noc50009 · Cited by 563
Personality and substance use disorders: A prospective study.
Sher, K. J., Bartholow, B. D., & Wood, M. D. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.5.818 · Cited by 483
Leyton, M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00366-4 · Cited by 476
Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome
Evans, A. H., Katzenschlager, R., Paviour, D. C., O’Sullivan, J. D., Appel, S., Lawrence, A. D., & Lees, A. J. (2004) · Movement Disorders · doi:10.1002/mds.20045 · Cited by 474
Self-citationBIS/BAS levels and psychiatric disorder: An epidemiological study
Johnson, S. L., Turner, R. J., & Iwata, N. (2003) · Journal of Psychopathology and Behavioral Assessment · doi:10.1023/a:1022247919288 · Cited by 458
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436
Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome
Evans, A., Katzenschlager, R., Paviour, D. C., Appel‐Cresswell, S., Lawrence, A., & Lees, A. J. (2004) · UCL Discovery (University College London) · Cited by 401
Self-citationPathological gambling associated with dopamine agonist therapy in Parkinson’s disease
Driver‐Dunckley, E. D., Samanta, J., & Stacy, M. A. (2003) · Neurology · doi:10.1212/01.wnl.0000076478.45005.ec · Cited by 317
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300420 · Cited by 306
Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?
Lawrence, A. D., Evans, A. H., & Lees, A. J. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00529-5 · Cited by 287
Self-citationDopamine dysregulation syndrome in Parkinson's disease
Evans, A. H., & Lees, A. J. (2004) · Current Opinion in Neurology · doi:10.1097/01.wco.0000137528.23126.41 · Cited by 257
Self-citationRelationship between reward-enhancing and stereotypical effects of psychomotor stimulant drugs
ROBBINS, T. W. (1976) · Nature · doi:10.1038/264057a0 · Cited by 241
Neural and psychological mechanisms underlying appetitive learning: links to drug addiction
Cardinal, R. N., & Everitt, B. J. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.004 · Cited by 218
Motivational deficits after brain injury: effects of bromocriptine in 11 patients.
Powell, J. H., Al‐Adawi, S., Morgan, J., & Greenwood, R. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.4.416 · Cited by 213
Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease
Evans, A. H., Lawrence, A. D., Potts, J., Appel, S., & Lees, A. J. (2005) · Neurology · doi:10.1212/01.wnl.0000184487.72289.f0 · Cited by 207
Self-citationEndogenous dopamine release after pharmacological challenges in Parkinson's disease
Piccini, P., Pavese, N., & Brooks, D. (2003) · Annals of Neurology · doi:10.1002/ana.10526 · Cited by 157
Self-citationIndividual Differences in Behavioral and Subjective Responses to Alcohol
de Wit, H., UHLENHUTH, E. H., Pierri, J. N., & Johanson, C. E. (1987) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1987.tb01263.x · Cited by 132
Zilberman, M. L., Tavares, H., & el‐Guebaly, N. (2003) · BMC Psychiatry · doi:10.1186/1471-244x-3-1 · Cited by 120
Mahieux, F., Michelet, D., Manifacier, M.-J., Boller, F., Fermanian, J., & Guillard, A. (1995) · Behavioural Neurology · doi:10.1155/1995/304876 · Cited by 116
Fiorino, D. F., & Phillips, A. G. (1999) · Psychopharmacology · doi:10.1007/s002130050880 · Cited by 110
Capper-Loup, C., Canales, J. J., Kadaba, N., & Graybiel, A. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06218.2002 · Cited by 108
Nocjar, C., & Panksepp, J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00321-7 · Cited by 106
van der Kooy, D., Swerdlow, N. R., & Koob, G. F. (1983) · Brain Research · doi:10.1016/0006-8993(83)91071-5 · Cited by 100
The Natural History of Parkinson’s Disease in the Pre-Levodopa and Post-Levodopa Eras
Hoehn, M. M. M. (1992) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30213-5 · Cited by 95
Mahieux, F., Michelet, D., Manifacier, M.-J., et al. (1995) · PubMed · doi:10.3233/ben-1995-8102 · Cited by 89
Meszaros, K., Lenzinger, E., Hornik, K., Füreder, T., Willinger, U., Fischer, G., Schönbeck, G., Aschauer, H. N., & on behalf of The European Fluvoxamine in Alcoholism Study Group (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04141.x · Cited by 82
The Rate of Intravenous Cocaine Administration Determines Susceptibility to Sensitization
Samaha, A., Li, Y., & Robinson, T. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03244.2002 · Cited by 76
Psychiatric aspects in Parkinsonism treated with L-dopa
Damásio, A. R., Lobo-Antunes, J., & Macedo, C. (1971) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.34.5.502 · Cited by 75
Bearn, J., Evans, A. H., Kelleher, M., Turner, K., & Lees, A. J. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.06.005 · Cited by 52
Self-citationAudrain-McGovern, J. E., Tercyak, K. P., Shields, A. E., Bush, A., Espinel, C. F., & Lerman, C. E. (2003) · Health Communication · doi:10.1207/s15327027hc1504_07 · Cited by 32
L-dopa, behavioral activation and psychopathology.
Dl, M. (1972) · PubMed · Cited by 30
Katajamäki, J., Honkanen, A., Piepponen, P. T., Lindén, I., Zharkovsky, A., & Ahtee, L. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00394-8 · Cited by 17
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Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
Liking, wanting, and the incentive-sensitization theory of addiction
Berridge, K. C., & Robinson, T. E. (2016) · American Psychologist · doi:10.1037/amp0000059 · Cited by 1,440
Metadata
- Authors
- Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Hammersmith Hospital (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- Corresponding author
- Piccini, Paola
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2006-03-23
- Volume
- 59
- Issue
- 5
- Pages
- 852-858
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2115622614
- Cited by
- 473
- References
- 52
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 15 · 2021: 17 · 2020: 76 · 2019: 10 · 2018: 25 · 2017: 20 · 2016: 17 · 2015: 30 · 2014: 23 · 2013: 30 · 2012: 30
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- dopamine dysregulation syndrome, compulsive drug use, Parkinson's disease, ventral striatum, dopamine signaling, levodopa challenge, dopamine release, punding, drug liking, substance dependence
- MeSH terms
- Aged, Brain Mapping, Dopamine, Exploratory Behavior, Female, Humans, Levodopa, Male, Middle Aged, Synaptic Transmission, Psychological Tests, Dopamine Agents, Neostriatum, Receptors, Dopamine D2, Dopamine Antagonists, Substance-Related Disorders, Raclopride, Positron-Emission Tomography, Receptors, Dopamine D3
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