Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype Are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
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Background: The Apolipoprotein E4 (ApoE4) genotype is strongly associated with Alzheimer’s disease (AD), although the presence of the ApoE4 allele alone is not sufficient to explain AD. The pathophysiology of amnestic mild cognitive impairment (aMCI) remains unclear. Objective: This study aims to examine associations between peripheral blood biomarkers coupled with ApoE4 and episodic and semantic memory. Methods: The CERAD battery was completed and various biomarkers were assayed in 60 subjects with aMCI, 60 with AD, and 62 healthy controls. Results: Deficits in semantic and episodic memory were significantly predicted by anion gap and bicarbonate, albumin, and glucose coupled with ApoE4. Furthermore, these peripheral biomarkers interacted with ApoE to predict greater memory impairments. Conclusions: Peripheral blood biomarkers may interact with pathways related to ApoE4 to predict greater semantic and episodic memory impairments, thus contributing to the pathophysiology of aMCI and AD. Our data suggest that the transition from aMCI to AD could at least in some cases be associated with significant interactions between ApoE4 and those peripheral blood biomarkers.
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The anti-epileptic drug gabapentin, which inhibits BCATc, has proved successful in treating behavioural alterations in subjects with AD.
“In addition, the anti-epileptic drug gabapentin, which inhibits BCATc, has proved successful in treating behavioural alterations in subjects with AD (Cooney et al. 2013; Supasitthumrong et al. 2019).”
From Alzheimer’s disease: Targeting the glutamatergic system (2020) · cites this paper as Supasitthumrong et al. 2019
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Alzheimer’s disease: Targeting the glutamatergic system
Conway, M. E. (2020) · Biogerontology · doi:10.1007/s10522-020-09860-4 · Cited by 180 · see citing works
- Authors
- Supasitthumrong, T., Tunvirachaisakul, C., Aniwattanapong, D., Tangwongchai, S., Chuchuen, P., Tawankanjanachot, I., Snabboon, T., Hemrungrojn, S., Carvalho, A. F., & Maes, M.
- Affiliations
- Chulalongkorn University (TH)
- Centre for Addiction and Mental Health (CA)
- Deakin University (AU)
- Corresponding author
- Maes, Michael
- ORCID
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2019-08-14
- Volume
- 71
- Issue
- 3
- Pages
- 797-811
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2911482820
- Cited by
- 13
- References
- 74
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- APOE ε4, amnestic mild cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Data Interpretation, Statistical, Female, Genotype, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Socioeconomic Factors, Verbal Behavior, Biomarkers, Neural Networks, Computer, Apolipoprotein E4, Cognitive Dysfunction
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