Cited by 293Historical and Modern Theater StudiesCognitive Functions and MemoryDementia and Cognitive Impairment Research

Dysexecutive syndrome: diagnostic criteria and validation study

Godefroy, Olivier, Azouvi, Philippe, Robert, Philippe, Roussel, Martine, LeGall, Didier, Meulemans, Thierry, Behalf of the Groupe de Réflexion sur l'Evaluation des Fonctions Exécutives Study Group·2010·Annals of Neurology

Abstract

OBJECTIVE: Disorders of executive functions are among the most frequent cognitive deficits, but they remain poorly defined and are subject to heterogeneous assessment. To address this major issue, the Groupe de Réflexion sur l'Evaluation des Fonctions Exécutives (GREFEX) group has proposed criteria for behavioral and cognitive dysexecutive syndromes and has designed a battery including a specific heteroquestionnaire and 7 cognitive tests. We investigated the frequency of behavioral and cognitive dysexecutive disorders in patients suffering from various diseases and the association of these disorders with loss of autonomy. METHODS: A total of 461 patients aged between 16 and 90 years with severe traumatic brain injury, stroke, mild cognitive impairment, Alzheimer disease, multiple sclerosis, and Parkinson disease were recruited into this prospective cohort study by 21 centers between September 2003 and June 2006. Behavioral and cognitive dysexecutive disorders were examined using the GREFEX battery. RESULTS: A dysexecutive syndrome was observed in 60% of patients, concerning both behavioral and cognitive domains in 26% and dissociated in 34%. All behavioral and cognitive dysexecutive disorders discriminated (p = 0.001, all) patients from controls. The pattern of cognitive syndrome differed (p = 0.0001) according to the disease. Finally, behavioral (odds ratio [OR], 4.6; 95% confidence interval [CI], 2. 3-9.1; p = 0.0001) and cognitive (OR, 3.36; 95% CI, 1.7-6.6; p = 0.001) dysexecutive syndromes and Mini Mental State Examination score (OR, 0.79; 95% CI, 0.68-0.91; p = 0.002) were independent predictors of loss of autonomy. INTERPRETATION: This study provided criteria of dysexecutive syndrome and showed that both behavioral and cognitive syndromes contribute to loss of autonomy. Profiles vary across patients and diseases, and therefore systematic assessment of behavioral and cognitive disorders in reference to diagnostic criteria is needed.

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Crossref · 10.1002/ana.22117

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  • Cognition is affected early and progresses with disease severity and involves dopaminergic, serotoninergic, noradrenergic, and cholinergic systems.

    “Cognition is affected early and progresses with disease severity and involves a number of neurotransmitter systems including dopaminergic, serotoninergic, noradrenergic, and cholinergic 60, 61.”

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Authors
Godefroy, O., Azouvi, P., Robert, P., Roussel, M., LeGall, D., Meulemans, T., & Behalf of the Groupe de Réflexion sur l'Evaluation des Fonctions Exécutives Study Group
Affiliations
  • Centre Hospitalier Universitaire Amiens-Picardie (FR)
  • Hôpital Raymond-Poincaré (FR)
  • Centre Hospitalier Universitaire de Nice (FR)
  • Université d'Angers (FR)
  • University of Liège (BE)
Corresponding author
Godefroy, Olivier
Venue
Annals of Neurology
Publisher
Wiley
Published
2010-12
Volume
68
Issue
6
Pages
855-864
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2098389807
Cited by
293
References
44
Citations by year
2026: 5 · 2025: 14 · 2024: 16 · 2023: 21 · 2022: 17 · 2021: 20 · 2020: 14 · 2019: 19 · 2018: 19 · 2017: 28 · 2016: 24 · 2015: 23 · 2014: 19 · 2013: 29 · 2012: 17
FWCI
18.93
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
dysexecutive syndrome, executive dysfunction, diagnostic criteria, loss of autonomy, traumatic brain injury, stroke, mild cognitive impairment, Alzheimer's disease, multiple sclerosis, Parkinson's disease, cognitive assessment
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cognition Disorders, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Personality Disorders, Personal Autonomy, Young Adult, Executive Function

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